. Références-bibliographiques-1, J. Bourhis, C. Amand, and J. Pignon, Update of MACH-NC (Meta-Analysis of Chemotherapy in Head & Neck Cancer) database focused on concomitant chemoradiotherapy, Proc Am Soc Clin Oncol, vol.22, p.488, 2004.

J. Pignon, B. Baujat, and J. Bourhis, Apport des m??ta-analyses sur donn??es individuelles au traitement des cancers ORL, Cancer/Radioth??rapie, vol.9, issue.1, pp.31-37, 2005.
DOI : 10.1016/j.canrad.2004.11.002

J. Pignon, J. Bourhis, C. Domenge, and L. Designe, Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta analysis of chemotherapy on head and neck cancer, Cancer/Radioth??rapie, vol.5, issue.2, pp.949-55, 2000.
DOI : 10.1016/S1278-3218(00)00073-1

D. Adelstein, P. Lavertu, and J. Saxton, Mature results of a Phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy alone in patients with Stage III and IV squamous cell carcinoma of the head and neck, Cancer, vol.17, issue.4, pp.876-83, 2000.
DOI : 10.1093/jnci/88.13.890

F. Denis, P. Garaud, and E. Bardet, Final Results of the 94???01 French Head and Neck Oncology and Radiotherapy Group Randomized Trial Comparing Radiotherapy Alone With Concomitant Radiochemotherapy in Advanced-Stage Oropharynx Carcinoma, Journal of Clinical Oncology, vol.22, issue.1, pp.69-76, 2004.
DOI : 10.1200/JCO.2004.08.021

P. Olmi, S. Crispino, and C. Fallai, Locoregionally advanced carcinoma of the oropharynx: conventional radiotherapy vs. accelerated hyperfractionated radiotherapy vs. concomitant radiotherapy and chemotherapy???a multicenter randomized trial, International Journal of Radiation Oncology*Biology*Physics, vol.55, issue.1, pp.78-92, 2003.
DOI : 10.1016/S0360-3016(02)03792-6

J. Bernier, C. Domenge, and M. Ozsahin, Postoperative Irradiation with or without Concomitant Chemotherapy for Locally Advanced Head and Neck Cancer, New England Journal of Medicine, vol.350, issue.19, pp.1945-52, 2004.
DOI : 10.1056/NEJMoa032641

J. Cooper, T. Pajak, and A. Forastiere, Postoperative Concurrent Radiotherapy and Chemotherapy for High-Risk Squamous-Cell Carcinoma of the Head and Neck, New England Journal of Medicine, vol.350, issue.19, pp.1937-1981, 2004.
DOI : 10.1056/NEJMoa032646

L. Smid, M. Budihna, and B. Zakotnik, Postoperative concomitant irradiation and chemotherapy with mitomycin C and bleomycin for advanced head-and-neck carcinoma Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review, Int J Radiat Oncol Biol Phys Radiother Oncol, vol.5666, issue.12, pp.1055-62253, 2003.

K. Fu, T. Pajak, and A. Trotti, A radiation therapy oncology group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003, International Journal of Radiation Oncology*Biology*Physics, vol.48, issue.1, pp.7-16, 2000.
DOI : 10.1016/S0360-3016(00)00663-5

J. Horiot, P. Bontemps, and W. Van-den-bogaert, Accelerated fractionation (AF) compared to conventional fractionation (CF) improves loco-regional control in the radiotherapy of advanced head and neck cancers: results of the EORTC 22851 randomized trial, Radiotherapy and Oncology, vol.44, issue.2, pp.111-132, 1997.
DOI : 10.1016/S0167-8140(97)00079-0

J. Overgaard, H. Hansen, and L. Specht, Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial, The Lancet, vol.362, issue.9388, pp.933-973, 2003.
DOI : 10.1016/S0140-6736(03)14361-9

M. Poulsen, J. Denham, and L. Peters, A randomised trial of accelerated and conventional radiotherapy for stage III and IV squamous carcinoma of the head and neck: a Trans-Tasman Radiation Oncology Group Study Very accelerated versus conventional radiotherapy in HNSCC: Results of the GORTEC 94-02 randomized trial Meta-analysis of conventional versus altered fractionated radiotherapy in head and neck squamous cell carcinoma (HNSCC): Final analysis A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck, Wendt TG, Grabenbauer GG, Rodel CM, et al. Simultaneous radiochemotherapy versus radiotherapy alone in advanced head and neck cancer: a randomized multicenter study, pp.113-135, 2000.

B. Jeremic, Y. Shibamoto, and B. Milicic, Hyperfractionated Radiation Therapy With or Without Concurrent Low-Dose Daily Cisplatin in Locally Advanced Squamous Cell Carcinoma of the Head and Neck: A Prospective Randomized Trial, Journal of Clinical Oncology, vol.18, issue.7, pp.1458-64, 2000.
DOI : 10.1200/JCO.2000.18.7.1458

W. Dobrowsky, J. Naude, M. Albers, and S. Fisher, Continuous hyperfractionated accelerated radiotherapy with/without mitomycin C in head and neck cancers Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer, Radiother Oncol Brizel DM N Engl J Med, vol.57338, issue.23, pp.119-241798, 1998.

R. Bensadoun, K. Benezery, and A. Ramaioli, Phase III multicenter randomized study of concurrent twice-a-day radiotherapy with and without cisplatin-5FU (BiRCF) in unresectable pharyngeal carcinoma. 24 months results (FNCLCC-GORTEC) Very intense radio-chemotherapy in non resectable stage IV locally advanced HNSCC: Results of a GORTEC randomized trial, Int J Radiat Oncol Biol Phys Bourhis J Radiother Oncol Lancet Oncol, vol.607, pp.161-25175, 2004.

P. Huguenin, D. Taussky, and K. Moe, Quality of life in patients cured from a carcinoma of the head and neck by radiotherapy: the importance of the target volume, International Journal of Radiation Oncology*Biology*Physics, vol.45, issue.1, pp.47-52, 1999.
DOI : 10.1016/S0360-3016(99)00128-5

P. Giraud, C. Jaulerry, and F. Brunin, Cancers des voies a??rodigestives sup??rieures??: b??n??fices cliniques de la radioth??rapie conformationnelle et de la modulation d???intensit??, Cancer/Radioth??rapie, vol.6, issue.1, pp.37-48, 2002.
DOI : 10.1016/S1278-3218(02)00211-1

S. Zefkili, M. Tomsej, and P. Aletti, 66 Recommendations for a head and neck IMRT quality assurance protocol, Radiotherapy and Oncology, vol.76, pp.364-79, 2004.
DOI : 10.1016/S0167-8140(05)81044-8

C. Marchal, M. Lapeyre, and V. Beckendorf, Preliminary results of the assessment of intensity modulated radiotherapy (IMRT) for prostatic and head and neck tumors, Cancer Radiother, vol.8, issue.1, pp.121-128, 2001.

T. Hong, W. Tome, R. Chappell, P. Chinnaiyan, M. Mehta et al., The impact of daily setup variations on head-and-neck intensity-modulated radiation therapy, International Journal of Radiation Oncology*Biology*Physics, vol.61, issue.3, pp.779-88, 2005.
DOI : 10.1016/j.ijrobp.2004.07.696

M. Manning, Q. Wu, and R. Cardinale, The effect of setup uncertainty on normal tissue sparing with IMRT for head-and-neck cancer A double exposed portal image comparison between electronic portal imaging hard copies and port films in radiation therapy treatment setup confirmation to determine its clinical application in a radiotherapy center, Int J Radiat Oncol Biol Phys Int J Radiat Oncol Biol Phys, vol.5149, issue.33, pp.1400-9191, 2001.

L. Pisani, D. Lockman, D. Jaffray, D. Yan, A. Martinez et al., Setup error in radiotherapy: on-line correction using electronic kilovoltage and megavoltage radiographs, International Journal of Radiation Oncology*Biology*Physics, vol.47, issue.3, pp.825-864, 2000.
DOI : 10.1016/S0360-3016(00)00476-4

K. Hatherly, J. Smylie, and A. Rodger, A comparison of field-only electronic portal imaging hard copies with double exposure port films in radiation therapy treatment setup confirmation to determine its clinical application in a radiotherapy center, International Journal of Radiation Oncology*Biology*Physics, vol.45, issue.3, pp.791-797, 1999.
DOI : 10.1016/S0360-3016(99)00249-7

O. Morin, A. Gillis, and J. Chen, Megavoltage cone-beam CT: System description and clinical applications, Medical Dosimetry, vol.31, issue.1, pp.51-61, 2006.
DOI : 10.1016/j.meddos.2005.12.009

J. Pouliot, A. Bani-hashemi, and J. Chen, Low-dose megavoltage cone-beam CT for radiation therapy, International Journal of Radiation Oncology*Biology*Physics, vol.61, issue.2, pp.552-60, 2005.
DOI : 10.1016/j.ijrobp.2004.10.011

J. Pouliot, O. Morin, and M. Aubin, M??gavoltage cone-beam CT??: r??cents d??veloppements et??applications cliniques pour??la??radioth??rapie conformationnelle avec??modulation d'intensit??, Cancer/Radioth??rapie, vol.10, issue.5, pp.258-68, 2006.
DOI : 10.1016/j.canrad.2006.05.010

J. Cheung, J. Aubry, S. Yom, A. Gottschalk, J. Celi et al., Dose Recalculation and the Dose-Guided Radiation Therapy (DGRT) Process Using Megavoltage Cone-Beam CT, International Journal of Radiation Oncology*Biology*Physics, vol.74, issue.2
DOI : 10.1016/j.ijrobp.2008.12.034

S. Nijsten, W. Van-elmpt, and B. Mijnheer, Prediction of DVH parameter changes due to setup errors for breast cancer treatment based on 2D portal dosimetry, Medical Physics, vol.67, issue.1, pp.583-9283, 2009.
DOI : 10.1016/j.ijrobp.2006.11.047

W. Hu, P. Graff, T. Boettger, and J. Pouliot, A spatially encoded dose difference maximal intensity projection map for patient dose evaluation: A new first line patient quality assurance tool, Medical Physics, vol.25, issue.2, pp.1748-53, 2011.
DOI : 10.1109/TPAMI.2003.1177156

V. Gregoire, A. Eisbruch, M. Hamoir, and P. Levendag, Proposal for the delineation of the nodal CTV in the node-positive and the post-operative neck, Radiotherapy and Oncology, vol.79, issue.1, pp.15-20, 2006.
DOI : 10.1016/j.radonc.2006.03.009

V. Gregoire, P. Levendag, and K. Ang, CT-based delineation of lymph node levels and related CTVs in the node-negative neck: DAHANCA, EORTC, GORTEC, NCIC,RTOG consensus guidelines, Radiotherapy and Oncology, vol.69, issue.3, pp.227-263, 2003.
DOI : 10.1016/j.radonc.2003.09.011

K. Chao, G. Ozyigit, and A. Blanco, Intensity-modulated radiation therapy for oropharyngeal carcinoma: impact of tumor volume, International Journal of Radiation Oncology*Biology*Physics, vol.59, issue.1, pp.43-50, 2004.
DOI : 10.1016/j.ijrobp.2003.08.004

K. Chao, G. Ozyigit, B. Tran, M. Cengiz, J. Dempsey et al., Patterns of failure in patients receiving definitive and postoperative IMRT for head-and-neck cancer, International Journal of Radiation Oncology*Biology*Physics, vol.55, issue.2, pp.312-333, 2003.
DOI : 10.1016/S0360-3016(02)03940-8

K. Chao, F. Wippold, G. Ozyigit, B. Tran, J. Dempsey et al., Determination and delineation of nodal target volumes for head-and-neck cancer based on patterns of failure in patients receiving definitive and postoperative IMRT Recurrences near base of skull after IMRT for head-and-neck cancer: implications for target delineation in high neck and for parotid gland sparing, Int J Radiat Oncol Biol Phys Int J Radiat Oncol Biol Phys, vol.5359, pp.1174-8428, 2002.

M. Yao, K. Chang, and G. Funk, The Failure Patterns of Oral Cavity Squamous Cell Carcinoma After Intensity-Modulated Radiotherapy???The University of Iowa Experience, International Journal of Radiation Oncology*Biology*Physics, vol.67, issue.5, pp.1332-1373, 2007.
DOI : 10.1016/j.ijrobp.2006.11.030

M. Yao, K. Dornfeld, and J. Buatti, Intensity-modulated radiation treatment for head-and-neck squamous cell carcinoma--the University of Iowa experience Intensity-modulated radiotherapy for locally advanced cancers of the larynx and hypopharynx Intensity-modulated radiotherapy for oral cavity squamous cell carcinoma: patterns of failure and predictors of local control, Int J Radiat Oncol Biol Phys Head Neck Int J Radiat Oncol Biol Phys, vol.633380, issue.51, pp.410-21103, 2005.

M. Lapeyre, C. Bailly, I. Toledano, A. Montalban, and M. Russier, Cancer de l???hypopharynx et du larynx : proposition de s??lection et d??limitation des volumes cibles microscopiques p??ri-tumoraux (aires ganglionnaires exclues), Cancer/Radioth??rapie, vol.14, issue.1, pp.43-51, 2010.
DOI : 10.1016/S1278-3218(10)70007-X

M. Lapeyre, P. Henrot, and M. Alfonsi, Proposition de s??lection et d??limitation des volumes cibles microscopiques p??ritumoraux dans les cancers de la cavit?? buccale et de l'oropharynx (aires ganglionnaires exclues), Cancer/Radioth??rapie, vol.9, issue.4, pp.261-70, 2005.
DOI : 10.1016/j.canrad.2005.03.005

M. Lapeyre, V. Marchesi, and A. Mege, Intrafraction motions of the larynx during radiotherapy Acceptance tests and quality control (QC) procedures for the clinical implementation of intensity modulated radiotherapy (IMRT) using inverse planning and the sliding window technique: experience from five radiotherapy departments Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer Quantitative dose-volume response analysis of changes in parotid gland function after radiotherapy in the head-and-neck region, Cancer Radiother Int J Radiat Oncol Biol Phys Radiother Oncol Int J Radiat Oncol Biol Phys Roesink JM Int J Radiat Oncol Biol Phys, vol.856654551, issue.58, pp.134-47384, 1999.

K. Chao, J. Deasy, and J. Markman, A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results, International Journal of Radiation Oncology*Biology*Physics, vol.49, issue.4, pp.907-923, 2001.
DOI : 10.1016/S0360-3016(00)01441-3

M. Munter, C. Karger, and S. Hoffner, Evaluation of salivary gland function after treatment of head-and-neck tumors with intensity-modulated radiotherapy by quantitative pertechnetate scintigraphy, International Journal of Radiation Oncology*Biology*Physics, vol.58, issue.1, pp.175-84, 2004.
DOI : 10.1016/S0360-3016(03)01437-8

Y. Li, J. Taylor, T. Haken, R. Eisbruch, and A. , The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radiation therapy, International Journal of Radiation Oncology*Biology*Physics, vol.67, issue.3, pp.660-669, 2007.
DOI : 10.1016/j.ijrobp.2006.09.021

N. Aaronson, S. Ahmedzai, and B. Bergman, The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology Quality of life in head and neck cancer patients: validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-H&N35, J Natl Cancer Inst J Clin Oncol, vol.8517, issue.63, pp.365-761008, 1993.

M. Hjermstad, P. Fayers, K. Bjordal, and S. Kaasa, Health-related quality of life in the general Norwegian population assessed by the European Organization for Research and Treatment of Cancer Core Quality-of-Life Questionnaire: the QLQ=C30 (+ 3)., Bjordal K, de Graeff A, Fayers PM, et al. A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module, pp.1188-96, 1998.
DOI : 10.1200/JCO.1998.16.3.1188

A. Sherman, S. Simonton, D. Adams, E. Vural, B. Owens et al., Assessing Quality of Life in Patients With Head and Neck Cancer, Archives of Otolaryngology???Head & Neck Surgery, vol.126, issue.4, pp.459-67, 2000.
DOI : 10.1001/archotol.126.4.459

N. Aaronson, P. Fayers, K. Bjordal, M. Groenvold, D. Curran et al., Brussels (Belgium): European Organisation for Research and Treatment of Cancer Complications associated with therapeutic neck radiation, J Oral Maxillofac Surg, vol.54, pp.1409-1424, 1996.

J. Epstein, M. Robertson, S. Emerton, N. Phillips, P. Stevenson-moore et al., Quality of life and oral function in patients treated with radiation therapy for head and neck cancer Patients with head and neck cancer cured by radiation therapy: a survey of the dry mouth syndrome in long-term survivors, Head Neck Head Neck, vol.2324, issue.70, pp.389-98737, 2001.

M. Hjermstad, P. Fayers, K. Bjordal, and S. Kaasa, Using reference data on quality of life-the importance of adjusting for age and gender

C. Zocchetti, D. Consonni, P. Bertazzi, P. Xia, K. Fu et al., Relationship between prevalence rate ratios and odds ratios in cross-sectional studies Comparison of treatment plans involving intensity-modulated radiotherapy for nasopharyngeal carcinoma Treatment planning and delivery of intensitymodulated radiation therapy for primary nasopharynx cancer Improvements in target coverage and reduced spinal cord irradiation using intensity-modulated radiotherapy (IMRT) in patients with carcinoma of the thyroid gland, Int J Epidemiol Int J Radiat Oncol Biol Phys Int J Radiat Oncol Biol Phys Nutting CM Radiother Oncol, vol.26484960, issue.75, pp.220-223, 1997.

Q. Wu, M. Manning, R. Schmidt-ullrich, and R. Mohan, The potential for sparing of parotids and escalation of biologically effective dose with intensity-modulated radiation treatments of head and neck cancers: a treatment design study, International Journal of Radiation Oncology*Biology*Physics, vol.46, issue.1, pp.195-205, 2000.
DOI : 10.1016/S0360-3016(99)00304-1

E. Adams, C. Nutting, and D. Convery, Potential role of intensity-modulated radiotherapy in the treatment of tumors of the maxillary sinus, International Journal of Radiation Oncology*Biology*Physics, vol.51, issue.3, pp.579-88, 2001.
DOI : 10.1016/S0360-3016(01)01655-8

J. Cooper, S. Mukherji, and A. Toledano, An evaluation of the variability of tumor-shape definition derived by experienced observers from CT images of supraglottic carcinomas (ACRIN protocol 6658) Intensity-modulated radiotherapy increases dose to the brachial plexus compared with conventional radiotherapy for head and neck cancer, Int J Radiat Oncol Biol Phys Br J Radiol, vol.6784, issue.79, pp.972-558, 2007.

N. Lee, P. Xia, N. Fischbein, P. Akazawa, C. Akazawa et al., Intensity-Modulated Radiation Therapy for Head and Neck Cancer, Int J Radiat Oncol Biol Phys Int J Radiat Oncol Biol Phys, vol.5770, pp.49-60660, 2003.
DOI : 10.1007/978-1-4419-9464-6_18

M. Daly, Y. Lieskovsky, and T. Pawlicki, Evaluation of patterns of failure and subjective salivary function in patients treated with intensity modulated radiotherapy for head and neck squamous cell carcinoma Dose-volume analysis of locoregional recurrences in head and neck IMRT, as determined by deformable registration: a prospective multi-institutional trial Marginal misses after postoperative intensity-modulated radiotherapy for head and neck cancer Patterns of failure and toxicity after intensity-modulated radiotherapy for head and neck cancer, Head Neck Radiother Oncol Int J Radiat Oncol Biol Phys Int J Radiat Oncol Biol Phys, vol.29998071, issue.85, pp.211-220101, 2007.

N. Lee, P. Xia, and J. Quivey, Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience, International Journal of Radiation Oncology*Biology*Physics, vol.53, issue.1, pp.12-22, 2002.
DOI : 10.1016/S0360-3016(02)02724-4

M. Kam, P. Teo, and R. Chau, Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: The Hong Kong experience, International Journal of Radiation Oncology*Biology*Physics, vol.60, issue.5, pp.1440-50, 2004.
DOI : 10.1016/j.ijrobp.2004.05.022

D. Kwong, E. Pow, and J. Sham, Intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma, Cancer, vol.49, issue.7, pp.1584-93363, 2004.
DOI : 10.1177/00220345810600070101

K. Huang, P. Xia, and C. Chuang, Intensity-modulated chemoradiation for treatment of stage III and IV oropharyngeal carcinoma, Cancer, vol.60, issue.3, pp.497-507438, 2007.
DOI : 10.1016/j.ijrobp.2004.05.058

N. Lee, O. Meara, W. Chan, and K. , Concurrent chemotherapy and intensitymodulated radiotherapy for locoregionally advanced laryngeal and hypopharyngeal cancers
DOI : 10.1016/j.ijrobp.2007.03.013

M. Schwartz and C. Rasch, Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: which anatomic structures are affected and can they be spared by IMRT? Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: a dose-effect relationship Dysphagia after chemoradiotherapy for head-and-neck squamous cell carcinoma: dose-effect relationships for the swallowing structures al. Can IMRT or brachytherapy reduce dysphagia associated with chemoradiotherapy of head and neck cancer? The Michigan and Rotterdam experiences Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: early dose-effect relationships for the swallowing structures, Int J Radiat Oncol Biol Phys Int J Radiat Oncol Biol Phys Radiother Oncol Int J Radiat Oncol Biol Phys Int J Radiat Oncol Biol Phys Int J Radiat Oncol Biol Phys, vol.696085756968, issue.95, pp.459-681425, 2004.

G. Studer, E. Peponi, S. Kloeck, T. Dossenbach, G. Huber et al., Surviving Hypopharynx???Larynx Carcinoma in the Era of IMRT, International Journal of Radiation Oncology*Biology*Physics, vol.77, issue.5, pp.1391-1397, 2010.
DOI : 10.1016/j.ijrobp.2009.07.005

D. Gomez, J. Zhung, and J. Gomez, Intensity-Modulated Radiotherapy in Postoperative Treatment of Oral Cavity Cancers, International Journal of Radiation Oncology*Biology*Physics, vol.73, issue.4, pp.1096-103, 2009.
DOI : 10.1016/j.ijrobp.2008.05.024

G. Studer, R. Zwahlen, K. Graetz, B. Davis, and C. Glanzmann, IMRT in oral cavity cancer, Radiation Oncology, vol.2, issue.1, p.16, 2007.
DOI : 10.1186/1748-717X-2-16

M. Posner, J. Quivey, P. Akazawa, P. Xia, C. Akazawa et al., Dose optimization for the treatment of anaplastic thyroid carcinoma: a comparison of treatment planning techniques, International Journal of Radiation Oncology*Biology*Physics, vol.48, issue.2, pp.475-83, 2000.
DOI : 10.1016/S0360-3016(00)00621-0

B. Rosenbluth, V. Serrano, and L. Happersett, Intensity-modulated radiation therapy for the treatment of nonanaplastic thyroid cancer, International Journal of Radiation Oncology*Biology*Physics, vol.63, issue.5, pp.1419-1445, 2005.
DOI : 10.1016/j.ijrobp.2005.05.043

D. Schwartz, M. Lobo, and K. Ang, Postoperative External Beam Radiotherapy for Differentiated Thyroid Cancer: Outcomes and Morbidity With Conformal Treatment, International Journal of Radiation Oncology*Biology*Physics, vol.74, issue.4, pp.1083-91, 2009.
DOI : 10.1016/j.ijrobp.2008.09.023

G. Jiang, K. Ang, L. Peters, C. Wendt, M. Oswald et al., Maxillary sinus carcinomas: natural history and results of postoperative radiotherapy, Radiotherapy and Oncology, vol.21, issue.3, pp.193-200, 1991.
DOI : 10.1016/0167-8140(91)90037-H

P. Pommier, C. Ginestet, and M. Sunyach, Conformal radiotherapy for paranasal sinus and nasal cavity tumors: three-dimensional treatment planning and preliminary results in 40 patients, International Journal of Radiation Oncology*Biology*Physics, vol.48, issue.2, pp.485-93, 2000.
DOI : 10.1016/S0360-3016(00)00616-7

B. Khademi, A. Moradi, S. Hoseini, and M. Mohammadianpanah, Malignant neoplasms of the sinonasal tract: report of 71 patients and literature review and analysis, Oral and Maxillofacial Surgery, vol.62, issue.4, pp.191-200, 2009.
DOI : 10.1016/S0030-6657(08)70287-7

P. Dirix, S. Nuyts, and Y. Geussens, Malignancies of the Nasal Cavity and Paranasal Sinuses: Long-Term Outcome With Conventional or Three-Dimensional Conformal Radiotherapy, International Journal of Radiation Oncology*Biology*Physics, vol.69, issue.4
DOI : 10.1016/j.ijrobp.2007.04.044

C. Thorup, L. Sebbesen, and H. Dano, Carcinoma of the nasal cavity and paranasal sinuses in Denmark 1995???2004, Acta Oncologica, vol.112, issue.3, pp.389-94, 1995.
DOI : 10.1097/00005537-200211000-00010

D. Huang, P. Xia, and P. Akazawa, Comparison of treatment plans using intensity-modulated radiotherapy and three-dimensional conformal radiotherapy for paranasal sinus carcinoma, International Journal of Radiation Oncology*Biology*Physics, vol.56, issue.1, pp.158-68, 2003.
DOI : 10.1016/S0360-3016(03)00080-4

M. Daly, A. Chen, and M. Bucci, Intensity-modulated radiation therapy for malignancies of the nasal cavity and paranasal sinuses, International Journal of Radiation Oncology*Biology*Physics, vol.67, issue.1, pp.151-158, 2007.
DOI : 10.1016/j.ijrobp.2006.07.1389

W. Duthoy, T. Boterberg, and F. Claus, Postoperative intensity-modulated radiotherapy in sinonasal carcinoma, Cancer, vol.26, issue.1, pp.71-82, 2005.
DOI : 10.1001/archotol.1996.01890190061014

P. Dirix, B. Vanstraelen, M. Jorissen, V. Vander-poorten, and S. Nuyts, Intensity-Modulated Radiotherapy for Sinonasal Cancer: Improved Outcome Compared to Conventional Radiotherapy, International Journal of Radiation Oncology*Biology*Physics, vol.78, issue.4
DOI : 10.1016/j.ijrobp.2009.09.067

D. Chua, J. Sham, L. Leung, and G. Au, Reirradiation of nasopharyngeal carcinoma withintensity-modulated radiotherapy, Radiotherapy and Oncology, vol.77, issue.3, pp.290-294, 2005.
DOI : 10.1016/j.radonc.2005.10.010

F. Roeder, F. Zwicker, and L. Saleh-ebrahimi, Intensity modulated or fractionated stereotactic reirradiation in patients with recurrent nasopharyngeal cancer, Radiation Oncology, vol.6, issue.1, p.22, 2011.
DOI : 10.1097/01.coc.0000180389.86104.68

F. Janot, D. De-raucourt, and E. Benhamou, Randomized Trial of Postoperative Reirradiation Combined With Chemotherapy After Salvage Surgery Compared With Salvage Surgery Alone in Head and Neck Carcinoma, Journal of Clinical Oncology, vol.26, issue.34, pp.5518-5541, 2008.
DOI : 10.1200/JCO.2007.15.0102

N. Kramer, E. Horwitz, and J. Cheng, Toxicity and outcome analysis of patients with recurrent head and neck cancer treated with hyperfractionated split-course reirradiation and concurrent cisplatin and paclitaxel chemotherapy from two prospective phase I and II studies, Head & Neck, vol.25, issue.5, pp.406-420, 2005.
DOI : 10.1093/oxfordjournals.annonc.a010793

C. Langer, J. Harris, and E. Horwitz, Phase II Study of Low-Dose Paclitaxel and Cisplatin in Combination With Split-Course Concomitant Twice-Daily Reirradiation in Recurrent Squamous Cell Carcinoma of the Head and Neck: Results of Radiation Therapy Oncology Group Protocol 9911, Journal of Clinical Oncology, vol.25, issue.30, pp.4800-4805, 2007.
DOI : 10.1200/JCO.2006.07.9194

J. Salama, E. Vokes, and S. Chmura, Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-and-neck squamous cell carcinoma, International Journal of Radiation Oncology*Biology*Physics, vol.64, issue.2, pp.382-91, 2006.
DOI : 10.1016/j.ijrobp.2005.07.005

S. Spencer, R. Wheeler, and G. Peters, Phase 1 trial of combined chemotherapy and reirradiation for recurrent unresectable head and neck cancer, Head & Neck, vol.47, issue.2, pp.118-140, 2003.
DOI : 10.1016/0360-3016(90)90341-G

S. Spencer, J. Harris, and R. Wheeler, RTOG 96-10: reirradiation with concurrent hydroxyurea and 5-fluorouracil in patients with squamous cell cancer of the head and neck, International Journal of Radiation Oncology*Biology*Physics, vol.51, issue.5
DOI : 10.1016/S0360-3016(01)01745-X

E. Sulman, D. Schwartz, and T. Le, IMRT Reirradiation of Head and Neck Cancer???Disease Control and Morbidity Outcomes, International Journal of Radiation Oncology*Biology*Physics, vol.73, issue.2, pp.399-409, 2009.
DOI : 10.1016/j.ijrobp.2008.04.021

M. Biagioli, M. Harvey, and E. Roman, Intensity-Modulated Radiotherapy With Concurrent Chemotherapy for Previously Irradiated, Recurrent Head and Neck Cancer, International Journal of Radiation Oncology*Biology*Physics, vol.69, issue.4, pp.1067-73, 2007.
DOI : 10.1016/j.ijrobp.2007.04.057

D. Sher, R. Haddad, C. Norris, and . Jr, Efficacy and toxicity of reirradiation using intensity-modulated radiotherapy for recurrent or second primary head and neck cancer, Cancer, vol.29, issue.20, pp.4761-4769, 2010.
DOI : 10.1016/j.ijrobp.2005.07.005

N. Lee, K. Chan, and J. Bekelman, Salvage Re-Irradiation for Recurrent Head and Neck Cancer, International Journal of Radiation Oncology*Biology*Physics, vol.68, issue.3, pp.731-771, 2007.
DOI : 10.1016/j.ijrobp.2006.12.055

A. Diaz-arnold and C. Marek, The impact of saliva on patient care: A literature review, The Journal of Prosthetic Dentistry, vol.88, issue.3
DOI : 10.1067/mpr.2002.128176

J. Cooper, K. Fu, J. Marks, and S. Silverman, Late effects of radiation therapy in the head and neck region, International Journal of Radiation Oncology*Biology*Physics, vol.31, issue.5, pp.1141-64, 1995.
DOI : 10.1016/0360-3016(94)00421-G

M. Chambers, A. Garden, M. Kies, and J. Martin, Radiation-induced Xerostomia in patients with head and neck cancer: Pathogenesis, impact on quality of life, and management, Head & Neck, vol.49, issue.9, pp.796-807, 2004.
DOI : 10.14219/jada.archive.2001.0056

H. Guchelaar, A. Vermes, and J. Meerwaldt, Radiation-induced xerostomia: pathophysiology, clinical course and supportive treatment, Supportive Care in Cancer, vol.5, issue.4, pp.281-289, 1997.
DOI : 10.1007/s005200050075

L. Franzen, U. Funegard, T. Ericson, and R. Henriksson, Parotid gland function during and following radiotherapy of malignancies in the head and neck, European Journal of Cancer, vol.28, issue.2-3, pp.457-62, 1992.
DOI : 10.1016/S0959-8049(05)80076-0

M. Leslie and S. Dische, Parotid gland function following accelerated and conventionally fractionated radiotherapy, Radiotherapy and Oncology, vol.22, issue.2, pp.133-142, 1991.
DOI : 10.1016/0167-8140(91)90009-6

R. Liu, T. Fleming, B. Toth, and H. Keene, Salivary flow rates in patients with head and neck cancer 0.5 to 25 years after radiotherapy, Oral Surgery, Oral Medicine, Oral Pathology, vol.70, issue.6, pp.724-733, 1990.
DOI : 10.1016/0030-4220(90)90008-G

K. Mossman, Quantitative Radiation Dose-Response Relationships for Normal Tissues in Man. II. Response of the Salivary Glands during Radiotherapy, Radiation Research, vol.95, issue.2, pp.392-400, 1983.
DOI : 10.2307/3576264

H. Tsujii, Quantitative dose-response analysis of salivary function following radiotherapy using sequential RI-sialography, Int J Radiat Oncol Biol Phys, vol.11, pp.1603-1615, 1985.

B. Emami, J. Lyman, and A. Brown, Tolerance of normal tissue to therapeutic irradiation, International Journal of Radiation Oncology*Biology*Physics, vol.21, issue.1, pp.109-131, 1991.
DOI : 10.1016/0360-3016(91)90171-Y

A. Eisbruch, J. Ship, and M. Martel, Parotid gland sparing in patients undergoing bilateral head and neck irradiation: Techniques and early results, International Journal of Radiation Oncology*Biology*Physics, vol.36, issue.2, pp.469-80, 1996.
DOI : 10.1016/S0360-3016(96)00264-7

T. Nishioka, H. Shirato, and T. Arimoto, Reduction of radiation-induced xerostomia in nasopharyngeal carcinoma using CT simulation with laser patient marking and three-field irradiation technique, International Journal of Radiation Oncology*Biology*Physics, vol.38, issue.4, pp.705-717, 1997.
DOI : 10.1016/S0360-3016(97)00054-0

K. Chao, N. Majhail, and C. Huang, Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: a comparison with conventional techniques, Radiotherapy and Oncology, vol.61, issue.3, pp.275-80, 2001.
DOI : 10.1016/S0167-8140(01)00449-2

B. Henson, M. Inglehart, A. Eisbruch, and J. Ship, Preserved salivary output and xerostomia-related quality of life in head and neck cancer patients receiving parotid-sparing radiotherapy, Oral Oncology, vol.37, issue.1, pp.84-93, 2001.
DOI : 10.1016/S1368-8375(00)00063-4

A. Maes, C. Weltens, and P. Flamen, Preservation of parotid function with uncomplicated conformal radiotherapy, Radiotherapy and Oncology, vol.63, issue.2, pp.203-214, 2002.
DOI : 10.1016/S0167-8140(02)00013-0

J. Malouf, C. Aragon, B. Henson, A. Eisbruch, and J. Ship, Influence of parotid-sparing radiotherapy on xerostomia in head and neck cancer patients, Cancer Detection and Prevention, vol.27, issue.4, pp.305-315, 2003.
DOI : 10.1016/S0361-090X(03)00095-3

A. Lin, H. Kim, J. Terrell, L. Dawson, J. Ship et al., Quality of life after parotid-sparing IMRT for head-and-neck cancer: A prospective longitudinal study, International Journal of Radiation Oncology*Biology*Physics, vol.57, issue.1, pp.61-70, 2003.
DOI : 10.1016/S0360-3016(03)00361-4

M. Parliament, R. Scrimger, and S. Anderson, Preservation of oral health???related quality of life and salivary flow rates after inverse-planned intensity- modulated radiotherapy (IMRT) for head-and-neck cancer, International Journal of Radiation Oncology*Biology*Physics, vol.58, issue.3, pp.663-73, 2004.
DOI : 10.1016/S0360-3016(03)01571-2

A. Eisbruch, H. Kim, J. Terrell, L. Marsh, L. Dawson et al., Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer, International Journal of Radiation Oncology*Biology*Physics, vol.50, issue.3, pp.695-704, 2001.
DOI : 10.1016/S0360-3016(01)01512-7

M. Sprangers, A. Cull, K. Bjordal, M. Groenvold, and N. Aaronson, The European Organization for Research and treatment of cancer approach to quality of life assessment: guidelines for developing questionnaire modules, Quality of Life Research, vol.80, issue.4, pp.287-95, 1993.
DOI : 10.1007/BF00434800

T. Conroy, M. Mercier, and J. Bonneterre, French version of FACT-G: validation and comparison with other cancer-specific instruments, European Journal of Cancer, vol.40, issue.15, pp.2243-52, 2004.
DOI : 10.1016/j.ejca.2004.06.010

K. Bjordal, S. Kaasa, and A. Mastekaasa, Quality of life in patients treated for head and neck cancer: A follow-up study 7 to 11 years after radiotherapy, International Journal of Radiation Oncology*Biology*Physics, vol.28, issue.4, pp.847-56, 1994.
DOI : 10.1016/0360-3016(94)90104-X

L. Harrison, M. Zelefsky, and D. Pfister, Detailed quality of life assessment in patients treated with primary radiotherapy for squamous cell cancer of the base of the tongue, Head & Neck, vol.8, issue.3, pp.169-75, 1997.
DOI : 10.1016/0360-3016(94)90371-9

S. Rogers, G. Humphris, D. Lowe, J. Brown, and E. Vaughan, The impact of surgery for oral cancer on quality of life as measured by the Medical Outcomes Short Form 36, Oral Oncology, vol.34, issue.3, pp.171-180, 1998.
DOI : 10.1016/S1368-8375(97)00069-9

E. Gritz, C. Carmack, and C. De-moor, First Year After Head and Neck Cancer: Quality of Life, Journal of Clinical Oncology, vol.17, issue.1, pp.352-60, 1999.
DOI : 10.1200/JCO.1999.17.1.352

M. List, A. Siston, and D. Haraf, Quality of Life and Performance in Advanced Head and Neck Cancer Patients on Concomitant Chemoradiotherapy: A Prospective Examination, Journal of Clinical Oncology, vol.17, issue.3, pp.1020-1028, 1999.
DOI : 10.1200/JCO.1999.17.3.1020

E. Hammerlid, M. Ahlner-elmqvist, and K. Bjordal, A prospective multicentre study in Sweden and Norway of mental distress and psychiatric morbidity in head and neck cancer patients, British Journal of Cancer, vol.80, issue.5-6, pp.766-74, 1999.
DOI : 10.1038/sj.bjc.6690420

E. Hammerlid, E. Silander, L. Hornestam, and M. Sullivan, Health-related quality of life three years after diagnosis of head and neck cancer?A longitudinal study, Head & Neck, vol.16, issue.2, pp.113-138, 2001.
DOI : 10.1200/JCO.1998.16.3.1188

N. Pourel, D. Peiffert, E. Lartigau, E. Desandes, E. Luporsi et al., Quality of life in long-term survivors of oropharynx carcinoma, International Journal of Radiation Oncology*Biology*Physics, vol.54, issue.3, pp.742-51, 2002.
DOI : 10.1016/S0360-3016(02)02959-0

S. Jabbari, H. Kim, and M. Feng, Matched case???control study of quality of life and xerostomia after intensity-modulated radiotherapy or standard radiotherapy for head-and-neck cancer: Initial report, International Journal of Radiation Oncology*Biology*Physics, vol.63, issue.3, pp.725-756, 2005.
DOI : 10.1016/j.ijrobp.2005.02.045

E. Pow, D. Kwong, A. Mcmillan, M. Wong, and J. Sham, Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized controlled clinical trial, International Journal of Radiation Oncology*Biology*Physics, vol.66, issue.4, pp.981-991, 2006.
DOI : 10.1016/j.ijrobp.2006.06.013

N. Lee, F. De-arruda, D. Puri, and S. Wolden, A comparison of intensity-modulated radiation therapy and concomitant boost radiotherapy in the setting of concurrent chemotherapy for locally advanced oropharyngeal carcinoma, International Journal of Radiation Oncology*Biology*Physics, vol.66, issue.4, pp.966-974, 2006.
DOI : 10.1016/j.ijrobp.2006.06.040

P. Braam, C. Terhaard, J. Roesink, and C. Raaijmakers, Intensity-modulated radiotherapy significantly reduces xerostomia compared with conventional radiotherapy, International Journal of Radiation Oncology*Biology*Physics, vol.66, issue.4, pp.975-980, 2006.
DOI : 10.1016/j.ijrobp.2006.06.045

M. Kam, S. Leung, and B. Zee, Prospective Randomized Study of Intensity-Modulated Radiotherapy on Salivary Gland Function in Early-Stage Nasopharyngeal Carcinoma Patients, Journal of Clinical Oncology, vol.25, issue.31, pp.4873-4882, 2007.
DOI : 10.1200/JCO.2007.11.5501

F. Fang, W. Tsai, and H. Chen, Intensity-modulated or conformal radiotherapy improves the quality of life of patients with nasopharyngeal carcinoma, Cancer, vol.61, issue.2, pp.313-334, 2007.
DOI : 10.1016/0360-3016(94)90104-X

L. Graff and . Desandes, Impact of Intensity-Modulated Radiotherapy on Health-Related Quality of Life for Head and Neck Cancer Patients: Matched-Pair Comparison with Conventional Radiotherapy, International Journal of Radiation Oncology*Biology*Physics, vol.67, issue.5, pp.1309-1317, 2007.
DOI : 10.1016/j.ijrobp.2006.11.012

M. Yao, L. Karnell, G. Funk, H. Lu, K. Dornfeld et al., Health-Related Quality-of-Life Outcomes Following IMRT Versus Conventional Radiotherapy for Oropharyngeal Squamous Cell Carcinoma, International Journal of Radiation Oncology*Biology*Physics, vol.69, issue.5, pp.1354-60, 2007.
DOI : 10.1016/j.ijrobp.2007.05.003

F. Fang, C. Chien, and W. Tsai, Quality of Life and Survival Outcome for Patients With Nasopharyngeal Carcinoma Receiving Three-Dimensional Conformal Radiotherapy vs. Intensity-Modulated Radiotherapy???A Longitudinal Study, International Journal of Radiation Oncology*Biology*Physics, vol.72, issue.2, pp.356-64, 2008.
DOI : 10.1016/j.ijrobp.2007.12.054

M. Vergeer, P. Doornaert, D. Rietveld, C. Leemans, B. Slotman et al., Intensity-Modulated Radiotherapy Reduces Radiation-Induced Morbidity and Improves Health-Related Quality of Life: Results of a Nonrandomized Prospective Study Using a Standardized Follow-Up Program, International Journal of Radiation Oncology*Biology*Physics, vol.74, issue.1, pp.1-8, 2009.
DOI : 10.1016/j.ijrobp.2008.07.059

C. Nutting, J. Morden, and K. Harrington, Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3

S. Van-der-plas, B. Hansen, and J. De-boer, Generic and disease-specific health related quality of life in non-cirrhotic, cirrhotic and transplanted liver patients: a cross-sectional study, BMC Gastroenterology, vol.10, issue.1, p.33, 2003.
DOI : 10.7182/prtr.10.4.e455k83x2n7j76l5

O. Morin, J. Chen, and M. Aubin, Dose calculation using megavoltage cone-beam CT, International Journal of Radiation Oncology*Biology*Physics, vol.67, issue.4
DOI : 10.1016/j.ijrobp.2006.10.048

S. Petit, W. Van-elmpt, P. Lambin, and A. Dekker, Dose recalculation in megavoltage cone-beam CT for treatment evaluation: Removal of cupping and truncation artefacts in scans of the thorax and abdomen, Radiotherapy and Oncology, vol.94, issue.3, pp.359-66, 2010.
DOI : 10.1016/j.radonc.2009.12.001

J. Aubry, J. Pouliot, and L. Beaulieu, Correction of megavoltage cone-beam CT images for dose calculation in the head and neck region, Medical Physics, vol.64, issue.3, pp.900-907, 2008.
DOI : 10.1016/j.ijrobp.2005.07.957

P. Castadot, X. Geets, J. Lee, N. Christian, and V. Gregoire, Assessment by a deformable registration method of the volumetric and positional changes of target volumes and organs at risk in pharyngo-laryngeal tumors treated with concomitant chemo-radiation, Radiotherapy and Oncology, vol.95, issue.2, pp.209-226, 2010.
DOI : 10.1016/j.radonc.2010.03.007

W. Van-elmpt, S. Nijsten, S. Petit, B. Mijnheer, P. Lambin et al., 3D In Vivo Dosimetry Using Megavoltage Cone-Beam CT and EPID Dosimetry, International Journal of Radiation Oncology*Biology*Physics, vol.73, issue.5, pp.1580-1587, 2009.
DOI : 10.1016/j.ijrobp.2008.11.051

C. Lee, K. Langen, and W. Lu, Assessment of Parotid Gland Dose Changes During Head and Neck Cancer Radiotherapy Using Daily Megavoltage Computed Tomography and Deformable Image Registration, International Journal of Radiation Oncology*Biology*Physics, vol.71, issue.5, pp.1563-71, 2008.
DOI : 10.1016/j.ijrobp.2008.04.013

J. Robar, A. Day, and J. Clancey, Spatial and Dosimetric Variability of Organs at Risk in Head-and-Neck Intensity-Modulated Radiotherapy, International Journal of Radiation Oncology*Biology*Physics, vol.68, issue.4, pp.1121-1151, 2007.
DOI : 10.1016/j.ijrobp.2007.01.030

L. Zhang, A. Garden, and J. Lo, Multiple regions-of-interest analysis of setup uncertainties for head-and-neck cancer radiotherapy, International Journal of Radiation Oncology*Biology*Physics, vol.64, issue.5, pp.1559-69, 2006.
DOI : 10.1016/j.ijrobp.2005.12.023

S. Van-kranen, S. Van-beek, C. Rasch, M. Van-herk, and J. Sonke, Setup Uncertainties of Anatomical Sub-Regions in Head-and-Neck Cancer Patients After Offline CBCT Guidance, International Journal of Radiation Oncology*Biology*Physics, vol.73, issue.5, pp.1566-73, 2009.
DOI : 10.1016/j.ijrobp.2008.11.035

B. Van-asselen, H. Dehnad, C. Raaijmakers, J. Roesink, J. Lagendijk et al., The dose to the parotid glands with IMRT for oropharyngeal tumors: the effect of reduction of positioning margins, Radiotherapy and Oncology, vol.64, issue.2, pp.197-204, 2002.
DOI : 10.1016/S0167-8140(02)00152-4

S. Van-beek, S. Van-kranen, and A. Mencarelli, First clinical experience with a multiple region of interest registration and correction method in radiotherapy of head-and-neck cancer patients, Radiotherapy and Oncology, vol.94, issue.2, pp.213-220, 2010.
DOI : 10.1016/j.radonc.2009.12.017

T. Clinique, I. , and P. ). , En cas de zone douteuse sur au moins 1 des modalités d'évaluation

C. Les, Ils ne doivent pas correspondre à une extension automatique des GTV (notamment pas de débord sur l'os ou dans l'air)

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@. Ctv2n and =. Gtvn, 5 mm (10 mm selon les cas) pour tenir compte du risque d'effraction capsulaire (quelque soit la taille de l'adénopathie)

M. Lapeyre, V. Marchesi, and A. Mege, Radioth??rapie conformationnelle avec modulation d'intensit?? des cancers des voies a??rodigestives sup??rieures avec irradiation bilat??rale du cou??: r??sultats pr??liminaires, Cancer/Radioth??rapie, vol.8, issue.3, pp.134-147, 2004.
DOI : 10.1016/j.canrad.2004.03.001

W. Hall, M. Guiou, and N. Lee, Development and Validation of a Standardized Method for Contouring the Brachial Plexus: Preliminary Dosimetric Analysis Among Patients Treated With IMRT for Head-and-Neck Cancer, International Journal of Radiation Oncology*Biology*Physics, vol.72, issue.5, pp.1362-1367, 2008.
DOI : 10.1016/j.ijrobp.2008.03.004

D. Soto, M. Kessler, and M. Piert, Correlation between pretreatment FDG-PET biological target volume and anatomical location of failure after radiation therapy for head and neck cancers, Radiotherapy and Oncology, vol.89, issue.1, pp.13-18, 2008.
DOI : 10.1016/j.radonc.2008.05.021

D. Cannon and N. Lee, Recurrence in Region of Spared Parotid Gland After Definitive Intensity-Modulated Radiotherapy for Head and Neck Cancer, International Journal of Radiation Oncology*Biology*Physics, vol.70, issue.3, pp.660-665, 2008.
DOI : 10.1016/j.ijrobp.2007.09.018

S. Apisarnthanarax, D. Elliott, and A. El-naggar, Determining optimal clinical target volume margins in head-and-neck cancer based on microscopic extracapsular extension of metastatic neck nodes, International Journal of Radiation Oncology*Biology*Physics, vol.64, issue.3, pp.678-683, 2006.
DOI : 10.1016/j.ijrobp.2005.08.020

V. Gregoire, A. Eisbruch, and M. Hamoir, Proposal for the delineation of the nodal CTV in the node-positive and the post-operative neck, Radiotherapy and Oncology, vol.79, issue.1, pp.15-20, 2006.
DOI : 10.1016/j.radonc.2006.03.009

A. Eisbruch, R. Foote, O. Sullivan, and B. , Intensity-modulated radiation therapy for head and neck cancer: Emphasis on the selection and delineation of the targets, Seminars in Radiation Oncology, vol.12, issue.3, pp.238-249, 2002.
DOI : 10.1053/srao.2002.32435

M. Lapeyre, P. Henrot, and M. Alfonsi, Proposition de s??lection et d??limitation des volumes cibles microscopiques p??ritumoraux dans les cancers de la cavit?? buccale et de l'oropharynx (aires ganglionnaires exclues), Cancer/Radioth??rapie, vol.9, issue.4, pp.261-270, 2005.
DOI : 10.1016/j.canrad.2005.03.005

F. Bidault, J. Bourhis, and B. Luboinski, ??tablissement des volumes cibles anatomocliniques (Clinical Target Volume) pour les cancers laryng??s en fonction de la localisation de d??part et des modalit??s d'extension, Cancer/Radioth??rapie, vol.9, issue.4, pp.271-279, 2005.
DOI : 10.1016/j.canrad.2005.05.003

K. Chao, F. Wippold, and G. Ozyigit, Determination and delineation of nodal target volumes for head-and-neck cancer based on patterns of failure in patients receiving definitive and postoperative IMRT, International Journal of Radiation Oncology*Biology*Physics, vol.53, issue.5, pp.1174-1184, 2002.
DOI : 10.1016/S0360-3016(02)02881-X

V. Gregoire, P. Levendag, and K. Ang, CT-based delineation of lymph node levels and related CTVs in the node-negative neck Recurrences near base of skull after IMRT for head-and-neck cancer: implications for target delineation in high neck and for parotid gland sparing Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer, Radiother Oncol Int J Radiat Oncol Biol Phys Int J Radiat Oncol Biol Phys, vol.695945, pp.227-23628, 1999.

J. Roesink, M. Moerland, and J. Battermann, Qantitative dose-volume response analysis of changes in parotid gland function after radiotheraphy in the head-and-neck region, International Journal of Radiation Oncology*Biology*Physics, vol.51, issue.4, pp.938-946, 2001.
DOI : 10.1016/S0360-3016(01)01717-5

K. Chao, J. Deasy, and J. Markman, A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results, International Journal of Radiation Oncology*Biology*Physics, vol.49, issue.4, pp.907-916, 2001.
DOI : 10.1016/S0360-3016(00)01441-3

M. Munter, C. Karger, and S. Hoffner, Evaluation of salivary gland function after treatment of head-and-neck tumors with intensity-modulated radiotherapy by quantitative pertechnetate scintigraphy, International Journal of Radiation Oncology*Biology*Physics, vol.58, issue.1, pp.175-184, 2004.
DOI : 10.1016/S0360-3016(03)01437-8

S. Chan, W. Ng, and K. Kam, Sensorineural Hearing Loss After Treatment of Nasopharyngeal Carcinoma: A Longitudinal Analysis, International Journal of Radiation Oncology*Biology*Physics, vol.73, issue.5, pp.1335-1342, 2009.
DOI : 10.1016/j.ijrobp.2008.07.034

C. Murdoch-kinch, H. Kim, and K. Vineberg, Dose-Effect Relationships for the Submandibular Salivary Glands and Implications for Their Sparing by Intensity Modulated Radiotherapy, International Journal of Radiation Oncology*Biology*Physics, vol.72, issue.2, pp.373-382, 2008.
DOI : 10.1016/j.ijrobp.2007.12.033

A. Eisbruch, M. Schwartz, and C. Rasch, Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: Which anatomic structures are affected and can they be spared by IMRT?, International Journal of Radiation Oncology*Biology*Physics, vol.60, issue.5, pp.741-7491425, 2004.
DOI : 10.1016/j.ijrobp.2004.05.050

P. Graff, M. Lapeyre, and E. Desandes, P3 The impact of intensity-modulated radiotherapy on health-related quality of life for head and neck cancer patients. Matched-pair comparison with conventional radiotherapy, Oral Oncology Supplement, vol.2, issue.1, pp.131-132, 2007.
DOI : 10.1016/S1744-7895(07)70281-X

. Titre, Préservation de la qualité de vie des patients traités pour un cancer des voies aérodigestives supérieures: apport de la radiothérapie conformationnelle avec modulation d'intensité

P. Graff, M. Lapeyre, and E. Desandes, Pr??servation delaqualit?? devie despatients trait??s pouruncancer desvoies a??rodigestives sup??rieures: apport delaradioth??rapie conformationnelle avecmodulation d'intensit??, Cancer/Radioth??rapie, vol.11, issue.6-7, pp.403-404, 2007.
DOI : 10.1016/j.canrad.2007.09.073

. Titre, Setup differences when using different IGRT alignment practices for head and neck IMRT patients

P. Graff, M. D. , *. Michel-lapeyre, M. D. , ?. Emmanuel-desandes et al., * Departments of *Radiation Oncology and ? Clinical Research

. Results, Two comparable groups (67 pairs) were available Better scores were observed on the head and neck cancer module QOL questionnaire for the IMRT group, especially for dry mouth and sticky saliva

R. Requests, P. Graff, and M. D. , Service de Radiothérapie , Centre Alexis Vautrin

. Fax, 3-83-59-83-91; E-mail: p.graff@nancy.fnclcc.fr Supported by the French League Against Cancer (Meuse De- partment) Conflict of interest: none, 2006.

. Imrt, The nonadjusted and adjusted POR was 3.89 (p 0.0003) and 4.20 (p 0.0008), respectively. Of the prevalent cases of " very much " sticky saliva, 34 (55.7%) and 11 (18.0%) were in the CRT and IMRT groups, respectively. The nonadjusted and adjusted POR was 4, 002), respectively. REFERENCES, pp.5-53

O. Wijers, P. Levendag, and M. Braaksma, Patients with head and neck cancer cured by radiation therapy: A survey of the dry mouth syndrome in long-term survivors, Head & Neck, vol.42, issue.8, pp.737-747, 2002.
DOI : 10.1016/S0360-3016(98)00224-7

F. Denis, P. Garaud, and E. Bardet, Final Results of the 94???01 French Head and Neck Oncology and Radiotherapy Group Randomized Trial Comparing Radiotherapy Alone With Concomitant Radiochemotherapy in Advanced-Stage Oropharynx Carcinoma, Journal of Clinical Oncology, vol.22, issue.1, pp.69-76, 2004.
DOI : 10.1200/JCO.2004.08.021

C. Clark, A. Bidmead, and C. Mubata, Intensity-modulated radiotherapy improves target coverage, spinal cord sparing and allows dose escalation in patients with locally advanced cancer of the larynx, Radiotherapy and Oncology, vol.70, issue.2, pp.189-198, 2004.
DOI : 10.1016/j.radonc.2003.10.012

M. Lapeyre, V. Marchesi, and A. Mege, Radioth??rapie conformationnelle avec modulation d'intensit?? des cancers des voies a??rodigestives sup??rieures avec irradiation bilat??rale du cou??: r??sultats pr??liminaires, Cancer/Radioth??rapie, vol.8, issue.3, pp.134-147, 2004.
DOI : 10.1016/j.canrad.2004.03.001

H. Pacholke, R. Amdur, and D. Louis, The Role of Intensity Modulated Radiation Therapy for Favorable Stage Tumor of the Nasal Cavity or Ethmoid Sinus, American Journal of Clinical Oncology, vol.28, issue.5, pp.474-478, 2005.
DOI : 10.1097/01.coc.0000182600.51019.de

D. Huang, P. Xia, and P. Akazawa, Comparison of treatment plans using intensity-modulated radiotherapy and three-dimensional conformal radiotherapy for paranasal sinus carcinoma, International Journal of Radiation Oncology*Biology*Physics, vol.56, issue.1, pp.158-168, 2003.
DOI : 10.1016/S0360-3016(03)00080-4

M. Parliament, M. Alidrisi, and M. Munroe, Implications of radiation dosimetry of the mandible in patients with carcinomas of the oral cavity and nasopharynx treated with intensity modulated radiation therapy, International Journal of Oral and Maxillofacial Surgery, vol.34, issue.2, pp.114-121, 2005.
DOI : 10.1016/j.ijom.2004.06.013

N. Aaronson, S. Ahmedzai, and B. Bergman, The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology, JNCI Journal of the National Cancer Institute, vol.85, issue.5, pp.365-376, 1993.
DOI : 10.1093/jnci/85.5.365

M. Hjermstad, P. Fayers, and K. Bjordal, Health-related quality of life in the general Norwegian population assessed by the European Organization for Research and Treatment of Cancer Core Quality-of-Life Questionnaire: the QLQ=C30 (+ 3)., Journal of Clinical Oncology, vol.16, issue.3, pp.1188-1196, 1998.
DOI : 10.1200/JCO.1998.16.3.1188

K. Bjordal, E. Hammerlid, and M. Ahlner-elmqvist, Quality of Life in Head and Neck Cancer Patients: Validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-H&N35, Journal of Clinical Oncology, vol.17, issue.3, pp.1008-1019, 1999.
DOI : 10.1200/JCO.1999.17.3.1008

K. Bjordal, A. De-graeff, and P. Fayers, for the EORTC Quality of Life Group A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H&N35)

A. Sherman, S. Simonton, and D. Adams, Assessing Quality of Life in Patients With Head and Neck Cancer, Archives of Otolaryngology???Head & Neck Surgery, vol.126, issue.4, pp.459-467, 2000.
DOI : 10.1001/archotol.126.4.459

N. Aaronson, P. Fayers, and K. Bjordal, The EORTC QLQ- C30 Scoring Manual Belgium: European Organisation for Research and Treatment of Cancer, 2001.

M. Hjermstad, P. Fayers, and K. Bjordal, Using reference data on quality of life???the importance of adjusting for age and gender, exemplified by the EORTC QLQ-C30 (+3), European Journal of Cancer, vol.34, issue.9, pp.1381-1389, 1998.
DOI : 10.1016/S0959-8049(98)00136-1

C. Zocchetti, D. Consonni, and P. Bertazzi, Relationship between prevalence rate ratios and odds ratios in cross-sectional studies., International Journal of Epidemiology, vol.26, issue.1, pp.220-223, 1997.
DOI : 10.1093/ije/26.1.220

J. Malouf, C. Aragon, and B. Henson, Influence of parotid-sparing radiotherapy on xerostomia in head and neck cancer patients, Cancer Detection and Prevention, vol.27, issue.4, pp.305-310, 2003.
DOI : 10.1016/S0361-090X(03)00095-3

A. Lin, H. Kim, and J. Terrell, Quality of life after parotid-sparing IMRT for head-and-neck cancer: A prospective longitudinal study, International Journal of Radiation Oncology*Biology*Physics, vol.57, issue.1, pp.61-70, 2003.
DOI : 10.1016/S0360-3016(03)00361-4

M. Parliament, R. Scrimger, and S. Anderson, Preservation of oral health???related quality of life and salivary flow rates after inverse-planned intensity- modulated radiotherapy (IMRT) for head-and-neck cancer, International Journal of Radiation Oncology*Biology*Physics, vol.58, issue.3, pp.663-673, 2004.
DOI : 10.1016/S0360-3016(03)01571-2

N. Pourel, D. Peiffert, and E. Lartigau, Quality of life in long-term survivors of oropharynx carcinoma, International Journal of Radiation Oncology*Biology*Physics, vol.54, issue.3, pp.742-751, 2002.
DOI : 10.1016/S0360-3016(02)02959-0

S. Van-der-plas, B. Hansen, and J. De-boer, Generic and disease-specific health related quality of life in non-cirrhotic, cirrhotic and transplanted liver patients: a cross-sectional study, BMC Gastroenterology, vol.10, issue.1, p.33, 2003.
DOI : 10.7182/prtr.10.4.e455k83x2n7j76l5

P. Rauch, J. Miny, and T. Conroy, Quality of Life Among Disease-Free Survivors of Rectal Cancer, Journal of Clinical Oncology, vol.22, issue.2, pp.354-360, 2004.
DOI : 10.1200/JCO.2004.03.137

S. Bowker, S. Pohar, and J. Johnson, A cross-sectional study of health-related quality of life deficits in individuals with comorbid diabetes and cancer, Health and Quality of Life Outcomes, vol.4, issue.1, p.17, 2006.
DOI : 10.1186/1477-7525-4-17

P. Allison, D. Locker, and S. Wood-dauphinee, Correlates of health-related quality of life in upper aerodigestive tract cancer patients, Quality of Life Research, vol.7, issue.8, pp.713-722, 1998.
DOI : 10.1023/A:1008880816543

C. Gotay and T. Moore, Assessing quality of life in head and neck cancer, Quality of Life Research, vol.42, issue.1, pp.5-17, 1992.
DOI : 10.1038/bjc.1988.20

P. Huguenin, D. Taussky, and K. Moe, Quality of life in patients cured from a carcinoma of the head and neck by radiotherapy: the importance of the target volume, International Journal of Radiation Oncology*Biology*Physics, vol.45, issue.1, pp.47-52, 1999.
DOI : 10.1016/S0360-3016(99)00128-5

J. Epstein, M. Robertson, and S. Emerton, Quality of life and oral function in patients treated with radiation therapy for head and neck cancer, Head & Neck, vol.58, issue.5, pp.389-398, 2001.
DOI : 10.1002/(SICI)1097-0347(199611/12)18:6<487::AID-HED1>3.0.CO;2-Z

M. List, A. Siston, and D. Haraf, Quality of Life and Performance in Advanced Head and Neck Cancer Patients on Concomitant Chemoradiotherapy: A Prospective Examination, Journal of Clinical Oncology, vol.17, issue.3, pp.1020-1028, 1999.
DOI : 10.1200/JCO.1999.17.3.1020

E. Hammerlid, E. Silander, and L. Hornestam, Health-related quality of life three years after diagnosis of head and neck cancer?A longitudinal study, Head & Neck, vol.16, issue.2, pp.113-125, 2001.
DOI : 10.1200/JCO.1998.16.3.1188

K. Bjordal, M. Ahlner-elmqvist, and E. Hammerlid, A Prospective Study of Quality of Life in Head and Neck Cancer Patients. Part II: Longitudinal Data, The Laryngoscope, vol.80, issue.8, pp.1440-1452, 2001.
DOI : 10.1038/sj.bjc.6690420

H. Abendstein, M. Nordgren, and M. Boysen, Quality of Life and Head and Neck Cancer: A 5 Year Prospective Study, The Laryngoscope, vol.56, issue.12, pp.2183-2192, 2005.
DOI : 10.1097/01.MLG.0000181507.69620.14

B. Henson, M. Inglehart, and A. Eisbruch, Preserved salivary output and xerostomia-related quality of life in head and neck cancer patients receiving parotid-sparing radiotherapy, Oral Oncology, vol.37, issue.1, pp.84-93, 2001.
DOI : 10.1016/S1368-8375(00)00063-4

S. Jabbari, H. Kim, and M. Feng, Matched case???control study of quality of life and xerostomia after intensity-modulated radiotherapy or standard radiotherapy for head-and-neck cancer: Initial report, International Journal of Radiation Oncology*Biology*Physics, vol.63, issue.3, pp.725-731, 2005.
DOI : 10.1016/j.ijrobp.2005.02.045

A. Eisbruch, T. Haken, R. Kim, and H. , Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer, International Journal of Radiation Oncology*Biology*Physics, vol.45, issue.3, pp.577-587, 1999.
DOI : 10.1016/S0360-3016(99)00247-3

J. Roesink, M. Moerland, and J. Battermann, Qantitative dose-volume response analysis of changes in parotid gland function after radiotheraphy in the head-and-neck region, International Journal of Radiation Oncology*Biology*Physics, vol.51, issue.4, pp.938-946, 2001.
DOI : 10.1016/S0360-3016(01)01717-5

K. Chao, J. Deasy, and J. Markman, A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results, International Journal of Radiation Oncology*Biology*Physics, vol.49, issue.4, pp.907-916, 2001.
DOI : 10.1016/S0360-3016(00)01441-3

M. Munter, C. Karger, and S. Hoffner, Evaluation of salivary gland function after treatment of head-and-neck tumors with intensity-modulated radiotherapy by quantitative pertechnetate scintigraphy, International Journal of Radiation Oncology*Biology*Physics, vol.58, issue.1, pp.175-184, 2004.
DOI : 10.1016/S0360-3016(03)01437-8

L. Bedford, Treatment planning for volumetric modulated arc therapy, Medical Physics, vol.90, issue.11, pp.5128-5138, 2009.
DOI : 10.1016/j.radonc.2008.11.009

G. Feygelman, C. Zhang, and . Stevens, Initial dosimetric evaluation of SmartArc - a novel VMAT treatment planning module implemented in a multi-vendor delivery chain, Journal of Applied Clinical Medical Physics, vol.49, issue.13, pp.99-116, 2010.
DOI : 10.1088/0031-9155/49/13/012

Y. Keane, M. Xiao, and . Machtay, Daily image guidance with cone-beam computed tomography for head-and-neck cancer intensity-modulated radiotherapy: A prospective study, Int. J. Radiat. Oncol., Biol., Phys, vol.76, pp.1353-1359, 2010.

Y. Zhang, R. Gong, Q. Zhong, and . Jiang, The clinical feasibility and effect of online cone beam computer tomography-guided intensitymodulated radiotherapy for nasopharyngeal cancer, Radiother. Oncol, vol.90, pp.221-227, 2009.

F. Aubry, J. Pouliot, and L. Beaulieu, Correction of megavoltage conebeam CT images for dose calculation in the head and neck region

. Pouliot, Dose recalculation and the dose-guided radiation therapy DGRT process using megavoltage cone-beam CT, Int. J. Radiat. Oncol ., Biol., Phys, vol.74, pp.583-592, 2009.

. Pouliot, Correction of megavoltage cone-beam CT images of the pelvic region based on phantom measurements for dose calculation purposes, J

D. A. Low, W. B. Harms, S. Mutic, and J. A. Purdy, A technique for the quantitative evaluation of dose distributions, Medical Physics, vol.23, issue.5, pp.656-661, 1998.
DOI : 10.1118/1.597714

J. Aubry and J. Pouliot, Imaging changes in radiation therapy: Does it matter?, Imaging Decisions MRI, vol.121, pp.3-4

J. Pouliot, W. Hu, J. Cheung, T. Boettger, S. Yom et al., Quality control of head & neck delivered dose using 3D dose recalculation with megavoltage cone-beam CT Practical cone-beam algorithm Megavoltage cone-beam CT: System description and clinical applications Decomposition of pencil beam kernels for fast dose calculations in three-dimensional treatment planning, Differential pencil beam dose computation model for photons, pp.639-640, 1984.

C. R. Maurer, J. , R. Qi, and V. Raghavan, A linear time algorithm for computing exact Euclidean distance transforms of binary images in arbitrary dimensions, IEEE Transactions on Pattern Analysis and Machine Intelligence, vol.25, issue.2, pp.6-11, 2003.
DOI : 10.1109/TPAMI.2003.1177156