J. V. Pham, M. A. Yilma, A. Feliz, M. T. Majid, N. Maffetone et al., A Review of the microbial production of bioactive natural products and biologics, Front. Microbiol, vol.10, p.1404, 2019.

E. A. Barka, P. Vatsa, L. Sanchez, N. Gaveau-vaillant, C. Jacquard et al., actinobacteria. Microbiol. Mol. Biol. Rev, vol.80, pp.1-43, 2016.

K. F. Chater, Recent advances in understanding Streptomyces, vol.5, p.2795, 2016.

G. P. Van-wezel and K. J. Mcdowall, The regulation of the secondary metabolism of Streptomyces: New links and experimental advances, Nat. Prod. Rep, 1311.

H. M. Alvarez and A. Steinbuchel, Triacylglycerols in prokaryotic microorganisms, Appl. Microbiol. Biotechnol, vol.60, pp.367-376, 2002.

T. Kieser, M. J. Bibb, M. J. Buttner, K. F. Chater, and D. A. Hopwood, Practical Streptomyces Genetics, 2000.

C. Esnault, T. Dulermo, A. Smirnov, A. Askora, M. David et al., Strong antibiotic production is correlated with highly active oxidative metabolism in Streptomyces coelicolor M145, 0200.
URL : https://hal.archives-ouvertes.fr/hal-01509613

L. Maréchal, P. Decottignies, P. Marchand, C. H. Degrouard, J. Jaillard et al., Comparative proteomic analysis of Streptomyces lividans Wild-Type and ppk mutant strains reveals the importance of storage lipids for antibiotic biosynthesis, Appl. Environ. Microbiol, vol.79, pp.5907-5917, 2013.

A. Millan-oropeza, C. Henry, C. Lejeune, M. David, and M. Virolle, Expression of genes of the Pho regulon is altered in, S. coelicolor. Sci. Rep, vol.10, 2020.

H. Chouayekh and M. J. Virolle, The polyphosphate kinase plays a negative role in the control of antibiotic production in Streptomyces lividans, Mol. Microbiol, vol.43, pp.919-930, 2002.

S. Ghorbel, Regulation of ppk expression and in vivo function of Ppk in Streptomyces lividans TK24, J. Bacteriol, vol.188, pp.6269-6276, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00101164

M. Virolle, A challenging view: Antibiotics play a role in the regulation of the energetic metabolism of the producing bacteria, Antibiotics, vol.2020, p.83
URL : https://hal.archives-ouvertes.fr/hal-02495695

E. Tenconi, M. F. Traxler, C. Hoebreck, G. P. Wezel, and S. Rigali, Production of prodiginines is part of a programmed cell death process in streptomyces coelicolor, Front. Microbiol, vol.9, p.1742, 2018.

E. R. Olukoshi and N. M. Packter, Importance of stored triacylglycerols in Streptomyces: Possible carbon source for antibiotics, vol.140, pp.931-943, 1994.

N. M. Packter and E. R. Olukoshi, Ultrastructural studies of neutral lipid localisation in Streptomyces, Arch. Microbiol, vol.164, pp.420-427, 1995.

T. L. Foley, B. S. Young, and M. D. Burkart, Phosphopantetheinyl transferase inhibition and secondary metabolism: PPTase inhibition and secondary metabolism, FEBS J, vol.276, pp.7134-7145, 2009.

A. Craney, C. Ozimok, S. M. Pimentel-elardo, A. Capretta, and J. R. Nodwell, Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism, Chem. Biol, vol.19, pp.1020-1027, 2012.

C. Banchio and H. Gramajo, A stationary-phase acyl-coenzyme A synthetase of streptomyces coelicolor A3(2) is necessary for the normal onset of antibiotic production, Appl. Environ. Microbiol, vol.68, pp.4240-4246, 2002.

W. Wang, S. Li, Z. Li, J. Zhang, K. Fan et al., Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces, Nat. Biotechnol, vol.2020, pp.76-83

Y. Chen, J. Metz, R. K. Miller-xavier, and G. Wang, Unlocking a new target for streptomycetes strain improvement, Synth. Syst. Biotechnol, vol.2020, pp.33-34

C. Schauner, A. Dary, A. Lebrihi, P. Leblond, B. Decaris et al., Modulation of lipid metabolism and spiramycin biosynthesis in Streptomyces ambofaciens unstable mutants, Appl. Environ. Microbiol, vol.65, pp.2730-2737, 1999.
URL : https://hal.archives-ouvertes.fr/hal-01658995

P. Vitry, R. Rebois, E. Bourillot, A. Deniset-besseau, M. Virolle et al., Combining infrared and mode synthesizing atomic force microscopy: Application to the study of lipid vesicles inside Streptomyces bacteria, Nano Res, vol.9, pp.1674-1681, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02394465

A. Deniset-besseau, C. B. Prater, M. Virolle, and A. Dazzi, Monitoring TriAcylGlycerols accumulation by atomic force microscopy based infrared spectroscopy in streptomyces species for biodiesel applications, J. Phys. Chem. Lett, vol.5, pp.654-658, 2014.

A. Millan-oropeza, R. Rebois, M. David, F. Moussa, A. Dazzi et al., Attenuated total reflection fourier transform infrared (ATR FT-IR) for rapid determination of microbial cell lipid content: Correlation with gas chromatography-mass spectrometry (GC-MS), Appl. Spectrosc, vol.71, pp.2344-2352, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02390043

K. Blin, T. Wolf, M. G. Chevrette, X. Lu, C. J. Schwalen et al., 0-improvements in chemistry prediction and gene cluster boundary identification, Nucleic Acids Res, vol.45, pp.36-41, 2017.

R. F. Seipke and M. I. Hutchings, The regulation and biosynthesis of antimycins, Beilstein J. Org. Chem, vol.9, pp.2556-2563, 2013.

R. Joynt and R. F. Seipke, A phylogenetic and evolutionary analysis of antimycin biosynthesis, Microbiology, vol.164, pp.28-39, 2018.

P. Shanbhag, S. Bhave, A. Vartak, A. Kulkarni-almeida, G. Mahajan et al., Screening of microbial extracts for anticancer compounds using streptomyces kinase inhibitor assay, Nat. Prod. Commun, vol.10, pp.1287-1291, 2015.

M. G. Chevrette, K. Gutiérrez-garcía, N. Selem-mojica, C. Aguilar-martínez, A. Yañez-olvera et al., Evolutionary dynamics of natural product biosynthesis in bacteria, Nat. Prod. Rep, vol.37, pp.566-599, 2020.

P. Yagüe, M. T. Lopez-garcia, B. Rioseras, J. Sanchez, and A. Manteca, New insights on the development of Streptomyces and their relationships with secondary metabolite production, Curr. Trends Microbiol, vol.8, pp.65-73, 2012.

T. Brettin, J. J. Davis, T. Disz, R. A. Edwards, S. Gerdes et al., RASTtk: A modular and extensible implementation of the RAST algorithm for building custom annotation pipelines and annotating batches of genomes, Sci. Rep, vol.5, 2015.

L. Valledor, T. Furuhashi, L. Recuenco-muñoz, S. Wienkoop, and W. Weckwerth, System-level network analysis of nitrogen starvation and recovery in Chlamydomonas reinhardtii reveals potential new targets for increased lipid accumulation, Biotechnol. Biofuels, vol.7, p.171, 2014.

E. C. Goncalves, J. Koh, N. Zhu, M. Yoo, S. Chen et al., Nitrogen starvation-induced accumulation of triacylglycerol in the green algae: Evidence for a role for ROC40, a transcription factor involved in circadian rhythm, Plant J, vol.85, pp.743-757, 2016.

N. Morin, J. Cescut, A. Beopoulos, G. Lelandais, V. Le-berre et al., Transcriptomic analyses during the transition from biomass production to lipid accumulation in the oleaginous yeast Yarrowia lipolytica, PLoS ONE, 2011.
URL : https://hal.archives-ouvertes.fr/hal-01191312

G. Liu, K. F. Chater, G. Chandra, G. Niu, and H. Tan, Molecular regulation of antibiotic biosynthesis in streptomyces. Microbiol, Mol. Biol. Rev, vol.77, pp.112-143, 2013.

A. Husain, D. Sato, G. Jeelani, T. Soga, and T. Nozaki, Dramatic increase in glycerol biosynthesis upon oxidative stress in the anaerobic protozoan parasite Entamoeba histolytica, PLoS Negl. Trop. Dis, 1831.

A. K. Pahlman, K. Granath, R. Ansell, S. Hohmann, and L. Adler, The yeast glycerol 3-phosphatases Gpp1p and Gpp2p are required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic, anaerobic, and oxidative stress, J. Biol. Chem, vol.276, pp.3555-3563, 2001.

L. Agledal, M. Niere, and M. Ziegler, The phosphate makes a difference: Cellular functions of NADP, Redox Rep, vol.15, pp.2-10, 2010.

T. Beites, P. Oliveira, B. Rioseras, S. D. Pires, R. Oliveira et al., Streptomyces natalensis programmed cell death and morphological differentiation are dependent on oxidative stress, Sci. Rep, vol.5, p.12887, 2015.

T. Beites, S. D. Pires, C. L. Santos, H. Osório, P. Moradas-ferreira et al., Crosstalk between ROS homeostasis and secondary metabolism in S. natalensis ATCC 27448: Modulation of pimaricin production by intracellular ROS, PLoS ONE, 2011.

R. U. Miranda, L. E. Gómez-quiroz, M. Mendoza, A. Pérez-sánchez, F. Fierro et al., Reactive oxygen species regulate lovastatin biosynthesis in Aspergillus terreus during submerged and solid-state fermentations, Fungal Biol, vol.118, pp.979-989, 2014.

M. E. Bibián, A. Pérez-sánchez, A. Mejía, and J. Barrios-gonzález, Penicillin and cephalosporin biosyntheses are also regulated by reactive oxygen species, Appl. Microbiol. Biotechnol, vol.2020, pp.1773-1783

D. Prajapati, N. Kumari, K. Dave, V. Chatupale, and J. Pohnerkar, Chromomycin, an antibiotic produced by Streptomyces flaviscleroticus might play a role in the resistance to oxidative stress and is essential for viability in stationary phase, Environ. Microbiol, vol.21, pp.814-826, 2019.

C. J. Thompson, J. M. Ward, and D. A. Hopwood, DNA cloning in Streptomyces: Resistance genes from antibiotic-producing species, Nature, vol.286, pp.525-527, 1980.

M. Young, V. Artsatbanov, H. R. Beller, G. Chandra, K. F. Chater et al., Genome sequence of the Fleming strain of Micrococcus luteus, a simple free-living actinobacterium, J. Bacteriol, vol.192, pp.841-860, 2010.

I. Szczerba, Susceptibility to antibiotics of bacteria from genera Micrococcus, Kocuria, Nesterenkonia, Kytococcus and Dermacoccus. Medycyna Do?wiadczalna i Mikrobiologia, vol.55, pp.75-80, 2003.

R. C. Team, A Language and Environment for Statistical Computing; R Foundation for Statistical Computing, 2013.

M. Hervé and . Rvaidememoire, Testing and Plotting Procedures for Biostatistics. R Package Version 0.9-75, 2020.

J. Folch, M. Lees, and G. H. Sloane-stanley, A simple method for the isolation and purification of total lipides from animal tissues, J. Biol. Chem, vol.226, pp.497-509, 1957.

S. Abreu, A. Solgadi, and P. Chaminade, Optimization of normal phase chromatographic conditions for lipid analysis and comparison of associated detection techniques, vol.1514, pp.54-71, 2017.

R. W. Dixon and D. S. Peterson, Development and testing of a detection method for liquid chromatography based on aerosol charging, Anal. Chem, vol.74, pp.2930-2937, 2002.

S. Graves, H. Piepho, L. Selzer, S. Dorai-raj, and . Multcompview, Visualizations of Paired Comparisons, 2019.

R. R. Wick, L. M. Judd, C. L. Gorrie, K. E. Holt, and . Unicycler, Resolving bacterial genome assemblies from short and long sequencing reads, PLoS Comput. Biol, vol.13, p.1005595, 2017.

Y. Moriya, M. Itoh, S. Okuda, A. C. Yoshizawa, and M. Kanehisa, KAAS: An automatic genome annotation and pathway reconstruction server, Nucleic Acids Res, vol.35, pp.182-185, 2007.

S. F. Altschul, W. Gish, W. Miller, E. W. Myers, and D. J. Lipman, Basic local alignment search tool, J. Mol. Biol, vol.215, pp.403-410, 1990.