Recent progress in the toxicity of nitric oxide-releasing nanomaterials - Université de Lorraine Access content directly
Journal Articles Materials Advances Year : 2021

Recent progress in the toxicity of nitric oxide-releasing nanomaterials


Nitric oxide (NO) is a signaling molecule controlling important biological processes. Depending on its concentration, location and cellular environment, NO can have protective or toxic effects. As NO is a free radical, several classes of NO donors/generators have been prepared and combined with nanomaterials, in particular with polymeric nanoparticles. Engineered nanoparticles are attractive nanocarriers extensively used in biomedical applications, in particular in cancer biology due to their ability to promote a site-target therapeutic effect, with minimum side effects to health tissues. NO-releasing nanoparticles can have direct toxic effects to tumor cells, or it can promote cancer cells sensitization to traditional cancer treatments. The combination of NO-releasing nanoparticles with conventional anticancer therapies is a promising approach in the reversion of multidrug resistance (MDR) cells. This review presents and discusses the recent progress in the cytotoxicity (tumoral and non-tumoral cell lines) of NO-releasing polymeric and/or polymer-coated nanomaterials and the in vivo biocompatibility of NO-releasing nanoparticles. Moreover, the ability of these nanoparticles to combat MDR, their mechanisms of toxicity and drawbacks are also discussed.
Fichier principal
Vignette du fichier
d1ma00532d.pdf (804.89 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03369765 , version 1 (07-10-2021)





Joana Claudio Pieretti, Milena T Pelegrino, Ariane Boudier, Amedea Barozzi Seabra. Recent progress in the toxicity of nitric oxide-releasing nanomaterials. Materials Advances, 2021, ⟨10.1039/D1MA00532D⟩. ⟨hal-03369765⟩
29 View
48 Download



Gmail Facebook X LinkedIn More