Skip to Main content Skip to Navigation
New interface
Journal articles

Design of surface ligands for blood compatible gold nanoparticles: Effect of charge and binding energy

Abstract : Gold nanoparticle (AuNP) interaction with the blood compartment as a function of their charge and the binding energy of their surface ligand was explored. Citrate, polyallylamine and cysteamine stabilized AuNP along with dihydrolipoic acid and polyethylene glycol capped AuNP were synthesized and fully characterized. Their interactions with model proteins (human albumin and human fibrinogen) were studied. Complexes formed between AuNP and protein revealed several behaviors ranging from corona formation to aggregation. Protein fluorescence quenching as a function of temperature and AuNP concentration allowed the determination of the thermodynamic parameters describing these interactions. The hemolysis induced by AuNP was also probed: an increasing or a decreasing of hemolysis ratio induced by AuNP was observed as of function of protein corona formation. Taken together, our results drew up a composite sketch of an ideal surface ligand for blood compatible AuNP. This capping agent should be strongly bound to the gold core by one or more thiol groups and it must confer a negative charge to the particles.
Document type :
Journal articles
Complete list of metadata

https://hal.univ-lorraine.fr/hal-02922664
Contributor : Accord Elsevier CCSD Connect in order to contact the contributor
Submitted on : Monday, August 22, 2022 - 10:11:24 AM
Last modification on : Tuesday, September 27, 2022 - 4:22:28 AM
Long-term archiving on: : Wednesday, November 23, 2022 - 7:07:38 PM

File

S0378517320302283.pdf
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License

Identifiers

Citation

Jordan Beurton, Philippe Lavalle, Arnaud Pallotta, Thomas Chaigneau, Igor Clarot, et al.. Design of surface ligands for blood compatible gold nanoparticles: Effect of charge and binding energy. International Journal of Pharmaceutics, 2020, 580, pp.119244. ⟨10.1016/j.ijpharm.2020.119244⟩. ⟨hal-02922664⟩

Share

Metrics

Record views

76

Files downloads

8