Impact of protease inhibitors on intrahepatic hepatitis C virus viral load.

Abstract : During chronic hepatitis C, hepatitis C virus (HCV) load in plasma was shown to be higher in HIV-co-infected than in immunocompetent patients [1]. The reason for this increased HCV replication is not known. It may be as a result of HIV-induced immune deficiency [2], although some authors did not find any correlation with the CD4 cell count [3]. A direct interaction between HCV and HIV was also hypothesized [4]. Protease inhibitors (PI) used in highly active antiretroviral therapy (HAART) have no HCV reduction effect during the first months of treatment [5-8]. However, a decrease in HCV plasma load was recently described in patients treated with HAART for a year [9,10]. We therefore investigated the potential impact of HAART on intrahepatic HCV load.
Complete list of metadatas

https://hal.univ-lorraine.fr/hal-02014623
Contributor : Evelyne Schvoerer <>
Submitted on : Monday, February 11, 2019 - 4:31:30 PM
Last modification on : Friday, May 24, 2019 - 4:58:46 PM

Identifiers

  • HAL Id : hal-02014623, version 1
  • PUBMED : 11546953

Citation

Didier Neau, P. Trimoulet, M Winnock, B. Le Bail, Evelyne Schvoerer, et al.. Impact of protease inhibitors on intrahepatic hepatitis C virus viral load.. AIDS, Lippincott, Williams & Wilkins, 2001, 15 (13), pp.1736-8. ⟨hal-02014623⟩

Share

Metrics

Record views

34