, Le délai avant la réalisation de l'exploration fonctionnelle respiratoire au diagnostic de maladie à anti-SRP était de 12,2 ± 3,4 mois avec une médiane de 1,8 mois. Un SNIP test (« Sniff Nasal Inspiratory Pressure ») était réalisé dans 20, une exploration fonctionnelle respiratoire était réalisée dans 89,4% des cas (pour n=47), vol.15, p.8

, 1% des cas, entre 40-60% dans 11,1% des cas avec une moyenne à 85,8 ± 2,7%. La mesure de la capacité vitale (CV) était disponible dans 71,7% des cas (n=66) avec une valeur supérieure à 100% dans 21,2% des cas, entre 80-100% dans 27,3% des cas, entre 60-80% dans 40,9% des cas, entre 4060% dans 9, 3% des cas avec une moyenne à 61,10 ± 5,2%. La mesure de la capacité pulmonaire totale (CPT) était disponible dans 78,3% des cas (n=72) avec une valeur supérieure à 100% dans 26,4% des cas, entre 80-100% dans 26,4% des cas, entre 60-80% dans, vol.26

, 3% des cas avec une moyenne à 88,1 ± 10,4%. La mesure du volume résiduel (VR) était disponible dans 46,7% des cas (n=43) avec une valeur supérieure à 100% dans 39,5% des cas, p.3

. , avec une moyenne à 98,0 ± 4,4%. La mesure de la diffusion libre du monoxyde de carbone (DLCO) était disponible dans 47,8% des cas (n=44) avec une valeur supérieure à 100%

, 3% des cas, entre 60-80% dans 25,0% des cas, entre 40-60% dans 34,1% des cas, entre 20-40% dans 6,8%, entre 10-20% dans 2,3% des cas avec une moyenne à 65,5 ± 3,3%. Le rapport DLCO/VA était disponible dans 41,3% des cas (n=38) avec une valeur supérieure à 100% dans 28, Spécificités antigéniques des anticorps anti-nucléaires, vol.27

, Des anticorps anti-ADN natifs étaient retrouvés dans 2,9% des cas (pour n=136)

, Un anticorps anti-SSA était retrouvé dans 29,9% des cas, de type anti-SSA/52 kDa (anti-TRIM21) dans 21, 8% des cas ou de type anti-SSA/60 kDa dans 8,2% des cas (pour n=143). Un anticorps anti-SSB était retrouvé dans 4,9% des cas (pour n=143). Un anticorps anti-Sm était retrouvé dans 1,4% des cas

, Un anticorps anti-RNP était retrouvé dans 2,8% des cas (pour n=144), vol.30, p.146

, Auto-anticorps spécifiques de myosite

, 7% des cas ; des anti-PL12 dans 0,7% des cas ; des anti-Mi2 dans 2,0% des cas ; des anti-Ku dans 1,4% des cas ; des anti-PmScl dans 2,0% des cas ; des anti-TIF1 gamma dans 0,7% des cas. Il n'y avait pas d'association rapportée avec d'autres anticorps spécifiques de myosite (anti-Jo1 ; anti-EJ ; anti-OJ ; antiHMGcoA, D'autres auto-anticorps spécifiques de myosite différents des anti-SRP étaient présents dans 6,1% des cas avec des auto-anticorps anti-PL7 dans 0, vol.30, p.146

, Auto-anticorps divers et autres anomalies biologiques dysimmunitaires

, 1% des cas (anticoagulant circulant lupique dans 0,7% des cas, anticardiolipine dans 2,7% des cas, anti-beta2Gp1 dans 2,0% des cas), des anticorps antimuscles lisses dans 2,0% des cas, des anticorps anti-mitochondrie (M2) dans 1,4% des cas, des anticorps anti-TPO dans 2, 6% des cas, des anticorps anti-peptides citrullinés (ACPA) dans 1,4% des cas, des anticorps anti-phopholipides dans, vol.4, p.146

, Ce travail de compilation montre que plus de la moitié des cas rapportés avec anticorps anti-SRP sont issus d'études asiatiques (50,2%) [35,315, Nous avons réalisé une revue l'ensemble des données existantes sur les myopathies nécrosantes à anti-SRP dans la littérature médicale, vol.321, pp.357-360

, Les études européennes ne représentent seulement que 18% des cas rapportés dont 11,7% d'études françaises, vol.172, p.354

, La majorité des patients de notre travail étaient suivis et recrutés par l'intermédiaire des services de médecine interne avec une origine géographique prédominante en Île-de

. France and F. Nord-et-À-l'est-de-la,

, Si nous observons une prédominance féminine chez nos patients avec anticorps anti-SRP, cette particularité diffère des autres cas de myopathie nécrosante sans anticorps anti-SRP, Le sexe-ratio de notre étude était de 1,41 femmes pour un homme alors qu'il semble y avoir plus de femmes dans les études déjà publiées après analyse synthétique des différentes études disponibles (1,73 femmes pour homme)

, Concernant l'origine ethnique, on retrouve 20,4% de sujets mélanodermes dans notre travail contre plus d'un tiers (34%) dans les études déjà publiées mais cette information n'était pas toujours disponible dans de nombreuses études. Ainsi, l'origine ethnique était rarement précisée dans les séries asiatiques, vol.347, pp.357-360

, Concernant les antécédents de cancers solides et d'hémopathies malignes

, comme cela était déjà décrit dans les études d'associations clinico-sérologiques

, 5%) est notable, d'autant que la prévalence dans la population générale est largement inférieure à 2% [414] et que l'association entre myopathies inflammatoires et dysthyroïdies est connue

, Une exposition aux statines comme traitement potentiellement myotoxique était retrouvée chez 12,9% des patients alors que les myopathies nécrosantes à anti-HMG-CoA BIBLIOGRAPHIE

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, ANNEXE 1 : récépissé de soumission d'article 205, p.206