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Article Dans Une Revue Journal of Antimicrobial Chemotherapy Année : 2018

Metrics to assess the quantity of antibiotic use in the outpatient setting: a systematic review followed by an international multidisciplinary consensus procedure

Bojana Beović
  • Fonction : Collaborateur
Luis Bavestrello
  • Fonction : Collaborateur
Jon Cohen
  • Fonction : Collaborateur
Pieter-Jan Cortoos
  • Fonction : Collaborateur
Harpal Dhillon
  • Fonction : Collaborateur
Richard Drew
  • Fonction : Collaborateur
Prabhavathi Fernandes
  • Fonction : Collaborateur
David Findlay
  • Fonction : Collaborateur
Ian Friedland
  • Fonction : Collaborateur
Ian Gould
  • Fonction : Collaborateur
Lauri Hicks
  • Fonction : Collaborateur
Christopher Longshaw
  • Fonction : Collaborateur
Carl Llor
  • Fonction : Collaborateur
Allison Mcgeer
  • Fonction : Collaborateur
Iruka Okeke
  • Fonction : Collaborateur
Diamantis Plachouras
  • Fonction : Collaborateur
Garyfallia Poulakou
  • Fonction : Collaborateur
John Rex
  • Fonction : Collaborateur
Thomas Tängdén
  • Fonction : Collaborateur
Laura Trolle Saust
  • Fonction : Collaborateur
Claudine Richon
  • Fonction : Collaborateur
France Roblot
  • Fonction : Collaborateur
Robert Vander Stichele
  • Fonction : Collaborateur
Marcel Verweij
  • Fonction : Collaborateur
Heiman Wertheim
  • Fonction : Collaborateur

Résumé

Background: The international Innovative Medicines Initiative (IMI) project DRIVE-AB (Driving Reinvestment in Research and Development and Responsible Antibiotic Use) aims to develop a global definition of 'responsible' antibiotic use. Objectives: To identify consensually validated quantity metrics for antibiotic use in the outpatient setting. Methods: First, outpatient quantity metrics (OQMs) were identified by a systematic search of literature and web sites published until 12 December 2014. Identified OQMs were evaluated by a multidisciplinary, international stakeholder panel using a RAND-modified Delphi procedure. Two online questionnaires and a face-to-face meeting between them were conducted to assess OQM relevance for measuring the quantity of antibiotic use on a nine-point Likert scale, to add comments or to propose new metrics. Results: A total of 597 articles were screened, 177 studies met criteria for full-text screening and 138 were finally included. Twenty different OQMs were identified and appraised by 23 stakeholders. During the first survey, 14 OQMs were excluded and 6 qualified for discussion. During the face-to-face meeting, 10 stakeholders retained five OQMs and suggestions were made considering context and combination of metrics. The final set of metrics included defined daily doses, treatments/courses and prescriptions per defined population, treatments/courses and prescriptions per defined number of physician contacts and seasonal variation of total antibiotic use. Conclusions: A small set of consensually validated metrics to assess the quantity of antibiotic use in the outpatient setting was obtained, enabling (inter)national comparisons. The OQMs will help build a global conceptual framework for responsible antibiotic use.

Dates et versions

hal-02381251 , version 1 (26-11-2019)

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Citer

Ann Versporten, Inge Gyssens, Céline Pulcini, Annelie Monnier, Jeroen Schouten, et al.. Metrics to assess the quantity of antibiotic use in the outpatient setting: a systematic review followed by an international multidisciplinary consensus procedure. Journal of Antimicrobial Chemotherapy, 2018, 73 (suppl_6), pp.vi59-vi66. ⟨10.1093/jac/dky119⟩. ⟨hal-02381251⟩
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