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Theses

Qualité de vie et fatigue en cancérologie : cancer colorectal et cancer du sein

Abstract : Since 2004, cancer is the leading cause of death in France. Health-related quality of life (HRQoL) is now considered an important endpoint in cancer clinical trials. To study the Quality of Life (QoL) of a group of patients affected by the same disease or receiving the same treatment and to make comparisons, standardized instruments and a well designed study are necessary and end in a statistical evaluation allowing a rigorous appreciation. We tried to approach these two points by a methodological work which consisted to test the psychometric properties of two French colorectal cancer (CRC) specific QoL questionnaires: the QLQ-CR38 and the FACT-C and by a thematic work with the development of a longitudinal study with invasive breast cancer (BC) patients (FATSEIN study).The first study confirmed the value of the FACT-C and suggested some limits of the QLQ-CR38 for patients with CRC. The purpose of the FATSEIN study was to identify factors associated with cancer-related fatigue before, during and after adjuvant treatment for invasive BC. Patients completed 3 questionnaires (fatigue, QoL and anxiety) at several times. Fatigue is considered like a major disturbing side effect. In addition, the impact of fatigue on QoL is considerable. So, it was important to take into account better this symptom which was neglected for a long time. These results, their implication in research and clinical practice are discussed
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https://hal.univ-lorraine.fr/tel-01746150
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  • HAL Id : tel-01746150, version 1

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Christine Rotonda. Qualité de vie et fatigue en cancérologie : cancer colorectal et cancer du sein. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2011. Français. ⟨NNT : 2011NAN10013⟩. ⟨tel-01746150⟩

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