N. A. Almontashiri, R. O. Vilmundarson, N. Ghasemzadeh, S. Dandona, R. Roberts et al.,

A. F. Stewart, Plasma PCSK9 levels are elevated with acute myocardial infarction in two independent retrospective angiographic studies, PLoS One, vol.9, issue.9, p.106294, 2014.

M. Arcopinto, A. Salzano, F. Giallauria, E. Bossone, J. Isgaard et al., Growth Hormone Deficiency Is Associated with Worse Cardiac Function, Physical Performance, and Outcome in Chronic Heart Failure: Insights from the, PLoS One, vol.12, issue.1, 2017.

A. Bayes-genis, J. Nunez, F. Zannad, J. P. Ferreira, S. D. Anker et al., The PCSK9-LDL Receptor Axis and Outcomes in Heart Failure: BIOSTAT-CHF Subanalysis, J Am Coll Cardiol, vol.70, issue.17, pp.2128-2136, 2017.

A. E. Berezin, A. A. Kremzer, Y. V. Martovitskaya, T. A. Berezina, and E. A. Gromenko, Pattern of endothelial progenitor cells and apoptotic endothelial cell-derived microparticles in chronic heart failure patients with preserved and reduced left ventricular ejection fraction, EBioMedicine, vol.4, pp.86-94, 2016.

L. M. Blanco-colio, TWEAK/Fn14 Axis: A Promising Target for the Treatment of Cardiovascular Diseases, Front Immunol, vol.5, p.3, 2014.

M. Brankovic, K. Martijn-akkerhuis, H. Mouthaan, A. Constantinescu, K. Caliskan et al.,

I. Kardys, Utility of temporal profiles of new cardio-renal and pulmonary candidate biomarkers in chronic heart failure, Int J Cardiol, 2018.

A. Calderone, L. Castagnoli, and G. Cesareni, mentha: a resource for browsing integrated protein-interaction networks, Nat Methods, vol.10, issue.8, pp.690-691, 2013.

A. Chatr-aryamontri, R. Oughtred, L. Boucher, J. Rust, C. Chang et al., The BioGRID interaction database: 2017 update, Nucleic Acids Res, vol.45, issue.D1, pp.369-379, 2017.

H. N. Chen, D. J. Wang, M. Y. Ren, Q. L. Wang, and S. J. Sui, TWEAK/Fn14 promotes the proliferation and collagen synthesis of rat cardiac fibroblasts via the NF-small ka, CyrillicB pathway, Mol Biol Rep, vol.39, issue.8, pp.8231-8241, 2012.

O. Chioncel, M. Lainscak, P. M. Seferovic, S. D. Anker, M. G. Crespo-leiro et al.,

G. Filippatos, Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry, Eur J Heart Fail, vol.19, issue.12, pp.1574-1585, 2017.

A. Y. Chong, G. J. Caine, B. Freestone, A. D. Blann, and G. Y. Lip, Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure, J Am Coll Cardiol, vol.43, issue.3, pp.423-428, 2004.

J. Czucz, L. Cervenak, Z. Forhecz, T. Gombos, Z. Pozsonyi et al.,

Z. Prohaszka, Serum soluble E-selectin and NT-proBNP levels additively predict mortality in diabetic patients with chronic heart failure, Clin Res Cardiol, vol.100, issue.7, pp.587-594, 2011.

K. Damman, M. A. Valente, A. A. Voors, C. M. O'connor, D. J. Van-veldhuisen et al., Renal impairment, worsening renal function, and outcome in patients with heart failure: an updated meta-analysis, Eur Heart J, vol.35, issue.7, pp.455-469, 2014.

J. Dankiewicz, A. Linder, M. Annborn, M. Rundgren, and H. Friberg, Heparin-binding protein: an early indicator of critical illness and predictor of outcome in cardiac arrest, Resuscitation, vol.84, issue.7, pp.935-939, 2013.

S. M. Dehm and K. Bonham, SRC gene expression in human cancer: the role of transcriptional activation, Biochem Cell Biol, vol.82, issue.2, pp.263-274, 2004.

N. L. Diny, X. Hou, J. G. Barin, G. Chen, M. V. Talor et al., Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart, Eur J Immunol, vol.46, issue.12, pp.2749-2760, 2016.

E. Economou, D. Tousoulis, A. Katinioti, C. Stefanadis, A. Trikas et al., Chemokines in patients with ischaemic heart disease and the effect of coronary angioplasty, Int J Cardiol, vol.80, issue.1, pp.55-60, 2001.

A. Fabregat, S. Jupe, L. Matthews, K. Sidiropoulos, M. Gillespie et al., The Reactome Pathway Knowledgebase, Nucleic Acids Res, vol.46, issue.D1, pp.649-655, 2018.

G. Ferraccioli and E. Gremese, B cell activating factor (BAFF) and BAFF receptors: fakes and facts, Clin Exp Immunol, vol.190, issue.3, pp.291-292, 2017.

C. Franssen, S. Chen, A. Unger, H. I. Korkmaz, G. W. De-keulenaer et al., Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction, JACC Heart Fail, vol.4, issue.4, pp.312-324, 2016.

J. K. Frazer, D. G. Jackson, J. P. Gaillard, M. Lutter, Y. J. Liu et al., Identification of centerin: a novel human germinal center B cell-restricted serpin, Eur J Immunol, vol.30, issue.10, pp.3039-3048, 2000.

N. Gautam, A. M. Olofsson, H. Herwald, L. F. Iversen, E. Lundgren-akerlund et al., Heparinbinding protein (HBP/CAP37): a missing link in neutrophil-evoked alteration of vascular permeability, Nat Med, vol.7, issue.10, pp.1123-1127, 2001.

C. Hage, E. Michaelsson, C. Linde, E. Donal, J. C. Daubert et al., Inflammatory Biomarkers Predict Heart Failure Severity and Prognosis in Patients With Heart Failure With Preserved Ejection Fraction: A Holistic Proteomic Approach, Circ Cardiovasc Genet, issue.1, p.10, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01446558

J. Hamann, G. Aust, D. Arac, F. B. Engel, C. Formstone et al., International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors, Pharmacol Rev, vol.67, issue.2, pp.338-367, 2015.

Q. He and M. C. Lapointe, Src and Rac mediate endothelin-1 and lysophosphatidic acid stimulation of the human brain natriuretic peptide promoter, Hypertension, vol.37, issue.2, pp.478-484, 2001.

K. Y. Huang and H. H. Lin, The Activation and Signaling Mechanisms of GPR56/ADGRG1 in Melanoma Cell, Front Oncol, vol.8, p.304, 2018.

R. B. Huang and O. Eniola-adefeso, Shear stress modulation of IL-1beta-induced E-selectin expression in human endothelial cells, PLoS One, vol.7, issue.2, 2012.

O. Huttin, A. G. Fraser, S. Coiro, E. Bozec, C. Selton-suty et al., Impact of Changes in Consensus Diagnostic Recommendations on the Echocardiographic Prevalence of Diastolic Dysfunction, J Am Coll Cardiol, vol.69, issue.25, pp.3119-3121, 2017.

S. J. Hwang, V. Melenovsky, and B. A. Borlaug, Implications of coronary artery disease in heart failure with preserved ejection fraction, J Am Coll Cardiol, vol.63, issue.25, pp.2817-2827, 2014.

K. Ikezoe, S. Ohshima, M. Osoegawa, M. Tanaka, K. Ogawa et al., Expression of granulysin in polymyositis and inclusion-body myositis, J Neurol Neurosurg Psychiatry, vol.77, issue.10, pp.1187-1190, 2006.

A. Ivetic, A head-to-tail view of L-selectin and its impact on neutrophil behaviour, Cell Tissue Res, vol.371, issue.3, pp.437-453, 2018.

G. T. Jones, L. V. Phillips, M. J. Williams, A. M. Van-rij, and T. D. Kabir, Two C-C Family Chemokines, Eotaxin and RANTES, Are Novel Independent Plasma Biomarkers for Abdominal Aortic Aneurysm, J Am Heart Assoc, vol.5, issue.5, 2016.

D. P. Kao, J. D. Lewsey, I. S. Anand, B. M. Massie, M. R. Zile et al., Characterization of subgroups of heart failure patients with preserved ejection fraction with possible implications for prognosis and treatment response, Eur J Heart Fail, vol.17, issue.9, pp.925-935, 2015.

W. A. Kibbe, C. Arze, V. Felix, E. Mitraka, E. Bolton et al.,

L. M. Schriml, Disease Ontology 2015 update: an expanded and updated database of human diseases for linking biomedical knowledge through disease data, Nucleic Acids Res, vol.43, pp.1071-1078, 2015.

K. Kotsch, M. F. Mashreghi, G. Bold, P. Tretow, J. Beyer et al.,

P. Reinke, Enhanced granulysin mRNA expression in urinary sediment in early and delayed acute renal allograft rejection, Transplantation, vol.77, issue.12, pp.1866-1875, 2004.

J. Kumar, S. Okada, C. Clayberger, and A. M. Krensky, Granulysin: a novel antimicrobial, Expert Opin Investig Drugs, vol.10, issue.2, pp.321-329, 2001.

K. W. Lee, G. Y. Lip, and A. D. Blann, Plasma angiopoietin-1, angiopoietin-2, angiopoietin receptor tie-2, and vascular endothelial growth factor levels in acute coronary syndromes, Circulation, vol.110, issue.16, pp.2355-2360, 2004.

X. Li, M. Tjwa, L. Moons, P. Fons, A. Noel et al., Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors, J Clin Invest, vol.115, issue.1, pp.118-127, 2005.

A. Linder, P. Akesson, M. Inghammar, C. J. Treutiger, A. Linner et al., Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock, Crit Care, vol.16, issue.3, p.90, 2012.

A. Linder, O. Soehnlein, and P. Akesson, Roles of heparin-binding protein in bacterial infections, J Innate Immun, vol.2, issue.5, pp.431-438, 2010.

D. Lu and P. A. Insel, Hydrolysis of extracellular ATP by ectonucleoside triphosphate diphosphohydrolase (ENTPD) establishes the set point for fibrotic activity of cardiac fibroblasts, J Biol Chem, vol.288, issue.26, pp.19040-19049, 2013.

M. Lundberg, A. Eriksson, B. Tran, E. Assarsson, and S. Fredriksson, Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-abundant proteins in human blood, Nucleic Acids Res, vol.39, issue.15, p.102, 2011.

R. Luo, S. J. Jeong, Z. Jin, N. Strokes, S. Li et al., G protein-coupled receptor 56 and collagen III, a receptorligand pair, regulates cortical development and lamination, Proc Natl Acad Sci, vol.108, issue.31, 2011.

X. L. Ma, A. S. Weyrich, D. J. Lefer, M. Buerke, K. H. Albertine et al., Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reperfused cat myocardium, Circulation, vol.88, issue.2, pp.649-658, 1993.

J. Medamana, R. A. Clark, and J. Butler, Platelet-Derived Growth Factor in Heart Failure, Handb Exp Pharmacol, vol.243, pp.355-369, 2017.

H. Moreno, . Jr, K. Metze, A. C. Bento, E. Antunes et al., Chronic nitric oxide inhibition as a model of hypertensive heart muscle disease, Basic Res Cardiol, vol.91, issue.3, pp.248-255, 1996.

A. C. Morrison, L. A. Bare, M. M. Luke, J. S. Pankow, T. H. Mosley et al., Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study, Cerebrovasc Dis, vol.26, issue.4, pp.420-424, 2008.

M. Nagasawa, K. Ogawa, S. Imashuku, and S. Mizutani, Serum granulysin is elevated in patients with hemophagocytic lymphohistiocytosis, Int J Hematol, vol.86, issue.5, pp.470-473, 2007.

K. L. Ong, N. Hui, A. S. Januszewski, N. O. Kaakoush, A. Xu et al., High plasma FGF21 levels predicts major cardiovascular events in patients treated with atorvastatin (from the Treating to New Targets, TNT] Study). Metabolism, vol.93, pp.93-99, 2019.

D. M. Ornitz and N. Itoh, The Fibroblast Growth Factor signaling pathway, Wiley Interdiscip Rev Dev Biol, vol.4, issue.3, pp.215-266, 2015.

J. Pardo, P. Perez-galan, S. Gamen, I. Marzo, I. Monleon et al.,

A. Anel, A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis, J Immunol, vol.167, issue.3, pp.1222-1229, 2001.

W. J. Paulus, C. Tschope, J. E. Sanderson, C. Rusconi, F. A. Flachskampf et al.,

D. L. Brutsaert, How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology, Eur Heart J, vol.28, issue.20, pp.2539-2550, 2007.

V. Persic, A. Ruzic, B. Miletic, D. T. Samsa, M. Rakic et al., Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event, Scand J Immunol, vol.75, issue.2, pp.231-242, 2012.

J. Pinero, A. Bravo, N. Queralt-rosinach, A. Gutierrez-sacristan, J. Deu-pons et al., DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants, Nucleic Acids Res, vol.45, issue.D1, pp.833-839, 2017.

P. Ponikowski, A. A. Voors, S. D. Anker, H. Bueno, J. G. Cleland et al., 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC, Eur Heart J, vol.37, issue.27, pp.2129-2200, 2016.

K. Ptaszynska-kopczynska, M. Marcinkiewicz-siemion, A. Lisowska, E. Waszkiewicz, M. Witkowski et al.,

K. A. Kaminski, Alterations of soluble TWEAK and CD163 concentrations in patients with chronic heart failure, Cytokine, vol.80, pp.7-12, 2016.

Y. N. Reddy, R. E. Carter, M. Obokata, M. M. Redfield, and B. A. Borlaug, A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction, Circulation, vol.138, issue.9, pp.861-870, 2018.

P. Rossignol, A. F. Hernandez, S. Solomon, and F. Zannad, Heart failure drug treatment, Lancet, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02510811

D. B. Rubin, Multiple Imputation for Nonresponse in Surveys, 2004.

M. S. Sabatine, R. P. Giugliano, A. C. Keech, N. Honarpour, S. D. Wiviott et al.,

T. R. Pedersen, Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease, N Engl J Med, vol.376, issue.18, pp.1713-1722, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01896445

A. Salzano, A. M. Marra, F. Ferrara, M. Arcopinto, E. Bobbio et al., Multiple hormone deficiency syndrome in heart failure with preserved ejection fraction, Int J Cardiol, vol.225, pp.1-3, 2016.

A. Salzano, A. M. Marra, R. D'assante, M. Arcopinto, T. Suzuki et al., Growth Hormone Therapy in Heart Failure, Heart Fail Clin, vol.14, issue.4, pp.501-515, 2018.

S. Sanchez-martinez, N. Duchateau, T. Erdei, G. Kunszt, S. Aakhus et al., Machine Learning Analysis of Left Ventricular Function to Characterize Heart Failure With Preserved Ejection Fraction, Circ Cardiovasc Imaging, vol.11, issue.4, p.7138, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02282401

S. Sanders-van-wijk, V. Van-empel, N. Davarzani, M. T. Maeder, R. Handschin et al., Circulating biomarkers of distinct pathophysiological pathways in heart failure with preserved vs. reduced left ventricular ejection fraction, Eur J Heart Fail, vol.17, issue.10, pp.1006-1014, 2015.

R. Santhanakrishnan, J. P. Chong, T. P. Ng, L. H. Ling, D. Sim et al., Growth differentiation factor 15, ST2, high-sensitivity troponin T, and N-terminal pro brain natriuretic peptide in heart failure with preserved vs. reduced ejection fraction, Eur J Heart Fail, vol.14, issue.12, pp.1338-1347, 2012.

J. Sevigny, C. Sundberg, N. Braun, O. Guckelberger, E. Csizmadia et al.,

S. C. Robson, Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation, Blood, issue.8, pp.2801-2809, 2002.

S. J. Shah, D. H. Katz, S. Selvaraj, M. A. Burke, C. W. Yancy et al., Phenomapping for novel classification of heart failure with preserved ejection fraction, Circulation, vol.131, issue.3, pp.269-279, 2015.

Y. J. Shimada and C. P. Cannon, PCSK9 (Proprotein convertase subtilisin/kexin type 9) inhibitors: past, present, and the future, Eur Heart J, vol.36, issue.36, pp.2415-2424, 2015.

. Endoglin, , p.17813

, Retinoic acid receptor responder protein 1 (RARRES1), p.49788

-. Fetuin, , pp.9-14

, Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) Q7LG56 Ficolin-2 (FCN2), p.15485

A. Serpin, , pp.86-93

. Glutaminyl-peptide-cyclotransferase, , p.16769

, Tyrosine-protein kinase receptor UFO (AXL) P30530 Interleukin-2 receptor subunit beta, p.14784

, Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS-1) P78324

, Urokinase plasminogen activator surface receptor (U-PAR) Q03405 Interleukin-5 (IL5), p.5113

, Urokinase-type plasminogen activator (uPA), vol.6, p.5231

, Thymic stromal lymphopoietin, pp.969-978

, TNF-related activation-induced cytokine (TRANCE), p.14788

. Interleukin-10, , vol.10, p.22301

, TNF-related apoptosis-inducing ligand (TRAIL), p.50591

, Interleukin-10 receptor subunit alpha (IL-10RA) Q13651 Transforming growth factor alpha (TGF-alpha) P01135

, Interleukin-10 receptor subunit beta (IL-10RB) Q08334 Tumor necrosis factor (Ligand) superfamily, member 12(TWEAK), p.43508

, Interleukin-12 subunit beta (IL-12B) P29460 Tumor necrosis factor, p.1375

, Interleukin-13 (IL-13) P35225 Tumor necrosis factor ligand superfamily member, vol.14, p.43557

, Interleukin-15 receptor subunit alpha (IL-15RA) Q13261 Tumor necrosis factor receptor superfamily member, vol.9, p.7011

. Interleukin-17a,

, Urokinase-type plasminogen activator (uPA), p.749

, Interleukin-17C (IL-17C) Q9P0M4

, Vascular endothelial growth factor A (VEGF-A) P15692

, Interleukin-18 (IL-18) Q14116

, Interleukin-18 receptor 1 (IL-18R1) Q13478

, Interleukin-20 receptor subunit alpha (IL-20RA) Q9UHF4

, Interleukin-22 receptor subunit alpha-1 (IL-22 RA1) Q8N6P7

, Latency-associated peptide transforming growth factor beta-1 (LAP TGF-beta-1) P01137

, Leukemia inhibitory factor, p.15018

, Leukemia inhibitory factor receptor, p.42702

, Matrix, p.9238

, Monocyte chemotactic protein, vol.1, issue.1, p.13500

, Monocyte chemotactic protein, vol.2, issue.2, p.80075

, Neurotrophin-3 (NT-3) P20783

. Neurturin, , p.99748

-. Oncostatin, , p.13725

. Osteoprotegerin, , p.300

, Signaling lymphocytic activation molecule, p.13291

, SIR2-like protein, vol.2, pp.8-14

, STAM-binding protein, p.95630

, Stem cell factor (SCF), p.21583

1. Sulfotransferase, , p.50225

, T cell surface glycoprotein CD6 isoform, issue.CD6, pp.8-15

, T-cell surface glycoprotein CD5 (CD5), p.6127

, T-cell surface glycoprotein CD8 alpha chain (CD8A), p.1732

. Tnf-beta, , p.1374

, Legend: TIE2, angiopoietin-1 receptor

, ENTPD2

, TNFSF13B, tumor necrosis factor ligand superfamily member 13B

, PDGFC, platelet-derived growth factor C; SELL, Lselectin

, TWEAK, tumor necrosis factor (Ligand) superfamily, member 12; NOS3, nitric oxide synthase

. Gnly, E. Sele, and . -selectine,

, Proto-oncogene tyrosine-protein kinase Src

, ADGRG1, adhesion G-protein coupled receptor G1; FGF_21_1, fibroblast growth factor 21

G. Gh and . Hormone,

, Biomarker results depict log2-normalized protein expression (NPX) data and an increase of 1 NPX confers therefore a doubling in concentration of the specific biomarker. For every biomarker the mean and standard