, Certaines études comme l'étude MONICA ne sont pas en faveur de ce « French Paradox » et elle a même démontré un taux semblable de maladies cardiovasculaires

, Il conviendrait davantage de parler de « Paradoxe Nord-Sud » qui inclurait en plus de la consommation de vin rouge, une alimentation de type méditerranéenne

, Enfin les polyphénols de pépins de raisin se révèlent être des ingrédients phares dans de nombreuses gammes de cosmétologie

M. Abert, . O. Coulomb-p, and . J. Coulomb-p, L'un des agents du "French Paradox": le resvératrol du vin rouge, Phytothérapie Européenne, vol.13, pp.5-8, 2003.

A. J. Jonhson-r, Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice, Rejuvenation Research, vol.12, issue.6, pp.445-453, 2009.

A. S. , Polyphénols de l'alimentation: extraction, pouvoir antioxydant et intéraction avec des ions métalliques, p.261, 2013.

. Travail, Cancer et environnement. Portail santé, environnement, travail

. Agpiii, Classification for the orders and families of flowering plants, Botanical Journal of the Linnean Society, vol.161, pp.105-121, 2009.

M. Alcaraz, . Rosa-b, J. Castillo, . Benavente-garcia-o, J. Lorente et al., Protective effects of several plant polyphenols against chromosomal damage induced in vivo by X-rays comparative study versus diosmin and rutin. Radiological protection of patients in diagnostic and interventional radiology, nuclear medicine and radiotherapy contributed papers, pp.26-30, 2001.

. I. Aruoma-o, . Murcia-a, and J. Butler, Evaluation of the Antioxidant and Prooxidant Actions of Gallic Acid and its Derivatives, Journal of Chemistry, vol.41, pp.1880-1885, 1993.

D. S. Asha, . K. Sagar-chandrasekar-b, . R. Manjula-k, and . Ishii-n, Grape seed proanthocyanidin lowers brain oxidative stress in adult and middle-aged rat, Exp Gerontol, vol.46, pp.958-964, 2011.

. Auberval-l and . Dal-s, Beneficial effects of a red wine polyphenol extract on high-fat diet-induced metabolic syndrome in rats, European Journal of Nutrition, pp.1-9, 2016.

M. Baarine, . J. Thandapilly-s, . L. Louis-x, F. Mazue, D. Delmas et al., Pro-apoptotic versus anti-apoptotic properties of dietary resveratrol on tumoral and normal cardiac cells, Genes Nutr, vol.6, issue.2, pp.161-169, 2011.

C. O. Bacon-r, J. Lasnier, -. Mcfadden, and . Smith, Guide d'identification des principales maladies de la vigne, Canada Agriculture et Agroalimentaire, 2006. Disponible sur

M. Balu, P. Sangeetha, and G. Murali, Age-related oxidative protein damages in central nervous system of rats: modulatory role of grap seed extact, Int J Dev Neurosci, vol.23, pp.501-507, 2005.

. Barros-d, . B. Amaral-o, L. Izquierdo, C. Do, . Bassols-raseira-m et al., Behavioral and genoprotective effects of Vaccinium berries intake in mice, Pharmacol Biochem Behav, vol.84, pp.229-234, 2006.

. Bennetau-pelissero-c, Polyphénols et voies de signalisation, données récentes. Cahiers de nutrition et de diététique, pp.151-159, 2014.

J. Bensalem, Effets des polyphénols de baies sur le déclin cognitif lié au vieillissement chez la souris. Thèse : Doctorat spécialité Nutrition, p.276, 2014.

. Bertelli-a, J. Caen, and . J. Hendricks-h, Cahiers scientifiques et techniques sur le vin et les maladies cardiovasclulaires. Office international de la vigne et du vin, 1994.

. Bertelli-a-[, Plasma and tissue resveratrol concentrations and pharmacological activity, Drugs Exp Clin Res, vol.24, pp.133-138, 1998.

L. Bertrand-m.-et, Angine de poitrine par arthérosclérose coronaire. Encyclopédie de Médecine Chirurgicale, Cardiologie-angéiologie, 1991.

. Bessis-r, P. Jeandet, A. M. Breuil-a, D. Blache, . Meunier-p.-et et al., Un polyph remarqué: le resvératrol, Guide Vin et Santé: Les Editions du Voyage, pp.61-73, 1998.

J. Blesa, S. Phani, and . Jackson-lewis-v, Classic and new animal models of Parkinson's disease, Journal of Biomedicine and Biotechnology, p.10, 2012.

. J. Blot-w, J. K. Mclaughlin, . M. Winn-d, . F. Austin-d, . S. Greenberg-r et al., Smoking and drinking in relation to oral and pharyngeal cancer, Cancer Research, vol.48, issue.11, pp.3282-3287, 1988.

. Boismoreau-n, Le raisin: effets toxiques et bénéfiques. Thèse: Vétérinaire, p.84, 2005.

. Boneu-b.-et and J. P. Cazenave, Introduction à l'étude de l'hémostase et de la thrombose, Reims : Laboratoires Boehringer Ingelheim, 1992.

. Boneu-b.-et and J. P. Cazenave, Introduction à l'étude l'hémostase et de la thrombose, Reims : Laboratoires Boehringer Ingelheim, 1982.

. Botineau-m, Botanique systématique et appliquée des plantes à fleurs. Tec and Doc Lavoisier, p.1336, 2010.

C. Bouchardy, F. Clavel, V. C. La, . Raymond-l.-et, and . Boyle-p,

, Alcohol, vol.45, issue.5, pp.842-846, 1990.

. Braidy-n, . E. Jugder-b, . Poljak-a, T. Jayasena, H. Mansour et al., Resveratrol as a potential therapeutic candidate for the treatment and management of alzheimer's disease, Curr. Top. Med. Chem, issue.17, pp.1951-1960, 2016.

J. Brandt and . Vasey-c, Les cures de santé : Régénération et détoxication; l'exemple de la cure de raisin, 2010.

. Braunwald-e, Cardiovascular medicine at the turn of the millenium: triumphs, concerns, and opportunities, N Engk J Med, vol.337, pp.1360-1369, 1997.

. Bravo-l, . Abia-r, . A. Eastwood-m, and . Saura-calixto-f, Degradation of polyphenols (catechin and tannic acid) in intestinal tract. Effect on colonic fermentation and fecal output, Br.J.Nutr, issue.6, pp.933-946, 1994.

. Brunet-p, Le vin et les vins au restaurant. Elaboration, origine, dégustations, conservation, service. Paris: BPI : 1990, pp.20-24

J. Bruneton, Pharmacognosie Phytochimie Plantes médicinales. Tec and doc, pp.435-436, 2009.

. Buchter-weisbrodt-h.-raisins and . Chantecler, , p.79, 2004.

C. Callec, Vins du monde, p.511, 2002.

. Caruso-f, J. Tanski, . Villegas-estrada-a, and . Rossi-m, Structural basis for antioxidant activity of trans-resveratrol: an initio calculations and crystal and molecular structure, Journal Agric.Food.Chem, vol.52, pp.7304-7310, 2004.

. Cathiard-thomas-m, La santé par le raisin et la vinothérapie, Médicis-entrelacs, p.122, 1998.

. Caudalie, Disponible sur, 2015.

C. Wu-d, Ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E, Mol Cell Biochem, vol.204, pp.154-167, 2000.

C. A. Wu-d, Oxidative Stress, and Free Radical Damage, Alcohol Res Health, vol.27, issue.4, pp.277-284, 2003.

C. S. , Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells, Neuroreport, vol.8, pp.1499-1502, 1997.

. Chastang-t, Etude de la synthèse du resvératrol et de ses dérivés (viniférines) par des suspensions de cellules de vigne et optimisation de la production en bioréacteur, p.193, 2014.

. Cheng-z, S. Guo, K. Copps, . Dong-x, . Kollipara-r et al., Foxo1 integrates insulin signaling with mitochondrial function in the liver, National Med, vol.15, pp.1307-1311, 2009.

. Cheynier-v, H. Fulcrand, and . Souquet-jm, Stabilisation Tanins-Anthocyanes : Données générales, 1998.

B. G. Chiva- and . Urpi-sarda-m, Red wine polyphenols : Non-Alcoholic Red Wine May Help Reduce High Blood Pressure, 2012.

. Chouchan-d, Du raisin pour prévenir les cancers, vol.164, p.8, 1997.

C. P. , FUTURA-SCIENCES: la chimie du vin, p.3, 2004.

. Cisbani-g, An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity, Cell Death and Disease, vol.2012, issue.3, p.121

. Clausse-f, Radicaux libres et molécules à activité anti-oxydante, p.94

. J. Clifford-a, . E. Ebeler-s, J. D. Ebeler, . D. Bills-n, . H. Hinrichs-s et al., Delayed tumor onset in transgenic mice fed an amino acid-based diet supplemented with red wine solids, Am. J.Clin.Nutr, vol.64, pp.748-756, 1996.

. Collombet-f.-et and J. P. Paireault, Grands et Petits vins de France, 1998.

. Commenges-d, V. Scotet, R. S. Jacqmin-gadda, and H. Barberger-,

. Gateau-p.-et and J. F. Dartiques, Intake of flavonoids and risk of dementia, Eur J Epidemiol, vol.16, pp.357-363, 2000.

. Corder-r, J. A. Douthwaite, . M. Lees-d, . Q. Khan-n, . Viseu et al., Endothelin-1 synthesis reduceb by wine, Nature, issue.6866, pp.863-864, 2001.

. Corder-r, Inhibition of cyclic strain-induced endothelin-1 gene expression by resveratrol, Hypertension, vol.42, pp.1198-1205, 2003.

. V. Culpitt-s, . F. Rogers-d, . S. Fenwick-p, . Shah-p, . De-matos-c et al., Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD, Thorax, vol.58, issue.11, pp.942-946, 2003.

. Dangles-o, Antioxidant activity of plant phenol: chemical mechanims and biological significance, Current Organic Chemistry, vol.16, pp.692-714, 2012.

. Dangles-o and . Dufour-c, Flavonoids: chemistry, biochemistry and applications

O. Andersen, K. Markham, and . Press, , vol.9, pp.443-469, 2006.

. Dangles-o and . Dufour-c, Recent advances in Polyphenol Research, pp.67-87, 2008.

. Dangles-o, Propriétés chimiques des polyphénols dans les polyphénols en agroalimentaire . Lavoisier, Collection Sciences et Techniques agroalimentaires, pp.29-50, 2006.

. J. Day-a, Y. Bao, . R. Morgan-m, and . Williamson-g, Conjugation position of quercetin glucoronides anf effets on bilogical activity, Free Radical Biology and Medicine, vol.29, pp.1234-1243, 2000.

. De-crevoisier-r, Cancérogénèse, développement tumoral, classification, 2010.

G. De-gaetano and . Di-castelnuovo-a, The mediterranean lecture: wine and thrombosis from epidemiology to physiology and back, Pathophysiology of Haemostasis and Thrombosis, vol.33, issue.5-6, pp.466-471, 2003.

. De-lorgeril-m, Mediteranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease, Lancet, vol.343, pp.1454-1459, 1994.

M. C. De-rijk, . Tzourio-c.-et, and . M. Breteler-m, Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON collaborative study. European Community Concerted Action on the Epidemiology of Parkinson's disease, Journal of Neurology Neurosurgery and Psychiatry, vol.62, issue.1, pp.10-15, 1997.

. Deak-m and . Falk-h, On the chemistry of resveratrol diastéromers, vol.134, pp.883-888, 2003.

J. Delarue, . Husson-m.-et, and . Schellenberg-f, Serum lipoprotein(a) (Lp(a)) in alcoholic men; effect of withdrawal, Alcohol, vol.13, issue.3, pp.309-314, 1996.

. Delmas-d, C. D. Lancon-a, B. Jannin, and L. N. Et, Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer, Current Drug Targets, vol.7, issue.4, pp.423-442, 2006.

. Delmas-d, V. Aires, E. Limagne, P. Dutartre, F. Mazue et al.,

F. , Transport, stability, and biological activity of resveratrol, Ann N Y Acad Sci, pp.58-59, 1215.

. Dembinska-kiec-a and . Mykkanen-o.-et-kiec-wilk-b, Antioxydant phytochemicals against type 2 diabetes, British Journal of Nutrition, vol.99, pp.109-117, 2008.

H. S. Demrow and F. Slane-p.r.-et, Administration of wine and graps juice inhibits in vivo platelets activity and throbosis in stenosed canine coronary arteries, Circulation, vol.91, pp.1182-1188, 1995.

. Desquiret-dumas-v, . Gueguen-n.-et, and . Leman-g, Resveratrol induces a mitochondrial complex i-dependent increase in nadh oxidation responsible for sirtuin activation in liver cells, The Journal of Biological Chemistry, vol.288, issue.51, pp.36662-36675, 2013.

D. A. Jolitha-a and . Ishii-n, Grape seed proanthocyanidin extact (GSPE) and antioxidant defense in the brain of adult rats, Med Sci Monit, vol.12, pp.124-129, 2006.

. Ducasse-m-a, Impact des enzymes sur la composition en polysaccharides et en polyphénols des vins rouges. Etude l'évolution des ces composés en solution modèle vin, chimie et technologie des aliments. Montpellier: Sciences des Procédés, p.242, 2009.

P. Ducimetiere, . Lang-t, P. Amouyel, and . Arveiler-d, Rates of coronary events are similar in France and southern Europe, BMJ, vol.320, pp.249-250, 2000.

P. Ducimetiere, J. L. Richard, F. Cambien, and C. J. Rakotovao-r.-et, Coronary heart disease in middle-aged Frenchmen. Comparaison between Paris Prospective Study, Seven Countries and Pooling Project, Lancet, vol.1, pp.1346-1350, 1990.

. Ducimetiere-p.-et and J. L. Ichard, Dietary lipids and coronary heart disease: is there a French paradox?, Nutr Metab Cardiovasc Disease, issue.2, pp.195-201, 1992.

. S. Duncan-r, . L. Goad-d, M. A. Grillo, and K. S. Payne-a, Control of intercellular calcium signaling as a neuroprotective strategy, Molecules, vol.15, issue.3, pp.1168-1195, 2010.

. Feng-x and . Liang-n, Resveratrol inhibits Beta-amyloids-induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathway, PLoS ONE, vol.8, issue.3, 2013.

. F. Fitzpatrick-d, . L. Hirschfield-s, and . G. Coffey-r, Endothelium-dependent vasorelaxing activity of wine and other grape products, Am J. Physiol, vol.265, pp.774-778, 1993.

. F. Fitzpatrick-d, . L. Hirschfield-s, and . G. Coffey-r, Endothelium-dependent vasorelaxing activity of wine and other grape products, Am J Physiol, vol.265, pp.774-778, 1993.

. A. Fleck-r, . V. Rao-l, . I. Rapaport-s, and . Varki-n, Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody, Thromb Res, vol.59, pp.421-437, 1990.

C. Frankel, Guide des cépages et terroirs, Delachaux et Niestlé, issue.269, pp.26-27, 2013.

F. L. , Biological effects of resveratrol, Life Sci, vol.66, pp.663-673, 2000.

M. Fujimura, Y. Morita-fujimura, N. Noshita, T. Sugawara, and . Kawase,

M. H. Chan-p, The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome C in ischemic brain after transient focal cerebral ischemia in mice, Journal Neuroscience, vol.20, issue.8, pp.2017-2024

. R. Fukumoto-l and . Mazza-g, Assessing antioxidant and prooxidant activities of phenolis compounds, Journal of Agriculture and Food Chemistry, vol.48, pp.3596-3604, 2000.

H. H. Gaballah, . S. Zakaria-s, . M. Elbatsh-m, and . Tahoon-n.m, Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson's disease, vol.25, pp.10-16, 2016.

. K. Ganjam-g, . Y. Dimova-e, and . G. Unterman-t, Fox01 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by resveratol, J.Biol Chem, 2009.

. Gasser-t, Genetic of Parkinson's disease, Current Opinion in Neurology, vol.18, pp.363-369, 2005.

. D. Gehm-b, . S. Levenson-a, H. Liu, . J. Lee-e, . M. Amundsen-b et al., Estrogenic effect of resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors: role of AF-1 and AF-2, J. Steroids Biochem Mol Biol, vol.88, pp.223-234, 2004.

. I. Giasson-b, H. Ischiropoulos, . M. Lee-v, and . Trojanowski-j.q, The relationship between oxidative/nitrative stress and pathological inclusions in

, Alzheimer's and Parkinson's diseases, Free Radical Biology and Medicine, vol.32, issue.12, pp.1264-1275, 2002.

H. Gin, V. Rigalleau, O. Caubet, and J. Masquelier, Effects of red wine, tannic acid, or ethanol on glucose tolerance in non -insulin-dependent diabetic patients and on starch digestibility in vitro, Metabolism, vol.48, pp.1179-1183, 1999.

H. Gin, . Morlat-p, and J. M. Ragnaud, Short-term effect of red wine (consumed during meals) on insulin requirement and glucose tolerance in diabetic patients, Diabetes Care, issue.4, pp.546-548, 1992.

. Godichaus-s and . Krisa-s, Desactivation of culture humain liver myofibroblasts by trans-resveratrol, a grapevine-derived polyphenol, Hepatology, vol.31, pp.922-931, 2000.

. Goldberg-d.m, . E. Hahn-s, and . Parkes-j.g, Beyond alcohol: beverage consumption and cardiovascular mortality, Clin Chim Acta, vol.237, issue.1-2, pp.155-187, 1995.

P. Gresele, C. Cerletti, and . Guglielmini, Effects of resveratrol and othe wine polyphenols on vascular function: an update, Journal of Nutritional Biochemistry, vol.22, pp.201-211, 2011.

. Gronbaek-m, Mortality associated with moderate intakes of wine, beer, or spirit, Brit. Med. Journ, vol.310, pp.1165-1169, 1995.

. J. Gryglewski-r and . Korbut-r, On the mechanism of antithrombotic action of flavonoids, Biochemistry and Pharmacology, vol.36, pp.317-322, 1987.

. Halliwell-b, Free radicals and antioxidants: A personnal view, Nutrition Reviews, vol.994, issue.52, pp.253-265

B. H. Havsteen, The biochemistry and medical significance of flavonoids, vol.96, pp.67-202

Y. He, . Lee-t.-et, and . K. Leong-s, 6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra, Brain Research, issue.1, pp.163-166, 2000.

. E. Heim-k, . R. Tagliaferro-a, and . J. Bobilya-d, Flavonoids antioxidants: chemistry, metabolism and structure-activity relationships, Journal of Nutritional Biochemistry, vol.13, pp.572-584, 2002.

H. S. Zhang-l, Antioxidant properties and bioactive components of Norton (Vitis aestivalis) and Cabernet Franc (Vitis vinifera) wine grapes, Food Science and Technology, p.42, 2009.

. R. Huxley-r and . A. Neil-h, The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies

, European Journal of Clinical Nutrition, vol.57, pp.904-908, 2003.

. Ignatowicz-e and . Baer-dubowska-w, Resveratrol, a natural chemopreventive agent against degenerative diseases, Pol J Pharmacol, vol.53, pp.557-569, 2001.

C. Ihling, T. Szombathy, B. Bohrmann, M. Brockhaus, . E. Hans-s et al., Co-expression of endothelin-converting enzyme-1 and endothelin-1 in different stages of human atherosclerosis, Circulation, vol.104, pp.864-869, 2001.

. Imen-z, Etude de l'évolution et de l'extractabilité des composés phénoliques du raisin en milieu hydroalcoolique pendant la maturation. Lien avec les propriétes mécaniques de la baie, Angers, p.330, 2011.

. Inrap, Institut National de Recherches Archéologiques Préventives

. Jang-m, . Cai-l, . O. Udeani-g, . F. Thomas-c, . Beecher-c;w et al., Cancer chemopreventive activity of resveratrol, a natural product derived from grapes, Sciences, vol.275, pp.218-220, 1997.

P. Jeandet, . Bessis-r, and . F. Maume-b, Analysis of resveratrol in Burgundy wines, J.Wine Res, pp.79-85, 1993.

. V. Jovanovic-s, S. Steenken, M. Tosic, . Marjanovic-b.-et, and . Simic-m.g, Flavonoids as antioxidants, Journal of Biological Chemistry society, vol.116, pp.4846-4851, 1994.

. Kalt-w, . Hanneken-a, . Milbury-p.-et, and . Tremblay-f, Recent research on polyphenolic in vision and eye health, J.Agric.Food.Chem, issue.7, pp.4001-4007, 2010.

. Kawashima-s.-et and . Yokoyama, Dysfunction of endothelial nitric oxide synthase ans atherosclerosis, Arterioscler Thromb Vasc Biol, vol.24, pp.998-1005, 2004.

. Keys-a, Seven Countries: A Multivariate Analysis of Death and Coronary Heart Disease, vol.245, pp.511-512, 1980.

. I. Kirk-r, J. A. Deitch, J. M. Wu, and . M. Lerea-k, Resveratrol decreases early signaling events in washed platelets but has a little effect of platelet in whole food, Blood Cells Mol Dis, vol.26, pp.144-150, 2000.

. Krikorian-r, . A. Nash-t, M. D. Shidler, and J. J. Shukitt-hale-b.-et, Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment, Br J Nutr, pp.730-734, 2010.

. Kumar-p, . S. Padi-s, . S. Naidu-p, and . Kumar-a, Cyclooxygenase inhibition attenuates 3-nitropropionic acid-induced neurotoxicity in rats: possible antioxydant mechanisms. Fundamental and Clinical Pharmacology, vol.21, pp.297-306, 2007.

J. K. Kundu, Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives, Cancer Letters, vol.269, issue.2, pp.243-261, 2008.

. Lajoie-p.-et and . L. Snapp-e, Formation and toxicity of soluble polyglutamine oligomers in living cells, PLoS ONE, issue.12, p.5, 2010.

. E. Lands-w, Alcohol and cardio-vascular disease, Alcohol Health Res. World, vol.14, pp.340-312, 1990.

A. Le-roux, E. Josset, S. Benzina, B. Nadal, and . Desage-el-murr-m,

. Heurtaux-b, Evaluation of the radioprotective potential of the polyphenol norbadione A. Letters in drug Design and discovery, vol.9, pp.48-53, 2012.

. Lefief-delcourt-a, Le raisin malin, p.191, 2010.

. Lerman-a, . S. Edwards-b, J. W. Hallett, . M. Heublein-d, . M. Sandberg-s et al., Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis, N.Engl J Med, vol.325, pp.997-1001, 1991.

. Letenneur-l, . Larrieu-s.-et, and . Barberger-gateau-p, Alcohol and tobacco consumption as risk factors of dementia : a reviex of epidemiological studies, Biomed Pharmacother, vol.58, pp.95-99, 2004.

L. Barbato, D. Baldelli, S. Pagliei, B. Aquilano-k.-et, and . R. Ciriolo-m, Caloric restriction and the nutrient-sensing PGC-1? in mitochondrial homeostasis : new perspectives in neurogeneration, International Journal of Cell Biology, 2012.

L. C. Chen-c.-et and . Liang-y, Molecular modeling of flavonoids that inhibits xanthine oxydase, Bioscience, Biotechnology and Biophysical Research Communications, vol.294, pp.167-172, 2002.

. L. Liu-b, . Zhang-x, . Zhang-w.-et, and . Zhen-h.n, New enlightenment of French Paradox: Resveratrol's potential for cancer chemoprevention and anti-cancer therapy, Cancer Biol Ther, vol.6, issue.12, pp.1833-1836, 2007.

J. Louvieux, Mesure de l'efficacité d'extraits d'algues sur la vigne (Vitis vinifera L.), en conditions contrôlées et au vignoble, validée par la mesure de l'activité photosynthétique et les analyses chimiques, 2004.

. E. Macdonald-m, . M. Ambrose-c, and . P. Duyao-m, A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group, Cell, vol.72, issue.6, pp.971-983, 1993.

. Maestre-r, J. D. Douglass, S. Kodukula, and . Medina-i, Alterations in the intestinal assimilation of oxidized PUFAs are ameliorated by a polyphenol-rich grape seed extract in an in vitro model and caco-2 cells, The Journal of Nutrition, vol.143, issue.3, pp.295-301, 2013.

C. Mambrini, In vino veritas": polyphénols du raisin et leurs applications, p.110, 2004.

M. I. , Resveratrol for Alzheimer's disease, Sci Transl Med, vol.2017, issue.375, p.9

J. Masquelier, Action bactéricide et antivirale du vin. C.R 104e Congr, Natl.Soc.Sav, pp.447-457, 1979.

. Mazue-f, Effets des polyphénols de vin rouge sur la prolifération cellulaire et sur le métabolisme du resvératrol. Thèse : Docteur de l'université de Bourgogne spécialitée biochimie, biologie cellulaire et moléculaire, p.191, 2011.

K. E. Mccalley-a and . J. Payne-a, Resveratrol and calcium signaling: molecular mechanisms and clinical relevance, Molecules, vol.19, issue.6, pp.7327-7340, 2014.

J. M. Merillon, B. Fauconneau, . W. Tequo-p, L. Barrier, and . Vercauteren,

J. , Newly Extracted from Vitis vinifera Cell Cultures, Antioxidant Activity of the Stilbene Astringin, vol.43, issue.6, pp.1092-1093, 1997.

P. Montoro, S. Piacente, and . Oleszek-w, Liquid chromatography/tandem mass spectrometry of unusual phenols from Yucca schildigera bark: comaparison with other analytical techniques, J.Mass.Spectrosc, vol.39, pp.1131-1138, 2004.

. Mukherjee-s, . Das-s.k, and . M. Vasudevan-d, Protective role of extracts of grape skin and grape flesh on ethanol-induced oxidative stres, inflammation and histological alterations in rat brain [Article] // Archives of physiology and biochemistry, vol.121, pp.144-151, 2015.

. Mukherjee-s, . K. Das-s, and . M. Vasudevan-d, Dietary grapes (Vitis vinifera) feeding attenuates ethanol-induced oxidative stress in blood and modulates immune functions in mice, Indian J Biochem Biophys, issue.5, pp.379-385, 2012.

. Nagao-a and M. Seki, Inhibition of xanthine oxidase by flavonoids, Bioscience, Biotechnoogy and Biochemistry, vol.63, issue.10, pp.1787-1790, 1999.

. Navarre-c.-et-langlade-f.-l'oenologie, Lassay-les-Châteaux : Tec and Doc, p.364, 2003.

. Nordmann-r and C. Ribiere, Alcool et radicaux libres: données actuelles. M/S (Médecine/sciences), pp.336-345, 1988.

N. Science, . Nutrition, . Prevention, . Sante, and . Le,

, Disponible sur

. O. Obisesan-t, . Hirsch-r, O. Kosoko, . Carlson-l.-et, and . Parrott-m, Moderate wine consumption is associated with decreased odds of developing agerelated macular degeneration in NHANES-1, J Am Geriatr Soc, vol.46, pp.1-7, 1998.

J. M. Orgogozo, J. F. Dartiques, S. Lafont, L. Letenneur, D. Commenges et al., Wine consumption and dementia in the elderly:a prospective community study in the Bordeaux area, Rev Neurol, vol.153, pp.185-192, 1997.

J. F. Ouradou, Le raisin, ses coproduits et leur utilisation pour l'homme, p.132, 1998.

P. B. Isaac-m and . Jayant-d.-et-charpentier-c, Occurrence of resveratrol and pterostilbene in age-old darakchasava, an ayurvedic medicine from India, Journal Ethnopharmacologie, vol.68, issue.1-3, pp.71-76, 1999.

. R. Pendurthi-u, J. T. Williams, and . V. Rao-l, Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : a possible mechanism for the cardiovascular benefits associated with moderate consumption of wine, Arterioscler Thromb. Vasc. Biol, vol.19, pp.419-426, 1999.

. Pervaiz-s, Resveratrol: from grapevines to mammalian biology, FASEB J, vol.17, pp.1975-1985, 2003.

P. P. , Flanonoids as antioxidants, Journal of Natural Production, vol.63, pp.1035-1042, 2000.

. A. Potter-g, The cancer preventive agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1, Br J Cancer, vol.86, issue.5, pp.774-778, 2002.

. Pozo-guisado-e, The antiproliferative activity of resveratrol results in apoptosis in MCF-7 but not in MDA-MB-231 human breast cancer cells, J. Steroids Biochem. Biol, vol.84, pp.149-157, 2003.

. Quezada-calvillo-r, . Robayo-torres-c.c, . Hamaker-b;r, . Quaroni-a, . D. Brayer-g et al., Luminal substate "brake" on mucosal maltase-glucoamylase activity regulates total rate of starch digestion to glucose, Journal Pediatr. Gastroenterol.Nutr, vol.45, pp.32-43, 2007.

. Quezada-calvillo-r, . Sim-l, Z. Ao, . Hamaker-b;r, . Quaroni-a et al., Luminal substrate "brake" on maltase-glucoamyase activity is located within the glucoamylase subunit, J. Nutr, vol.138, pp.685-692, 2008.

. R. Ramirez-m, . Izquierdo-i, . Do, . Bassols-raseira-m, J. A. Zuanazzi et al., Effect of lyophilised Vaccinium berries on memory, anxiety and locomotion in adult rats, Pharmacol Res, vol.52, pp.457-462, 2005.

R. S. Gueguen-r and . Schenker-j.-et-d'houtaud-a, Alcohol and mortality in middle-aged men from eastern France, Epidemiology, vol.9, issue.2, pp.184-188, 1998.

R. S. De-lorgeril-m, Wine, alcohol, platelets and the French Paradox for coronary heart disease, Lancet, vol.339, pp.1523-1526, 1992.

R. S. Gueguen-r, J. Schenker, and . Et-d', HOUTAUD A Alcohol and mortality in middle-aged men from eastern France, Epidemiology, vol.9, issue.2, pp.184-188, 1998.

. Retournard-d.-la-vigne and . Rustica, , p.111, 1997.

J. P. Rifler, F. Lorcerie, . Durand-p, D. Delmas, K. Ragot et al., A moderate red wine intake improves blood lipid parameters and erythrocytes membrane fluidity in post myocardial infarct patients, Mol. Nutr. Food. Res, 2011.

. M. Robert-a and . Robert-l, Etude de l'effet des oligomères procyanidoliques sur la fibrillogénèse de la cornée, Journal Français d'Opthalmologie, vol.10, issue.28, pp.1017-1025, 2005.

. I. Rocha-gonzalez-h, . Ambriz-tututi-m, . Granados-soto-v, and . Resveratrol, A natural compound with pharmacological potential in neurodegenerative diseases, CNS Neuroscience and Therapeutics, vol.14, issue.3, pp.234-247, 2008.

. Rosenberg-l, J. R. Palmer, . R. Miller-d, . A. Clarke-e, and . Shapiro-s, A case-control study of alcoholic beverage consumption and breast cancer, Am. J. Epidemiol, vol.131, pp.6-14, 1990.

. Roullier-gall-c, Analyses métaboliques du vin : "chemical messages in a bottle, 2014.

J. C. Ruf and J. L. Berger, Platelet rebound effect of alcohol with drawal and wine drinking in rats. Relation to tannins and lipid peroxidation

, Arteriosclerosis Thromb. Vasc. Biol, vol.15, pp.140-144, 1995.

. Sakanaka-s and . Kim-m, Preventive Effect of Green Tea Polyphenols against Dental Caries in Conventional Rats, Bioscience, Biotechnology and Biochemistry, vol.56, issue.4, pp.592-594, 1992.

. Sanche-fidalgo-s, . Cardeno-a, . Villegas-i, . Talero-e.et, and C. A. De-la-castra, Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice, Eur. J. Pharmacol, pp.78-84, 2010.

. Scalbert-a, C. Manach, C. Morand, . Remesy-c, and . Jimenez-l, Dietary polyphenols and the prevention of diseases, Critical Reviews in Food Science and Nutrition, vol.45, pp.287-306, 2005.

. Scheromm-p.-quand-le-raisin-se-fait-vin and . Versailles, , pp.64-65, 2011.

. Shukitt-hale-b, . Carey-a, . Simon-l, and J. A. Mark-d, Effects of Concord grape juice on cognitive and motor deficits in aging, Nutrition, vol.22, pp.295-302, 2006.

. H. Siemmann-e and . L. Creasy-l, Concentration of the phytoalexin resveratrol in wine, Am.J.Enol.Vitic, vol.43, pp.49-52, 1992.

P. R. Soares-filho, . Castro-i.-et, and . Stahlschmidt-a, Effect of wine associated with physical exercise in the cardiovascular system of spontaneously hipertensive rats, Arq Bras Cardiol, vol.96, issue.4, pp.277-283, 2011.

. J. Soleas-g, . P. Diamandis-e, and . M. Goldberg-d, The world of resveratrol, Nutr.Cancer.Prev, vol.3, pp.159-182, 2000.

. J. Surmeier-d, J. N. Guzman, J. Sanchez-padilla, and . A. Goldberg-j, The origins of oxidant stress in Parkinson's disease and therapeutic strategies, Antioxidants and Redox Signaling, vol.14, issue.7, pp.1289-1301, 2011.

. Tan-l, H. P. Yang, W. Pang, H. Lu, Y. D. Hu et al., Cyanidin-3-O-galactoside and Blueberry Extracts Supplementation Improves Spatial Memory and Regulates Hippocampal ERK Expression in Senescence-accelerated Mice, Biomed. Environ. Sci, vol.27, pp.186-196, 2014.

. Tang-h-r, . D. Covingtone-a, and . A. Hancock-r, Structure activity relationships in the hydrophobic interactions of polyphenols with cellulose and collagen, vol.70, pp.403-413, 2003.

. B. Taubman-m, J. T. Fallon, . D. Schecter-a, P. Giesen, M. Mendlowitz et al., Tissue factor in the pathogenesis of atherosclerosis, Thromb Haemost, vol.78, pp.200-204, 1997.

. W. Teguo-p, . Descendit-a, . Krisa-s, G. Deffieux, and M. Vercauteren-j.-et, The accumulation of stilbene glycosides in Vitis vinifera cell suspension cultures, J.Nat.Prod, vol.59, pp.1189-1191, 2001.

H. Temsamani, Etude des effets neuroprotecteurs des stilbènes de la vigne sur la maladie de Parkinson. Thèse: Sciences et vie de la terre spécialité interface chimie biologique, p.165, 2015.

. V. Thiruvikraman-s, . Guha-a, J. Roboz, M. B. Taubman, Y. Nemerson et al., In situ localization of tissue factor in human atherosclerotic plaques by binding of digoxigenin-labeled factors Vila and X, Lab. Invest, vol.75, pp.451-461, 1996.

. Tonnessen-t, . Giaid-a, . Saleh-d, P. A. Naess, M. Yanagisawa et al., Increased in vivo expression and production of endothelin-1 by porcine cardiomycocytes subjected to ischemia, Circulation Res, vol.76, pp.767-772, 1995.

. Toussaint-g, Les vertus du raisin, Abyx : Collectorsanté, p.38, 2007.

. Trahan-b, Votre nouvel ami, le resvératrol, l'UQTR découvre comment il arrive à nous protéger du cancer, 2007.

. H. Tzeng-s, . C. Ko-w, and . N. Ko-f, Inhibition of platelet agregation by some flavonoids, Thromb. Res, vol.64, pp.94-100, 1991.

J. Vercauteren, J. C. Delaunay, and C. Castagnino, Preparative isolation of polyphenolic compounds from Vitis vinifera by centrigugal partition chromatography, J. Chromatogr. A, pp.123-128, 2002.

. Vingtdeux-v, . Dreses-werringloer-u, Z. Haitan, and . Davies-p, Therapeutic potential of resveratrol Alzheimer's disease, BMC Neurosci, vol.9, issue.2, p.6, 2008.

J. P. Vonsattel and . Difiglia-m.-huntington-disease, Journal of Neuropathology and Experimental Neurology, vol.57, issue.5, pp.369-384, 1998.

W. Z. Huang, Y. Zou, J. Cao, K. Xu, and Y. Wu-j.m, Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro, Int. J. Mol. Med, vol.9, pp.77-79, 2002.

M. E. Weisse, Wine as a digestive aid: comparative antimicrobial effects of bismuth salicylate and red and white wine, Brit.Med.J, pp.1657-1660, 1995.

J. N. Wilcox, . M. Smith-k, . M. Scwartz-s, and . Gordon-d, Localization of tissue factor in the normal vessel wall and in atherosclerotic plaque, Proc. Natl. Acad. Sci. USA, pp.2839-2843, 1989.

X. Y. Liu-t, . Zhan-l.-et, and . Zhou-x, The effects of tea polyphenols on the adherence of cariogenic bacterium to the collagen in vitro, vol.18, pp.340-342, 2000.

Y. Y. Piao-y, Effects of resveratrol on secondary damage after acute spinal cord injury in rats, Acta.Pharmacol.Sin, vol.24, issue.7, pp.703-710, 2003.

Y. G. Duh-p and . Tsai-h.i, Antioxidant and pro-oxidant properties of ascorbic and gallic acid, Journal of Food Chemistry, vol.79, issue.3, pp.307-313, 2002.

. M. Zeiher-a, H. Goebel, and . Schachinger-v, Tissue endothelin-1 immunoreactivity in the active coronary atherosclerotic plaque. A clue to the mechanism of increased vasoreactivity of the culprit lesion in unstable angina

, Ciruculation, vol.91, pp.941-947, 1995.

. F. Zhang-z, . Li-q, J. Liang, . Q. Dai-x, Y. Ding et al.,

, Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone condition, Phytomedicine, vol.17, pp.14-18, 2010.

. Zouid-i, Etude de l'évolution et de l'extractibilité des composés phénoliques du raisin en mileu hydroalcoolique pendant la maturation-Lien avec les propriétés mécaniques de la baie. Thèse : doctorat spécialité sciences agroalimentaires, Angers, p.330, 2011.

. Diplome-d'etat-de-docteur-en-pharmacie-présenté-par, Chloé KREMER Sujet : Le raisin et ses intérêts thérapeutiques

!. ,