L. .. Des-abreviations,

I. .. De-l'etude,

A. , La prévalence de la consommation de SPA chez la femme enceinte

B. , Les conséquences de la consommation de SPA sur la grossesse et la santé de l'enfant, vol.21

C. , Les autres facteurs intervenant dans le devenir de l'enfant

. , D. Les particularités de la parentalité chez les femmes ayant un trouble de l'usage

E. Présentation-de-l'étude and .. .. ,

A. I. ,

B. Materiels and . .. Methodes,

C. R. ,

E. C. ,

F. R. ,

. B. Iv,

M. Cassen, J. M. Delile, M. Facy, J. P. Gachie, E. Pohier et al., Maternité et toxicomanies, enquête anit/grrita/inserm sur 171 mères toxicomanes et leurs 302 enfants

A. Alcoologie, , vol.26, 2004.

L. P. Finnegan, Morbidité et mortalité périnatales dans les familles d'usagers de drogues : effets et stratégies d'intervention, Bulletin des Stupéfiants, vol.46, issue.1, pp.17-37, 1994.

L. P. Finnegan and S. R. Kandall, Perinatal substance use, drug dependance, motherhood, and the newborn, Textbook of substance abuse Treatment, 4 ème ed

F. D. Eyler, M. Behnke, and . Early, Development of infants exposed to drug prenatally, Clin Perinatol, vol.26, issue.1, pp.107-50, 1999.

M. Behnke and V. C. Smith, Prenatal substance abuse : short and long term effects on the exposed fetus, Pediatrics, vol.131, issue.3, pp.1009-1033, 2013.

S. Shankaran, Impact of maternal substance use during pregnancy on childhood outcome, Semin Fetal Neonatal Med, vol.12, issue.2, pp.143-150, 2007.

T. Sithisam, D. T. Granger, and H. S. Bada, Consequence of prenatal substance use, Int J Adolesc Med Health, vol.24, pp.105-117, 2012.

A. H. Schempf and D. M. Stobino, Illicit drug use and adverse birth outcomes : Is it drugs or contexte, Journal of Urban Health, vol.25, pp.858-73, 2008.

N. E. Suchman and S. S. Luthar, Maternal addiction, child maladjustment and socio-demographic risks : implications for parenting behavior, Addiction, vol.95, pp.1417-1428, 2000.

. Dumas, Grossesse et substance psychoactives : étude de la prévalence de la consommation déclarée, vol.37, pp.770-78, 2008.

C. Lejeune, J. C. Robert, and S. Montamat, Devenir médico-social de 59 nouveau-nés de mère toxicomane, J Gynecol Obstet Biol Reprod, vol.26, pp.395-404, 1997.

M. Hepburn, Substance abuse in pregnancy, Current Obstetrics and Gynaecology, vol.14, issue.6, pp.419-425, 2004.

B. D. Holbrook and W. F. Rayburn, Teratogenic risks from exposure to illicit drugs, Obstet Gynecol Clin North Am, vol.41, issue.2, pp.229-268, 2014.

C. Osborn and L. M. Berger, Parental substance abuse and child well-being a consideration of parents'gender and coresidence, Journal of Family Issues, 2008.

A. Mcgalde, R. Ware, and M. Crawford, Child protection outcomes for infants of substanceusing mothers : a matched-cohort study, Pediatrics, vol.124, issue.1, pp.285-93, 2009.

, Conduites addictives chez les adolescents enquête Inserm

J. Williams and L. Ross, Consequences of prenatal toxin exposure for mental health in children and adolescents, Eur Child Adolesc Psychiatry, vol.16, pp.243-53, 2007.

N. Goel, Perinatal outcome of illicit substance use in pregnancy comarative and contemporary socio-clinical profile in UK, Eur J Pediatr, vol.170, issue.2, pp.199-205, 2011.

C. Lejeune, J. C. Robert, and S. Montamat, Devenir médico-social de 59 nouveau-nés de mère toxicomane, J Gynecol Obstet Biol Reprod, vol.26, pp.395-404, 1997.

C. Lejeune, Évolution des modalités de prise en charge des femmes enceintes toxicomanes et de leurs enfants, Archives de Pédiatrie 7 suppl, vol.2, pp.283-284, 2000.

L. Claude, S. Laurence, A. Sandrine, and G. Laurent,

, Grossesse et substitution. Enquête sur les femmes enceintes substituées à la méthadone ou à la buprénorphine haut dosage et caractéristiques de leurs nouveau, 2003.

H. Autorité-de-santé, Suivi et orientation des femmes enceintes en fonction des situations à risque identifiées. Recommandation de bonnes pratiques, 2016.

M. A. Amstrong, Perinatal substance intervention in obstretrical clinics decreases neonatal outcomes, Journal of Perinatology, vol.23, issue.3, pp.3-9, 2003.

L. P. Finnegan, Comprehensive care of the pregnant addict and its effevt on maternal and infant outcome, Contemporary Drud Problems, vol.1, pp.795-809, 1972.

P. H. Hughes, Retaining cocaine-abusing women in a therapeutic community : the effect of a child live in program, American Journal of Public Health, vol.85, pp.1149-52, 1995.

L. Jansson, Pregnancy and addiction : a comprehensive care model, vol.13, pp.321-350, 1996.

E. Day and . George, Management og drug misuse in pregnancy, Advances in Psychiatric Treatment, vol.11, pp.253-61, 2005.

C. Brulet, Multidisciplinary monitoring and psychosocial support reduce complications of opiate dependance in pregnant women : 114 pregnancy, La Presse Medicale, vol.36, issue.11, pp.1571-80, 2007.

B. Blondel, N. Lelong, M. Kermarrec, and F. Goffinet, Journal de Gynécologie obstétrique et Biologie de la Reproduction, vol.41, pp.151-66, 1995.

J. H. Williams, Consequences of prenatal toxin exposure for mental health in children and adolescents : a systematic review, Eur Child Adolesc Psychiatry, vol.16, issue.4, pp.243-253, 2007.

L. Simmat-durand, Les professionnels de la maternité et de l'enfance et le signalement des enfants de mère toxicomane, Psychotropes, vol.14, issue.3, pp.179-199, 2008.

M. L. Hudak and R. C. Tan, Neonatal drug withdrawal, Pediatrics, vol.129, issue.2, pp.540-60, 2012.

J. L. Rementeria and K. Bhatt, Withdrawal symptoms in neonates from intrauterine exposure to diazepam, J Pediatr, vol.0, issue.1, pp.123-126, 1977.

L. Simmat-durand, L. Genest, C. Et, and . Lejeune, Les séparations des mères consommatrices de substances psychoactives de leurs enfants : résultats dans une cohorte rétrospective française », vol.18, pp.123-172, 2012.

P. Morissette, Le partenaire des mères consommatrices de SPA : un acteur clé pour la sécurité et le developpement optimal des enfants. Parentalité : alcool et drogues, pp.195-213, 2009.

. Iv and L. Simmat-durand, Les professionnels de la maternité et de l'enfance et le signalement des enfants de mère toxicomane, Psychotropes, vol.14, issue.3, pp.179-99, 2008.

L. Simmat-durand, La mère toxicomane, au carrefour des normes et des sanctions, Déviance et Société, vol.31, issue.3, pp.305-330, 2007.

R. H. Van-oppenraaij and A. H. Koning, The effect of smoking on early chorionic villous vascularisation, Epub, vol.33, issue.8, pp.645-51, 2012.

R. Wickström, Effects of nicotine during pregnancy : human and experimental evidence, Curr Neuropharmacol, vol.5, issue.3, pp.213-235, 2007.

J. Blood-siegfried and E. K. Rende, The long terme effects of prenatal nicotine exposure in neurologic development, J Midwifery Women Health, vol.55, issue.2, pp.143-52, 2010.

T. A. Slotkin and S. Skavicus, Prenatal nicotine changes the response to postnatal chlopyrifos : interactions targeting serotonergic synaptic function and cognition, Brain Res Bull, vol.111, pp.84-96, 2015.

H. Mg and K. North, Conception and active and passive smoking. The Avon Longitudinal Study of Pregnancy and Childhood Study Team, Fertil Steril, vol.74, issue.4, pp.725-758, 2000.

P. Habib, Quelles sont les conséquences du tabagisme sur la grossesse et l'accouchement ? Journal de gynécologie obstétrique et biologie de la reproduction, pp.253-369, 2005.

J. Roelands and M. G. Jamison, Consequences of smocking during pregnancy on maternal health, vol.18, pp.867-72, 2009.

B. L. Pineles and E. Park, Systematic review and meta-analysis of Miscarriage and Maternal Exposure to Tobacco Smoke During Pregnancy, Am J epidemio, vol.179, issue.7, pp.807-823, 2014.

V. Godding, Does in utero exposure to heavy maternal smocking induce withdrawal symptoms in neonates ?, Pediatric Research, vol.4, pp.645-51, 2004.

B. Alm and S. Norvenius, Changes in the epidemiology of sudden infant death syndrom in Sweden 1973-1996, Arc Dis Child, vol.84, issue.1, pp.24-30, 2001.

K. Wisborg and U. Kesmodel, A prospective study of smocking during pregnancy and SIDS, Arch Dis Child, vol.83, issue.3, pp.203-206, 2000.

H. Bakker and V. Jaddoe, Cardiovascular and metabolic influences of fetal smoke exposure, Eur J Epidemiol, vol.26, issue.10, pp.763-770, 2001.

F. D. Gilliland and K. Berhane, Effects of early onset asthma and in utero exposure to maternal smoking on childhood lung function, Am J Respir Crit Care Med, vol.167, issue.6, pp.917-941, 2003.

A. Lc and U. H. Winzer-serhan, Smocking during pregnancy : lessons learned from epidemiological studies and experimental studies in animal models, Critical Reviews in Toxicology, vol.42, pp.279-303, 2012.

P. A. Fried, Adolescents prenatally exposed to marijuana : examination of facets of complex behaviors and comparaisons with the influence of in utero cigarettes, J Clin Pharmacol, vol.42, issue.11, pp.97-102, 2002.

R. A. Sherwood, Substance misuse in early pregnancy and relationship to fetal outcome, Eur J Pediatr, vol.158, pp.488-92, 1999.

B. Zuckerman and D. A. Franck, Effects of maternal marijuana and cocaine use on fetal growth, N Engl J Med, vol.320, pp.762-770, 1989.

R. K. Scragg, Maternal cannabis use in the sudden death syndrome, Acta Paediatr, vol.90, pp.57-60, 2001.

S. L. Leech, G. A. Richardson, L. Goldschmidt, and N. L. Day, Prenatal substance exposure : effets on attention and impulsivity of 6 years-old, Neurotoxicol Teratol, vol.21, pp.109-127, 1999.

A. M. Smith, Effects of prenatal marijuana on reponse inhibition : an Fmri study og young adults, Neurotoxicology and Teratology, vol.26, issue.4, pp.533-575, 2004.

L. Goldschmidt, G. A. Richardson, M. D. Cornelius, and N. L. Day, Prenatal marijuana and alcohol exposure and academic achievement at age 10, Neurotoxicol Teratol, vol.26, issue.4, pp.521-553, 2004.

. Réseau-périnatal-naitre and . Grandir-en-languedoc-roussillon, Référentiel périnatalité et opiacés. Référentiels périnatalité et addictions du, 2015.

M. Behnke and V. C. Smith, Prenatal substance abuse : short and long term effects on the exposed fetus, Pediatrics, vol.131, issue.3, pp.1009-1033, 2013.

L. P. Finnegan and S. R. Kandall, Maternal and neonatal effets of drug dependance and pregnancy. Substance Abuse : a comprehensive Textbook, 1992.

K. M. Gillogley, The perinatal impact of cocaine, amphetamine, and opioate use detected by universal intrapartum screening, American Journal of Obstetrics and Gynecology, vol.63, pp.1535-1577, 1990.

M. L. Hudak and R. C. Tan, Neonatal drug withdrawal, Pediatrics, vol.129, issue.2, p.54060, 2012.

R. M. Kliegman, D. Madura, R. Kiwi, I. Eisenberg, and T. Yamashita, Relation of maternal cocaine use to the risks of prematurity and low birth weignt, J of Pediatrics, vol.124, pp.751-56, 1994.

E. S. Bandstra, Intrauterine growth of full-term infants : impact of prenatal cocaine exposure, Pediatrics, vol.16, pp.178-201, 2001.

A. J. Hadeed and S. R. Siegel, Maternal cocaine use during pregnancy : effect on the newborn infant, Journal of psychopharmacology, vol.19, pp.554-561, 2005.

L. T. Singer, S. Minnes, M. O. Min, B. A. Lewis, and E. J. Short, Prenatal cocaine exposure and child outcomes : a conference report based on prospective study from Cleveland, Hum Psychopharmacol, vol.30, issue.4, pp.285-294, 2015.

. Enquête-inserm-expertise, Alcool, effets sur la santé, Exposition prénatale à l'alcool : données épidémiologiques. Pairs : Ed Inserm, pp.143-163, 2001.

L. Goldschimdt, G. A. Richardson, D. S. Stoffer, D. Geva, and N. L. Day, Prenatal alcohol exposure and academic achievment at age six : a nonlinear fit, Alcohol Clin Exp Res, vol.20, issue.4, pp.763-70, 1996.

B. Larroque, Prenatal alcohol exposure and signs of minor neurological dysfunction at prescholl age, DevMed Child Neurol, vol.42, pp.508-522

F. Ferraro, La grossesse et la drogue Collection que sais-je ?, Ed PUF, vol.341, p.126, 1998.

K. L. Jones and D. W. Smith, Recognition of the fetal alcohol syndrome in early infancy, Lancet, vol.302, issue.7836, pp.999-1001, 1973.

S. Astley, Neuropsychological and behavioral outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders, Journal canadien de pharmacologie clinique, vol.16, pp.178-201, 2009.

J. Bertrand, Fetal alcohol syndrome : guidelines for referral and diagnosis, 2004.

S. Astley, Comparaison of the 4-digit diagnostic code and the Hoyme diagnostic guidelines for fetal alcohol spectrum disorders, Pediatrics, vol.118, pp.1532-1577, 2006.

C. Rasmussen and J. Bisanz, Exploring mathematics difficulties in children with fetal alcohol spectrum disorders, Child development Perspectives, vol.29, issue.4, pp.125-155, 2009.

P. Dehaene, Diagnosis and Prevalence of fetal alcoholism in maternity, Press Med, vol.20, issue.21, p.1002, 1991.

P. Lemoine, Outcome of children of acoholic mother (study of 105 cases followed to adult age) and various prophylactic findings, Ann Pediatr, vol.39, issue.4, pp.226-261, 1992.

T. Sithisam, D. T. Granger, and H. S. Bada, Consequence of prenatal substance use, Int J Adolesc Med Health, vol.24, pp.105-117, 2012.

A. E. Chudley, Ensemble des troubles causés par l'alcoolisation foetale : lignes directrices canadiennes concernant le diagnostic, Santé Canada, vol.172, issue.5, pp.1-21, 2005.

, Réseau périnatal Naitre et Grandir en

, Référentiel Grossesse et médicaments psychotropes. Référentiels périnatalité et addictions du, 2015.

J. L. Rementeria and K. Bhatt, Withdrawal symptoms in neonates from intrauterine exposure to diazepam, J Pediatr, vol.0, issue.1, pp.123-126, 1977.

A. H. Schempf and D. M. Stobino, Illicit drug use and adverse birth outcomes : Is it drugs or contexte ?, Journal of Urban Health, vol.85, pp.858-873, 2008.

N. E. Suchman and S. S. Luthar, Maternal addiction, child maladjustment and sociodemographic risks : implications for parenting behavior, Addiction, vol.95, pp.1417-1428, 2000.

S. Wierviorka, Quand les parents sont toxicomanes, Enfances & Psy, vol.37, issue.4, pp.90-100, 2007.

M. Cassen, J. M. Delile, M. Facy, J. P. Gachie, E. Pohier et al., « Maternité et toxicomanies », enquête anit/grrita/inserm sur 171 mères toxicomanes et leurs 302 enfants, Alcoologie et Addictologie, vol.26, issue.2, 2004.

L. Claude, S. Laurence, A. Sandrine, and G. Laurent, Grossesse et substitution. Enquête sur les femmes enceintes substituées à la méthadone ou à la buprénorphine haut dosage et caractéristiques de leurs nouveau-nés-Paris, 2003.

C. Lejeune, J. C. Robert, and S. Montamat, Devenir médico-social de 59 nouveau-nés de mère toxicomane, J Gynecol Obstet Biol Reprod, vol.26, pp.395-404, 1997.