Treat to target versus standard of care for patients with Crohn's disease treated with ustekinumab (STARDUST): an open-label, multicentre, randomised phase 3b trial - Université de Lorraine Access content directly
Journal Articles The Lancet Gastroenterology & Hepatology Year : 2022

Treat to target versus standard of care for patients with Crohn's disease treated with ustekinumab (STARDUST): an open-label, multicentre, randomised phase 3b trial

Silvio Danese (1, 2) , Severine Vermeire (3) , Geert d'Haens (4) , Julian Panés (5, 6, 7) , Axel Dignass (8) , Fernando Magro (9) , Maciej Nazar , Manuela Le Bars (10) , Marjolein Lahaye , Lioudmila Ni , Ivana Bravata , Frederic Lavie (10) , Marco Daperno (11) , Milan Lukáš , Alessandro Armuzzi (12, 13) , Mark Löwenberg (4) , Daniel Gaya (14) , Laurent Peyrin‐biroulet (15, 16) , Rodolfo Rocca , Susana Lopes , Flavio Caprioli , Sandro Ardizzone , Ana Echarri Piudo , Paolo Gionchetti , Xavier Roblin , Ursula Seidler , David Andersson , Kamal Patel , Pierre Desreumaux , Simone Saibeni , Gustav From , Miroslav Fedurco , Milos Gregus , Yoram Bouhnik , Andreas Luegering , Rocco Cosintino , Ivan Bunganic , Jaime Ramos , Mariam Aguas Peris , Olivier Dewit , Mariabeatrice Principi , Emma Wesley , Paula Lago , Stephane Nancey , María Dolores Martín Arranz , Pieter Hindryckx , Ambrogio Orlando , Andrea Geccherle , Maria Laura Annunziata , Bu'Hussain Hayee , Jozef Balaz , Francisco Portela , Cyrielle Gilletta , Torsten Kucharzik , Miguel Mínguez , Javier Pérez Gisbert , Ana Gutiérrez Casbas , Edouard Louis , Marco Marino , Gareth Parkes , Fraser Cummings , Bindia Jharap , Jens Kjeldsen , Luís Correia , Paula Ministro , Matthias Ebert , Erik Hertervig , Dirk Staessen , Joris Dutré , Arnaud Colard , Graham Morrison , Henning Glerup , Jens Frederik Dahlerup , Frank Wolfhagen , Marian Batovsky , Martin Molnar , Barbora Kadleckova , Paulo Caldeira , David Laharie , Xavier Hebuterne , Bruno Bonaz , Matthieu Allez , Andreas Fischer , Joaquín Ernesto Hinojosa del Val , Miriam Mañosa Ciria , Jose Manuel Herrera Justiniano , Charlotte Soderman , Rajiv Chandy , Craig Mowat , Peter Irving , Jan Fallingborg , Jan Matous , Tomas Douda , Romain Altwegg , Jose Manuel Benitez , María Teresa Arroyo Villarino , Jordi Guardiola Capón , Daniel Ginard Vicenc , Pieter Dewint , Sven Almer , Sebastien Kindt
Maciej Nazar
  • Function : Author
Marjolein Lahaye
  • Function : Author
Lioudmila Ni
  • Function : Author
Ivana Bravata
  • Function : Author
Milan Lukáš
  • Function : Author
Rodolfo Rocca
  • Function : Author
Susana Lopes
  • Function : Author
Flavio Caprioli
  • Function : Author
Sandro Ardizzone
  • Function : Author
Ana Echarri Piudo
  • Function : Author
Paolo Gionchetti
  • Function : Author
Xavier Roblin
  • Function : Author
Ursula Seidler
  • Function : Author
David Andersson
  • Function : Author
Kamal Patel
  • Function : Author
Pierre Desreumaux
  • Function : Author
Simone Saibeni
  • Function : Author
Gustav From
  • Function : Author
Miroslav Fedurco
  • Function : Author
Milos Gregus
  • Function : Author
Yoram Bouhnik
Andreas Luegering
  • Function : Author
Rocco Cosintino
  • Function : Author
Ivan Bunganic
  • Function : Author
Jaime Ramos
  • Function : Author
Mariam Aguas Peris
  • Function : Author
Olivier Dewit
  • Function : Author
Mariabeatrice Principi
  • Function : Author
Emma Wesley
  • Function : Author
Paula Lago
  • Function : Author
Stephane Nancey
María Dolores Martín Arranz
  • Function : Author
Pieter Hindryckx
  • Function : Author
Ambrogio Orlando
  • Function : Author
Andrea Geccherle
  • Function : Author
Maria Laura Annunziata
  • Function : Author
Bu'Hussain Hayee
  • Function : Author
Jozef Balaz
  • Function : Author
Francisco Portela
  • Function : Author
Cyrielle Gilletta
  • Function : Author
Torsten Kucharzik
  • Function : Author
Miguel Mínguez
  • Function : Author
Javier Pérez Gisbert
  • Function : Author
Ana Gutiérrez Casbas
  • Function : Author
Edouard Louis
  • Function : Author
Marco Marino
  • Function : Author
Gareth Parkes
  • Function : Author
Fraser Cummings
  • Function : Author
Bindia Jharap
  • Function : Author
Jens Kjeldsen
  • Function : Author
Luís Correia
  • Function : Author
Paula Ministro
  • Function : Author
Matthias Ebert
  • Function : Author
Erik Hertervig
  • Function : Author
Dirk Staessen
  • Function : Author
Joris Dutré
  • Function : Author
Arnaud Colard
  • Function : Author
Graham Morrison
  • Function : Author
Henning Glerup
  • Function : Author
Jens Frederik Dahlerup
  • Function : Author
Frank Wolfhagen
  • Function : Author
Marian Batovsky
  • Function : Author
Martin Molnar
  • Function : Author
Barbora Kadleckova
  • Function : Author
Paulo Caldeira
  • Function : Author
David Laharie
  • Function : Author
Xavier Hebuterne
  • Function : Author
Bruno Bonaz
Matthieu Allez
  • Function : Author
Andreas Fischer
  • Function : Author
Miriam Mañosa Ciria
  • Function : Author
Jose Manuel Herrera Justiniano
  • Function : Author
Charlotte Soderman
  • Function : Author
Rajiv Chandy
  • Function : Author
Craig Mowat
  • Function : Author
Peter Irving
  • Function : Author
Jan Fallingborg
  • Function : Author
Jan Matous
  • Function : Author
Tomas Douda
  • Function : Author
Romain Altwegg
  • Function : Author
Jose Manuel Benitez
  • Function : Author
María Teresa Arroyo Villarino
  • Function : Author
Jordi Guardiola Capón
  • Function : Author
Daniel Ginard Vicenc
  • Function : Author
Pieter Dewint
  • Function : Author
Sven Almer
  • Function : Author
Sebastien Kindt
  • Function : Author

Abstract

A treat-to-target strategy, in which strictly defined treatment targets facilitate decision making in clinical practice, is advocated as an optimised management approach for some chronic disorders. The aim of the STARDUST trial was to assess whether a treat-to-target strategy with early endoscopy, regular biomarker and clinical symptom monitoring, and dose intensification for persistent inflammatory activity, was more successful in achieving endoscopic improvement at week 48 than a clinically driven maintenance strategy in patients with moderate-to-severe active Crohn's disease receiving ustekinumab.
Janssen-Cilag.

Dates and versions

hal-04165822 , version 1 (19-07-2023)

Identifiers

Cite

Silvio Danese, Severine Vermeire, Geert d'Haens, Julian Panés, Axel Dignass, et al.. Treat to target versus standard of care for patients with Crohn's disease treated with ustekinumab (STARDUST): an open-label, multicentre, randomised phase 3b trial. The Lancet Gastroenterology & Hepatology, 2022, 7 (4), pp.294-306. ⟨10.1016/S2468-1253(21)00474-X⟩. ⟨hal-04165822⟩
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