<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05407445</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-02T00:59:01+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Aprocitentan in Patients With Chronic Kidney Disease and Resistant Hypertension</title>
            <author role="aut">
              <persName>
                <forename type="first">Patrick</forename>
                <surname>Rossignol</surname>
              </persName>
              <email type="md5">001e75f035bdb9c79af439a0f1a9b4dd</email>
              <email type="domain">chu-nancy.fr</email>
              <idno type="idhal" notation="numeric">755843</idno>
              <idno type="halauthorid" notation="string">118750-755843</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8009-3873</idno>
              <idno type="IDREF">https://www.idref.fr/091581443</idno>
              <affiliation ref="#struct-223006"/>
              <affiliation ref="#struct-2621"/>
              <affiliation ref="#struct-443031"/>
              <affiliation ref="#struct-506806"/>
              <affiliation ref="#struct-354907"/>
              <affiliation ref="#struct-1171133"/>
              <affiliation ref="#struct-1222622"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Martine</forename>
                <surname>Clozel</surname>
              </persName>
              <idno type="halauthorid">3935214-0</idno>
              <affiliation ref="#struct-1068111"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Roland</forename>
                <forename type="middle">F</forename>
                <surname>Dreier</surname>
              </persName>
              <idno type="halauthorid">3935215-0</idno>
              <affiliation ref="#struct-1068111"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">John</forename>
                <forename type="middle">M</forename>
                <surname>Flack</surname>
              </persName>
              <idno type="idhal" notation="numeric">1621436</idno>
              <idno type="halauthorid" notation="string">3935216-1621436</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2584-5598</idno>
              <affiliation ref="#struct-1075119"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bruno</forename>
                <surname>Flamion</surname>
              </persName>
              <idno type="idhal" notation="numeric">763010</idno>
              <idno type="halauthorid" notation="string">483778-763010</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4458-7627</idno>
              <affiliation ref="#struct-1693777"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Johannes</forename>
                <surname>Mann</surname>
              </persName>
              <idno type="halauthorid">1553660-0</idno>
              <affiliation ref="#struct-311714"/>
              <affiliation ref="#struct-1693778"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Krzysztof</forename>
                <surname>Narkiewicz</surname>
              </persName>
              <idno type="halauthorid">1527684-0</idno>
              <affiliation ref="#struct-433868"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mouna</forename>
                <surname>Sassi-Sayadi</surname>
              </persName>
              <idno type="halauthorid">2658125-0</idno>
              <affiliation ref="#struct-1693777"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ji-Guang</forename>
                <surname>Wang</surname>
              </persName>
              <idno type="idhal" notation="numeric">1306308</idno>
              <idno type="halauthorid" notation="string">1829040-1306308</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8511-1524</idno>
              <affiliation ref="#struct-1693779"/>
              <affiliation ref="#struct-345809"/>
              <affiliation ref="#struct-305768"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michael</forename>
                <surname>Weber</surname>
              </persName>
              <idno type="idhal" notation="numeric">801290</idno>
              <idno type="halauthorid" notation="string">2533-801290</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8504-0831</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4950-5432</idno>
              <affiliation ref="#struct-361557"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Markus</forename>
                <surname>Schlaich</surname>
              </persName>
              <email type="md5">1845d8f5d45a2b19df8e05a93df849bb</email>
              <email type="domain">uwa.edu.au</email>
              <idno type="idhal" notation="numeric">827519</idno>
              <idno type="halauthorid" notation="string">2509908-827519</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1765-0195</idno>
              <affiliation ref="#struct-4177"/>
              <affiliation ref="#struct-321448"/>
              <affiliation ref="#struct-1693780"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Erwan</forename>
                <surname>BOZEC</surname>
              </persName>
              <email type="md5">7db5a1038b57520fc0c87b8723f54e89</email>
              <email type="domain">chru-nancy.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-12-09 16:20:48</date>
              <date type="whenModified">2026-03-12 09:40:01</date>
              <date type="whenReleased">2025-12-09 17:09:21</date>
              <date type="whenProduced">2025-12-09</date>
              <date type="whenEndEmbargoed">2025-12-09</date>
              <ref type="file" target="https://hal.univ-lorraine.fr/hal-05407445v1/document">
                <date notBefore="2025-12-09"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.univ-lorraine.fr/hal-05407445v1/file/rossignol-et-al-2025-aprocitentan-in-patients-with-chronic-kidney-disease-and-resistant-hypertension.pdf" id="file-5407445-4628166">
                <date notBefore="2025-12-09"/>
              </ref>
              <ref type="annex" n="0" target="https://hal.univ-lorraine.fr/hal-05407445v1/file/hyp-2025-25563-s01-1.pdf" id="file-5407445-4628167">
                <date notBefore="2025-12-09"/>
              </ref>
              <ref type="annex" n="0" target="https://hal.univ-lorraine.fr/hal-05407445v1/file/hyp-2025-25563-s03.pdf" id="file-5407445-4628168">
                <date notBefore="2025-12-09"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="885244">
                <persName>
                  <forename>Erwan</forename>
                  <surname>BOZEC</surname>
                </persName>
                <email type="md5">7db5a1038b57520fc0c87b8723f54e89</email>
                <email type="domain">chru-nancy.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05407445</idno>
            <idno type="halUri">https://hal.univ-lorraine.fr/hal-05407445</idno>
            <idno type="halBibtex">rossignol:hal-05407445</idno>
            <idno type="halRefHtml">&lt;i&gt;Hypertension&lt;/i&gt;, 2025, &lt;a target="_blank" href="https://dx.doi.org/10.1161/HYPERTENSIONAHA.125.25563"&gt;&amp;#x27E8;10.1161/HYPERTENSIONAHA.125.25563&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Hypertension, 2025, &amp;#x27E8;10.1161/HYPERTENSIONAHA.125.25563&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by-nc-sa/4.0/">CC BY-NC-SA 4.0 - Attribution - Non-commercial use - ShareAlike<ref corresp="#file-5407445-4628166"/><ref corresp="#file-5407445-4628167"/><ref corresp="#file-5407445-4628168"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-LORRAINE">Université de Lorraine</idno>
            <idno type="stamp" n="DCAC-UL">DCAC - Défaillance Cardiovasculaire Aiguë et Chronique</idno>
            <idno type="stamp" n="BMS-UL">Pôle scientifique Biologie, Médecine, Santé de l'Université de Lorraine</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Aprocitentan in Patients With Chronic Kidney Disease and Resistant Hypertension</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Patrick</forename>
                    <surname>Rossignol</surname>
                  </persName>
                  <email type="md5">001e75f035bdb9c79af439a0f1a9b4dd</email>
                  <email type="domain">chu-nancy.fr</email>
                  <idno type="idhal" notation="numeric">755843</idno>
                  <idno type="halauthorid" notation="string">118750-755843</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8009-3873</idno>
                  <idno type="IDREF">https://www.idref.fr/091581443</idno>
                  <affiliation ref="#struct-223006"/>
                  <affiliation ref="#struct-2621"/>
                  <affiliation ref="#struct-443031"/>
                  <affiliation ref="#struct-506806"/>
                  <affiliation ref="#struct-354907"/>
                  <affiliation ref="#struct-1171133"/>
                  <affiliation ref="#struct-1222622"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Martine</forename>
                    <surname>Clozel</surname>
                  </persName>
                  <idno type="halauthorid">3935214-0</idno>
                  <affiliation ref="#struct-1068111"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Roland</forename>
                    <forename type="middle">F</forename>
                    <surname>Dreier</surname>
                  </persName>
                  <idno type="halauthorid">3935215-0</idno>
                  <affiliation ref="#struct-1068111"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">John</forename>
                    <forename type="middle">M</forename>
                    <surname>Flack</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1621436</idno>
                  <idno type="halauthorid" notation="string">3935216-1621436</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2584-5598</idno>
                  <affiliation ref="#struct-1075119"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bruno</forename>
                    <surname>Flamion</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">763010</idno>
                  <idno type="halauthorid" notation="string">483778-763010</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4458-7627</idno>
                  <affiliation ref="#struct-1693777"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Johannes</forename>
                    <surname>Mann</surname>
                  </persName>
                  <idno type="halauthorid">1553660-0</idno>
                  <affiliation ref="#struct-311714"/>
                  <affiliation ref="#struct-1693778"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Krzysztof</forename>
                    <surname>Narkiewicz</surname>
                  </persName>
                  <idno type="halauthorid">1527684-0</idno>
                  <affiliation ref="#struct-433868"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mouna</forename>
                    <surname>Sassi-Sayadi</surname>
                  </persName>
                  <idno type="halauthorid">2658125-0</idno>
                  <affiliation ref="#struct-1693777"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ji-Guang</forename>
                    <surname>Wang</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1306308</idno>
                  <idno type="halauthorid" notation="string">1829040-1306308</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8511-1524</idno>
                  <affiliation ref="#struct-1693779"/>
                  <affiliation ref="#struct-345809"/>
                  <affiliation ref="#struct-305768"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michael</forename>
                    <surname>Weber</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">801290</idno>
                  <idno type="halauthorid" notation="string">2533-801290</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8504-0831</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4950-5432</idno>
                  <affiliation ref="#struct-361557"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Markus</forename>
                    <surname>Schlaich</surname>
                  </persName>
                  <email type="md5">1845d8f5d45a2b19df8e05a93df849bb</email>
                  <email type="domain">uwa.edu.au</email>
                  <idno type="idhal" notation="numeric">827519</idno>
                  <idno type="halauthorid" notation="string">2509908-827519</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1765-0195</idno>
                  <affiliation ref="#struct-4177"/>
                  <affiliation ref="#struct-321448"/>
                  <affiliation ref="#struct-1693780"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">22103</idno>
                <idno type="issn">0194-911X</idno>
                <idno type="eissn">1524-4563</idno>
                <title level="j">Hypertension</title>
                <imprint>
                  <publisher>American Heart Association</publisher>
                  <date type="datePub">2025-12-09</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1161/HYPERTENSIONAHA.125.25563</idno>
              <idno type="pubmed">41363010</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">antihypertensive agents ◼ blood pressure ◼ calcium channel blockers</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>BACKGROUND: Hypertension is a cause and consequence of chronic kidney disease (CKD). Resistant hypertension is common and often difficult to control in patients with CKD. This post hoc analysis evaluated the efficacy and safety of aprocitentan (with standardized background antihypertensive therapy) in patients with CKD and resistant hypertension, a group with high morbidity and mortality risk and limited treatment options. METHODS: The PRECISION study (Parallel-Group, Phase 3 Study With Aprocitentan in Subjects With Resistant Hypertension) consisted of part 1: 4-week, double-blind (aprocitentan 12.5 and 25 mg versus placebo); part 2: 32-week, single-blind (aprocitentan 25 mg); and part 3: 12-week, double-blind withdrawal (aprocitentan 25 mg versus placebo). In participants with CKD, aprocitentan’s effect on blood pressure (BP), urine albumin-to-creatinine ratio, and safety was evaluated. RESULTS: Of 730 participants in PRECISION, 147 had CKD categorized as KDIGO high risk or very high risk. At week 4, aprocitentan 12.5 mg, aprocitentan 25 mg, and placebo reduced office systolic BP by −13.5, −16.6, and −4.4 mm Hg, respectively; this was maintained with aprocitentan 25 mg to week 36 (−16.4 mm Hg). At week 4, reductions in nighttime ambulatory systolic BP were −9.6, −13.8, and −2.5 mm Hg, respectively. Changes in urine albumin-to-creatinine ratio were −47.1%, −59.6%, and −2.4%, respectively, maintained with aprocitentan 25 mg to week 36 (−61.6%). Aprocitentan was generally well tolerated (no change in potassium or estimated glomerular filtration rate); early peripheral edema was the most common adverse event. CONCLUSIONS: Aprocitentan was well tolerated; efficiently lowered BP, particularly nighttime ambulatory BP; and markedly reduced urine albumin-to-creatinine ratio in participants with CKD and resistant hypertension. Aprocitentan may confer considerable cardiovascular and kidney-protective benefits in these difficult-to-treat patients. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03541174.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-223006" status="VALID">
          <idno type="IdRef">181007126</idno>
          <idno type="RNSR">200919207T</idno>
          <idno type="IdUnivLorraine">[UL]RNL--</idno>
          <idno type="ROR">https://ror.org/05ft9wv42</idno>
          <orgName>Défaillance Cardiovasculaire Aiguë et Chronique</orgName>
          <orgName type="acronym">DCAC</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine - 9 avenue de la Forêt de Haye - BP 184 - 54500 Vandoeuvre les Nancy</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300157" type="direct"/>
            <relation name="U1116" active="#struct-303623" type="direct"/>
            <relation active="#struct-413289" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-2621" status="VALID">
          <orgName>Centre d'investigation clinique plurithématique Pierre Drouin [Nancy]</orgName>
          <orgName type="acronym">CIC-P</orgName>
          <date type="start">1995-01-01</date>
          <desc>
            <address>
              <addrLine>Hôpital Brabois – Bâtiment Louis Mathieu, 54500 Vandoeuvre-Les-Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://cic-p-nancy.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-254924" type="direct"/>
            <relation active="#struct-300157" type="indirect"/>
            <relation name="CIC1433" active="#struct-303623" type="indirect"/>
            <relation active="#struct-413289" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-443031" status="VALID">
          <orgName>Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy]</orgName>
          <orgName type="acronym">INI-CRCT</orgName>
          <desc>
            <address>
              <addrLine>4, rue du Morvan  - 54500 VANDOEUVRE-LES-NANCY-France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inicrct.org/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-303515" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-506806" status="VALID">
          <orgName>French-Clinical Research Infrastructure Network - F-CRIN [Paris]</orgName>
          <orgName type="acronym">Cardiovascular &amp; Renal Clinical Trialists - CRCT</orgName>
          <desc>
            <address>
              <addrLine>Paris.</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-354907" status="VALID">
          <orgName>Centre Hospitalier Princesse Grace</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chpg.mc/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1171133" status="INCOMING">
          <orgName>Monaco Private Hemodialysis Centre</orgName>
          <desc>
            <address>
              <country key="MC"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1222622" status="INCOMING">
          <orgName>M-CRIN (Monaco Clinical Research Infrastructure Network)</orgName>
          <desc>
            <address>
              <country key="MC"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1068111" status="VALID">
          <orgName>Idorsia Pharmaceuticals</orgName>
          <date type="start">2017-01-01</date>
          <desc>
            <address>
              <addrLine>DD Chemistry, Hegenheimermattweg 91, 4123 Allschwil</addrLine>
              <country key="CH"/>
            </address>
            <ref type="url">https://www.idorsia.com/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1075119" status="INCOMING">
          <orgName>Southern Illinois University School of Medicine</orgName>
          <desc>
            <address>
              <addrLine>Springfield, IL, USA</addrLine>
              <country key="US"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1693777" status="INCOMING">
          <orgName>Viatris Innovation GmbH</orgName>
          <desc>
            <address>
              <country key="CH"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-311714" status="VALID">
          <idno type="ROR">https://ror.org/00f7hpc57</idno>
          <orgName>Friedrich-Alexander Universität Erlangen-Nürnberg = University of Erlangen-Nuremberg</orgName>
          <orgName type="acronym">FAU</orgName>
          <desc>
            <address>
              <addrLine>Schlossplatz 4, 91054 Erlangen, Germany</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">http://www.fau.eu/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1693778" status="INCOMING">
          <orgName>KfH Kidney Centre</orgName>
          <desc>
            <address>
              <country key="DE"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-433868" status="VALID">
          <idno type="ROR">https://ror.org/019sbgd69</idno>
          <orgName>Medical University of Gdańsk</orgName>
          <date type="start">1945-10-08</date>
          <desc>
            <address>
              <addrLine>Marii Skłodowskiej-Curie 3a, 80-210 Gdańsk</addrLine>
              <country key="PL"/>
            </address>
            <ref type="url">https://mug.edu.pl/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1693779" status="INCOMING">
          <orgName>The Shanghai Institute of Hypertension</orgName>
          <desc>
            <address>
              <country key="CN"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-345809" status="INCOMING">
          <orgName>Shanghai Rui Jin Hospital</orgName>
          <desc>
            <address>
              <country key="CN"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-305768" status="VALID">
          <orgName>Shanghai Jiao Tong University School of Medicine</orgName>
          <desc>
            <address>
              <addrLine>800 Dongchuan RD. Minhang District, Shanghai</addrLine>
              <country key="CN"/>
            </address>
            <ref type="url">http://english.shsmu.edu.cn/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-361557" status="VALID">
          <idno type="IdRef">026425157</idno>
          <idno type="ROR">https://ror.org/01q1z8k08</idno>
          <orgName>State University of New York</orgName>
          <orgName type="acronym">SUNY</orgName>
          <desc>
            <address>
              <country key="US"/>
            </address>
            <ref type="url">http://www.suny.edu/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-4177" status="VALID">
          <idno type="ROR">https://ror.org/047272k79</idno>
          <orgName>The University of Western Australia</orgName>
          <orgName type="acronym">UWA</orgName>
          <desc>
            <address>
              <addrLine>35 Stirling HighwayPerth WA 6009 Australia</addrLine>
              <country key="AU"/>
            </address>
            <ref type="url">http://www.uwa.edu.au/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-321448" status="VALID">
          <orgName>Royal Perth Hospital</orgName>
          <desc>
            <address>
              <country key="AU"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1693780" status="INCOMING">
          <orgName>Royal Perth Hospital Research Foundation</orgName>
          <desc>
            <address>
              <country key="AU"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300157" status="VALID">
          <orgName>Centre Hospitalier Régional Universitaire de Nancy</orgName>
          <orgName type="acronym">CHRU Nancy</orgName>
          <desc>
            <address>
              <addrLine>Siège social : 29 avenue du Maréchal de Lattre de Tassigny, CO 60034, 54035 NANCY CEDEXHôpital Central : 29 Avenue du Maréchal de Lattre de Tassigny, 54035 NancyHôpitaux de Brabois / Enfants : Rue du Morvan, 54500 Vandœuvre-lès-NancyMaternité régionale :10 Avenue Dr Heydenreich, 54000 Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-nancy.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-413289" status="VALID">
          <idno type="IdRef">157040569</idno>
          <idno type="IdUnivLorraine">[UL]100--</idno>
          <idno type="ROR">https://ror.org/04vfs2w97</idno>
          <orgName>Université de Lorraine</orgName>
          <orgName type="acronym">UL</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lorraine.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-254924" status="VALID">
          <orgName>Centre d'investigation clinique [Nancy]</orgName>
          <orgName type="acronym">CIC</orgName>
          <desc>
            <address>
              <addrLine>4 rue du Morvan - Bâtiment Louis Mathieu - 54500 Vandoeuvre-les-Nancy Cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300157" type="direct"/>
            <relation name="CIC1433" active="#struct-303623" type="direct"/>
            <relation active="#struct-413289" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303515" status="VALID">
          <orgName>Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy]</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.reseau-chu.org/article/le-nouvel-institut-lorrain-du-coeur-et-des-vaisseaux-louis-mathieu/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>