J. Vernikos, Human physiology in space, Bioessays, vol.18, pp.1029-1037, 1996.

B. Crucian, A. Babiak-vazquez, S. Johnston, D. L. Pierson, C. M. Ott et al., Incidence of clinical symptoms during long-duration orbital spaceflight, Int J Gen Med, vol.9, pp.383-391, 2016.

J. P. Frippiat, B. E. Crucian, D. J. De-quervain, D. Grimm, N. Montano et al., Towards human exploration of space: The THESEUS review series on immunology research priorities, Npj Microgravity, vol.2, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01903866

N. Gueguinou, C. Huin-schohn, M. Bascove, J. L. Bueb, E. Tschirhart et al., Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit?, J Leukocyte Biol, vol.86, pp.1027-1038, 2009.

R. Boxio, C. Dournon, and J. P. Frippiat, Effects of a long-term spaceflight on immunoglobulin heavy chains of the urodele amphibian Pleurodeles waltl, J Appl Physiol, vol.98, pp.905-910, 2005.

M. Bascove, C. Huin-schohn, N. Gueguinou, E. Tschirhart, and J. P. Frippiat, Spaceflight-associated changes in immunoglobulin VH gene expression in the amphibian Pleurodeles waltl, Faseb Journal, vol.23, pp.1607-1615, 2009.

M. Bascove, N. Gueguinou, B. Schaerlinger, G. Gauquelin-koch, and J. P. Frippiat, Decrease in antibody somatic hypermutation frequency under extreme, extended spaceflight conditions, Faseb Journal, vol.25, pp.2947-2955, 2011.

M. D. Cooper and M. N. Alder, The evolution of adaptive immune systems, Cell, vol.124, pp.815-822, 2006.

C. Fonte, A. Gruez, S. Ghislin, and J. P. Frippiat, The urodele amphibian Pleurodeles waltl has a diverse repertoire of immunoglobulin heavy chains with polyreactive and speciesspecific features, Dev Comp Immunol, vol.53, pp.371-384, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01903862

J. P. Frippiat, Contribution of the urodele amphibian Pleurodeles waltl to the analysis of spaceflight-associated immune system deregulation, Mol Immunol, vol.56, pp.434-441, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01480653

B. Schaerlinger, M. Bascove, and J. P. Frippiat, A new isotype of immunoglobulin heavy chain in the urodele amphibian Pleurodeles waltl predominantly expressed in larvae, Mol Immunol, vol.45, pp.776-786, 2008.

C. C. Woods, K. E. Banks, R. Gruener, and D. Deluca, Loss of T cell precursors after spaceflight and exposure to vector-averaged gravity, Faseb Journal, vol.17, pp.1526-1528, 2003.

S. Ghislin, N. Ouzren-zarhloul, S. Kaminski, and J. P. Frippiat, Hypergravity exposure during gestation modifies the TCRbeta repertoire of newborn mice, Sci Rep, vol.5, p.9318, 2015.

C. Huin-schohn, N. Gueguinou, V. Schenten, M. Bascove, G. G. Koch et al., Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis, Faseb Journal, vol.27, pp.333-341, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01480291

C. Lescale, V. Schenten, D. Djeghloul, M. Bennabi, F. Gaignier et al., Hind limb unloading, a model of spaceflight conditions, leads to decreased B lymphopoiesis similar to aging, Faseb Journal, vol.29, pp.455-463, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01481935

F. E. Mercier, C. Ragu, and D. T. Scadden, The bone marrow at the crossroads of blood and immunity, Nat Rev Immunol, vol.12, pp.49-60, 2012.

L. M. Calvi, G. B. Adams, K. W. Weibrecht, J. M. Weber, D. P. Olson et al., Osteoblastic cells regulate the haematopoietic stem cell niche, Nature, vol.425, pp.841-846, 2003.

L. D. Wang and A. J. Wagers, Dynamic niches in the origination and differentiation of haematopoietic stem cells, Nat Rev Mol Cell Biol, vol.12, pp.643-655, 2011.

Y. Xie, T. Yin, W. Wiegraebe, X. C. He, D. Miller et al., Detection of functional haematopoietic stem cell niche using real-time imaging, Nature, vol.457, pp.97-101, 2009.

A. Andreev-andrievskiy, A. Popova, R. Boyle, J. Alberts, B. Shenkman et al., Mice in Bion-M 1 space mission: training and selection, PLoS One, vol.9, p.104830, 2014.

N. Gueguinou, M. Bojados, M. Jamon, H. Derradji, S. Baatout et al., Stress response and humoral immune system alterations related to chronic hypergravity in mice, Psychoneuroendocrinology, vol.37, pp.137-147, 2012.

C. Carapito, A. Burel, P. Guterl, A. Walter, F. Varrier et al., MSDA, a proteomics software suite for in-depth Mass Spectrometry Data Analysis using grid computing, Proteomics, vol.14, pp.1014-1019, 2014.

J. Cox, M. Y. Hein, C. A. Luber, I. Paron, N. Nagaraj et al., Accurate proteomewide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ, Mol Cell Proteomics, vol.13, pp.2513-2526, 2014.

J. A. Vizcaino, A. Csordas, N. Del-toro, J. A. Dianes, J. Griss et al., update of the PRIDE database and its related tools, Nucleic Acids Res, vol.44, pp.447-456, 2016.

, R: A language and environment for statistical computing. R Foundation for Statistical Computing, 2008.

M. Gerbaix, V. Gnyubkin, D. Farlay, C. Olivier, P. Ammann et al., Onemonth spaceflight compromises the bone microstructure, tissue-level mechanical properties, osteocyte survival and lacunae volume in mature mice skeletons, vol.7, p.2659, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01597312

M. C. Gerbaix, H. White, G. Courbon, B. Shenkman, G. Gauquelin-koch et al., Eight days of Earth reambulation worsen bone loss induced by 1-month spaceflight in the major weight-bearing ankle bones of mature mice, Front Physiol, vol.9, p.746, 2018.

L. Vico and A. Hargens, Skeletal changes during and after spaceflight, Nat Rev Rheumatol, vol.14, pp.229-245, 2018.
DOI : 10.1038/nrrheum.2018.37

M. Gerbaix, L. Vico, S. L. Ferrari, and N. Bonnet, Periostin expression contributes to cortical bone loss during unloading, Bone, vol.71, pp.94-100, 2015.
DOI : 10.1016/j.bone.2014.10.011

A. T. Ichiki, L. A. Gibson, T. L. Jago, K. M. Strickland, D. L. Johnson et al., Effects of spaceflight on rat peripheral blood leukocytes and bone marrow progenitor cells, J Leukoc Biol, vol.60, pp.37-43, 1996.

M. T. Ortega, M. J. Pecaut, D. S. Gridley, L. S. Stodieck, V. Ferguson et al., Shifts in bone marrow cell phenotypes caused by spaceflight, J Appl Physiol, vol.106, pp.548-555, 1985.
DOI : 10.1152/japplphysiol.91138.2008

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644250/pdf

E. V. Sotnezova, E. A. Markina, E. R. Andreeva, and L. B. Buravkova, Myeloid Precursors in the Bone Marrow of Mice after a 30-Day Space Mission on a Bion-M1 Biosatellite, Bull Exp Biol Med, vol.162, pp.496-500, 2017.

A. Vacek, T. V. Michurina, L. V. Serova, D. Rotkovska, and A. Bartonickova, Decrease in the number of progenitors of erythrocytes (BFUe, CFUe), granulocytes and macrophages (GM-CFC) in bone marrow of rats after a 14-day flight onboard the Cosmos-2044 Biosatellite, Folia Biol (Praha), vol.37, pp.35-41, 1991.

F. Gaignier, V. Schenten, M. De-carvalho-bittencourt, G. Gauquelin-koch, J. P. Frippiat et al., Three weeks of murine hindlimb unloading induces shifts from B to T and from th to tc splenic lymphocytes in absence of stress and differentially reduces cellspecific mitogenic responses, PLoS One, vol.9, p.92664, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01099973

H. Aviles, T. Belay, K. Fountain, M. Vance, and G. Sonnenfeld, Increased susceptibility to Pseudomonas aeruginosa infection under hindlimb-unloading conditions, J Appl Physiol, vol.95, pp.73-80, 1985.
DOI : 10.1152/japplphysiol.00968.2002

T. Belay, H. Aviles, M. Vance, K. Fountain, and G. Sonnenfeld, Effects of the hindlimbunloading model of spaceflight conditions on resistance of mice to infection with Klebsiella pneumoniae, J Allergy Clin Immunol, vol.110, pp.262-268, 2002.

F. P. Baqai, D. S. Gridley, J. M. Slater, X. Luo-owen, L. S. Stodieck et al., Effects of spaceflight on innate immune function and antioxidant gene expression, J Appl Physiol, vol.106, pp.1935-1942, 1985.
DOI : 10.1152/japplphysiol.91361.2008

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692779/pdf

J. B. Boonyaratanakornkit, A. Cogoli, C. F. Li, T. Schopper, P. Pippia et al., Key gravity-sensitive signaling pathways drive T cell activation, FASEB J, vol.19, pp.2020-2022, 2005.
DOI : 10.1096/fj.05-3778fje

T. T. Chang, I. Walther, C. F. Li, J. Boonyaratanakornkit, G. Galleri et al., The Rel/NF-kappaB pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity, J Leukoc Biol, vol.92, pp.1133-1145, 2012.

C. S. Thiel, S. Hauschild, A. Huge, S. Tauber, B. A. Lauber et al., Dynamic gene expression response to altered gravity in human T cells, vol.7, p.5204, 2017.
DOI : 10.1038/s41598-017-05580-x

URL : https://www.nature.com/articles/s41598-017-05580-x.pdf