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Au Nanoparticle-Based Amplified DNA Detection on Poly-l-lysine Monolayer-Functionalized Electrodes

Abstract : Affinity sensing of nucleic acids is among the most investigated areas in biosensing due to the growing importance of DNA diagnostics in healthcare research and clinical applications. Here, we report a simple electrochemical DNA detection layer, based on poly-l-lysine (PLL), in combination with gold nanoparticles (AuNPs) as a signal amplifier. The layer shows excellent reduction of non-specific binding and thereby high contrast between amplified and non-amplified signals with functionalized AuNPs; the relative change in current was 10-fold compared to the non-amplified signal. The present work may provide a general method for the detection of tumor markers based on electrochemical DNA sensing.
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https://hal.univ-lorraine.fr/hal-03562538
Contributor : Almudena Marti Connect in order to contact the contributor
Submitted on : Wednesday, February 9, 2022 - 9:27:45 AM
Last modification on : Thursday, February 10, 2022 - 11:54:02 AM

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Almudena Marti, Jurriaan Huskens. Au Nanoparticle-Based Amplified DNA Detection on Poly-l-lysine Monolayer-Functionalized Electrodes. Nanomaterials, MDPI, 2022, 12 (2), pp.242. ⟨10.3390/nano12020242⟩. ⟨hal-03562538⟩

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