Y. Bakhle, Conversion of Angiotensin I to Angiotensin II by Cell-free Extracts of Dog Lung, Nature, vol.220, issue.5170, pp.919-940, 1968.
DOI : 10.1038/220919a0

A. Balaban, Highly discriminating distance-based topological index, Chemical Physics Letters, vol.89, issue.5, pp.399-404, 1982.
DOI : 10.1016/0009-2614(82)80009-2

B. Baldo and M. Fisher, Anaphylaxis to muscle relaxant drugs: Cross-reactivity and molecular basis of binding of IgE antibodies detected by radioimmunoassay, Molecular Immunology, vol.20, issue.12, pp.1393-400, 1983.
DOI : 10.1016/0161-5890(83)90171-2

B. Baldo and M. Fisher, Substituted ammonium ions as allergenic determinants in drug allergy, Nature, vol.4, issue.5940, pp.262-266, 1983.
DOI : 10.1016/S0021-9673(01)94777-6

B. Baldo and M. Fisher, Mechanisms in IgE-dependent anaphylaxis to anaesthetic drugs, Annales Fran??aises d'Anesth??sie et de R??animation, vol.12, issue.2, pp.131-171, 1993.
DOI : 10.1016/S0750-7658(05)81022-6

B. Baldo and N. Pham, Structure-Activity Studies on Drug-Induced Anaphylactic Reactions, Chemical Research in Toxicology, vol.7, issue.6
DOI : 10.1021/tx00042a001

B. Baldo, N. Pham, and J. Weiner, Detection and side-chain specificity of IgE antibodies to flucloxicillin in allergic subjects, Journal of Molecular Recognition, vol.18, issue.3, pp.171-178, 1995.
DOI : 10.1159/000234435

B. Baldo, Diagnosis of Allergy to Penicillins and Cephalosporins, Allergy & Clinical Immunology International - Journal of the World Allergy Organization, vol.12, issue.5, pp.206-218, 2000.
DOI : 10.1027/0838-1925.12.5.206

B. Baldo, M. Fisher, and N. Pham, On the origin and specificity of antibodies to neuromuscular blocking (muscle relaxant) drugs: an immunochemical perspective, Clinical & Experimental Allergy, vol.39, issue.3, pp.325-369, 2009.
DOI : 10.1007/978-3-642-69088-4_3

A. Barbaud, P. Trechot, F. Weber-muller, G. Ulrich, N. Commun et al., Drug skin tests in cutaneous adverse drug reactions to pristinamycin: 29 cases with a study of cross-reactions between synergistins, Contact Dermatitis, vol.40, issue.1, pp.22-28, 2004.
DOI : 10.1046/j.1365-2133.1998.02313.x

M. Barratt, D. Basketter, M. Chamberlain, G. Admans, and J. Langowski, An expert system rulebase for identifying contact allergens, Toxicology in Vitro, vol.8, issue.5, pp.1053-60, 1994.
DOI : 10.1016/0887-2333(94)90244-5

D. Basketter, G. Gerberick, and I. Kimber, Measurement of allergenic potency using the local lymph node assay, Trends in Pharmacological Sciences, vol.22, issue.6, pp.264-269, 2001.
DOI : 10.1016/S0165-6147(00)01704-1

B. Begaud, J. Evreux, J. Jouglard, and G. Lagier, Imputabilité des effets inattendus ou toxiques des medicaments : actualisation de la méthode utilisée en France, Therapie, vol.40, pp.111-119, 1985.

M. Bellin and A. Van-der-molen, Extracellular gadolinium-based contrast media: An overview, European Journal of Radiology, vol.66, issue.2
DOI : 10.1016/j.ejrad.2008.01.023

M. Blanca, J. Cornejo-garcia, M. Torres, and C. Mayorga, Specificities of B cell reactions to drugs, Toxicology, vol.209, issue.2, pp.181-185, 2005.
DOI : 10.1016/j.tox.2004.12.018

J. Brange, D. Owens, S. Kang, and A. Volund, Monomeric Insulins and Their Experimental and Clinical Implications, Diabetes Care, vol.13, issue.9, pp.923-54, 1990.
DOI : 10.2337/diacare.13.9.923

A. Brik and C. Wong, HIV-1 protease: mechanism and drug discovery, Organic & Biomolecular Chemistry, vol.1, issue.1, pp.5-14, 2003.
DOI : 10.1039/b208248a

K. Brockow, A. Romano, M. Blanca, J. Ring, W. Pichler et al., General considerations for skin test procedures in the diagnosis of drug hypersensitivity, Allergy, vol.57, pp.45-51, 2002.

L. Byers and R. Wolfenden, Binding of the by-product analog benzylsuccinic acid by carboxypeptidase A, Biochemistry, vol.12, issue.11, pp.2070-2078, 1973.
DOI : 10.1021/bi00735a008

S. Cho, W. Zheng, and A. Tropsha, Focus-2D: a new approach to the design of targeted combinatorial chemical libraries, Pac Symp Biocomput, pp.305-321, 1998.

C. Christiansen, X-ray contrast media???an overview, Toxicology, vol.209, issue.2, pp.185-192, 2005.
DOI : 10.1016/j.tox.2004.12.020

S. Coopman and H. Degreef, Identification of cross-reaction patterns in allergic contact dermatitis from topical corticosteroids, British Journal of Dermatology, vol.26, issue.564, pp.27-34, 1989.
DOI : 10.1007/978-3-642-67807-3_33

A. Crum-brown and T. Fraser, V.???On the Connection between Chemical Constitution and Physiological Action. Part. I.???On the Physiological Action of the Salts of the Ammonium Bases, derived from Strychnia, Brucia, Thebaia, Codeia, Morphia, and Nicotia, Transactions of the Royal Society of Edinburgh, vol.lxxxix, issue.01, pp.151-203, 1868.
DOI : 10.1017/S0080456800028155

D. Cushman and M. Ondetti, History of the design of captopril and related inhibitors of angiotensin converting enzyme, Hypertension, vol.17, issue.4, pp.589-92, 1991.
DOI : 10.1161/01.HYP.17.4.589

J. Hadley, Cephalosporin use in treatment of patients with penicillin allergies, J Am Pharm Assoc, vol.48, pp.530-570, 2008.

J. Charpin and D. Vervloet, Role of the quaternary ammonium ion determinants in allergy to muscle relaxants, J Allergy Clin Immunol, vol.79, pp.578-84, 1987.

G. Dupuis and C. Benezra, Allergic contact dermatitis to simple chemicals. A molecular approach

L. Clerck and W. Stevens, Flow-assisted allergy diagnosis: current applications and future perspectives, Allergy, vol.61, pp.1028-1067, 2006.

E. Estrada, G. Patlewicz, M. Chamberlain, D. Basketter, and S. Larbey, Computer-Aided Knowledge Generation for Understanding Skin Sensitization Mechanisms: The TOPS-MODE Approach, Chemical Research in Toxicology, vol.16, issue.10, pp.1226-1261, 2003.
DOI : 10.1021/tx034093k

E. Estrada, G. Patlewicz, and Y. Gutierrez, From Knowledge Generation to Knowledge Archive. A General Strategy Using TOPS-MODE with DEREK To Formulate New Alerts for Skin Sensitization, Journal of Chemical Information and Computer Sciences, vol.44, issue.2, pp.688-98, 2004.
DOI : 10.1021/ci0342425

S. Ferreira, A BRADYKININ-POTENTIATING FACTOR (BPF) PRESENT IN THE VENOM OF BOTHROPS JARARACA, British Journal of Pharmacology and Chemotherapy, vol.200, issue.suppl. 1, pp.163-172, 1965.
DOI : 10.1111/j.1749-6632.1963.tb17664.x

T. Fischer and H. Maibach, Patch testing in allergic contact dermatitis: an update, Sem Dermatol, vol.5, pp.214-238, 1986.

J. Flacke, W. Flacke, B. Bloor, A. Van-etton, and B. Kripke, Histamine Release by Four Narcotics, Anesthesia & Analgesia, vol.66, issue.8, pp.723-753, 1987.
DOI : 10.1213/00000539-198708000-00005

E. Florvaag, Anaphylactic reactions during general anaesthesia, New Horiz, vol.2, pp.1-6, 2005.

E. Florvaag, S. Johansson, H. Öman, T. Harboe, and A. Nopp, Pholcodine stimulates a dramatic increase of IgE in IgE-sensitized individuals. A pilot study, Allergy, vol.61, issue.1, pp.49-55, 2006.
DOI : 10.1111/j.1398-9995.2005.00870.x

E. Florvaag and S. Johansson, The Pholcodine Story, Immunology and Allergy Clinics of North America, vol.29, issue.3, pp.419-446, 2009.
DOI : 10.1016/j.iac.2009.04.002

S. Free and J. Wilson, A Mathematical Contribution to Structure-Activity Studies, Journal of Medicinal Chemistry, vol.7, issue.4, pp.395-404, 1964.
DOI : 10.1021/jm00334a001

T. Fujita, J. Iwasa, and C. Hansch, A New Substituent Constant, ??, Derived from Partition Coefficients, Journal of the American Chemical Society, vol.86, issue.23, pp.5175-80, 1964.
DOI : 10.1021/ja01077a028

H. Gao and J. Bajorath, Comparison of binary and 2D QSAR analyses using inhibitors of human carbonic anhydrase II as a test case, Molecular Diversity, vol.4, issue.2, pp.115-145, 1999.
DOI : 10.1023/A:1026449704559

B. Goodwin and D. Roberts, Structure-activity relationships in allergic contact dermatitis, Food and Chemical Toxicology, vol.24, issue.6-7, pp.795-803, 1986.
DOI : 10.1016/0278-6915(86)90188-2

S. Green and G. Marshall, 3D-QSAR: a current perspective, Trends in Pharmacological Sciences, vol.16, issue.9, p.285, 1995.
DOI : 10.1016/S0165-6147(00)89052-5

L. Hall and L. Kier, Structure???Activity Studies Using Valence Molecular Connectivity, Journal of Pharmaceutical Sciences, vol.66, issue.5, pp.642-646, 1977.
DOI : 10.1002/jps.2600660509

L. Hammett, The Effect of Structure upon the Reactions of Organic Compounds. Benzene Derivatives, Journal of the American Chemical Society, vol.59, issue.1, p.96, 1937.
DOI : 10.1021/ja01280a022

C. Hansch, P. Maloney, T. Fujita, and R. Muir, Correlation of Biological Activity of Phenoxyacetic Acids with Hammett Substituent Constants and Partition Coefficients, Nature, vol.26, issue.4824, pp.178-80, 1962.
DOI : 10.1021/cr60165a003

C. Hansch and T. Fujita, -??-?? Analysis. A Method for the Correlation of Biological Activity and Chemical Structure, Journal of the American Chemical Society, vol.86, issue.8, pp.1616-1642, 1964.
DOI : 10.1021/ja01062a035

D. Harle, B. Baldo, and J. Well, Drugs as allergens: Detection and combining site specificities of IgE antibodies to sulfamethoxazole, Molecular Immunology, vol.25, issue.12, pp.1347-54, 1988.
DOI : 10.1016/0161-5890(88)90050-8

D. Harle, B. Baldo, N. Coroneos, and M. Fisher, Anaphylaxis following Administration of Papaveretum. Case Report, Anesthesiology, vol.71, issue.4, pp.489-94, 1989.
DOI : 10.1097/00000542-198910000-00003

D. Harle and B. Baldo, Identification of penicillin allergenic determinants that bind IgE antibodies in the sera of subjects with penicillin allergy, Molecular Immunology, vol.27, issue.11, pp.1063-71, 1990.
DOI : 10.1016/0161-5890(90)90094-G

F. Hasdenteufel, S. Luyasu, J. Renaudin, P. Trechot, and G. Kanny, Anaphylactic Shock Associated with Cefuroxime Axetil: Structure???Activity Relationships, Annals of Pharmacotherapy, vol.54, issue.6, pp.1069-72, 2007.
DOI : 10.1093/clinids/8.Supplement_3.S237

D. Vautrin and G. Kanny, Anaphylactic shock after first exposure to gadoterate meglumine: two case reports documented by positive allergy assessment, J Allergy Clin Immunol Reply. J Allergy Clin Immunol, vol.121, issue.122, pp.527-8216, 2008.

F. Hasdenteufel, J. Waton, V. Cordebar, M. Studer, O. Collignon et al., Delayed hypersensitivity reactions cause by iodixanol: an assessment of cross-reactivity in 22 patients, J Allergy Clin Immunol, 2011.

M. Hauessler, Safety and patient comfort with iodixanol: A postmarketing surveillance study in 9515 patients undergoing diagnostic CT examinations, Acta Radiologica, vol.51, issue.8, pp.924-957, 2010.
DOI : 10.3109/02841851.2010.504739

C. Herborn, E. Honold, M. Wolf, J. Kemper, S. Kinner et al., Clinical Safety and Diagnostic Value of the Gadolinium Chelate Gadoterate Meglumine (Gd-DOTA), Investigative Radiology, vol.42, issue.1, pp.58-62, 2007.
DOI : 10.1097/01.rli.0000248893.01067.e5

H. Hosoya, Topological Index. A Newly Proposed Quantity Characterizing the Topological Nature of Structural Isomers of Saturated Hydrocarbons, Bulletin of the Chemical Society of Japan, vol.44, issue.9, pp.2332-2341, 1971.
DOI : 10.1246/bcsj.44.2332

M. Isaksson, M. Bruze, A. Goossens, and J. Lepoittevin, Patch-testing with Serial Dilutions of Tixocortol Pivalate and Potential Cross-reactive Substances, Acta Dermato-Venereologica, vol.80, issue.1, pp.33-41, 2000.
DOI : 10.1080/000155500750012496

J. Sainte-laudy and D. Moneret-vautrin, T cell-mediated reactions to iodinated contrast media: Evaluation by skin and lymphocyte activation tests, J Allergy Clin Immunol, vol.115, pp.179-85, 2005.

A. Karlberg, M. Bergström, A. Börje, K. Luthman, and J. Nilsson, Allergic Contact Dermatitis??????Formation, Structural Requirements, and Reactivity of Skin Sensitizers, Chemical Research in Toxicology, vol.21, issue.1, pp.53-69, 2008.
DOI : 10.1021/tx7002239

L. Kier and L. Hall, Molecular connectivity in chemistry and drug research

L. Kier and L. Hall, Molecular connectivity in structure-activity analysis, 1986.

S. Kim, J. Choi, and H. Park, Heterogeneity of the IgE response to allergenic determinants of cefaclor in serum samples from patients with cefaclor-induced anaphylaxis, Annals of Allergy, Asthma & Immunology, vol.94, issue.6, pp.700-704, 2005.
DOI : 10.1016/S1081-1206(10)61331-2

I. Kimber, J. Hilton, R. Dearman, G. Gerberick, C. Ryan et al., An international evaluation of the murine local lymph node assay and comparison of modified procedures, Toxicology, vol.103, issue.1, pp.63-73, 1995.
DOI : 10.1016/0300-483X(95)03114-U

H. Kubinyi, 3D-QSAR in drug design: theory, methods and applications, 1993.

G. Kuerzel, U. Shukla, H. Scholtz, S. Pretorius, D. Wessels et al., Biotransformation of insulin glargine after subcutaneous injection in healthy subjects, Current Medical Research and Opinion, vol.19, issue.1, pp.34-40, 2003.
DOI : 10.1185/030079902125001416

D. Kumar, Immunoreactivity of Insulin Antibodies in Insulin-treated Diabetics: Significance of the Beta-chain Carboxyterminal Amino Acid (B-30) of Insulin, Diabetes, vol.28, issue.11, pp.994-1000, 1979.
DOI : 10.2337/diab.28.11.994

K. Landsteiner and J. Jacobs, STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS. II, Journal of Experimental Medicine, vol.64, issue.4, pp.625-664, 1936.
DOI : 10.1084/jem.64.4.625

J. Lepoittevin, J. Drieghe, and A. Dooms-goossens, Studies in patients with corticosteroid contact allergy. Understanding cross-reactivity among different steroids, Archives of Dermatology, vol.131, issue.1, pp.31-38, 1995.
DOI : 10.1001/archderm.131.1.31

J. Lepoittevin, Development of structure-activity relationships (SARs) in allergic contact dermatitis, Cell Biology and Toxicology, vol.15, issue.1, pp.47-55, 1999.
DOI : 10.1023/A:1007502723275

B. Levine, Immunologic Mechanisms of Penicillin Allergy, New England Journal of Medicine, vol.275, issue.20, pp.1115-1140, 1966.
DOI : 10.1056/NEJM196611172752009

A. Li, C. Wong, M. Wong, C. Lee, A. Yeung et al., Acute adverse reactions to magnetic resonance contrast media ??? gadolinium chelates, The British Journal of Radiology, vol.79, issue.941, pp.368-71, 2006.
DOI : 10.2214/ajr.159.4.1529856

Y. Li, Y. Tseng, D. Pan, J. Liu, P. Kern et al., 4D-Fingerprint Categorical QSAR Models for Skin Sensitization Based on the Classification of Local Lymph Node Assay Measures, Chemical Research in Toxicology, vol.20, issue.1, pp.114-142, 2007.
DOI : 10.1021/tx6002535

P. Magee, J. Hostynek, and M. Maibach, A Classification Model for Allergic Contact Dermatitis, QSAR & Combinatorial Science, vol.283, issue.1
DOI : 10.1021/ci00037a002

S. Marcy and J. Klein, The isoxazolyl penicillins: oxacillin, cloxacillin and dicloxacillin, Med Clin North Am, vol.54, pp.1127-1170, 1970.

G. Marshall, R. Cramer, and . Iii, Three-dimensional structure-activity relationships, Trends in Pharmacological Sciences, vol.9, issue.8, 1988.
DOI : 10.1016/0165-6147(88)90012-0

Y. Martin, Quantitative drug design, 1978.
DOI : 10.1201/9781420071009

J. Mayer, F. Zhang, and R. Dimarchi, Insulin structure and function, Biopolymers, vol.7, issue.5, pp.687-713, 2007.
DOI : 10.1016/S0140-6736(87)92619-5

J. Frendt, D. Brezeanu, M. Bouaziz, H. Guéant, and J. , Hypersensitivity reactions to neuromuscular blocking agents, Curr Pharm Des, vol.14, pp.2809-2834, 2008.

A. Peranesthésiques, Anaphylaxis during anesthesia in France: an 8-year national survey, J Allergy Clin Immunol, 2011.

H. Meyer and . Zur-theorie-der-alkoholnarkose, Zur Theorie der Alkoholnarkose, Archiv f??r Experimentelle Pathologie und Pharmakologie, vol.XXXVI, issue.2-4, p.109, 1899.
DOI : 10.1007/BF01834479

N. Moore, G. Paux, B. Begaud, M. Biour, E. Loupi et al., ADVERSE DRUG REACTION MONITORING: DOING IT THE FRENCH WAY, The Lancet, vol.326, issue.8463, pp.1056-1064, 1985.
DOI : 10.1016/S0140-6736(85)90918-3

S. Morcos, Extracellular gadolinium contrast agents: Differences in stability, European Journal of Radiology, vol.66, issue.2, pp.175-184, 2008.
DOI : 10.1016/j.ejrad.2008.01.025

M. Lima, L. Barreiro, and E. , Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design, Current Medicinal Chemistry, vol.12, issue.1, pp.23-49, 2005.
DOI : 10.2174/0929867053363540

M. Morisset, D. Moneret-vautrin, V. Loppinet, and S. Grandidier, Cross-allergy to ranitidine and nizatidine, Allergy, vol.102, issue.7, pp.682-685, 2000.
DOI : 10.1016/S0002-9343(96)00356-7

D. Naisbitt, Drug hypersensitivity reactions in skin: understanding mechanisms and the development of diagnostic and predictive tests, Toxicology, vol.194, issue.3, pp.179-96, 2004.
DOI : 10.1016/j.tox.2003.09.004

C. Naranjo, U. Busto, and E. Sellers, A method for estimating the probability of adverse drug reactions, Clinical Pharmacology and Therapeutics, vol.30, issue.2, pp.239-284, 1981.
DOI : 10.1038/clpt.1981.154

P. Darke and J. Springer, Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1, Nature, vol.337, pp.615-635, 1989.

H. Neu, ??-Lactam Antibiotics: Structural Relationships Affecting in Vitro Activity and Pharmacologic Properties, Clinical Infectious Diseases, vol.8, issue.Supplement_3, pp.237-59, 1986.
DOI : 10.1093/clinids/8.Supplement_3.S237

A. Neugut, A. Ghatak, and R. Miller, Anaphylaxis in the United States, Archives of Internal Medicine, vol.161, issue.1, pp.15-21, 2001.
DOI : 10.1001/archinte.161.1.15

A. Novalbos, J. Sastre, J. Cuesta, D. Las-heras, M. Lluch-bernal et al., Lack of allergic cross-reactivity to cephalosporins among patients allergic to penicillins, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.137, issue.3, pp.438-481, 2001.
DOI : 10.1016/S0140-6736(99)00449-3

M. Ondetti, R. B. Cushman, and D. , Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents, Science, vol.196, issue.4288, pp.441-445, 1977.
DOI : 10.1126/science.191908

M. Patlak, From viper???s venom to drug design: treating hypertension, The FASEB Journal, vol.18, issue.3, p.421, 2004.
DOI : 10.1096/fj.03-1398bkt

G. Patrick, An introduction to medicinal chemistry, 2001.

R. Patterson, M. Roberts, and L. Grammer, Insulin allergy: re-evaluation after two decades, Ann Allergy, vol.64, pp.459-62, 1990.

N. Pham and B. Baldo, ??-Lactam drug allergens: Fine structural recognition patterns of cephalosporin-reactive IgE antibodies, Journal of Molecular Recognition, vol.18, issue.4, pp.287-96, 1996.
DOI : 10.1159/000230197

M. Pichichero, A Review of Evidence Supporting the American Academy of Pediatrics Recommendation for Prescribing Cephalosporin Antibiotics for Penicillin-Allergic Patients, PEDIATRICS, vol.115, issue.4, pp.1048-57, 2005.
DOI : 10.1542/peds.2004-1276

S. Poston, H. Jennings, and K. Poe, Cefazolin Tolerance Does Not Predict Ceftriaxone Hypersensitivity: Unique Side Chains Precipitate Anaphylaxis, Pharmacotherapy, vol.8, issue.5, pp.668-72, 2004.
DOI : 10.1016/S1081-1206(10)62893-1

M. Randi?, Characterization of molecular branching, Journal of the American Chemical Society, vol.97, issue.23, pp.6609-6624, 1975.
DOI : 10.1021/ja00856a001

J. Renaudin, G. Kanny, F. Codreanu, E. Beaudouin, and D. Moneret-vautrin, Severe Drug-Induced Anaphylaxis: Survey of Case Reports by Allergy Vigilance Network, Journal of Allergy and Clinical Immunology, vol.119, issue.1, p.36, 2007.
DOI : 10.1016/j.jaci.2006.11.160

I. Riezzo, S. Bello, M. Neri, E. Turillazzi, and V. Fineschi, Ceftriaxone intradermal test-related fatal anaphylactic shock: a medico-legal nightmare, Allergy, vol.121, issue.1, pp.130-139, 2010.
DOI : 10.1016/j.jaci.2007.08.061

D. Roberts and D. Williams, The derivation of quantitative correlations between skin sensitisation and physio-chemical parameters for alkylating agents, and their application to experimental data for sultones, Journal of Theoretical Biology, vol.99, issue.4, pp.807-832, 1982.
DOI : 10.1016/0022-5193(82)90199-0

A. Ritchie, D. Taylor, G. Thomas, and P. Machin, Rational design of peptide-based HIV proteinase inhibitors, Science, vol.248, pp.358-61, 1990.

A. Romano, M. Viola, R. Guéant-rodriguez, R. Valluzzi, and J. Guéant, Selective immediate hypersensitivity to cefodizime, Allergy, vol.46, issue.12, pp.1545-1551, 2005.
DOI : 10.1034/j.1398-9995.57.s72.18.x

F. Sanchez-sancho, E. Perez-inestrosa, R. Suau, M. Montañez, C. Mayorga et al., Synthesis, characterization and immunochemical evaluation of cephalosporin antigenic determinants, Journal of Molecular Recognition, vol.18, issue.3, pp.148-56, 2003.
DOI : 10.1111/j.1365-2222.1988.tb02904.x

G. Scherntaner, Immunogenicity and Allergenic Potential of Animal and Human Insulins, Diabetes Care, vol.16, issue.Supplement_3, pp.155-65, 1993.
DOI : 10.2337/diacare.16.3.155

C. Seitz, P. Pfeuffer, P. Raith, E. Bröcker, and A. Trautmann, Radiocontrast media-associated exanthema: Identification of cross-reactivity and tolerability by allergologic testing, European Journal of Radiology, vol.72, issue.1, pp.167-71, 2009.
DOI : 10.1016/j.ejrad.2008.06.010

C. Selassie, Burger's medicinal chemistry and drug discovery

N. Silberstein, D. Breilh, K. Macquin, A. Bailly, B. Placet et al., Les produits de contraste iodés, Lyon pharmaceutique, vol.51, pp.184-96, 2000.

Z. Simon, Specific Interactions. Intermolecular Forces, Steric Requirements, and Molecular Size, Angewandte Chemie International Edition in English, vol.11, issue.11
DOI : 10.1021/jm00334a001

URL : https://hal.archives-ouvertes.fr/hal-01606777

M. Smal, B. Baldo, and D. Harle, Drugs as allergens, Allergy, vol.1, issue.3, pp.184-91, 1988.
DOI : 10.1016/S0750-7658(85)80189-1

A. Sola-gazagnes, C. Pecquet, M. Bemba, J. Larger, E. Slama et al., Type I and type IV allergy to the insulin analogue detemir, The Lancet, vol.369, issue.9562, pp.637-645, 2007.
DOI : 10.1016/S0140-6736(07)60301-8

P. Demoly, E. Group-on-drug, and . Hypersensitivity, Diagnosis of immediate allergic reactions to beta-lactam antibiotics, Allergy, vol.58, pp.961-72, 2003.

S. Vella and . Hiv, Update on a proteinase inhibitor, Aids, vol.8, pp.25-34, 1994.
DOI : 10.1097/00002030-199409001-00006

B. Verdel, P. Souverein, A. Egberts, and H. Leufkens, Difference in Risks of Allergic Reaction to Sulfonamide Drugs Based on Chemical Structure, Annals of Pharmacotherapy, vol.68, issue.6, pp.1040-1046, 2006.
DOI : 10.1016/S1543-5946(03)90004-3

C. Vernassiere, P. Trechot, N. Commun, J. Schmutz, and A. Barbaud, Low negative predictive value of skin tests in investigating delayed reactions to radio-contrast media, Contact Dermatitis, vol.26, issue.6, pp.359-66, 2004.
DOI : 10.1007/s003300000729

D. Vervloet, A. Arnaud, M. Senft, A. Didier, P. Bongrand et al., Anaphylactic reactions to suxamethonium prevention of mediator release by choline, Journal of Allergy and Clinical Immunology, vol.76, issue.2, pp.222-227, 1985.
DOI : 10.1016/0091-6749(85)90705-5

K. Weiss, Severe anaphylactoid reaction after IV Gd-DTPA, Magnetic Resonance Imaging, vol.8, issue.6, pp.817-825, 1990.
DOI : 10.1016/0730-725X(90)90019-X

C. Wermuth, C. Ganellin, P. Lindberg, and L. Mitscher, Glossary of terms used in medicinal chemistry (IUPAC Recommendations 1998), Pure and Applied Chemistry, vol.70, issue.5, pp.1129-1172, 1998.
DOI : 10.1351/pac199870051129

H. Wiener, Structural Determination of Paraffin Boiling Points, Journal of the American Chemical Society, vol.69, issue.1, pp.17-20, 1947.
DOI : 10.1021/ja01193a005

L. Clawson, J. Schneider, and S. Kent, Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease, Science, vol.245, pp.616-637, 1989.

H. Yokoyama, S. Fukumoto, H. Koyama, M. Emoto, Y. Kitagawa et al., Insulin allergy; desensitization with crystalline zinc-insulin and steroid tapering, Diabetes Research and Clinical Practice, vol.61, issue.3, pp.161-167, 2003.
DOI : 10.1016/S0168-8227(03)00114-1

R. 1. Wermuth, C. Ganellin, C. Lindberg, P. Mit-'\cher, and L. , Glossary of terms used in medicinal chemistry (IUPAC Recommendations 1998), Pure and Applied Chemistry, vol.70, issue.5, pp.1129-1172, 1998.
DOI : 10.1351/pac199870051129

B. Goodwin and D. Roberts, Structure-activity relationships in allergic contact dermatitis, Food and Chemical Toxicology, vol.24, issue.6-7, pp.795-803, 1986.
DOI : 10.1016/0278-6915(86)90188-2

D. Harle, B. Baldo, and J. Weil, Drugs as allergens: Detection and combining site specificities of IgE antibodies to sulfamethoxazole, Molecular Immunology, vol.25, issue.12, pp.1347-540161, 1988.
DOI : 10.1016/0161-5890(88)90050-8

B. Baldo, N. Pham, and J. Weiner, Detection and side-chain specificity of IgE antibodies to flucloxicillin in allergic subjects, Journal of Molecular Recognition, vol.18, issue.3, pp.171-7300080302, 1995.
DOI : 10.1159/000234435

F. Sanchez-sancho, E. Pcrez-lnestrosa, and R. Suau, Synthesis, characterization and immunochemical evaluation of cephalosporin antigenic determinants, Journal of Molecular Recognition, vol.18, issue.3, pp.148-56, 2003.
DOI : 10.1111/j.1365-2222.1988.tb02904.x

A. Neugut, A. Ghatak, and R. Miller, Anaphylaxis in the United States, an investigation into its epidemiology, Arch Tntem Med, vol.200, issue.161, pp.15-21

. Renaudîn-lmc, G. Kanny, F. Codreanu, E. Beaudouin, and D. Moneret-vautrin, Severe Drug-Induced Anaphylaxis: Survey of Case Reports by Allergy Vigilance Network, Journal of Allergy and Clinical Immunology, vol.119, issue.1, p.36, 2007.
DOI : 10.1016/j.jaci.2006.11.160

M. Atanaskovic-markovic and T. Vel-ickovic, Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children, Pediatric Allergy and Immunology, vol.103, issue.5, pp.341-348, 2005.
DOI : 10.1016/0002-9378(88)90506-6

I. Novalbos, A. Sastre, J. Cuesta, J. Busto, U. Sellers et al., Lack of allergie cross-reactivity to cephalosporins among patients allergic to penicillins A method forestimating the probability of adverse drug reactions, Clin Exp Allergy Clin Pharmacol Ther, vol.2003130, issue.1, pp.438-43239, 1981.

K. Brockow, A. Romano, B. M. Ring, J. Pichler, W. Demoly et al., General considerations for skin test procedures in the diagnosis of drug hypersensitivity, Allergy, vol.57, pp.45-51, 2002.

M. Torres, M. Blanca, and J. Fernandez, Diagnosis of immediate allergic reactions ta beta-lactam antibiotics, Al1ergy, vol.58, pp.961-72, 2003.

B. Saenz-de-san-pedro, C. Mayorga, T. Ml, J. Rorido, J. Quiralte et al., Boosted IgE response after anaphylaxis reaction to cefuroxime with cross-reactivity with cefotaxime, Annals of Allergy, Asthma & Immunology, vol.89, issue.1, pp.101-104, 2002.
DOI : 10.1016/S1081-1206(10)61919-9

A. Romano, C. Mayorga, and T. Ml, Immediate allergic reactions ta cephalosporins: cross-reactivity and selective responses, J Allergy Clin Immunol, vol.2106, pp.1177-83

S. Marcy and J. Klein, The isoxazolyl penicillins: oxacillin , cloxacillin and dicloxacillin, Med Clin North Am, vol.54, pp.1127-1170, 1970.

N. He, structural relationships affecting in vitro activity and pharmacologic properties 3):S237~59. Lellers to the Editor An up hylu c li c s h oc k a llot fitU .. po s ute 10 ga - dOl0tala m og lumin a: Two e a U tOP OtU d oe umonlod by po s itive ull otgy us .... monl TOIh<EJiw' We "'po" Z ca",. of life-tln, Rev Infect Dis, vol.8, issue.0, 1986.

. .. Stal, . Eur@bullet, . Jalcowll-for-'pi-'fo, . By-gadoli....-m..-"....-ining-prod><..-i.., . .. Deo>-gd·dora-i et al., hove lIe.n "idely usOO .? nd tbey 1y 30% of 011 m'gne'ic. g .. g ( Mkl) ~dn ? . Allophylac'ic .\hoct i_. m-oon ... inilli prodlc' "ith high o!IDObUIy Syophylun 'eMl;OII$IO Gd· triP5a;lIed ;n 1990.' A l''';e.'' "itb hi . ? ocy oh, nj«'ion ofGd-D1VA. Sine. ohi ?? a1y ,epo<I . ..,.... $<Vere c:os .. of .... JiIybnoid ",anio ... (gfaoe III '0, 1988.

.. .. Gd·, D. Iv, . \-'or, N. Aca-ofalle-'x-'"...-hi...........-b....-!-r-'iously-oeponed, and . .. @bullet, Gd· DOTA' hav. bee n doo'd ;n'lIe li JiIyIa UOco""'dbyGd·DOrA dorumeotled by posi, ri of tJrug AliergylEurope.n Academy of

A. .. Cidennal and E. .. Cool, I 1 mnuoology oerommeodal (IDr.) "ith .:tiffe,dium). srr, dilli" 15 min· 9% .nd n"lalive '0 Ille ro""oI"'i ... IDr. were perfonned by ..... de

U. .. Er-3-mm-ioro, ered . pooitiv diale"'adilli ?? 15 mioote~ Ten ro

@. Ulkt and . Th, Two orller Pal Table 1 ? ..,mlllOriz.,..1Ie "' . ... ~. of borh.slin .nd biologicol 1. a 61 .ye3f"Old WOOllIII "ithOU!.n .lIergy histocy p, Addi.iOllOI LllkT w RMu I .. of tI<lft and I>olog ica l " .. II .... ...... At_l" ~

!. , +. Iot-unoe-'xoioa-co, and . Id, ngiogrnJiIY for "'Ille isd>em, Sheh:oslwl ...,gery oflumbat disl hPmia Gd·DOTA srr

!. Idr-wu-pooitive-gad, G. Dit-'a, and . Magn, 28 mg!ml). sP'r.nd IDr, ?. lIaye' Il.00thC.e Ph Wa)n ?. NJ). pdobe

. Ptioc, . Gj·-ij1-'pa·iima-'ornru, and . Co, 00.hr_. Pti UliU wu pooitiv. fo, Gd·DOrA

. Ln-c..-d, JiIybnic shool (hfooclloliz.d ""icoria. f.ciol angioedemiohin mioot .. ru'''g a co",bctI Mkl "ithGd·DOrA. lb.short w:OS''''aled "ith i, ove ?? " .. fluid$ ... d ind CO<liro,.eroid$ llef"", .>dm .... oo in.n i, issue.0

G. Dofa-ali and !. .. Sp-'rand-idrwitb-meglum, 100 mi'mL IDr. "i'hother pdoI

D. Doc, slin ,est ?? nd LllkT The hyporlleu. of oonspecilk hi

. .. Ile-pi....-ible-llec.......-nonsp<cilic-hi. and . @bullet-mile..-c........., CO<ltro" lwI negalive .tinO\'e f. .1Ie "ility of pdolinium .bo.>ed c_, ... 'ge, d in

Y. and .. .. Dia-'ed-oilergy-c, hoü. 100 '" 400 .ime. tlle. dby ""'gklm'" i.ruI.d 00' byul" with othe, Mkl c, nd Gd· IIOP'rA) lbingly .? nd ?? l"",i "",ly oe$CIibed by Rahman'" 01 .' Ille .. ca...,. of'IIOJilYIac

P. .. , @. Id, @. Iioi-plo-"-'...., . Reanioo, . Fter-fi..-blod et al., ) w:os fOOIId in th, oI"'ady lIe.n de.rnlled fo fo r ,!lido immedi Il coold Ile po . ? "'aled thal ?itllle a ?? k1 .. Ie G"'OT'A G"'a.U sn LET1H!STOniEHlTOII demon .. fo, Mkl l''0''''i.''u in !he, Clic .Ir""IU", .im · ib"o Gd·OOfA coold ho"" .. _.d, vol.1, issue.1 1

G. Dora, IIIer Mkl eurn i ... ,ioo ao weil ao c_. 01 Ig&medi, III. import, vol.01, issue.11 2

_. , .. Om, and ~. A. ",,-"...., A5, 0

@. I. Stin-i-",-io.-., @. Monocying, A. Ad, . .. In-tr, . .. Arro-)-con et al., of d.byed. ')1" h )1 IlllIjOfil)' oll, 10 chrooic inlt, pp.3-10

I. .. Maler-of, P. Foi-fillding, @. R. Cou, M. .. R>, and . .. Dy-iiid, ,llI",d il> ,il ", 'ho' 19E-fll<~iI. l'',,n-opecilic T c<ll> eftic","'1)' thon .Uerg io" lllroogh oon-Ig &mediooe for noo-lgE-medi ? a, 1I"g"" Il''' ? 1 )moI«"'., weig"'. 17.4 lDaJ)' ..,d

@. Iu-lac-'i, D. .. Stin-manif, . Wllcfi, . De, and . Fi, III. full T· oe Il ? 1 aI,d i _<1 io n of im e· ')1" >lin ,eac'io.-..) fo, Arr, i" l''''i.,, "illl A D. We peffo'med .sti. priek le .? ' and APlO in 5 l''''i.,, "ilh AD and bi« h poli. allerg '" penon "i,hoU: bio-dl poU"" allergy . ? nd 2 noo· .U"g'" indi.wal. ".ing rlle, ? 1 or ? ru;'; of !he 2 rll'" ? 1 mgrn<"'" (FI' am'" moi> 1-74, F2: a mi oo moi> 7S-160) ·Ib. de"'"'if'l'hic. c~niC>.1. and .. roi IgE ,ea<tivily '0 ,Ile, ? 1 .. d rlle' v 1 mgrn<,d showed 'ho' each 01 III. 6 l A·F) c_ .ined rll", v l-opecilic IgE (Fig 1 and TabI. 1: 1 J. ~ 100 WAIL ). ru' n Ile, v 1 mgrn<, FZ: aminoacido 7S-160 ImoI«riu,ioo of tr.. in.mioe .... i. oummarized in Tob .. ,.illl bi" h poI" n aUergybec ...... ,.,h of tr

C. Aptofinn, . Ile, @. Urg, L. Epi, and U. .. Or-ho, ? 1 ou m;,; c_ aini", 110 l'-i ol .. dl rll'" ? 1 fi'll ?? poe,i. w. found 'ho' rlle' ? 1 in· oeoed a pooi'i ??, ily in .. dl REFERENCES M.m..'w JS, pp.1213411-54, 2008.

H. Hô, J. Doiovi<h, and . Uoole-'lp-inhal, ion provo<, min R<if>it M"d 1'IlI3, pp.2-4

. Inmo-"-mi-), R. Watsoo, I. Coruroft, U. Woog, .. .. et al., PM . Rel''oà>cibi~ty of aU«g<tl. ;,.oe«dIy aoo 1gy <-1 ;" Immuooll'l'l5~,II~I ·5 216 CORRESPONDENCE gadopentelate dimeglumine. gadobcnale dimeglumioc. and gado:Iiamide: . Ille aulhors poslulaled lliai a mocrocycli<, p.1

. Dise, 1 çonfl ", ol in"'«St' 1h< aJthon

R. A. Ces-li, C. Ng, and M. Woog, CM, Au y"Utlg MC Acu

V. Rung< and R. Mogn, ty olol'l'fOval MR <00, p.13, 2000.

K. Mu-'floy, J. <. Srunh<-'g-la.-collan-rhru, J. Am, and . Ro, 10 g.adol;";um <00, pp.1147-1156

. O. Koloj<fomitro, <. ~. M~-aig<wg<finoo-ci, and . Int, XS, Spanoudal:i N, ()-<go<oo sa AI"ltlyl .. ~ '0 g.adoh<, pp.14415-14416, 2007.

L. S. Hhd<nufd-f, R. , P. Iu»-'il, C. Idooio, E. Ao-ofl< et al., m<gklm in", IWO car "'~. docum< nt<d by pooiôv< .aI, pp.121-126

!. Jm, M. Pott, and S. , (.1;";<>1 .ru 00, pp.20-76, 2006.

M. Cornpa, ol (id-(TI\\-S MA) (Om (id(HI'· 1X)3A) (ProHanc< ) ",l3ô", to g.adolioium, Ruol, issue.1 1, pp.41112-41120, 2006.

/. Iinnphy, Follow-up of Il desensieization protoco/ by busophil activnrio n test s. LUYd

@. .. Bl<d-'uo, Y. .. @bullet-unt-ob, and ~. '''''>oc, o,:i ~ j ~ p d 'un pro toc o ~ d n, proI OOIlllrlt 6. 0;0, ", " ttin' d 'un ~~bM. d. trPt 1 p,~.tn m:ol!b, >I N. tt , ~ " iJ,. 1 pout Uo _; 0- n<! "'" I",-<I ! pt 00, p.0

~. <a-'i-'!-! and <. , I' n<.l' xq u;s;hon C1JI.i ' fs, Il Mo un>tll, do, vol.16, issue.1 1, p.111
URL : https://hal.archives-ouvertes.fr/in2p3-00025562

!. Un-'m-',-~-o-li-'ctiq and !. 1. Too, ' I;v>t I1 ~ N "":t'" <lr!1I.rlir ~, mocI;r.U," d, mi>< '" p!oc ? .,. tt~ _ o~ .. d , ' u;v, o . I' .c~u:t. e> 21)10 Soc

~. W. Bo-t-llt,., L. N. Hu-n, and . Ta-hu..,,......-~-r.....-olt>-...., 1 im lXct~ ,00.:1 '0 ~u rn.l n in su lin ;o "OOrt!. I l''<rI''''''''''" p«tlXoi w Uy ,-<> 1<1 typt l <I; _~ _j lll: ,Ilt oulxU, idtnc«l of" 1i:E -O>t<l~ t «l monitOft<! Dy sI:'n tt~

. ~_-ti><-doc, 00 I I>< bl><>phil of b.»ophil ""' il'';111)' mn..: fo<, spKiflc li:E . 001(G41>< i mpO, pp.10-11

I. Ail, 00 01 1r.. rrm i to ~ llI 01 1r.. tolm,.:. inlOOiOfl ., lOlO ~ ",t iOO . ~ r, "1' ''' oe _ ' I l <' i!t, pp.1-1

". Nliorai-'i and E. D. Ppk-d...-rpq...., ? l'in.oli ~ dlOC hyj)<'n .n.ib ili t" im~i.1' .. . Un, moIkul. , ... poo"bI. d'on ?? n.lphyl>Xi. j)<'ut ~ tr. j"i:~ indi'j)<'n"bI,otocol ?? ~ ' ''''cou'u''''IK. 1 4 1 . L 'objKnl .... d'indoi" u n "'t d, 101"'1"1<' vi<--l_vi, du roed iw, .. nr , .. poo"lII, <l, lrun' . in , i!On obli .. tion poo' l, tr . it, ? . (" ... , d,n

. Ioc, n , l'indocnoo d. 1. tol' _ "n«. Ain ... il ~ Itl mootr 1 ?? b.I 'op hi .... p.o,tic ipon' ? l' ~ <<ooru,,", oc, tt-l. q"' ,yl IS)

. Yl>etiqu, . O. !-'combi, . V<-'<o, I. Mk>ni, and E. Nt, cl-< d'on "'0_01, d '..:coutum. oc , " pide' l'in.olin. hUlTUi, dlpo .pkifiques l Iln.ulin,. L ·..:q"i.inon d

@. , B. .. Tab~-l>-b.-i, and . Mi-bi-lit~-d, d. 1, pp.1-4

U. Nom, <'int d'un di.1bH, de tyj)<' 2 . . ... i' tr. it (6~j). ,o' i&litllo"" (4mz'j) .. un, i~.i<'< ­ tioo

(. U~in, . .. Imui>, _. <i, . Dostiq, . .. L<o-insuli et al., un pruri' ,ln". Ii , 1 immkli"."",nt .prl-< 1 ... inj!'Ction ?n , qt>t c .. 1> n '. i. monvl d, IDR~ l<on inj...: .. n' O.OlmL d '.I1. II"pul. d. }li 4 mm soit obten ... : un ? ?

/. Iooul, uxcooc .ntr>tion. de O,OlS' lSO)Li:/ml. ~ pouvoi, bI"'I L .mt du, Iru m ... rt Ov, vol.1

M. U. <i-"-oi-'''nt and ,. V<-'<-le.-ur, (d'un f

. Mlli, . O. @bullet, . Idr-",-i-'nt-de<-mlt..-n, . .. @bullet-<ioiy-'ioiovq, . L>-"-'.. et al., rt dOIini , p.;o' un , I.na;<'< in , ulint-"rum .utoIOl: .... p;I' ,.wo" . ux mil, ?? insuIiM _"rom ph.,..iol. Iyc'miq ... ... ti>l. i

Y. Ïndocnoo-de-t, . ~. Tolo, . .. @bullet@bullet-_-lisk-nim.-hon-mmiu, . !-'combi, and . .. Ac-c\lt-u,, El'" , oo,i"'it ,n un. inj<'Ction tout..< 1 ... lOminut ... dïn, ulin, hUlTUi jusqu'l ob, de< volu ...... tt d ... cooc ,ntuhon. <Ioi I ... nt intu ? .,miq u ..... 1 ...... uiv. nt, issue.1

I. , .. Dïnsuli, G. Dt, I. Iolli-d..-min, E. 1. Pki-fiq et al., un, inj<'ction """-<Il .. n~ d'iMoli .. v",in ? .u ,oodl". Vina;t-q ... ", h'U'" . prl! 1. d'bu, du p,otocol. d '..:cootom. oc ,. 1 ... injec'ion. "'i.~ t , ?? lisks .u domi,il de l'in.ohn ? ? in , i quo d ?? TAB l '''i,n' , ? ? h, flux (Alltf,.nicity 1ot"'.lmmuoot...:h. M.1, ... ille ). A", .. u

*. .. , 5. ". Pi, and I. , 1 d .... titnt Il.'r I",ut.! ;ov« un. >0100011 ) .. d. d i lutio

. .. Looull-ml and . Jpin, -ncU"'l 50. d. t"ti .. ~on rn>Xi ..... , ?? muldpli~ pat 100 17, J. lo ml .... point ""~'~q ... ~, vol.1

. Popui<-d and . Imo-;-'codfj..-r,....., 1 ) mm. ri

I. Coiioeni>1 and . Roilst..........-'....-en, PlllI'IH~ tlrioo et ltoi, bien ,01 .. 1. hormi. d ...... 110 ... lryrMm>

@. Ji-'''<, @. Portlin, and . .. @bullet-li, 1II

. Uoh, . Lo-d.....-d-'insuli, . ~&~-a, @. Roh-moi, . If> et al., ft.it '.pff""rt 1 oeil

.. .. Niemt and @. Moi, -II monlr'; ?? 11< moindre rfoctMtt

. ~. Pou-'idii-po and . La, 10-'-'1&> 10

. Dkelter-au-".-i-cl<-ljlkl\fl-n·ki....-".., dftecms_ l.! ptotO, .I'In ? ...tI ... I>u ..... , ... boi

H. Mol.-r-"..., ln "wc dlr1'4 .p&i.liq ... cIe 11n,ulio. h

.. In and @. @bullet, liml, i re'PfC~ 26 moi~ Les TAII I" ?? nt po>itif> po u, 1101.

D. Itoi and . Mois......-i-'......-oe-"..-d·....-d....., TAliI il 00 ?? h~""fl.i, r>fJ,Itif(f i:e-l~ On obr, Ir<Ii .. t6f114mof .. ,. " ~ ~ , ? 1 " ?

'. ___, N. It, I. , L. .. , and ~. _l, Ii ,n' l'f ken .. i, un ? ? ll flll< cie rypo " E-<k'pooo. nt vi ?? 1·

. Cl<-oe:-oddilif and . @bullet-"...-dcouru, _rit j "n _<>«II

~. .. Pm, I. .. @bullet-@bullet, and . Rx, on' rro:>tÎo+ il mi" on pl

M. If-hu, 17 Jn point cl< w ?? tnoctureI.I

'. .. , .. .. @bullet@bullet-lin, I. .. Ii-'",, and . @bullet@bullet, m<>dilicotion. fi . miok , ux po,;. tions 81!," 819, <1< ,<II. d. l'InIf : ce .. PO"''' ~ ,'.xpI

T. _. and _. .. An, LeUer to the Edilor O . lay. d hyp ? ? ?? n . iti"ily ? ?? ç tio n . ç .. u sed by l o di, · ? ?? ç Uvity in 22 pati e n ts 1<> JO m,ho. oocIin:ud_.,... _ .. (ICM) 'rrjo

.. Cu-",,-"...-pprmi..., ' wh, 1y 0. , .. 01

!. Cm and &. , 103-.01 ' 1>< poti, 1_ ? .uotl>< .... w irhool, vol.1

.. H_, of 1Ct.!: 'he 01D< ro, Iwol da)" , ........... 80'10

O. .. Irr, .. Publi, .. , .. Ali, and @. I<ri, 2-1_. y(90-') .. ) p. oded ., 'br: pro" i, ? ? nd

. No, . Wort, A. Drnll, . 'iy-'e...., . Iiilati-'1»-'................. et al., Aclderny of AII<'i"IoV C~ni<.1 ImmtlOO!ot in, iodiunol ( V''''PI'I''r

A. .. , ~. , ~. .. @bullet@bullet-ioe, .. Oddi-'....->li, .. Ô>on· et al., 1 (1'1, 1· ll U<I 15018) S<:b< .. Jl. ...... 01 (I ... poqo.o<. Amtnh . . -- 1 --? - 1 -,ft 'K ft K -,.,. ,.-,~ "".hh~ iopromide (Ulnvill. ~<filo.l:~ aIIIl ........ 1 (Opr.-~

. Lor_-~-polid,.......-h, 14had oddi~

. .. Sl, O. .. Pnd-'u,, and .. .. Di, 1 <:<>Mi<I<mI ? poortiYO im-.li ?? rupo_ 1, po"' ..... 01 ( ..... ). Xluilio ... d p<>$Îliv< .,. dol.,..d ... odinp if ? ? ..ytocm ? ., ... i...t ..... "'d POI"'I' ..,.. oIo"...,od, p.24

A. and H. .. Icm-'''...., d pu:h ,eoo "~. Arr

P. Lot-'..... and I. , 1 bm p<>oiriv lIadbntl> del>yed pooiliv< IDT.IIII!

. Ross, I. Ij-'n-'i-of, and .. B<-'.., 14 (Ion"io;. non· iOllie. 0< both I)

T. Ble, Results 01 skin and challenge tests 01 patients who had pos~ive skin test re stJks Po";';" ?? Ici

. Woil·toi, 24 h) PT + (48 h) [oh",01 (lOT. LDldilulOd. 24 hl [open'oI (lOT. undi[ulOd, 48 h) [oug[al< (IDT. umi .. "cd 48 h)

~. Amidouizoal<, (. Idt, . P. Midi, and . Tio, cd 24 hl Iohtridol (lOT. undilulOd. 24 hl [oh",01 (lOT. LDldilulOd. 24 hl Iohtridol Iomo:pml TA BLE Il Challenge test re stJlts in patients with a delayed hypersensitivity reaet ion to iodixanol and either a positive or negati"" skin test res ult to iodixanol [obinidol [obinidol + iomepol Iohnol [omo:pml Iopami<hl 10

. It, ID "dixaJ><>! provided guidance loalternalive ICM that mighl be admini"ered 10 lhe,e patient, if funher ICM -ba

R. Le, wa, guided by the finding Ihat the", patient, had negative ,kin le,t re,uh, 10 thi, compound and thal iobiuidol ha, a quile different, p.10

T. Large, 10 date 10 have inve,tigated lhe u",fulne" of ,kin le"ing 10Ien a '<afe ICM for ('hallenging palient, wilh nonimmediate hyper;en<ilivilY reanion, 10 iodixanoL "Mirie Hasdt, Corn.ha, Mrf M Mrf Oiid"C<>l5&t1m1. PhIf S"nu LII)""~ ' MU Eti

M. ". Mori and M. , PIoD" Gü, ny. MD. PIoD

. Di-",., . Tho, I. .. Ibo, Ç. Refe-rences-Ç-!-ri<ti, and . X_<-', <h<y Iu« Oô

O. .. Pich and . .. Morio-dron.....-'media,-"., ! 01. T «II mediM«l. ion by "in onl l,.m"I'I( ~y!o ""i>'>!ion, AlI"l.)' Çlin In .... nol 100

~. Dmnotiti>loij-',, J. , P. .. Con, and ~. Sch, ~ hi" _I'IoIOJ:iaol "ili>tion, pp.1004-66

A. Ab, .. , A. A. B_~, and . Bonoobl, P; «d . S,in "'tinJ in f>O!ie'" ~im hYP<"'n"'i>ity .-:ri, tic<" ... !ru<ly. All..-fy 1009

A. Blan<>, M. Rinj-1, . Pich, M. M. Omord, . M. Kola et al., in ,ho dillJo<>!" of dnoi h"P<"''' ''' i,·ity. Ali..-» 100, of T «II. ' 1'"<ifI< lor iod noediIL 1 AlI"'lY O in In1<>'J6 oo;,IO.IOI6/j.jo<i .lO ll.QI.OJ.l, pp.1-100