, cellules mimant la fonction rénale tout en limitant le dépôt protéique et entraîner une perte minimale de protéines sanguines

A. K. Morel and A. Garcia, Rapport IGAS RM2010-154P "Evolution et maîtrise de la dépense des dispositifs médicaux, 2010.

E. Cdc, Directive 93/42/CEE relative aux dispositifs médicaux, 1993.

C. Parlement-européen, Directive 2007/47/CE relative aux dispositifs médicaux

E. Cdc, Directive 90/385/CEE concernant le rapprochement des législations des États membres relatives aux dispositifs médicaux implantables actifs, 1990.

. Iso, Norme ISO 10-993 "Evaluation biologique des dispositifs médicaux, 2010.

A. P. Serro, A. C. Fernandes, B. Saramago, J. Lima, and M. A. Barbosa, Apatite deposition on titanium surfaces-the role of albumin adsorption, Biomaterials, vol.18, issue.14, pp.963-971, 1997.

F. Rupp, L. Scheideler, D. Rehbein, D. Axmann, and J. Geis-gerstorfer, Roughness induced dynamic changes of wettability of acid etched titanium implant modifications, Nanotechnologies-Terminology and definitions for nano-objects, nanoparticle, nanofibre and nanoplate, vol.25, pp.1429-1467, 2004.

G. P. Walters and I. P. , The incorporation of noble metal nanoparticles into host matrix thin films: synthesis, characterisation and applications, Journal of Materials Chemistry, vol.19, issue.5, pp.574-90, 2009.

C. Lee, Silver and manganese oxide catalysts supported on mesoporous ZrO2 nanofiber mats for catalytic removal of benzene and diesel soot, Catalysis Today, vol.281, issue.3, pp.460-466, 2017.

L. B. Chen, P. Li, and W. , Preparation of a novel magnesium oxide nanofilm of honeycomb-like structure and investigation of its properties, Chemical Engineering Journal, vol.303, pp.588-95, 2016.

H. Jeong, S. Ranallo, M. Rossetti, J. Heo, J. Shin et al., Electronic Activation of a DNA Nanodevice Using a Multilayer Nanofilm, Small, vol.12, issue.40, pp.5572-5580, 2016.

. Iso/ts, Norme ISO/TS 80004-2 "Nanotechnologies-Vocabulaire-Partie 2 : Nanoobjets, 2015.

P. De-thier, J. Bacharouche, J. F. Duval, S. Skali-lami, and G. Francius, Atomic force microscopy analysis of IgG films at hydrophobic surfaces: a promising method to probe IgG orientations and optimize ELISA tests performance, Biochimica et biophysica acta, vol.1854, issue.2, pp.138-183, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01159533

T. Cedervall, I. Lynch, S. Lindman, T. Berggard, E. Thulin et al.,

, Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles, Proceedings of the National Academy of Sciences of the United States of America, vol.104, issue.7, pp.2050-2055, 2007.

A. P. Alberola and J. O. Radler, The defined presentation of nanoparticles to cells and their surface controlled uptake, Biomaterials, vol.30, issue.22, pp.3766-70, 2009.

Y. Akiyama, T. Mori, Y. Katayama, and T. Niidome, The effects of PEG grafting level and injection dose on gold nanorod biodistribution in the tumor-bearing mice, Journal of controlled release : official journal of the Controlled Release Society, vol.139, issue.1, pp.81-85, 2009.

B. Ballou, B. C. Lagerholm, L. A. Ernst, M. P. Bruchez, and A. S. Waggoner, Noninvasive imaging of quantum dots in mice, Bioconjugate chemistry, vol.15, issue.1, pp.79-86, 2004.

P. Aggarwal, J. B. Hall, C. B. Mcleland, M. A. Dobrovolskaia, and S. E. Mcneil, Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy, vol.61, pp.428-465, 2009.

A. Nel, T. Xia, L. Madler, and N. Li, Toxic potential of materials at the nanolevel, Science, vol.311, issue.5761, pp.622-629, 2006.

C. Wang, L. Wang, and W. Yang, Preparation and characterization of functional inorganic/organic composite microspheres via electrostatic interaction, J Colloid Interface Sci, vol.333, issue.2, pp.749-56, 2009.

D. L. Astruc, F. Aranzaes, and J. R. , Nanoparticles as recyclable catalysts: the frontier between homogeneous and heterogeneous catalysis, Angewandte Chemie, vol.44, pp.7852-72, 2005.

J. E. Skebo, C. M. Grabinski, A. M. Schrand, J. J. Schlager, and S. M. Hussain, Assessment of metal nanoparticle agglomeration, uptake, and interaction using high-illuminating system, International journal of toxicology, vol.26, issue.2, pp.135-176, 2007.

A. R. Petosa, D. P. Jaisi, I. R. Quevedo, M. Elimelech, and N. Tufenkji, Aggregation and deposition of engineered nanomaterials in aquatic environments: role of physicochemical interactions. Environmental science & technology, vol.44, pp.6532-6581, 2010.

J. Tournebize, A. Boudier, A. Sapin-minet, P. Maincent, P. Leroy et al., Role of gold nanoparticles capping density on stability and surface reactivity to design drug delivery platforms, ACS applied materials & interfaces, vol.4, issue.11, pp.5790-5799, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00776302

C. N. Rao and K. Biswas, Characterization of nanomaterials by physical methods. Annual review of analytical chemistry, vol.2, pp.435-62, 2009.

M. A. Meyers, A. Mishra, and D. J. Benson, Mechanical properties of nanocrystalline materials, Progress in Materials Science, vol.51, issue.4, 2006.

S. V. Dorozhkin, Nanosized and nanocrystalline calcium orthophosphates, Acta Biomater, vol.6, issue.3, pp.715-749, 2010.

F. Watari, N. Takashi, A. Yokoyama, M. Uo, T. Akasaka et al., Material nanosizing effect on living organisms: non-specific, biointeractive, physical size effects, Journal of the Royal Society, Interface, vol.6, issue.3, pp.371-88, 2009.

Y. Liu and H. Wang, Nanomedicine: Nanotechnology tackles tumours, Nature nanotechnology, vol.2, issue.1, pp.20-21, 2007.

M. Jager, C. Zilkens, K. Zanger, and R. Krauspe, Significance of nano-and microtopography for cell-surface interactions in orthopaedic implants, Journal of biomedicine & biotechnology, issue.8, p.69036, 2007.

M. Sato and T. J. Webster, Nanobiotechnology: implications for the future of nanotechnology in orthopedic applications. Expert review of medical devices, vol.1, pp.105-119, 2004.

T. J. Webster and J. U. Ejiofor, Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V, and CoCrMo, Biomaterials, vol.25, pp.4731-4740, 2004.

L. Vroman, A. L. Adams, G. C. Fischer, and P. C. Munoz, Interaction of high molecular weight kininogen, factor XII, and fibrinogen in plasma at interfaces, Blood, vol.55, issue.1, pp.156-165, 1980.

Z. Sheikh, A. S. Khan, N. Roohpour, M. Glogauer, and I. U. Rehman, Protein adsorption capability on polyurethane and modified-polyurethane membrane for periodontal guided tissue regeneration applications. Materials science & engineering C, Materials for biological applications, vol.68, pp.267-75, 2016.

B. F. Lai, A. L. Creagh, J. Janzen, C. A. Haynes, D. E. Brooks et al., The induction of thrombus generation on nanostructured neutral polymer brush surfaces, Biomaterials, vol.31, issue.26, pp.6710-6718, 2010.

M. A. Rufin, M. E. Barry, P. A. Adair, M. L. Hawkins, J. E. Raymond et al., Protein resistance efficacy of PEO-silane amphiphiles: Dependence on PEO-segment length and concentration, Acta biomaterialia, vol.41, pp.247-52, 2016.

D. Dutta, S. K. Sundaram, J. G. Teeguarden, B. J. Riley, L. S. Fifield et al.,

, Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity, Nano Lett, vol.10, issue.5, pp.1664-70, 2010.

S. T. Stern and S. E. Mcneil, Toxicological sciences : an official journal of the Society of Toxicology, vol.101, pp.4-21, 2008.

A. A. Shvedova and V. E. Kagan, The role of nanotoxicology in realizing the 'helping without harm' paradigm of nanomedicine: lessons from studies of pulmonary effects of single-walled carbon nanotubes, Journal of internal medicine, vol.267, issue.1, pp.106-124, 2010.

R. Singh, D. Pantarotto, L. Lacerda, G. Pastorin, C. Klumpp et al., Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers, Proceedings of the National Academy of Sciences of the United States of America, vol.103, issue.9, pp.3357-62, 2006.

P. Cherukuri, C. J. Gannon, T. K. Leeuw, H. K. Schmidt, R. E. Smalley et al.,

, Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence, Proceedings of the National Academy of Sciences of the United States of America, vol.103, issue.50, pp.18882-18888, 2006.

K. Chaloupka, Y. Malam, and A. M. Seifalian, Nanosilver as a new generation of nanoproduct in biomedical applications, Trends in biotechnology, vol.28, issue.11, pp.580-588, 2010.

S. Pal, Y. K. Tak, and J. M. Song, Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli, Applied and environmental microbiology, vol.73, issue.6, pp.1712-1732, 2007.

J. R. Morones, J. L. Elechiguerra, A. Camacho, K. Holt, J. B. Kouri et al., The bactericidal effect of silver nanoparticles, Nanotechnology, vol.16, issue.10, pp.2346-53, 2005.

M. Trop, M. Novak, S. Rodl, B. Hellbom, W. Kroell et al., Silver-coated dressing acticoat caused raised liver enzymes and argyria-like symptoms in burn patient, The Journal of trauma, vol.60, issue.3, pp.648-52, 2006.

K. N. Stevens, O. Crespo-biel, E. E. Van-den-bosch, A. A. Dias, M. L. Knetsch et al., The relationship between the antimicrobial effect of catheter coatings containing silver nanoparticles and the coagulation of contacting blood, Biomaterials, vol.30, issue.22, pp.3682-90, 2009.

L. Englberger, H. V. Schaff, W. R. Jamieson, E. D. Kennard, K. A. Im et al.,

, Importance of implant technique on risk of major paravalvular leak (PVL) after St. Jude mechanical heart valve replacement: a report from the Artificial Valve Endocarditis Reduction Trial (AVERT), vol.28, pp.838-881, 2005.

G. L. Grunkemeier, J. R. Im, K. Holubkov, R. Kennard, E. D. Schaff et al., Time-related risk of the St. Jude Silzone heart valve. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, vol.30, pp.20-27, 2006.

M. Ip, S. L. Lui, V. K. Poon, I. Lung, and A. Burd, Antimicrobial activities of silver dressings: an in vitro comparison, Journal of medical microbiology, vol.55, pp.59-63, 2006.

M. Rai, A. Yadav, and A. Gade, Silver nanoparticles as a new generation of antimicrobials, Biotechnology advances, vol.27, issue.1, pp.76-83, 2009.

H. Q. Yin, R. Langford, and R. E. Burrell, Comparative evaluation of the antimicrobial activity of ACTICOAT antimicrobial barrier dressing, The Journal of burn care & rehabilitation, vol.20, issue.3, pp.195-200, 1999.

K. Dunn and V. Edwards-jones, The role of Acticoat with nanocrystalline silver in the management of burns, Burns : journal of the International Society for Burn Injuries, vol.30, issue.1, pp.1-9, 2004.

V. Alt, T. Bechert, P. Steinrucke, M. Wagener, P. Seidel et al., An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement, Biomaterials, vol.25, issue.18, pp.4383-91, 2004.

A. Erdemir and C. Donnet, Tribology of diamond-like carbon films: recent progress and future prospects, J Phys D: Appl Phys, vol.39, pp.311-338, 2006.

Z. Li, G. Zhu, R. Yang, A. C. Wang, and Z. L. Wang, Muscle-driven in vivo nanogenerator, Advanced materials, vol.22, issue.23, pp.2534-2541, 2010.

D. H. Kim, J. Viventi, J. J. Amsden, J. Xiao, L. Vigeland et al., Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics, Nature materials, vol.9, issue.6, pp.511-518, 2010.

R. K. Jha, P. K. Jha, K. Chaudhury, S. V. Rana, and S. K. Guha, An emerging interface between life science and nanotechnology: present status and prospects of reproductive healthcare aided by nano-biotechnology, Nano reviews, vol.5, 2014.

A. Pallotta, M. Parent, I. Clarot, L. Ming, V. Borr et al., Blood Compatibility

, Multilayerd Polyelectrolyte Films Containing Immobilized Gold Nanoparticles. Particle & Particle Systems Characterization, vol.34, p.1600184, 2017.

I. M. Cardio, , 2016.

P. A. Heidenreich, J. G. Trogdon, O. A. Khavjou, J. Butler, K. Dracup et al., Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association, Circulation, vol.123, issue.8, pp.933-977, 2011.

M. R. Bennett and M. O'sullivan, Mechanisms of angioplasty and stent restenosis: implications for design of rational therapy, Pharmacology & therapeutics, vol.91, issue.2, pp.149-66, 2001.

S. Venkatraman and F. Boey, Release profiles in drug-eluting stents: issues and uncertainties, Journal of controlled release : official journal of the Controlled Release Society, vol.120, issue.3, pp.149-60, 2007.

A. Tan, Y. Farhatnia, A. De-mel, J. Rajadas, M. S. Alavijeh et al., Inception to actualization: next generation coronary stent coatings incorporating nanotechnology, Journal of biotechnology, vol.164, issue.1, pp.151-70, 2013.

M. R. Bennett, In-stent stenosis: pathology and implications for the development of drug eluting stents, Heart, vol.89, issue.2, pp.218-242, 2003.

A. W. Carpenter and M. H. Schoenfisch, Nitric oxide release: part II. Therapeutic applications, Chemical Society reviews, vol.41, issue.10, pp.3742-52, 2012.

G. Acharya, C. H. Lee, and Y. Lee, Optimization of cardiovascular stent against restenosis: factorial design-based statistical analysis of polymer coating conditions, PloS one, vol.7, issue.8, p.43100, 2012.

A. De-mel, N. Naghavi, B. G. Cousins, I. Clatworthy, G. Hamilton et al., Nitric oxide-eluting nanocomposite for cardiovascular implants, Journal of materials science Materials in medicine, vol.25, issue.3, pp.917-946, 2014.

R. R. Costa and J. F. Mano, Polyelectrolyte multilayered assemblies in biomedical technologies, Chemical Society reviews, vol.43, issue.10, pp.3453-79, 2014.

G. Decher, Fuzzy nanoassemblies: Toward layered polymeric multicomposites, Science, vol.277, issue.5330, pp.1232-1239, 1997.

K. Sato, S. Takahashi, and J. Anzai, Layer-by-layer thin films and microcapsules for biosensors and controlled release, vol.28, pp.929-967, 2012.

M. C. Berg, L. Zhai, R. E. Cohen, and M. F. Rubner, Controlled drug release from porous polyelectrolyte multilayers, Biomacromolecules, vol.7, issue.1, pp.357-64, 2006.

Z. Kadlecova, L. Baldi, D. Hacker, F. M. Wurm, and H. A. Klok, Comparative study on the in vitro cytotoxicity of linear, dendritic, and hyperbranched polylysine analogues, Biomacromolecules, vol.13, issue.10, pp.3127-3164, 2012.

A. Warnecke, P. Luessen, J. Sandmann, M. Ikic, S. Rossa et al., Application of a stable-isotope dilution technique to study the pharmacokinetics of human 15N-labelled S-nitrosoalbumin in the rat: possible mechanistic and biological implications, Journal of chromatography B, Analytical technologies in the biomedical and life sciences, vol.877, issue.13, pp.1375-87, 2009.

J. Tournebize, A. Boudier, O. Joubert, H. Eidi, G. Bartosz et al., Impact of gold nanoparticle coating on redox homeostasis, International journal of pharmaceutics, vol.438, issue.1-2, pp.107-123, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01686082

J. Tournebize, A. Sapin-minet, R. Schneider, A. Boudier, P. Maincent et al., Simple spectrophotocolorimetric method for quantitative determination of gold in nanoparticles, Talanta, vol.83, issue.5, pp.1780-1783, 2011.
URL : https://hal.archives-ouvertes.fr/hal-01686072

M. Luo, A. Boudier, I. Clarot, P. Maincent, R. Schneider et al., Gold Nanoparticles Grafted by Reduced Glutathione With Thiol Function Preservation. Colloid and Interface Science Communications, vol.14, pp.8-12, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01372065

D. Kim, Y. Y. Jeong, and J. S. , A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer, ACS nano, vol.4, issue.7, pp.3689-96, 2010.

T. Boudou, T. Crouzier, K. Ren, G. Blin, and C. Picart, Multiple functionalities of polyelectrolyte multilayer films: new biomedical applications, Advanced materials, vol.22, issue.4, pp.441-67, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00670215

C. Cho and N. S. Zacharia, Film stability during postassembly morphological changes in polyelectrolyte multilayers due to acid and base exposure, Langmuir : the ACS journal of surfaces and colloids, vol.28, issue.1, pp.841-849, 2012.

J. W. Park and J. S. Shumaker-parry, Structural study of citrate layers on gold nanoparticles: role of intermolecular interactions in stabilizing nanoparticles, Journal of the American Chemical Society, vol.136, issue.5, pp.1907-1928, 2014.

Z. Lin, N. A. Monteiro-riviere, and J. E. Riviere, Pharmacokinetics of metallic nanoparticles. Wiley interdisciplinary reviews Nanomedicine and nanobiotechnology, vol.7, pp.189-217, 2015.

H. Cai and P. Yao, Gold nanoparticles with different amino acid surfaces: serum albumin adsorption, intracellular uptake and cytotoxicity, Colloids and surfaces B, Biointerfaces, vol.123, pp.900-906, 2014.

Z. Huang, H. Wang, and W. Yang, Gold Nanoparticle-Based Facile Detection of Human Serum Albumin and Its Application as an INHIBIT Logic Gate, ACS applied materials & interfaces, vol.7, issue.17, pp.8990-8998, 2015.

R. R. Burgess, Use of polyethyleneimine in purification of DNA-binding proteins, Methods in enzymology, vol.208, pp.3-10, 1991.

E. Guzman, J. A. Cavallo, R. Chulia-jordan, C. Gomez, M. C. Strumia et al., pHinduced changes in the fabrication of multilayers of poly(acrylic acid) and chitosan: fabrication, properties, and tests as a drug storage and delivery system, Langmuir : the ACS journal of surfaces and colloids, vol.27, issue.11, pp.6836-6881, 2011.

C. Tortiglione, A. Quarta, A. Tino, L. Manna, R. Cingolani et al., Synthesis and biological assay of GSH functionalized fluorescent quantum dots for staining Hydra vulgaris, Bioconjugate chemistry, vol.18, issue.3, pp.829-864, 2007.

A. Pallotta, A. Boudier, P. Leroy, and I. Clarot, Characterization and stability of gold nanoparticles depending on their surface chemistry: Contribution of capillary zone electrophoresis to a quality control, J Chromatogr A, vol.1461, pp.179-84, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01686093