D. Napierska, L. C. Thomassen, D. Lison, J. A. Martens, and P. H. Hoet, The nanosilica hazard: 438 another variable entity, Particle and Fibre Toxicology, vol.7, p.39, 2010.


E. Ecetoc and . Jacc-report, N°51 Synthetic Amorphous Silica, pp.1-237, 2006.

S. Murugadoss, D. Lison, L. Godderis, S. Van-den, J. Brule et al.,

P. H. Sebaihi and . Hoet, Toxicology of silica nanoparticles: an update, Archives of Toxicology, vol.91, pp.2967-3010, 2017.

Y. Guichard, M. A. Maire, S. Sebillaud, C. Fontana, C. Langlais et al.,

J. Roszak, M. Stepnik, V. Fessard, S. Binet, and L. Gate, Genotoxicity of synthetic amorphous 447 silica nanoparticles in rats following short-term exposure. Part 2: intratracheal instillation and 448 intravenous injection, Environmental and Molecular Mutagenesis, vol.56, pp.228-244, 2015.

S. Iarc and . Silicates, coal dust and para-Aramid fibrils, IARC Monographs on the 451 Evaluation of Carcinogenic Risks to Humans, vol.68, pp.1-506, 1997.

F. Pott and M. Roller, Carcinogenicity study with nineteen granular dusts in rats, European 453 Journal of Oncology, vol.10, pp.249-281, 2005.

A. Kolling, H. Ernst, S. Rittinghausen, and U. Heinrich, Relationship of pulmonary toxicity 455 and carcinogenicity of fine and ultrafine granular dusts in a rat bioassay, vol.23, pp.544-554, 2011.

C. Fontana, A. Kirsch, C. Seidel, L. Marpeaux, C. Darne et al., 458 In vitro cell transformation induced by synthetic amorphous silica nanoparticles, Mutation 459 Research/Genetic Toxicology and Environmental Mutagenesis, vol.823, pp.22-27, 2017.


S. Creton, M. J. Aardema, P. L. Carmichael, J. S. Harvey, F. L. Martin et al.,

K. O'donovan, A. Pant, A. Poth, K. Sakai, A. D. Sasaki et al., , p.463

N. Tanaka and H. Yasaei, Cell transformation assays for prediction of carcinogenic potential: 464 state of the science and future research needs, Mutagenesis, vol.465, pp.93-101, 2012.

C. Lasne, A. Gentil, and I. Chouroulinkov, Two-stage Malignant Transformation of Rat 467 Fibroblasts in Tissue Culture, Nature, pp.490-491, 1974.

K. Ohmori, M. Umeda, N. Tanaka, H. Takagi, I. Yoshimura et al.,

H. Sakai, M. Araki, H. Asakura, Y. Baba, S. Fushiwaki et al.,

H. Nakamura, S. Oishi, S. Sasaki, T. Shimada, Y. Tsuchiya et al., , p.471

Y. Yamamoto, E. Yamamura, and T. Yatsushiro, An inter-laboratory collaborative study by the 472

. Non-genotoxic, Carcinogen Study Group in Japan, on a cell transformation assay for tumour 473 promoters using Bhas 42 cells, Alternatives to Lab Animals, vol.33, pp.619-639, 2005.


K. Sasaki, H. Mizusawa, and M. Ishidate, Isolation and characterization of ras

, BALB/3T3 clone showing morphological transformation by 12-O-tetradecanoyl-phorbol-13-477 acetate, Japanese Journal of Cancer Research, vol.79, pp.921-930, 1988.


H. Maeshima, K. Ohno, S. Nakano, and T. Yamada, Validation of an in vitro screening test 480 for predicting the tumor promoting potential of chemicals based on gene expression, 481 Toxicology in Vitro, vol.24, pp.995-1001, 2010.

H. Maeshima, K. Ohno, Y. Tanaka-azuma, S. Nakano, and T. Yamada, Identification of 483 tumor promotion marker genes for predicting tumor promoting potential of chemicals in 484 BALB/c 3T3 cells, Toxicology in Vitro, vol.23, pp.148-157, 2009.


A. Sakai, K. Sasaki, D. Muramatsu, S. Arai, N. Endou et al.,

S. Lim, M. Yamazaki, N. Umeda, and . Tanaka, A Bhas 42 cell transformation assay on 98 488 chemicals: the characteristics and performance for the prediction of chemical carcinogenicity, 489 Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.702, pp.100-122, 2010.


, OECD, Guidance Document On the In Vitro Bhas 42 Cell Transformation Assay Series 492 on Testing & Assessment No. 231, ENV/JM/MONO(2016)1, p.493, 2016.

L. A. Loeb and C. C. Harris, Advances in chemical carcinogenesis: a historical review and 495 prospective, Cancer Res, vol.68, pp.6863-6872, 2008.

S. J. Sturla, A. R. Boobis, R. E. Fitzgerald, J. Hoeng, R. J. Kavlock et al.,

M. F. Whelan, M. C. Wilks, and . Peitsch, Systems Toxicology: From Basic Research to Risk 499 Assessment, Chemical Research in Toxicology, vol.27, pp.314-329, 2014.


Z. Elias, O. Poirot, M. C. Daniere, F. Terzetti, A. M. Marande et al.,

B. Fenoglio and . Fubini, Cytotoxic and transforming effects of silica particles with different 503 surface properties in Syrian hamster embryo (SHE) cells, Toxicology in Vitro, vol.14, pp.409-504, 2000.

D. Lindgren, F. Liedberg, A. Andersson, G. Chebil, S. Gudjonsson et al.,

T. Månsson, M. Fioretos, and . Höglund, Molecular characterization of early-stage bladder 507 carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q, Oncogene, vol.25, pp.2685-2696, 2006.

M. Vecchi, P. Nuciforo, S. Romagnoli, S. Confalonieri, C. Pellegrini et al.,

M. Quarto, G. C. Capra, E. Roviaro, C. Avesani, G. Corsi et al.,

. Bosari, Gene expression analysis of early and advanced gastric cancers, Oncogene, vol.26, pp.4284-4294, 2007.

A. Lingel, T. M. Weiss, M. Niebuhr, B. Pan, B. A. Appleton et al., Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP

, Receptors-Insight into Heterotrimeric IL-1 Signaling Complexes, vol.17, pp.1398-516, 2009.

J. Wang, Y. Jiang, C. Huang, P. Huang, M. Huang et al.,

K. J. Shen and Y. Ju, Proliferin enhances microvilli formation and cell growth of 519 neuroblastoma cells, Neuroscience Research, vol.56, pp.80-90, 2006.


J. T. Fassett and M. Nilsen-hamilton, Mrp3, a Mitogen-Regulated Protein/Proliferin Gene 522 Expressed in Wound Healing and in Hair Follicles*, Endocrinology, vol.142, pp.2129-2137, 2001.


M. Riener, F. R. Fritzsche, C. Soll, B. C. Pestalozzi, N. Probst-hensch et al.,

W. Jochum, A. Soltermann, H. Moch, and G. Kristiansen, Expression of the extracellular matrix 526 protein periostin in liver tumours and bile duct carcinomas, Histopathology, vol.56, pp.600-527, 2010.

E. M. Warren, H. Huang, E. Fanning, W. J. Chazin, and B. F. Eichman, Physical Interactions 529 between Mcm10, DNA, and DNA Polymerase ?, Journal of Biological Chemistry, vol.284, pp.24662-24672, 2009.

J. C. Higareda-almaraz, J. S. Ruiz-moreno, J. Klimentova, D. Barbieri, R. Salvador et al.,

R. Gallego, I. A. Ly, C. Valtierra-gutierrez, G. A. Dinsart, J. Rabinovich et al.,

. Rincon-orozco, Systems-level effects of ectopic galectin-7 reconstitution in cervical cancer 534 and its microenvironment, BMC Cancer, vol.16, p.680, 2016.

C. Seidel, A. Kirsch, C. Fontana, A. Visvikis, A. Remy et al., 537 Epigenetic changes in the early stage of silica-induced cell transformation, Nanotoxicology, vol.538, pp.923-935, 2017.

C. L. Parfett, T. Marquardt, and R. Pilon, Promotion of Morphological Transformation by 540 di-n-butyltin Dichloride in C3H/10T1/2 Cells: Prediction by Prior Expression of Tumour 541 Promoter-Responsive Genes, Food and Chemical Toxicology, vol.38, pp.339-349, 2000.


C. L. Parfett, R. Pilon, and A. A. Caldeira, Asbestos promotes morphological transformation 544 and elevates expression of a gene family invariably induced by tumor promoters in 545 C3H/10T1/2 cells, Carcinogenesis, vol.17, pp.2719-2726, 1996.


A. Rohrbeck, G. Salinas-riester, K. Maaser, J. Linge, S. Salovaara et al., 548 Toxicogenomics Applied to In Vitro Carcinogenicity Testing with Balb/c 3T3 Cells Revealed 549 a Gene Signature Predictive of Chemical Carcinogens, Toxicological Sciences, vol.118, pp.550-581, 2010.

C. L. Parfett and D. Desaulniers, A Tox21 Approach to Altered Epigenetic Landscapes: 552 Assessing Epigenetic Toxicity Pathways Leading to Altered Gene Expression and Oncogenic 553 Transformation In Vitro, International Journal of Molecular Sciences, vol.18, p.1179, 2017.


S. Hwang, H. Yeom, S. Y. Eom, Y. Lee, and M. Lee, Genome-Wide DNA Methylation 556 Changes in Transformed Foci Induced by Nongenotoxic Carcinogens, Environmental and 557 Molecular Mutagenesis, p.0, 2019.

P. M. Peeters, T. N. Perkins, E. F. Wouters, B. T. Mossman, and N. L. Reynaert, Silica 559 induces NLRP3 inflammasome activation in human lung epithelial cells, Particle and Fibre 560 Toxicology, vol.10, 2013.

T. N. Perkins, P. M. Peeters, A. Shukla, I. Arijs, J. Dragon et al.,

B. T. Reynaert and . Mossman, Indications for distinct pathogenic mechanisms of asbestos and 563 silica through gene expression profiling of the response of lung epithelial cells, Human 564 Molecular Genetics, vol.24, pp.1374-1389, 2015.

C. Pisani, J. Gaillard, V. Nouvel, M. Odorico, J. Armengaud et al., High-566 throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung 567 cells: grasping complex toxicity with a great depth of field, BMC Genomics, vol.16, p.315, 2015.


N. Decan, D. Wu, A. Williams, S. Bernatchez, M. Johnston et al., 570 Characterization of in vitro genotoxic, cytotoxic and transcriptomic responses following 571 exposures to amorphous silica of different sizes, Mutation Research/Genetic Toxicology and 572 Environmental Mutagenesis, vol.796, pp.8-22, 2016.


N. Q. Vuong, P. Goegan, F. De-rose, D. Breznan, E. M. Thomson et al.,

A. Karthikeyan, R. Williams, P. Vincent, and . Kumarathasan, Responses of A549 human lung 576 epithelial cells to cristobalite and ?-quartz exposures assessed by toxicoproteomics and gene 577 expression analysis, Journal of Applied Toxicology, vol.37, pp.721-731, 2017.


M. Fang, Y. Li, K. Huang, S. Qi, J. Zhang et al.,

P. Gozdz, A. Macek, M. Kowalik, E. Pasiarski, L. Grywalska et al., IL33 Promotes Colon Cancer Cell 582 Stemness via JNK Activation and Macrophage Recruitment, Cancer Research, vol.77, pp.2735-2745, 2017.

S. Karthikeyan, A. Russo, M. Dean, D. D. Lantvit, M. Endsley et al., Prolactin 585 signaling drives tumorigenesis in human high grade serous ovarian cancer cells and in a 21 586 spontaneous fallopian tube derived model, Cancer Letters, vol.433, pp.221-231, 2018.


D. Senfter, E. P. Erkan, E. Özer, G. Jungwirth, S. Madlener et al.,

O. Saydam and . Saydam, Overexpression of minichromosome maintenance protein 10 in 590 medulloblastoma and its clinical implications, Pediatric Blood & Cancer, vol.64, 2017.

W. M. Li, C. N. Huang, H. L. Ke, C. C. Li, Y. C. Wei et al., , p.593

P. I. Liang, B. W. Yeh, T. C. Chan, C. F. Li, and W. J. Wu, MCM10 overexpression implicates 594 adverse prognosis in urothelial carcinoma, Oncotarget, vol.7, pp.77777-77792, 2016.


F. Cui, J. Hu, S. Ning, J. Tan, and H. Tang, Overexpression of MCM10 promotes cell 597 proliferation and predicts poor prognosis in prostate cancer, The Prostate, vol.78, pp.1299-598, 2018.

R. Mahadevappa, H. Neves, S. M. Yuen, M. Jameel, Y. Bai et al., , p.600

Y. Zhu, H. F. Lin, and . Kwok, DNA Replication Licensing Protein MCM10 Promotes Tumor 601 Progression and Is a Novel Prognostic Biomarker and Potential Therapeutic Target in Breast 602 Cancer, Cancers, vol.10, p.282, 2018.

A. S. Lieu, T. S. Cheng, C. H. Chou, C. H. Wu, C. Y. Hsu et al.,

C. S. Loh, C. M. Chang, S. L. Hsu, Y. R. Howng, and . Hong, Functional characterization of AIBp, a 605 novel Aurora-A binding protein in centrosome structure and spindle formation, Int J Oncol, vol.606, pp.429-436, 2010.

S. Ueda, I. Kuwabara, and F. T. Liu, Suppression of tumor growth by galectin-7 gene transfer, 608 Cancer Research, vol.64, pp.5672-5676, 2004.

S. J. Kim, J. A. Hwang, J. Y. Ro, Y. S. Lee, and K. H. Chun, Galectin-7 is epigenetically-610 regulated tumor suppressor in gastric cancer, Oncotarget, vol.4, pp.1461-1471, 2013.


K. Biron-pain, A. Grosset, F. Poirier, L. Gaboury, and Y. St-pierre, Expression and 613 Functions of Galectin-7 in Human and Murine Melanomas, vol.8, p.63307, 2013.


C. J. Kim, N. Yoshioka, Y. Tambe, R. Kushima, Y. Okada et al., Periostin is down-616 regulated in high grade human bladder cancers and suppresses in vitro cell invasiveness and 617 in vivo metastasis of cancer cells, International Journal of Cancer, vol.117, pp.51-58, 2005.

P. Li, J. Qian, G. Yu, Y. Chen, K. Liu et al., Down-regulated SPARCL1 is 620 associated with clinical significance in human gastric cancer, Journal of Surgical Oncology, vol.621, pp.31-37, 2012.

F. Cao, K. Wang, R. Zhu, Y. W. Hu, W. Z. Fang et al., Clinicopathological 623 significance of reduced SPARCL1 expression in human breast cancer, Asian Pacific Journal 624 of Cancer Prevention, vol.14, pp.195-200, 2013.

P. J. Hurley, L. Marchionni, B. W. Simons, A. E. Ross, S. B. Peskoe et al.,

I. A. Vergara, M. Ghadessi, Z. Huang, B. Gurel, B. H. Park et al.,

D. M. Platz, E. M. Berman, and . Schaeffer, Secreted protein, acidic and rich in cysteine-like 1 628 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor 629 clinical outcome, Proceedings of the National Academy of Sciences, vol.109, pp.14977-630, 2012.

P. Lévy, D. Vidaud, K. Leroy, I. Laurendeau, J. Wechsler et al.,

M. Wolkenstein, I. Vidaud, and . Bièche, Molecular profiling of malignant peripheral nerve sheath 633 tumors associated with neurofibromatosis type 1, based on large-scale real-time RT-PCR, 634 Molecular Cancer, vol.3, p.20, 2004.

B. Kigel, A. Varshavsky, O. Kessler, and G. Neufeld, Successful Inhibition of Tumor 636 Development by Specific Class-3 Semaphorins Is Associated with Expression of Appropriate 637 Semaphorin Receptors by Tumor Cells, PLoS One, vol.3, p.3287, 2008.


X. Zhou, L. Ma, J. Li, J. Gu, Q. Shi et al., Effects of SEMA3G on migration and 640 invasion of glioma cells, Oncology Reports, vol.28, pp.269-275, 2012.


M. Dutertre, L. Gratadou, E. Dardenne, S. Germann, S. Samaan et al.,

P. Driouch, D. De-la-grange, and . Auboeuf, Estrogen Regulation and Physiopathologic 644 Significance of Alternative Promoters in Breast Cancer, Cancer Research, vol.70, pp.3760-645, 2010.

I. Kuwabara, Y. Kuwabara, R. Y. Yang, M. Schuler, D. R. Green et al., Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and 648 mitochondrial cytochrome cRelease, Journal of Biological Chemistry, vol.277, pp.3487-3497, 2002.


P. J. Neame, *. , C. J. Kay, D. J. Mcquillan, M. P. Beales et al., Independent 651 modulation of collagen fibrillogenesis by decorin and lumican, Cellular and Molecular Life 652, Sciences CMLS, vol.57, pp.859-863, 2000.

S. Chattopadhyay and A. Bielinsky, Human Mcm10 Regulates the Catalytic Subunit of 654 DNA Polymerase-? and Prevents DNA Damage during Replication, Molecular Biology of the 655 Cell, vol.18, pp.4085-4095, 2007.

L. Gillan, D. Matei, D. A. Fishman, C. S. Gerbin, B. Y. Karlan et al., Periostin 657 Secreted by Epithelial Ovarian Carcinoma Is a Ligand for ?V?3 and ?V?5 Integrins and 658 Promotes Cell Motility, Cancer Research, vol.62, pp.5358-5364, 2002.

X. Liu, S. Li, and F. Yi, Trop2 gene: a novel target for cervical cancer treatment, Journal of 660 Cancer Research and Clinical Oncology, vol.140, pp.1331-1341, 2014.


M. M. Sullivan, T. H. Barker, S. E. Funk, A. Karchin, N. S. Seo et al., , vol.663

T. N. Starcher, P. Wight, E. H. Puolakkainen, and . Sage, Matricellular Hevin Regulates Decorin 664 Production and Collagen Assembly, Journal of Biological Chemistry, vol.281, pp.27621-665, 2006.

L. Huang, Y. Xu, G. Cai, Z. Guan, and S. Cai, Downregulation of S100A4 expression by 667 RNA interference suppresses cell growth and invasion in human colorectal cancer cells, Oncology Reports, vol.668, pp.917-922, 2012.

K. Rasmussen, J. M. Mech, and J. Mast, Characterisation and Physico-Chemical Properties. 671 JRC Repository: NM-series of Representative Manufactured Nanomaterials, p.200, 2013.

Z. Elias, O. Poirot, I. Fenoglio, M. Ghiazza, M. C. Daniere et al.,

I. Coulais, B. Matekovits, and . Fubini, Surface reactivity, cytotoxic, and morphological 675 transforming effects of diatomaceous Earth products in Syrian hamster embryo cells, Toxicol 676 Sci, vol.91, pp.510-520, 2006.