Plasticity of the human IgM repertoire in response to long-term spaceflight - Université de Lorraine Access content directly
Journal Articles FASEB Journal Year : 2020

Plasticity of the human IgM repertoire in response to long-term spaceflight

Abstract

Immune dysregulation is among the main adverse outcomes of spaceflight. Despite the crucial role of the antibody repertoire in host protection, the effects of spaceflight on the human antibody repertoire are unknown. Consequently, using high‐throughput sequencing, we examined the IgM repertoire of five cosmonauts 25 days before launch, after 64 ± 11 and 129 ± 20 days spent on the International Space Station (ISS), and at 1, 7, and 30 days after landing. This is the first study of this kind in humans. Our data revealed that the IgM repertoire of the cosmonauts was different from that of control subjects (n = 4) prior to launch and that two out the five analyzed cosmonauts presented significant changes in their IgM repertoire during the mission. These modifications persisted up to 30 days after landing, likely affected the specificities of IgM binding sites, correlated with changes in the V(D)J recombination process responsible for creating antibody genes, and coincided with a higher stress response. These data confirm that the immune system of approximately half of the astronauts who spent 6 months on the ISS is sensitive to spaceflight conditions, and reveal individual responses indicating that personalized approaches should be implemented during future deep‐space exploration missions that will be of unprecedented durations

Domains

Immunology
Fichier principal
Vignette du fichier
202001403RR_Merged_PDF.pdf (580.22 Ko) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-03156297 , version 1 (02-03-2021)

Identifiers

Cite

Judith-Irina Buchheim, Stéphanie Ghislin, Nassima Ouzren, Eliane Albuisson, Anne Vanet, et al.. Plasticity of the human IgM repertoire in response to long-term spaceflight: Running title: Diversity of cosmonaut IgM repertoire. FASEB Journal, 2020, 34 (12), pp.16144-16162. ⟨10.1096/fj.202001403RR⟩. ⟨hal-03156297⟩
165 View
295 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More