I. 1. Definition,

I. 2. Synthese and . .. De-la-thiamine-:,

I. 3. Roles and A. .. Apports-conseilles,

I. 5. Les and . .. De-beriberi-:,

I. 7. Triade and C. .. ,

I. 8. Prevalence and D. .. ,

I. 9. Description-de-l'etude-:,

I. I. Patients and . .. Methodes,

I. 1. Schema-de-l'etude-:,

I. 3. Dosage,

A. , S. , A. , F. De-risque, D. De et al.,

. D. Iv,

I. 2. Variabilite,

I. 3. Dosage,

I. 5. and I. .. ,

V. C. ,

B. .. ,

R. .. ,

L. Grusse, J. Watier, and B. , Les vitamines, p.303, 1993.

J. Koolman and K. H. Röhm, Atlas de poche de Biochimie humaine, p.529, 2011.

G. Brown, Defects of thiamine transport and metabolism, J Inherit Metab Dis, 2014.

D. O. Kennedy, B Vitamins and the Brain : Mechanisms, Dose and Efficacy-A Review, Nutrients, vol.8, issue.2, p.68, 2016.

G. Dabar, C. Harmouche, B. Habr, M. Riachi, and B. Jaber, Shoshin Beriberi in Critically-Ill patients: case series, Nutr J, vol.14, p.51, 2015.

D. W. Mccandless, S. Schenker, and M. Cook, Encephalopathy of thiamine deficiency: studies of intracerebral mechanisms, J Clin Invest, vol.47, issue.10, pp.2268-80, 1968.

M. Benatti, A. Pazin-filho, and C. H. Miranda, Reversal of refractory severe lactic acidosis by thiamine replacement, Am J Emerg Med, vol.35, issue.3, p.521, 2017.

F. Depeint, W. R. Bruce, N. Shangari, R. Mehta, O. Brien et al., Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism, Chem Biol Interact, vol.163, issue.1-2, pp.94-112, 2006.

E. Abdou and A. S. Hazell, Thiamine Deficiency: An Update of Pathophysiologic Mechanisms and Future Therapeutic Considerations, Neurochem Res, 2015.

G. Sechi and A. Serra, Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management, Lancet Neurol, vol.6, issue.5, pp.442-55, 2007.

C. Stroh, F. Meyer, and T. Manger, Beriberi, a severe complication after metabolic surgery-review of the literature, Obes Facts, vol.7, issue.4, pp.246-52, 2014.

G. Manzo, D. Gennaro, A. Cozzolino, A. Serino, A. Fenza et al., MR in alcoholic and nonalcoholic acute Wernicke's encephalopathy: a review, Biomed Res Int, p.503596, 2014.

M. Giacalone, R. Martinelli, A. Abramo, A. Rubino, V. Pavoni et al., Rapid reversal of severe lactic acidosis after thiamine administration in critically ill adults: a report of 3 cases, Nutr Clin Pract, vol.30, issue.1, pp.104-114, 2015.

G. Zuccoli, S. Cruz, D. Bertolini, M. Rovira, A. Gallucci et al., MR imaging findings in 56 patients with Wernicke encephalopathy: nonalcoholics may differ fromalcoholics, AJNR Am J Neuroradiol, vol.30, issue.1, pp.171-177, 2009.

R. Faigle, M. Mohme, and M. Levy, Dry beriberi mimicking Guillain-Barre syndrome as the first presenting sign of thiamine deficiency, Eur J Neurol, vol.19, issue.2, pp.14-19, 2012.

H. Koike, K. Misu, N. Hattori, S. Ito, M. Ichimura et al., Postgastrectomy polyneuropathy with thiamine deficiency, J Neurol Neurosurg Psychiatry, 2001.

K. J. Carpenter, The discovery of thiamin, Ann Nutr Metab, vol.61, issue.3, pp.219-242, 2012.

H. Koike, S. Ito, S. Morozumi, Y. Kawagashira, M. Iijima et al., Rapidly developing weakness mimicking Guillain-Barré syndrome in beriberi neuropathy:two case reports. Nutrition, pp.776-80, 2008.

D. Samanta, Dry beriberi preceded Wernicke's encephalopathy: Thiamine deficiency after laparoscopicsleeve gastrectomy, J Pediatr Neurosci, vol.10, issue.3, pp.297-306, 2015.

H. S. Lee, S. A. Lee, H. S. Shin, H. M. Choi, S. J. Kim et al., A case of cardiac beriberi : a forgotten but memorable disease, Korean Circ J, vol.43, issue.8, pp.569-72, 2013.

N. Misumida, H. Umeda, and M. Iwase, Shoshin beriberi induced by long-term administration of diuretics: a case report, Case Rep Cardiol, p.878915, 2014.

A. Guler, S. Alpaydin, H. Sirin, C. Calli, and N. Celebisoy, A non-alcoholic Wernicke's encephalopathy case with atypical MRI findings: Clinic versusradiology, Neuroradiol J, vol.28, issue.5, pp.474-481, 2015.

R. Galvin, G. Bråthen, A. Ivashynka, M. Hillbom, R. Tanasescu et al., EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy, Eur J Neurol, vol.17, issue.12, pp.1408-1426, 2010.

G. Zuccoli and N. Pipitone, Neuroimaging findings in acute Wernicke's encephalopathy: review of the literature, AJR Am J Roentgenol, vol.192, issue.2, pp.501-509, 2009.

K. Sriram, W. Manzanares, and K. Joseph, Thiamine in nutrition therapy, Nutr Clin Pract, vol.27, issue.1, pp.41-50, 2012.

C. A. Gayet, Affection encéphalique (encéphalite diffuse probable) localisée aux étages supérieurs des pédoncles cérébraux et aux couches optiques

C. G. Harper, M. Giles, F. , and R. , Clinical signs in the Wernicke-Korsakoff complex: a retrospective analysis of 131cases diagnosed at necropsy, J Neurol Neurosurg Psychiatry, vol.49, issue.4, pp.341-345, 1986.

A. D. Thomson, C. C. Cook, I. Guerrini, D. Sheedy, C. Harper et al., Wernicke's encephalopathy: 'Plus ça change, plus c'est la même chose, Alcohol Alcohol, 2008.

Y. C. Jung, S. Chanraud, and E. V. Sullivan, Neuroimaging of Wernicke's encephalopathy and Korsakoff's syndrome, Neuropsychol Rev, vol.22, issue.2, pp.170-80, 2012.

N. D. Ha, Y. C. Weon, J. C. Jang, B. S. Kang, and S. H. Choi, Spectrum of MR imaging findings in Wernicke encephalopathy: are atypical areas of involvement only present in nonalcoholic patients?, AJNR Am J Neuroradiol, vol.33, issue.7, pp.1398-402, 2012.

C. Harper, P. Fornes, C. Duyckaerts, D. Lecomte, and J. J. Hauw, An international perspective on the prevalence of the Wernicke-Korsakoff syndrome. Metab Brain Dis, vol.10, pp.17-24, 1995.

G. S. Day and C. M. Campo, Wernicke encephalopathy: a medical emergency, CMAJ, vol.186, issue.8, p.295, 2014.

M. T. Infante, R. Fancellu, A. Murialdo, L. Barletta, L. Castellan et al., Challenges in Diagnosis and Treatment of Wernicke Encephalopathy: Report of 2 Cases, Nutr Clin Pract, vol.31, issue.2, pp.186-90, 2016.

Y. Nakashima, K. Ito, H. Nakashima, A. Shirakawa, Y. Abe et al.,

, Wernicke's encephalopathy that developed during the introduction period of peritonealdialysis, Intern Med, vol.52, issue.18, pp.2093-2100, 2013.

O. Attard, J. L. Dietemann, P. Diemunsch, T. Pottecher, A. Meyer et al., Wernicke encephalopathy: a complication of parenteral nutrition diagnosed bymagnetic resonance imaging, Anesthesiology, vol.105, issue.4, pp.847-855, 2006.

K. A. Cocksedge and A. Flynn, Wernicke-Korsakoff syndrome in a patient with self-neglect associated with severe depression. JRSM Open, vol.5, p.2042533313518915, 2014.

U. Indraccolo, G. Gentile, G. Pomili, G. Luzi, and C. Villani, Thiamine deficiency and beriberi features in a patient with hyperemesis gravidarum, Nutrition, 2005.

C. Zhong, L. Jin, and G. Fei, MR Imaging of Nonalcoholic Wernicke Encephalopathy: A Follow-Up Study, AJNR Am J Neuroradiol, vol.26, issue.9, pp.2301-2306, 2005.

J. Lu and E. L. Frank, Rapid HPLC measurement of thiamine and its phosphate esters in whole blood, Clin Chem, vol.54, issue.5, pp.901-907, 2008.

S. Kono, H. Miyajima, K. Yoshida, A. Togawa, K. Shirakawa et al., Mutations in a thiamine-transporter gene and Wernicke's-like encephalopathy, N Engl J Med, 2009.

, Apr, vol.23, issue.17, pp.1792-1796

A. Maiorana, G. Vergine, V. Coletti, M. Luciani, C. Rizzo et al., Acute thiamine deficiency and refeeding syndrome: Similar findings but differentpathogenesis, Nutrition, vol.30, issue.7-8, pp.948-52, 2014.

K. Amrein, W. Ribitsch, R. Otto, H. C. Worm, and R. E. Stauber, Severe lactic acidosis reversed by thiamine within 24 hours, Crit Care, vol.15, issue.6, p.457, 2011.

S. R. Prakasha, A. S. Mustafa, S. Baikunje, and K. Subramanyam, Dry" and "wet" beriberi mimicking critical illness polyneuropathy, Ann Indian Acad Neurol, 2013.

J. Restier, G. De-carsalade, A. Abdou, M. Valyi, L. Cuvelier et al., Shoshin béribéri : réémergence d'une pathologie ancienne ? À propos d'une série de 11 cas à Mayotte, Bull. Soc. Pathol. Exot, vol.105, pp.49-57, 2012.

E. Antunez, R. Estruch, C. Cardenal, J. M. Nicolas, J. Fernandez-sola et al., Usefulness of CT and MR imaging in the diagnosis of acute Wernicke's encephalopathy, AJR Am J Roentgenol, vol.171, issue.4, pp.1131-1138, 1998.

Y. T. Liu, J. L. Fuh, J. F. Lirng, A. F. Li, D. M. Ho et al., Correlation of magnetic resonance images with neuropathology in acute Wernicke's encephalopathy, Clin Neurol Neurosurg, vol.108, issue.7, pp.682-689, 2006.

S. Andrade, C. , T. Lucato, L. Da-graça-morais-martin, M. et al., Nonalcoholic Wernicke's encephalopathy: broadening the clinicoradiologicalspectrum

, Br J Radiol, vol.83, issue.989, pp.437-446, 2010.

G. Zuccoli, M. Gallucci, J. Capellades, L. Regnicolo, B. Tumiati et al., Wernicke encephalopathy: MR findings at clinical presentation in twenty-six alcoholic and nonalcoholic patients, AJNR Am J Neuroradiol, vol.28, issue.7, pp.1328-1359, 2007.

A. D. Thomson and E. J. Marshall, BNF recommendations for the treatment of Wernicke's encephalopathy: lost intranslation? Alcohol Alcohol, vol.48, pp.514-519, 2013.

M. W. Donnino, J. Vega, J. Miller, and M. Walsh, Myths and misconceptions of Wernicke's encephalopathy: what every emergency physician should know, Ann Emerg Med, vol.50, issue.6, pp.715-736, 2007.

C. Zubaran, J. G. Fernandes, and R. Rodnight, Wernicke-Korsakoff syndrome, Postgrad Med J, vol.73, issue.855, pp.27-31, 1997.

Y. Rensen, J. Egger, J. Westhoff, S. Walvoort, and R. Kessels, Errorless (re)learning of everyday activities in patients with Korsakoff's syndrome: A feasibility study, Neuropsychol Rehabil, vol.2, pp.1-15, 2017.

B. Kalidass, R. Sunnathkal, D. V. Rangashamanna, and R. Paraswani, Atypical Wernicke's encephalopathy showing involvement of substantia nigra, J Neuroimaging, 2012.

J. P. Aires-a-filipe, M. C. Garrett, and R. Real, Complex ophthalmoplaegia denoting Wernicke encephalopathy in a non-alcoholic individual, BMJ Case Rep, p.2014207284, 2015.

H. D. Kasmaei, A. Baratloo, M. Soleymani, and Z. Nasiri, Imaging-Based Diagnosis of Wernicke Encephalopathy: A Case Report. Trauma Mon, vol.19, p.17403, 2014.

A. Elefante, G. Puoti, R. Senese, C. Coppola, C. Russo et al., Non-alcoholic acute Wernicke's encephalopathy: role of MRI in non typical cases, Eur J Radiol, vol.81, issue.12, pp.4099-104, 2012.

E. Isenberg-grzeda, Y. Alici, V. Hatzoglou, C. Nelson, and W. Breitbart, Nonalcoholic Thiamine-Related Encephalopathy (Wernicke-Korsakoff Syndrome) Among Inpatients With Cancer: A Series of 18 Cases, Psychosomatics, vol.57, issue.1, pp.71-81, 2016.

K. C. Liou, S. F. Kuo, and L. A. Chen, Wernicke encephalopathy with atypical magnetic resonance imaging, Am J Emerg Med, vol.30, issue.9, pp.2086-2087, 2012.

N. Shah, E. Combeer, and R. Barker, Wernicke's encephalopathy: A diagnosis to consider early in patients with learning difficulties, Journal of the Intensive Care Society, vol.15, issue.2, pp.158-160, 2014.

L. F. Chen and C. E. Lin, Wernicke's encephalopathy mimicking an acute psychotic disorder, Neuropsychiatry Clin Neurosci. 2012 Fall, vol.24, issue.4, pp.15-21
DOI : 10.1176/appi.neuropsych.11090230

G. Q. Fei, C. Zhong, J. L. Wang, J. Zhang, Y. Zheng et al., Clinical characteristics and MR imaging features of nonalcoholic Wernicke encephalopathy, AJNR Am J Neuroradiol, vol.29, issue.1, pp.164-173, 2008.
DOI : 10.3174/ajnr.a0827

URL : http://www.ajnr.org/content/ajnr/29/1/164.full.pdf

B. Lapergue, I. Klein, J. M. Olivot, and P. Amarenco, Diffusion weighted imaging of cerebellar lesions in Wernicke's encephalopathy, J Neuroradiol, 2006.

H. Liang, L. Wu, L. L. Liu, J. Han, J. Zhu et al., A case report: Non-alcoholic Wernicke encephalopathy associated with polyneuropathy, J Int Med Res, 2017.

F. Caso, A. Fiorino, M. Falautano, L. Leocani, V. Martinelli et al., Treatment of Wernicke's encephalopathy with high dose of thiamine in a patient with pyloric sub-stenosis: description of a case, Neurol Sci, vol.31, issue.6, pp.859-61, 2010.

S. Q. Zhang and Y. T. Guan, Acute bilateral deafness as the first symptom of Wernicke encephalopathy, AJNR Am J Neuroradiol, vol.33, issue.3, pp.44-49, 2012.

W. Ammouri, H. Harmouche, L. Sbihi, M. Maamar, M. Tazi et al., GayetWernicke encephalopathy: A rare and serious complication of gastrointestinal involvement in HIV infection, Rev Neurol, vol.172, issue.4-5, pp.331-333, 2016.

C. Ong, K. Patel, E. Musiek, and G. Van-stavern, Mystery case: a young woman with isolated upbeating nystagmus, Neurology, vol.84, issue.4, pp.17-26, 2015.
DOI : 10.1212/wnl.0000000000001178

URL : http://n.neurology.org/content/84/4/e17.full.pdf