. .. Discussion,

.. .. Données,

.. .. Données-hémodynamiques,

. .. Modifications-thérapeutiques,

. .. Problématiques,

.. .. Points,

C. .. Générale,

A. .. ,

A. .. ,

B. .. ,

T. .. Des-tableaux:,

T. .. Des-figures,

B. 1. Kramoh, K. E. Ake-traboulsi, E. Konin, C. , N. 'goran et al., Management of hypertension in the elderly patient at abidjan cardiology institute (ivory coast), Int J Hypertens, p.651634, 2012.

M. Weber, Management of elderly hypertension: Whom to trat and how low to go, J Hypertens, vol.34, issue.1, p.182, 2016.

A. Benetos, P. Rossignol, A. Cherubini, L. Joly, T. Grodzicki et al., Polypharmacy in the Aging Patient: Management of Hypertension in Octogenarians, JAMA, vol.314, issue.2, pp.170-80, 2015.

N. Beckett, R. Peters, J. Tuomilehto, C. Swift, P. Sever et al., Immediate and late benefits of treating very elderly people with hypertension: results from active treatment extension to Hypertension in the Very Elderly randomised controlled trial, BMJ, vol.344, p.7541, 2011.
URL : https://hal.archives-ouvertes.fr/hal-01335743

A. Benetos, C. J. Bulpitt, M. Petrovic, A. Ungar, A. Rosei et al., An Expert Opinion From the European Society of Hypertension-European Union Geriatric Medicine Society Working Group on the Management of Hypertension in Very Old, Frail Subjects, vol.67, pp.820-825, 1979.

P. H. Novaes, D. T. Da-cruz, A. Lucchetti, I. Leite, and G. Lucchetti, The "iatrogenic triad": polypharmacy, drug-drug interactions, and potentially inappropriate medications in older adults, Int J Clin Pharm, 2017.

D. A. Butt, M. Mamdani, P. C. Austin, K. Tu, T. Gomes et al., The risk of hip fracture after initiating antihypertensive drugs in the elderly, Arch Intern Med, 2012.

T. M. Alhawassi, I. Krass, and L. G. Pont, Impact of Hospitalization on Antihypertensive Pharmacotherapy among Older Persons. Drugs-real world outcomes, vol.2, pp.239-286, 2015.

. Institut-de-veille and . Sanitaire, maladies cardio-neuro-vasculaires: L'hypertension artérielle, 2017.

J. Blacher, J. Halimi, O. Hanon, J. Mourad, A. Pathak et al., Recommandation prise en charge de l'hypertension artérielle. Société Française de l'hypertension artérielle

L. D. Ritchie, N. C. Campbell, and P. Murchie, New NICE guidelines for hypertension, BMJ, vol.343, p.5644, 2011.

G. Mancia, R. Fagard, K. Narkiewicz, J. Redon, A. Zanchetti et al., , 2013.

E. Esc, Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC), J Hypertens, 2013.

N. Parekh, A. Page, K. Ali, K. Davies, and C. Rajkumar, A practical approach to the pharmacological management of hypertension in older people, Ther Adv drug Saf, vol.8, issue.4, pp.117-149, 2017.

F. Buckinx, Y. Rolland, J. Reginster, C. Ricour, J. Petermans et al., Burden of frailty in the elderly population: perspectives for a public health challenge, Arch public Health, vol.73, issue.1, p.19, 2015.

M. E. Yeolekar and S. Sukumaran, Frailty Syndrome: A Review, J Assoc Physicians India, vol.62, issue.11, pp.34-42, 2014.

N. Veronese, B. Stubbs, M. Noale, M. Solmi, A. Pilotto et al., Polypharmacy Is Associated With Higher Frailty Risk in Older People: An 8-Year Longitudinal Cohort Study, J Am Med Dir Assoc, 2017.

K. Saum, B. Schottker, A. D. Meid, B. Holleczek, W. E. Haefeli et al., Is Polypharmacy Associated with Frailty in Older People? Results From the ESTHER Cohort Study, J Am Geriatr Soc, vol.65, issue.2, pp.27-32, 2017.

E. Rosted, M. Schultz, and S. Sanders, Frailty and polypharmacy in elderly patients are associated with a high readmission risk, Dan Med J, vol.63, issue.9, 2016.

G. Ogliari, R. Westendorp, M. Muller, D. Mari, E. Torresani et al., Blood pressure and 10-year mortality risk in the Milan Geriatrics 75+ Cohort Study: role of functional and cognitive status, Age Ageing, vol.44, issue.6, pp.932-939, 2015.

R. E. Hubbard, M. S. Mahony, and K. W. Woodhouse, Medication prescribing in frail older people, Eur J Clin Pharmacol, vol.69, issue.3, pp.319-345, 2013.

T. Ogihara, T. Saruta, H. Rakugi, I. Saito, K. Shimamoto et al., Combination therapy of hypertension in the elderly: a subgroup analysis of the Combination of OLMesartan and a calcium channel blocker or diuretic in Japanese elderly hypertensive patients trial, Hypertens Res, vol.38, issue.1, pp.89-96, 2015.

A. Benetos, C. Labat, P. Rossignol, R. Fay, Y. Rolland et al., Treatment With Multiple Blood Pressure Medications, Achieved Blood Pressure, and Mortality in Older Nursing Home Residents: The PARTAGE Study, JAMA Intern Med, vol.175, issue.6, pp.989-95, 2015.

M. Kuijpers, V. Marum, R. J. Egberts, A. Jansen, and P. , Relationship between polypharmacy and underprescribing, Br J Clin Pharmacol, vol.65, issue.1, pp.130-133, 2008.

L. Jardim, T. V. Jardim, . Souza-wksb-de, C. D. Pimenta, A. Sousa et al., Multiprofessional Treatment of High Blood Pressure in Very Elderly Patients. Arq Bras Cardiol, vol.108, pp.53-62, 2017.

, Comment améliorer la qualité et la sécurité des prescriptions de médicaments chez la personne âgée ?, HAS, 2014.

P. Mibielli, S. Rozenfeld, G. C. Matos, . De, and A. Acurcio-f-de,

, Cad Saude Publica, vol.30, issue.9, pp.1947-56, 2014.

L. Pont and T. Alhawassi, Challenges in the Management of Hypertension in Older Populations, Adv Exp Med Biol, vol.956, pp.167-180, 2017.

T. F. Butt, R. L. Branch, L. Beesley, and U. Martin, Managing hypertension in the very elderly: effect of adverse drug reactions (ADRs) on achieving targets, J Hum Hypertens, vol.24, issue.8, pp.514-522, 2010.

C. Ferri, L. Ferri, and G. Desideri, Management of Hypertension in the Elderly and Frail Elderly, vol.24, pp.1-11, 2017.

T. Van-middelaar, L. A. Van-vught, E. Van-charante, L. Eurelings, S. A. Ligthart et al., Lower dementia risk with different classes of antihypertensive medication in older patients, J Hypertens, 2017.

C. S. Wiysonge, H. A. Bradley, J. Volmink, B. M. Mayosi, and L. H. Opie, Beta-blockers for hypertension. Cochrane database Syst Rev, vol.1, p.2003, 2017.

L. A. Lipsitz, D. Habtemariam, M. Gagnon, I. Iloputaife, F. Sorond et al., Reexamining the Effect of Antihypertensive Medications on Falls in Old Age, Hypertens, vol.66, issue.1, pp.183-192, 1979.
URL : https://hal.archives-ouvertes.fr/hal-01152362

J. Warwick, E. Falaschetti, K. Rockwood, A. Mitnitski, L. Thijs et al., No evidence that frailty modifies the positive impact of antihypertensive treatment in very elderly people: an investigation of the impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placeb, BMC Med, vol.13, p.78, 2015.

S. E. Kjeldsen, A. Stenehjem, I. Os, P. Van-de-borne, M. Burnier et al., Treatment of high blood pressure in elderly and octogenarians: European Society of Hypertension statement on blood pressure targets, vol.25, pp.333-339, 2016.

G. Corrao, P. Mazzola, M. Compagnoni, M. Rea, F. Merlino et al., Antihypertensive Medications, Loop Diuretics, and Risk of Hip Fracture in the Elderly: A Population-Based Cohort Study of 81,617 Italian Patients Newly Treated Between, Drugs Aging, vol.32, issue.11, pp.927-963, 2005.

C. G. Musso and A. J. , Resistant hypertension in the elderly-second line treatments: aldosterone antagonists, central alpha-agonist agents, alpha-adrenergic receptor blockers, direct vasodilators, and exogenous nitric oxide donors, Cardiovasc Hematol Agents Med Chem, vol.12, issue.3, pp.170-173, 2015.

G. Ellis, M. A. Whitehead, D. Robinson, D. O'neill, and P. Langhorne, Comprehensive geriatric assessment for older adults admitted to hospital: meta-analysis of randomised controlled trials, BMJ, vol.343, p.6553, 2011.

M. Gutierrez-valencia, M. Izquierdo, V. Malafarina, J. Alonso-renedo, B. Gonzalez-glaria et al., Impact of hospitalization in an acute geriatric unit on polypharmacy and potentially inappropriate prescriptions: A retrospective study, Geriatr Gerontol Int, 2017.