C. Galaviz-hernandez, Plac8 and Plac9, novel placental-enriched genes identified through microarray analysis, Gene, vol.309, issue.2, pp.81-89, 2003.

K. Rogulski, Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway, Oncogene, vol.24, issue.51, pp.7524-7541, 2005.

S. F. Wu, The downregulation of onzin expression by PKC epsilon-ERK2 signaling and its potential role in AML cell differentiation, Leukemia, vol.24, issue.3, pp.544-551, 2010.

B. P. Kaistha, PLAC8 localizes to the inner plasma membrane of pancreatic cancer cells and regulates cell growth and disease progression through critical cell-cycle regulatory pathways, Cancer Res, vol.76, issue.1, pp.96-107, 2016.

L. Zou, Down-regulated PLAC8 promotes hepatocellular carcinoma cell proliferation by enhancing PI3K/Akt/GSK3?/Wnt/?catenin signaling, Biomed Pharmacother, vol.84, pp.139-146, 2016.

C. L. Lee, Discovery of genes from feces correlated with colorectal cancer progression, Oncology Lett, vol.12, issue.5, pp.3378-3384, 2016.

C. Li, Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer, J Clin Invest, vol.124, issue.5, pp.2172-2187, 2014.

M. Jimenez-preitner, X. Berney, and B. Thorens, Plac8 is required for white adipocyte differentiation in vitro and cell number control in vivo, PLoS One, vol.7, issue.11, p.48767, 2012.

M. Mourtada-maarabouni, D. Watson, M. Munir, F. Farzaneh, and G. T. Williams, Apoptosis suppression by candidate oncogene PLAC8 is reversed in other cell types, Curr Cancer Drug Targets, vol.13, issue.1, pp.80-91, 2013.

B. Cong and S. D. Tanksley, FW2.2 and cell cycle control in developing tomato fruit: a possible example of gene co-option in the evolution of a novel organ, Plant Mol Biol, vol.62, issue.6, pp.867-880, 2006.

Y. Dahan, R. Rosenfeld, V. Zadiranov, and V. Irihimovitch, A proposed conserved role for an avocado FW2.2-like gene as a negative regulator of fruit cell division, Planta, vol.232, issue.3, pp.663-676, 2010.

P. De-franceschi, Cell number regulator genes in Prunus provide candidate genes for the control of fruit size in sweet and sour cherry, Mol Breed, vol.32, issue.2, pp.311-326, 2013.
URL : https://hal.archives-ouvertes.fr/hal-02653132

Z. Li and C. He, Physalis floridana Cell Number Regulator1 encodes a cell membrane-anchored modulator of cell cycle and negatively controls fruit size, J Exp Bot, vol.66, issue.1, pp.257-270, 2015.

J. Tian, Cloning, localization and expression analysis of two fw2.2-like genes in small-and large-fruited pear species, J Integr Agric, vol.15, issue.2, pp.282-294, 2016.

M. Guo, Cell Number Regulator1 affects plant and organ size in maize: implications for crop yield enhancement and heterosis, Plant Cell, vol.22, issue.4, pp.1057-1073, 2010.

J. Xu, Molecular characterization and functional analysis of "fruit-weight 2.2-like" gene family in rice, Planta, vol.238, issue.4, pp.643-655, 2013.

W. Y. Song, A novel family of cys-rich membrane proteins mediates cadmium resistance in Arabidopsis, Plant Physiol, vol.135, issue.2, pp.1027-1039, 2004.

W. Y. Song, Arabidopsis PCR2 is a zinc exporter involved in both zinc extrusion and long-distance zinc transport, Plant Cell, vol.22, issue.7, pp.2237-2252, 2010.

S. Abbà, A PLAC8-containing protein from an endomycorrhizal fungus confers cadmium resistance to yeast cells by interacting with Mlh3p, Nucleic Acids Res, vol.39, issue.17, pp.7548-7563, 2011.

D. Vietro, L. Daghino, S. Abbà, S. Perotto, and S. , Gene expression and role in cadmium tolerance of two PLAC8-containing proteins identified in the ericoid mycorrhizal fungus Oidiodendron maius, Fungal Biol, vol.118, issue.8, pp.695-703, 2014.

C. Cabreira-cagliari, Revising the PLAC8 gene family: from a central role in differentiation, proliferation, and apoptosis in mammals to a multifunctional role in plants, Genome, vol.61, issue.12, pp.857-865, 2018.

M. Jimenez-preitner, Plac8 is an inducer of C/EBP? required for brown fat differentiation, thermoregulation, and control of body weight, Cell Metab, vol.14, issue.5, pp.658-70, 2011.

L. Min, Expression of placenta-specific 8 in human oocytes, embryos, and models of in vitro implantation, Fertility and Sterility, vol.106, pp.781-789, 2016.

C. Kinsey, Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression, Cell Reports, vol.7, pp.1143-1155, 2014.

Y. Li, K. Rogulski, Q. Zhou, P. J. Sims, and E. V. Prochownik, The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid scramblase, Mol Cell Biol, vol.26, issue.9, pp.3401-3413, 2006.

A. Hartwig, Mechanisms in cadmium-induced carcinogenicity: recent insights, Biometals, vol.23, issue.5, pp.951-960, 2010.

Y. H. Jin, Cadmium is a mutagen that acts by inhibiting mismatch repair, Nat Genet, vol.34, issue.3, pp.326-329, 2003.

C. Giaginis, E. Gatzidou, and S. Theocharis, DNA repair systems as targets of cadmium toxicity, Toxicol Appl Pharmacol, vol.213, issue.3, pp.282-290, 2006.

H. Flores-rozas and R. D. Kolodner, The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations, Proc Natl Acad Sci, vol.95, issue.21, pp.12404-12409, 1998.

H. T. Tran, J. D. Keen, M. Kricker, M. A. Resnick, and D. A. Gordenin, Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants, Mol Cell Biol, vol.17, issue.5, pp.2859-2865, 1997.

C. N. Greene and S. Jinks-robertson, Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteins, Mol Cell Biol, vol.17, issue.5, pp.2844-2850, 1997.

A. Cuypers, Cadmium stress: an oxidative challenge, Biometals, vol.23, issue.5, pp.927-940, 2010.

S. Singh, Aldehyde dehydrogenases in cellular responses to oxidative/electrophilic stress, Free Radic Biol Med, vol.56, pp.89-101, 2013.

O. Kurita and Y. Nishida, Involvement of mitochondrial aldehyde dehydrogenase ALD5 in maintenance of the mitochondrial electron transport chain in Saccharomyces cerevisiae, FEMS Microbiol Lett, vol.181, issue.2, pp.281-287, 1999.

C. M. Marobbio, G. Giannuzzi, E. Paradies, C. L. Pierri, and F. Palmieri, alpha-Isopropylmalate, a leucine biosynthesis intermediate in yeast, is transported by the mitochondrial oxalacetate carrier, J Biol Chem, vol.283, issue.42, pp.28445-28453, 2008.

G. B. Kohlhaw, Leucine biosynthesis in fungi: entering metabolism through the back door, Microbiol Mol Biol Rev, vol.67, issue.1, pp.1-15, 2003.

L. Bar-peled and D. M. Sabatini, Regulation of mTORC1 by amino acids, Trends Cell Biol, vol.24, pp.400-406, 2014.

L. S. Robertson, H. C. Causton, R. A. Young, and G. R. Fink, The yeast A kinases differentially regulate iron uptake and respiratory function, Proc Natl Acad Sci, vol.97, pp.5984-5988, 2000.

D. R. Richardson, Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol, Proc Natl Acad Sci, vol.107, issue.24, pp.10775-10782, 2010.

R. Lill and U. Mühlenhoff, Maturation of iron-sulfur proteins in eukaryotes: mechanisms, connected processes, and diseases, Annu Rev Biochem, vol.77, pp.669-700, 2008.

R. Lill, Function and biogenesis of iron-sulphur proteins, Nature, vol.460, pp.831-838, 2009.

O. Stehling and R. Lill, The role of mitochondria in cellular iron-sulfur protein biogenesis: mechanisms, connected processes, and diseases, Cold Spring Harb Perspect Biol, vol.5, issue.8, p.11312, 2013.

N. Maio and T. A. Rouault, Iron-sulfur cluster biogenesis in mammalian cells: new insights into the molecular mechanisms of cluster delivery, Biochim Biophys Acta, vol.1853, issue.6, pp.1493-1512, 2015.

J. Gerber, K. Neumann, C. Prohl, U. Mühlenhoff, and R. Lill, The yeast scaffold proteins Isu1p and Isu2p are required inside mitochondria for maturation of cytosolic Fe/S proteins, Mol Cell Biol, vol.24, issue.11, pp.4848-4857, 2004.

Y. Zhang, Dre2, a conserved eukaryotic Fe/S cluster protein, functions in cytosolic Fe/S protein biogenesis, Mol Cell Biol, vol.28, issue.18, pp.5569-5582, 2008.

T. Bedekovics, H. Li, G. B. Gajdos, and G. Isaya, Leucine biosynthesis regulates cytoplasmic iron-sulfur enzyme biogenesis in an Atm1p-independent manner, J Biol Chem, vol.286, issue.47, pp.40878-40888, 2011.

J. Ihrig, Iron regulation through the back door: iron-dependent metabolite levels contribute to transcriptional adaptation to iron deprivation in Saccharomyces cerevisiae, Eukaryot Cell, vol.9, pp.460-471, 2010.

G. Kispal, P. Csere, B. Guiard, and R. Lill, The ABC transporter Atm1p is required for mitochondrial iron homeostasis, FEBS Lett, vol.418, pp.346-350, 1997.

T. A. Rouault, The role of iron regulatory proteins in mammalian iron homeostasis and disease, Nat Chem Biol, vol.2, pp.406-414, 2006.

C. C. Philpott, S. Leidgens, and A. G. Frey, Metabolic remodeling in iron-deficient fungi, Biochim Biophys Acta, vol.1823, issue.9, pp.1509-1520, 2012.

R. Ruotolo, G. Marchini, and S. Ottonello, Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast, Genome Biol, vol.9, issue.4, p.67, 2008.

M. Thorsen, Genetic basis of arsenite and cadmium tolerance in Saccharomyces cerevisiae, BMC Genomics, vol.10, p.105, 2009.

E. Lesuisse and P. Labbe, Effects of cadmium and of YAP1 and CAD1/YAP2 genes on iron metabolism in the yeast Saccharomyces cerevisiae, Microbiology, vol.141, pp.2937-2943, 1995.

Y. Momose and H. Iwahashi, Bioassay of cadmium using a DNA microarray: genome-wide expression patterns of Saccharomyces cerevisiae response to cadmium, Environ Toxicol Chem, vol.20, issue.10, pp.2353-2360, 2001.

R. Ueta, N. Fujiwara, K. Iwai, and Y. Yamaguchi-iwai, Iron-induced dissociation of the Aft1p transcriptional regulator from target gene promoters is an initial event in iron-dependent gene suppression, Mol Cell Biol, vol.32, pp.4998-5008, 2012.

O. S. Chen, Transcription of the yeast iron regulon does not respond directly to iron but rather to iron-sulfur cluster biosynthesis, J Biol Chem, vol.279, pp.29513-29518, 2004.

M. F. White and M. S. Dillingham, Iron-sulphur clusters in nucleic acid processing enzymes, Curr Opin Struct Biol, vol.22, pp.94-100, 2012.

S. Puig, L. Ramos-alonso, A. M. Romero, and M. T. Mart?nez-pastor, The elemental role of iron in DNA synthesis and repair, Metallomics, vol.9, pp.1483-1500, 2017.

A. R. Arnold, M. A. Grodick, and J. K. Barton, DNA Charge Transport: from chemical principles to the cell, Cell Chem Biol, vol.23, issue.1, pp.183-197, 2016.

C. Zhang, Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control, Protein Cell, vol.5, issue.10, pp.750-760, 2014.

V. D. Paul and R. Lill, Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability, Biochim Biophys Acta, vol.1853, pp.1528-1539, 2015.

L. Guo, Global fitness profiling identifies arsenic and cadmium tolerance mechanisms in fission yeast, G3, vol.6, issue.10, pp.3317-3333, 2016.

Z. Zhou and S. J. Elledge, DUN1 encodes a protein kinase that controls the DNA damage response in yeast, Cell, vol.75, issue.6, pp.1119-1127, 1993.

N. Sanvisens, Yeast Dun1 kinase regulates ribonucleotide reductase small subunit localization in response to iron deficiency, J Biol Chem, vol.291, issue.18, pp.9807-9817, 2014.

J. Pijuan, C. María, E. Herrero, and G. Bellí, Impaired mitochondrial Fe-S cluster biogenesis activates the DNA damage response through different signaling mediators, J Cell Sci, vol.128, issue.24, pp.4653-4665, 2015.

F. J. Wang, Different responses of low grain-Cd-accumulating and high grain-Cd-accumulating rice cultivars to Cd stress, Plant Physiol Bioch, vol.96, pp.261-269, 2015.

M. Fontecave and S. Ollagnier-de-choudens, Iron-sulfur cluster biosynthesis in bacteria: Mechanisms of cluster assembly and transfer, Arch Biochem Biophys, vol.474, pp.226-237, 2008.

G. Kispal, H. Steiner, D. A. Court, B. Rolinski, and R. Lill, Mitochondrial and cytosolic branched-chain amino acid transaminases from yeast, homologs of the myc oncogene-regulated Eca39 protein, J Biol Chem, vol.271, issue.40, pp.24458-24464, 1996.

A. Eden, G. Simchen, and N. Benvenisty, Two yeast homologs of ECA39, a target for c-Myc regulation, code for cytosolic and mitochondrial branched-chain amino acid aminotransferases, J Biol Chem, vol.271, pp.20242-20245, 1996.

M. Eilers and R. N. Eisenman, Myc's broad reach, Genes Dev, vol.22, issue.20, pp.2755-2766, 2008.

M. Conacci-sorrell, L. Mcferrin, and R. N. Eisenman, An overview of MYC and its interactome. Cold Spring Harb Perspect Med, vol.4, p.14357, 2014.

O. Schuldiner, ECA39, a conserved gene regulated by c-Myc in mice, is involved in G1/S cell cycle regulation in yeast, Proc Natl Acad Sci, vol.93, issue.14, pp.7143-7148, 1996.

R. D. Gietz and R. A. Woods, Yeast transformation by the LiAc/SS carrier DNA/PEG method, Methods Mol Biol, vol.313, pp.107-120, 2006.

J. Sambrook and D. W. Russell, Analyzing yeast colonies by PCR, CSH Protoc, vol.1, 2006.

A. Dereeper, fr: robust phylogenetic analysis for the non-specialist, Nucleic Acids Res, vol.36, p.6629, 2008.
URL : https://hal.archives-ouvertes.fr/lirmm-00324099

M. N. Offman, Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity, Blood, vol.117, pp.1614-1621, 2001.

Ø. Hammer, D. A. Harper, and P. D. Ryan, PAST: Paleontological statistics software package for education and data analysis, Palaeontologia Electronica, vol.4, issue.1, p.9, 2001.

J. A. Heck, D. Gresham, D. Botstein, and E. Alani, Accumulation of recessive lethal mutations in Saccharomyces cerevisiae mlh1 mismatch repair mutants is not associated with gross chromosomal rearrangements, Genetics, vol.174, issue.1, pp.519-523, 2006.

W. J. Dixon and F. J. Massey, Introduction to Statistical Analysis, 1969.

H. Li and R. Durbin, Fast and accurate long-read alignment with Burrows-Wheeler transform, Bioinformatics, vol.26, issue.5, pp.589-595, 2010.

H. Li, Genome project data processing subgroup. The Sequence Alignment/Map format and SAMtools, Bioinformatics, vol.25, issue.16, pp.2078-2079, 1000.

S. Anders and W. Huber, Differential expression analysis for sequence count data, Genome Biol, vol.11, p.106, 2010.

B. T. Sherman, Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis, BMC Bioinformatics, vol.8, issue.1, p.426, 2007.

J. M. Cherry, Saccharomyces Genome Database: the genomics resource of budding yeast, Nucleic Acids Res, vol.40, pp.700-705, 2012.