B. Ostro, R. Broadwin, S. Green, W. Y. Feng, and M. Lipsett, Fine particulate air pollution and mortality in nine California counties: results from CALFINE, Environ Health Perspect, vol.114, issue.1, pp.29-33, 2006.

C. I. Falcon-rodriguez, A. R. Osornio-vargas, I. Sada-ovalle, and P. Segura-medina, Aeroparticles, composition, and lung diseases, Front Immunol, vol.7, pp.1-9, 2016.

Y. F. Xing, Y. H. Xu, M. H. Shi, and Y. X. Lian, The impact of PM2.5 on the human respiratory system, J Thorac Dis, vol.8, issue.1, pp.69-74, 2016.

K. Donaldson, L. Tran, and L. A. Jimenez, Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure, Part Fibre Toxicol, vol.2, pp.1-14, 2005.

L. G. Costa, T. B. Cole, J. Coburn, Y. C. Chang, K. Dao et al., Neurotoxicants are in the air: convergence of human, animal, and in vitro studies on the effects of air pollution on the brain, Biomed Res Int, 2014.

. Calderón-garcidueñas, Safety Evaluation -Environmental Air Pollution and Brain Damage, vol.30, pp.373-89, 2002.

A. Hartz, B. Bauer, M. L. Block, J. Hong, and D. S. Miller, Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein upregulation at the blood-brain barrier, FASEB J, vol.22, issue.8, pp.2723-2756, 2008.

M. L. Block and L. Calderón-garcidueñas, Air pollution: mechanisms of neuroinflammation and CNS disease, NIH Public Access, vol.32, issue.9, pp.506-522, 2010.

S. Genc, Z. Zadeoglulari, S. H. Fuss, and K. Genc, The adverse effects of air pollution on the nervous system, J Toxicol, 2012.

M. L. Block, A. Elder, and R. L. Auten, The outdoor air pollution and brain health workshop, NIH Public Access, vol.33, issue.5, pp.972-84, 2013.

B. Cruts, L. Van-etten, and H. Tornqvist, Exposure to diesel exhaust induces changes in EEG in human volunteers, Part Fibre Toxicol, vol.5, issue.1, 2008.

A. J. Ghio, C. B. Smith, and M. C. Madden, Diesel exhaust particles and airway inflammation, Curr Opin Pulm Med, vol.18, issue.2, pp.144-50, 2012.

L. Calderón-garcidueñas, A. Mora-tiscareño, and E. Ontiveros, Air pollution, cognitive deficits and brain abnormalities: a pilot study with children and dogs, Brain Cogn, vol.68, issue.2, pp.117-144, 2008.

L. K. Fonken, X. Xu, and Z. M. Weil, Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology, Mol Psychiatry, vol.16, issue.10, pp.987-95, 2011.

L. Calderón-garcidueñas, M. Franco-lira, and C. Henríquez-roldán, Urban air pollution: influences on olfactory function and pathology in exposed children and young adults, Exp Toxicol Pathol, vol.62, issue.1, pp.91-102, 2010.

M. C. Power, M. G. Weisskopf, S. E. Alexeeff, B. A. Coull, S. Avron et al., Trafficrelated air pollution and cognitive function in a cohort of older men, Environ Health Perspect, vol.119, issue.5, pp.682-689, 2011.

U. Ranft, T. Schikowski, D. Sugiri, J. Krutmann, and U. Krämer, Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly, Environ Res, vol.109, issue.8, pp.1004-1015, 2009.

L. Calderón-garcidueñas, W. Reed, and R. R. Maronpot, Brain inflammation and Alzheimer's-like pathology in individuals exposed to severe air pollution, Toxicol Pathol, vol.32, issue.6, pp.650-658, 2004.

H. J. Heusinkveld, T. Wahle, and A. Campbell, Neurodegenerative and neurological disorders by small inhaled particles, Neurotoxicology, vol.56, pp.94-106, 2016.

P. V. Moulton and W. Yang, Air pollution, oxidative stress, and alzheimer's disease, J Environ Public Health, p.2012, 2012.

L. Calderón-garcidueñas, M. Franco-lira, A. Mora-tiscareño, H. Medina-cortina, R. Torres-jardón et al., Early alzheimer's and parkinson's disease pathology in urban children: friend versus foe responses -it is time to face the evidence, Biomed Res Int, 2013.

L. Calderon-garciduenas and R. Torres-jardon, The impact of Air pollutants on the brain, JAMA Psychiatry, vol.59812, pp.5-6, 2015.

P. Grandjean, R. Barouki, and D. C. Bellinger, Life-long implications of developmental exposure to environmental stressors: new perspectives, Endocrinology, vol.156, issue.10, pp.3408-3423, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01187409

M. Guxens, I. Aguilera, and F. Ballester, Prenatal exposure to residential air pollution and infant mental development: modulation by antioxidants and detoxification factors, Environ Health Perspect, vol.120, issue.1, pp.144-153, 2012.

M. Guxens, R. Garcia-esteban, and L. Giorgis-allemand, Air pollution during pregnancy and childhood cognitive and psychomotor development: six european birth cohorts, Epidemiology, vol.25, issue.5, pp.636-683, 2014.

C. Freire, R. Ramos, and R. Puertas, Association of traffic-related air pollution with cognitive development in children, J Epidemiol Community Heal, vol.64, issue.3, pp.223-231, 2010.

T. A. Becerra, M. Wilhelm, J. Olsen, M. Cockburn, and B. R. Ritz, Ambient air pollution and autism in Los Angeles county, California. Environ Health, vol.121, issue.3, pp.380-386, 2013.

L. Calderón-garcidueñas, E. Leray, P. Heydarpour, R. Torres-jardón, and J. Reis, Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: the clinical impact on children and beyond, Rev Neurol (Paris), vol.172, issue.1, pp.69-80, 2016.

M. H. Harris, D. R. Gold, and S. L. Rifas-shiman, Prenatal and childhood trafficrelated air pollution exposure and childhood executive function and behavior, Neurotoxicol Teratol, 2016.

B. P. Lanphear, The impact of toxins on the developing brain, Annu Rev Public Health, vol.36, issue.1, pp.211-241, 2015.

N. C. Newman, P. Ryan, and G. Lemasters, Traffic-related Air Pollution exposure in the first year of life and behavioral scores at 7 years of age, Environ Health Perspect, vol.121, issue.6, pp.731-737, 2013.

S. Siddique, M. Banerjee, M. R. Ray, and T. Lahiri, Attention-deficit hyperactivity disorder in children chronically exposed to high level of vehicular pollution

, Eur J Pediatr, vol.170, issue.7, pp.923-932, 2011.

J. L. Allen, X. Liu, and S. Pelkowski, Early postnatal exposure to ultrafine particulate matter Air Pollution: persistent Ventriculomegaly, neurochemical disruption, and glial activation preferentially in male mice, Environ Health Perspect, vol.122, pp.939-984, 2014.

J. L. Bolton, N. C. Huff, and S. H. Smith, Maternal stress and effects of prenatal air pollution on offspring mental health outcomes in mice, Environ Health Perspect, vol.121, issue.9, pp.1075-82, 2013.

M. Ema, M. Naya, M. Horimoto, and H. Kato, Developmental toxicity of diesel exhaust: a review of studies in experimental animals, Reprod Toxicol, vol.42, pp.1-17, 2013.

K. S. Hougaard, L. Campagnolo, and P. Chavatte-palmer, A perspective on the developmental toxicity of inhaled nanoparticles, Reprod Toxicol, vol.56, pp.118-158, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02635361

M. Sugamata, T. Ihara, M. Sugamata, and K. Takeda, Maternal exposure to diesel exhaust leads to pathological similarity to autism in newborns, J Heal Sci, vol.52, issue.4, pp.486-494, 2006.

C. T. Wong, J. Wais, and D. A. Crawford, Prenatal exposure to common environmental factors affects brain lipids and increases risk of developing autism Spectrum disorders, Eur J Neurosci, 2015.

M. Sugamata, T. Ihara, H. Takano, S. Oshio, and K. Takeda, Maternal diesel exhaust exposure damages newborn murine brains, J Heal Sci, vol.52, issue.1, pp.82-86, 2006.

C. Klocke, J. L. Allen, and M. Sobolewski, Neuropathological consequences of gestational exposure to concentrated ambient fine and ultrafine particles in the mouse, Toxicol Sci, vol.156, issue.2, pp.492-508, 2017.

S. Yokota, N. Moriya, M. Iwata, M. Umezawa, S. Oshio et al., Exposure to diesel exhaust during fetal period affects behavior and neurotransmitters in male offspring mice, J Toxicol Sci, vol.38, issue.1, pp.13-23, 2013.

S. Yokota, K. Mizuo, N. Moriya, S. Oshio, I. Sugawara et al., Effect of prenatal exposure to diesel exhaust on dopaminergic system in mice

, Neurosci Lett, vol.449, issue.1, pp.38-41, 2009.

S. Yokota, S. Oshio, and K. Takeda, In utero exposure to diesel exhaust particles induces anxiogenic effects on male offspring via chronic activation of serotonergic neuron in dorsal raphe, Nucleus, vol.41, issue.5, pp.583-93, 2016.

T. Suzuki, S. Oshio, and M. Iwata, In utero exposure to a low concentration of diesel exhaust affects spontaneous locomotor activity and monoaminergic system in male mice, Part Fibre Toxicol, vol.7, 2010.

S. Yokota, A. Sato, M. Umezawa, S. Oshio, and K. Takeda, In utero exposure of mice to diesel exhaust particles affects spatial learning and memory with reduced N-methyl-d-aspartate receptor expression in the hippocampus of male offspring, Neurotoxicology, vol.50, pp.108-123, 2015.

K. S. Hougaard, J. Nordly, and P. , Effects of prenatal exposure to diesel exhaust particles on postnatal development, behavior, genotoxicity and inflammation in mice, Part Fibre Toxicol, vol.5, 2008.

J. L. Bolton, S. Marinero, and T. Hassanzadeh, Gestational exposure to air pollution alters cortical volume, microglial morphology, and microglianeuron interactions in a sex-specific manner, Front Synaptic Neurosci, vol.9, pp.1-16, 2017.

J. L. Bolton, S. H. Smith, and N. C. Huff, Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner, FASEB J, vol.26, issue.11, pp.12-210989, 2012.

R. L. Doty, Neurobiology of disease olfaction in Parkinson ' s disease and related disorders, Neurobiol Dis, vol.46, issue.3, pp.527-52, 2012.

N. L. Rey, D. W. Wesson, and P. Brundin, The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases, Neurobiol Dis, vol.109, pp.226-274, 2018.

L. Calderón-garcidueñas, G. Valencia-salazar, and A. Rodríguez-alcaraz, Ultrastructural nasal pathology in children chronically and sequentially exposed to air pollutants, Am J Respir Cell Mol Biol, vol.24, issue.2, pp.132-140, 2001.

S. Levesque, M. J. Surace, J. Mcdonald, and M. L. Block, Air pollution and the brain: subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease, J Neuroinflammation, vol.8, pp.1-10, 2011.

A. Peters, B. Veronesi, and L. Calderón-garcidueñas, Translocation and potential neurological effects of fine and ultrafine particles a critical update, Part Fibre Toxicol, vol.3, issue.13, 2006.

L. Calderón-garcidueñas, A. C. Solt, and C. Henríquez-roldán, Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and youn, Toxicol Pathol, vol.36, issue.2, pp.289-310, 2008.

R. L. Doty, Olfactory dysfunction in Parkinson disease, Nat Rev Neurol, vol.8, issue.6, pp.329-368, 2012.

J. Attems, F. Lintner, and K. A. Jellinger, Olfactory involvement in aging and Alzheimer ' s disease: An autopsy study, vol.7, pp.149-57, 2005.

S. Levesque, T. Taetzsch, and M. E. Lull, Diesel exhaust activates and primes microglia: Air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity, Environ Health Perspect, vol.119, issue.8, pp.1149-55, 2011.

E. Huisman and P. V. Hoogland, A 100% Increase of Dopaminergic Cells in the Olfactory Bulb May Explain Hyposmia in Parkinson ' s Disease, vol.19, pp.145-148, 2004.

E. Huisman, H. Uylings, and P. Hoogland, Gender-Related Changes in Increase of Dopaminergic Neurons in the Olfactory Bulb of Parkinson ' s Disease Patients, vol.23, pp.1407-1413, 2008.

I. C. Mundiñano, M. C. Caballero, and C. Ordóñez, Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders, Acta Neuropathol, vol.122, issue.1, pp.61-74, 2011.

I. Kovacs, Cholinergic structures and neuropathologic alterations in the olfactory bulb of Alzheimer ' s disease brain samples, pp.97-100, 1998.

S. A. Valentino, A. Tarrade, and J. Aioun, Maternal exposure to diluted diesel engine exhaust alters placental function and induces intergenerational effects in rabbits, Part Fibre Toxicol, vol.2016, pp.1-14
URL : https://hal.archives-ouvertes.fr/hal-02637441

B. Fischer, P. Chavatte-palmer, C. Viebahn, A. N. Santos, and V. Duranthon, Rabbit as a reproductive model for human health, Reproduction, vol.144, issue.1, pp.1-10, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01019868

J. Aïoun, A. Tarrade, and S. Valentino, Transplacental tranfer of nanoparticles inhaled due to maternal exposure to filtered diesel engine exhaust during pregnancy in a rabbit model, Placenta, 2016.

M. Migliore, F. Cavarretta, A. Marasco, E. Tulumello, M. L. Hines et al., Synaptic clusters function as odor operators in the olfactory bulb, Proc Natl Acad Sci, vol.112, issue.27, pp.8499-504, 2015.

D. C. Willhite, K. T. Nguyen, A. V. Masurkar, C. A. Greer, G. M. Shepherd et al., Viral tracing identifies distributed columnar organization in the olfactory bulb, Proc Natl Acad Sci, vol.103, issue.33, pp.12592-12599, 2006.

B. Schaal, G. Coureaud, D. Langlois, C. Giniès, E. Sémon et al., Chemical and behavioural characterization of the rabbit mammary pheromone, Nature, vol.424, issue.6944, pp.68-72, 2003.
URL : https://hal.archives-ouvertes.fr/hal-00103386

T. Blunk, D. F. Hochstrasser, J. C. Sanchez, B. W. Muller, and R. H. Muller, Colloidal carriers for intravenous drug targeting: plasma protein adsorption patterns on surface-modified latex particles evaluated by two-dimensiona polyacrylamide gel electrophoresis, Electrophoresis, vol.14, issue.1, pp.1382-87, 1993.

M. E. Gerlofs-nijland, D. Van-berlo, F. R. Cassee, R. Schins, K. Wang et al., Effect of prolonged exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain, Part Fibre Toxicol, vol.7, issue.1, p.12, 2010.

A. Gessner, R. Waicz, A. Lieske, B. R. Paulke, K. Mäder et al., Nanoparticles with decreasing surface hydrophobicities: influence on plasma protein adsorption, Int J Pharm, vol.196, issue.2, pp.432-441, 2000.

M. Lück, B. Paulke, W. Schröder, T. Blunk, and R. H. Müller, Analysis of plasma protein adsorption on polymeric nanoparticles with different surface characteristics, J Biomed Mater Res, vol.39, issue.3, pp.1097-4636, 1998.

B. A. Maher, I. Ahmed, and V. Karloukovski, Magnetite pollution nanoparticles in the human brain, Proc Natl Acad Sci, vol.113, issue.39, pp.10797-801, 2016.

M. R. Miller, J. B. Raftis, and J. P. Langrish, Inhaled nanoparticles accumulate at sites of vascular disease, ACS Nano, vol.11, issue.5, pp.4542-52, 2017.

H. E. Ibald-mulli-a,-wichmann, W. Kreyling, and . Peters-a, Epidemiological evidence on health effects of ultrafine particles, J Aerosol Med, vol.15, issue.2, pp.189-201, 2002.

A. Nel, Air Pollution -Related illness : Effects of Particles. Science (80-), vol.308, pp.804-810, 2005.

, Review of evidence on health aspects of air pollution -REVIHAAP Project, p.309, 2013.

R. J. Levy, Carbon monoxide pollution and neurodevelopment: a public health concern, Neurotoxicol Teratol, 2015.

E. Suades-gonzález, M. Gascon, M. Guxens, and J. Sunyer, Air Pollution and neuropsychological development: a review of the latest evidence, Endocrinology, p.20151403, 2015.

H. Schroeder, Developmental brain and behavior toxicity of Air pollutants: a focus on the effects of polycyclic aromatic hydrocarbons (PAHs), Crit Rev Environ Sci Technol, vol.41, issue.22, pp.2026-2073, 2011.

A. Elder, R. Gelein, and V. Silva, Translocation of Inhaled Ultrafine Manganese Oxide Particles to the Central Nervous System, 2006.

A. Nemmar, H. Vanbilloen, M. F. Hoylaerts, P. Verbruggen, A. Nemery et al., Passage of Intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster, About Am J Respir Crit Care Med, vol.164, issue.9, pp.1665-1673, 2001.

F. Hervé, N. Ghinea, and J. Scherrmann, CNS delivery via adsorptive transcytosis, AAPS J, vol.10, issue.3, pp.455-72, 2008.

N. Woodward, C. E. Finch, and T. E. Morgan, HHS Public Access, vol.2, issue.2, pp.353-73, 2016.

J. Machado, J. M. Chatkin, A. R. Zimmer, A. Goulart, and F. V. Thiesen, Cotinine and polycyclic aromatic hydrocarbons levels in the amniotic fluid and fetal cord at birth and in the urine from pregnant smokers, PLoS One, vol.9, issue.12, pp.1-12, 2014.

A. González-maciel, R. Reynoso-robles, R. Torres-jardón, and P. S. Mukherjee, Calderón-Garcidueñas L. Combustion-derived nanoparticles in key brain target cells and organelles in young urbanites: culprit hidden in plain sight in Alzheimer's disease development, J Alzheimers Dis, vol.59, issue.1, pp.189-208, 2017.

S. Yokota, S. Oshio, N. Moriya, and K. Takeda, Social isolation-induced territorial aggression in male offspring is enhanced by exposure to diesel exhaust during pregnancy, PLoS One, vol.11, issue.2, pp.1-15, 2016.

J. L. Bolton, R. L. Auten, and S. D. Bilbo, Prenatal air pollution exposure induces sexually dimorphic fetal programming of metabolic and neuroinflammatory outcomes in adult offspring, Brain Behav Immun, vol.37, pp.30-44, 2014.

J. L. Allen, X. Liu, and D. Weston, Developmental exposure to concentrated ambient ultrafine particulate matter air pollution in mice results in persistent and sex-dependent behavioral neurotoxicity and glial activation

, Toxicol Sci, vol.140, issue.1, pp.160-78, 2014.

L. Calderón-garcidueñas, A. Gónzalez-maciel, and R. Reynoso-robles, Hallmarks of Alzheimer disease are evolving relentlessly in metropolitan Mexico City infants, children and young adults. APOE4 carriers have higher suicide risk and higher odds of reaching NFT stage V at ? 40 years of age, Environ Res, vol.164, pp.475-87, 2017.

G. Coureaud, D. Langlois, G. Sicard, and B. Schaal, Newborn rabbit responsiveness to the mammary pheromone is concentration-dependent, Chem Senses, vol.29, issue.4, pp.341-50, 2004.

G. Coureaud, R. Charra, and F. Datiche, A pheromone to behave, a pheromone to learn: the rabbit mammary pheromone, J Comp Physiol A Neuroethol Sensory, vol.196, issue.10, pp.779-90, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00761404

R. Charra, F. Datiche, V. Gigot, B. Schaal, and G. Coureaud, Pheromone-induced odor learning modifies Fos expression in the newborn rabbit brain, Behav Brain Res, vol.237, issue.1, pp.129-169, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00745962

P. Mascagni, D. Consonni, G. Bregante, G. Chiappino, and F. Toffoletto, Olfactory function in workers exposed to moderate airborne cadmium levels, Neurotoxicology, vol.24, issue.4-5, p.24, 2003.

D. C. Dorman, M. F. Struve, E. A. Gross, B. A. Wong, and P. C. Howroyd, Sub-chronic inhalation of high concentrations of manganese sulfate induces lower airway pathology in rhesus monkeys, Respir Res, vol.6, pp.1-10, 2005.

P. J. Landrigan, B. Sonawane, R. N. Butler, L. Trasande, R. Callan et al., Early environmental origins of neurodegenerative disease in later life, Environ Health Perspect, vol.113, issue.9, pp.1230-1233, 2005.

E. J. Freney, M. R. Heal, and R. J. Donovan, A single-particle characterization of a mobile versatile aerosol concentration enrichment system for exposure studies, Part Fibre Toxicol, vol.3, pp.1-11, 2006.

P. Gamache, E. Ryan, C. Svendsen, K. Murayama, and I. N. Acworth, Simultaneous measurement of monoamines, metabolites and amino acids in brain tissue and microdialysis perfusates, J Chromatogr B Biomed Sci Appl, vol.614, issue.2, pp.213-233, 1993.

I. P. Kema, A. Schellings, C. Hoppenbrouwers, H. M. Rutgers, E. De-vries et al., High performance liquid chromatographic profiling of tryptophan and related indoles in body fluids and tissues of carcinoid patients, Clin Chim Acta, vol.221, issue.1-2, pp.90029-90033, 1993.

G. L. Ellman, K. D. Courtney, V. Andres, and R. M. Featherstone, A new and rapid colorimetric determination of acetylcholinesterase activity, Biochem Pharmacol, vol.7, issue.2, pp.90145-90154, 1961.

M. Dumont, R. Lalonde, J. F. Ghersi-egea, K. Fukuchi, and C. Strazielle, Regional acetylcholinesterase activity and its correlation with behavioral performances in 15-month old transgenic mice expressing the human C99 fragment of APP, J Neural Transm, vol.113, issue.9, pp.1225-1266, 2006.