Low-cost and multi-gram scale synthesis of chiral Nβ-Boc protected α-Nα-hydrazino diesters - Université de Lorraine Access content directly
Journal Articles Tetrahedron Letters Year : 2017

Low-cost and multi-gram scale synthesis of chiral Nβ-Boc protected α-Nα-hydrazino diesters

Abstract

An efficient and general low-cost method is described to obtain chiral Nβ-Boc protected α-Nα-hydrazino diester building-blocks (orthogonally and non-orthogonally protected diesters) on multi-gram scale (30 mmol) using two successive SN2 reactions. This method is also convenient for the introduction of both polar and nonpolar side chains on the Nα-atom and represents an inexpensive and attractive alternative compared to the more expensive method using commercial oxaziridine reagents for N-amination of α-amino acids
No file

Dates and versions

hal-02056826 , version 1 (04-03-2019)

Identifiers

Cite

Mohamed Mehawed Abdellatif, Samir Acherar. Low-cost and multi-gram scale synthesis of chiral Nβ-Boc protected α-Nα-hydrazino diesters. Tetrahedron Letters, 2017, 58 (12), pp.1216-1218. ⟨10.1016/j.tetlet.2017.02.026⟩. ⟨hal-02056826⟩
20 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More