Lack of desensitization of the cough reflex in ovalbumin-sensitized rabbits during exercise - Université de Lorraine Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2017

Lack of desensitization of the cough reflex in ovalbumin-sensitized rabbits during exercise

Résumé

Introduction Cough is a major symptom of asthma frequently experienced during exercise but little is known about interactions between cough and exercise. The goal of our study was to clarify the potential modulation of the cough reflex (CR) by exercise in a spontaneously breathing anaesthetized animal model of airway eosinophilic inflammation. Materials & methods Ten ovalbumin (OVA) sensitized adult rabbits and 8 controls were studied. The ventilatory response to direct tracheal stimulation, performed both at rest and during exercise was determined to quantify the incidence and the sensitivity of the CR. Broncho-alveolar lavages (BAL) and cell counts were performed to assess the level of the airway inflammation following OVA-induced sensitization. Exercise was mimicked by Electrically induced hindlimb Muscular Contractions (EMC). Results Among 494 tracheal stimulations, 261 were performed at rest and 233 at exercise. OVA challenges in sensitized rabbits caused a significant increase in the percentage of eosinophils (p = 0.008) in BAL. EMC increased minute ventilation by 36% and 35% in OVA and control rabbits respectively, compared to rest values. The sensitivity of the CR decreased during exercise compared to baseline in control rabbits (p = 0.0313) while it remained unchanged in OVA rabbits. Conclusion The desensitization of the CR during exercise in control rabbits was abolished in OVA rabbits. The precise role of airway inflammation in this lack of CR desensitization needs to be further investigated but it might contribute to the exercise-induced cough in asthmatics.
Fichier principal
Vignette du fichier
Toitiu A. et al., 2017.pdf (1.27 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02982405 , version 1 (29-10-2020)

Identifiants

Citer

Angelica Tiotiu, Bruno Chenuel, Laurent Foucaud, Bruno Demoulin, Silvia Demoulin-Alexikova, et al.. Lack of desensitization of the cough reflex in ovalbumin-sensitized rabbits during exercise. PLoS ONE, 2017, 12 (2), pp.e0171862. ⟨10.1371/journal.pone.0171862⟩. ⟨hal-02982405⟩
47 Consultations
64 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More