,
,
,
,
,
,
,
,
,
,
,
,
,
,
,
,
,
,
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care, Crit Care Med, vol.29, pp.1303-1313, 2001. ,
Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to, Crit Care Med, vol.35, pp.1414-1429, 2003. ,
The epidemiology of septic shock in French intensive care units: the prospective multicenter cohort EPISS study, Crit Care, vol.17, p.65, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-00873494
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock, Crit Care Med, vol.34, pp.1589-96, 2006. ,
Edusepsis Study Group: Effectiveness of treatments f or severe sepsis: A prospective, multicenter, observational study, Am J Respir Crit Care Med, vol.180, pp.861-66, 2009. ,
Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: Results of a three-year follow-up quasi-experimental study, Crit Care Med, vol.38, pp.1036-1079, 2010. ,
Emergency Medicine Shock Research Network (EMSHOCKNET): Association between timing of antibiotic administr ation and mortality from septic shock in patients treated with a quantitative resuscitation protocol, Crit Care Med, vol.39, pp.2066-71, 2011. ,
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock, Crit Care Med, vol.32, pp.858-73, 2004. ,
American College of Chest Physicians/Society of Critical Care Medecine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis, Crit Care Med, 1992. ,
,
, SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference, vol.29, pp.530-568, 2003.
Sepsis definitions: time for change, Lancet, vol.381, issue.9868, pp.774-75, 2013. ,
Incidence and prognostic value of the systemic inflammatory response syndrome and organ dysfunctions in ward patients, Am J Respir Crit Care Med, vol.192, issue.8, pp.958-64, 2015. ,
The third international consensus definitions for sepsis and septic shock (sepsis-3), JAMA, vol.315, pp.801-811, 2016. ,
An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence in Acutely ill Patients (SOAP) study, Intensive Care Med, vol.32, pp.421-448, 2006. ,
The predictive ability of a weighted systemic inflammatory response syndrome score for microbiologically confirmed-infection in hospitalized patients with suspected sepsis, Crit Care Resusc, vol.13, pp.146-50, 2011. ,
Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure, Intensive Care Med, vol.22, issue.7, pp.707-717, 1996. ,
Le choc septique de l'adulte en France: vingt ans de données épidémiologiques, Réanimation, vol.24, pp.303-312, 2015. ,
Current epidemiology of septic shock: the CUB-Rea Network, Am J Respir Crit Care Med, vol.168, pp.165-72, 2003. ,
The effect of age on the development and outcome of adult sepsis, Crit Care Med, vol.34, pp.15-21, 2006. ,
EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units, Intensive Care Med, vol.30, pp.580-588, 2004. ,
Racial variation in the incidence, care, and outcomes of severe sepsis: analysis of population, patient, and hospital characteristics, Am J Respir Crit Care Med, vol.1, pp.79-84, 2008. ,
Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis, JAMA, vol.3, issue.03, pp.495-503, 2010. ,
Genetic and environmental influences on premature death in adult adoptees, N Engl J Med, vol.318, pp.727-759, 1988. ,
,
, Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study, Lancet Respir Med, vol.3, pp.53-60, 2015.
Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients, Crit Care Med, vol.3, pp.3-45, 2007. ,
Chronic medical conditions and risk of sepsis, PLoS One, vol.7, p.48307, 2012. ,
Improved prognosis of septic shock in patients with cirrhosis: a multicenter study, Crit Care Med, vol.42, pp.1666-75, 2014. ,
EPIC II Group of Investigators. International study of the prevalence and outcomes of infection in intensive care units, JAMA, vol.3, pp.323-332, 2009. ,
Pathophysiologic basis of sepsis: considerations for future strategies of intervention, Crit Care Med, vol.28, issue.9, pp.4-8, 2000. ,
Toll-like receptors in the induction of the innate immune response, Nature, vol.406, pp.782-789, 2000. ,
Physiopathologie du sepsis sévère, Presse Med, vol.33, pp.256-61, 2004. ,
Endothelial and vascular smooth muscle function in sepsis, J Crit Care, vol.9, pp.262-80, 1994. ,
Mécanismes physiopathologiques impliqués dans la dysfonction d'organes au cours du sepsis, Rev Med Suisse, vol.6, pp.2406-2415, 2010. ,
Early goal-directed therapy in the treatment of severe sepsis and septic shock, N Engl J Med, vol.345, pp.1368-77, 2001. ,
Efficacy and safety of recombinant human activated protein C for severe sepsis, N Engl J Med, vol.344, pp.699-709, 2001. ,
Effect of treatment with low doses of hydrocortisone and fludrocortisones on mortality in patients with septic shock, JAMA, vol.288, pp.862-71, 2002. ,
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock, Crit Care Med, vol.36, pp.296-327, 2008. ,
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock 2012, Crit Care Med, vol.41, pp.580-637, 2013. ,
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis ,
, Crit Care Med, vol.38, pp.367-74, 2010.
, BMJ, vol.328, pp.1490-1498, 2004.
et al for the ProMISe trial investigators. Trial of early, goaldirected resuscitation for septic shock, N Engl J Med, 2015. ,
, Goal-directed resuscitation for patients with early septic shock, The ARISE Investigators and the ANZICS Clinical Trials Group, vol.371, pp.1496-1506, 2014.
A randomized trial of protocolbased care for early septic shock, ProCESS Investigators, vol.370, pp.1683-93, 2014. ,
Influence of antibiotic therapy on mortality of critical surgical illness caused or complicated by infection, Surg Infect (Larchmt), vol.6, pp.41-54, 2005. ,
Outcome of septic shock in older adults after implementation of the sepsis bundle, J Am Geriatr Soc, vol.56, pp.272-78, 2008. ,
Impact of the implementation of a sepsis protocol for the management of fluid refractory septic shock: A singlecenter, before-and-after study, Clin Ther, vol.32, pp.1285-93, 2010. ,
Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guidelinebased performance improvement program, Crit Care Med, vol.42, pp.1749-55, 2014. ,
The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection, J Intern Med, vol.244, pp.379-86, 1998. ,
The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting, Chest, vol.118, pp.146-55, 2000. ,
Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis, Am J Med, vol.115, pp.529-564, 2003. ,
Community acquired bloodstream infection in critically ill adult patients: impact of shock and inappropriate antibiotic therapy on survival, Chest, vol.123, pp.1615-1639, 2003. ,
Severe Sepsis and Septic Shock: Review of the Literature and Emergency Department Management Guidelines, Ann Emerg Med, vol.48, issue.1, 2006. ,
Prise en charge initiale des états septiques graves de l'adulte et de l'enfant / Initial management of severe sepsis in aldults and children, 2016. ,
, Early management of septic shock in emergency department
The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. Laboratory and epidemiologic observations, Rev Infect Dis, vol.5, pp.35-53, 1983. ,
The systemic inflammatory repose syndrome as a predictor of bacteraemia and outcome from sepsis, Q J Med, vol.89, pp.515-537, 1996. ,
, Antibiothérapie probabiliste des états septiques graves, 2004.
Impact of the Surviving Sepsis Campaign on the recognition and management of severe sepsis in the emergency department: are we failing, Emerg Med J, vol.28, pp.670-675, 2011. ,
Insights into severe sepsis in older patient: from epidemiology to evidence-based management, Clin Infect Dis, vol.40, issue.5, pp.719-746, 2005. ,
Ageing and infection, Lancet Infect Dis, vol.2, issue.11, pp.656-66, 2022. ,
Systemic Inflammatory Response Syndrome Criteria In Defining Severe Sepsis, New England journal of Medicine, 2015. ,
Diagnosis of infection in sepsis: an evidence-based review, Crit Care Med, vol.32, pp.466-475, 2004. ,
, Referal Recognize the need for clear referral guidelines that are accepted and adopted at a local level in all countries by initiating the developement of global guidelines