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et 12 mois, 3 et 12mois biomarqueur au modèle de prédiction clinique. L'IDI correspond à la différence moyenne entre le risque prédit par le modèle de prédiction clinique avec et sans le biomarqueur, chez les patients avec et sans l'événement d'intérêt respectivement. Nous avons utilisé dans cette étude ces 3 méthodes d'évaluation de la valeur ajoutée d'un marqueurs (DFGe, Delta DFG, vol.6 ,