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Recherche d'une hypercoagulabilité au cours de l'hypertension artérielle pulmonaire

Abstract : Pulmonary hypertension (PH) is an affection with an endothelial dysfunction and in situ thromboses. Hypercoagulable state was postulated but was never clearly demonstrated. Our main objective was to determine if patients with idiopathic pulmonary arterial hypertension (iPAH), associated PAH or PH of respiratory diseases had in vitro hypercoagulability with calibrated automated thrombography (CAT). The second objective was to study the endothelial dysfunction in patients with iPAH. We have shown that some patients with iPAH had a hypercoagulable state in vitro. But patients of the other groups had no hypercoagulability. The underlying disease could explain at least in part the difference but it still remain to establish. We have shown that patients with iPAH had an endothelial dysfunction with increase of von willebrand factor, Tissue Factor Pathway Inhibitor and decrease of thrombomodulin
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Agnès Brunette Brunette-Tournier. Recherche d'une hypercoagulabilité au cours de l'hypertension artérielle pulmonaire. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2010. Français. ⟨NNT : 2010NAN10133⟩. ⟨tel-01746387⟩



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