Chlordecone (Kepone) (CLD) is a highly persistent pesticide formerly used in the French West Indies. High levels of this pesticide may be found in soils and constitute a subsequent source of contamination for outdoor-reared animals due to involuntary ingestion of consistent amounts of soil. In that context, carbonaceous materials may be used to amend soil to efficiently decrease the bioavailability of such organic pollutants. The present study aims to assess the efficiency of diverse amendments of a contaminated Guadeloupe nitisol using two physiologically-based approaches. A set of 5 carbonaceous materials (ORBO, DARCO, Coco CO2, Oak P1.5, Sargasso biochar) was tested and used to amend Nitisol at 2% (mass basis). Bioaccessibility assessment was performed using the Ti-PBET assay (n=4). The relative bioavailability part involved 24 piglets randomly distributed into 6 experimental groups (n=4). All groups were exposed during 10 days to a contaminated soil, amended or not with carbon-based matrices. A significant decrease of relative bioaccessibility and CLD concentrations in liver were observed for all amended groups in comparison to the control group, with the exception of the biochar amended soil in the bioaccessibility assay (p<0.05). Extent of this reduction varied from 22% to more than 82% depending on the carbonaceous matrix. This decrease was particularly important for the ORBO TM activated carbon for which bioaccessibility and relative bioavailability were found lower than 10% for both methodologies.