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Exclusion of Intra-Atrial Thrombus Diagnosis Using D-Dimer Assay Before Catheter Ablation of Atrial Fibrillation

Antoine Milhem 1 Pierre Ingrand 2 Frédéric Tréguer 3 Olivier Cesari 4 Antoine da Costa 5 Dominique Pavin 6 Philippe Rivat 7 Nicolas Badenco 8 Sélim Abbey 9 Noura Zannad 10 Pierre François Winum 11 Jacques Mansourati Philippe Maury 12 Hugues Bader 13 Arnaud Savouré 14 Frédéric Sacher 15 Marius Andronache 16 Caroline Allix-Béguec 1 Christian de Chillou 17, 16 Frédéric Anselme 14 Alain Al Arnaout Walid Amara Mathieu Amelot Clément Bars Lucile Becoulet Paul Bru Philippe Chevalier Jean-Philippe Darmon Jean-Claude Deharo Antoine Dompnier Cécile Duplantier-Duchene Fabrice Extramiana Jean-Paul Faugier Charles Guenancia Jérôme Horvilleur François Jourda Gabriel Laurent Nicolas Lellouche Isabelle Magnin Poull Olivier Piot Antoine Roux Yannick Saludas Julien Seitz Jérôme Taieb 
Abstract : Objectives: This study hypothesized that the association of D-dimer blood level and several clinical items in a new risk score could predict the absence of atrial thrombus. Background: Symptomatic and drug resistant atrial fibrillation (AF) can be treated by catheter ablation. The procedure-related risk of thromboembolism is limited by the pre-operative use of transesophageal echocardiography (TEE) to detect atrial thrombi. Methods: Patients admitted for catheter ablation of AF (n = 2,494) were prospectively included in a multicenter study. TEE was systematically performed before the procedure to search for atrial thrombus (primary endpoint). D-dimer level, CHADS2 score, left ventricular ejection fraction, pre-operative anticoagulation regimen, and medical history were collected. A logistic regression model was used to identify factors associated with the presence of atrial thrombus (hypertension, history of stroke, heart failure, D-dimer level >270 ng/ml). These factors were aggregated in a new score called atrial thrombus exclusion (ATE). Results: The incidence of atrial thrombus was 1.92%. CHADS2 score and D-dimer level were significantly associated with atrial thrombus (p < 0.0001 and p < 0.0001, respectively). A zero CHADS2 score failed to exclude all atrial thrombi (5 false negatives; sensitivity: 89.58%, specificity: 52.2%). No false negative was found with a zero ATE score, which had a specificity of 37% and a higher sensitivity (100%) than the CHADS2 score (p < 0.031) to predict the absence of intra-atrial thrombi on TEE. Conversely, the positive predictive value was poor, and the ATE score should not be used to conclude a positive diagnosis of thrombus. Conclusions: An ATE score of zero was strongly associated with the absence of atrial thrombus. This new score could be useful to rule out a diagnosis of atrial thrombus before catheter ablation of AF.
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Submitted on : Monday, April 26, 2021 - 7:18:23 PM
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Antoine Milhem, Pierre Ingrand, Frédéric Tréguer, Olivier Cesari, Antoine da Costa, et al.. Exclusion of Intra-Atrial Thrombus Diagnosis Using D-Dimer Assay Before Catheter Ablation of Atrial Fibrillation. JACC: Clinical Electrophysiology, Elsevier, 2019, 5 (2), pp.223-230. ⟨10.1016/j.jacep.2018.09.009⟩. ⟨hal-03208817⟩



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