During a Loss of Coolant Accident (LOCA) in a Pressurized Water Reactor, partial or complete drying of fuel assemblies may take place. In these conditions, the fuel temperature increases and may lead to substantial deformation of the fuel rod cladding and a partial blockage of the fluid sub-channels. These regions could significantly affect the cooling capacity of the nuclear core during the reflooding phase by the emergency core cooling systems. Understanding the cooling process and the thermal-hydraulic characteristics of the flow in these deformed regions is decisive to guarantee nuclear safety. Looking to provide valuable experimental data to validate existing and new models, this work is an experimental study on the thermal hydraulics during the cooling of a vertical tube with an internal steam-droplets flow, representing the LOCA conditions at sub-channel scale. The effect of the blockage ratio on the tube temperature, heat dissipation, wall rewetting, and droplets characteristics is evaluated by testing three configurations (0%, 61% and 90%). Optical techniques were used for a comprehensive characterization of the process, being them infrared thermography, phase-Doppler analyzer and three-color laser induced fluorescence thermometry. In general, wall rewetting in the test section occurs from bottom to top, although there is a discontinuity in the rewetting front with the 90% blockage ratio configuration. The droplets diameter reduces downstream of the test section because of evaporation. Droplets breakup was specifically observed with 90% blockage ratio. In all the cases, the droplets temperature was approximately the same up-and downstream of the test section, which indicates they are in nearly thermal equilibrium state and, therefore, representative of a LOCA situation.