Skip to Main content Skip to Navigation
Theses

Recherche d'une hypercoagulabilité au cours de l'hypertension artérielle pulmonaire

Abstract : Pulmonary hypertension (PH) is an affection with an endothelial dysfunction and in situ thromboses. Hypercoagulable state was postulated but was never clearly demonstrated. Our main objective was to determine if patients with idiopathic pulmonary arterial hypertension (iPAH), associated PAH or PH of respiratory diseases had in vitro hypercoagulability with calibrated automated thrombography (CAT). The second objective was to study the endothelial dysfunction in patients with iPAH. We have shown that some patients with iPAH had a hypercoagulable state in vitro. But patients of the other groups had no hypercoagulability. The underlying disease could explain at least in part the difference but it still remain to establish. We have shown that patients with iPAH had an endothelial dysfunction with increase of von willebrand factor, Tissue Factor Pathway Inhibitor and decrease of thrombomodulin
Document type :
Theses
Complete list of metadata

Cited literature [68 references]  Display  Hide  Download

https://hal.univ-lorraine.fr/tel-01746387
Contributor : Thèses Ul <>
Submitted on : Thursday, March 29, 2018 - 10:33:14 AM
Last modification on : Friday, October 23, 2020 - 5:00:27 PM
Long-term archiving on: : Thursday, September 13, 2018 - 12:46:33 PM

File

SCD_T_2010_0133_BRUNETTE.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : tel-01746387, version 1

Collections

Citation

Agnès Brunette-Tournier. Recherche d'une hypercoagulabilité au cours de l'hypertension artérielle pulmonaire. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2010. Français. ⟨NNT : 2010NAN10133⟩. ⟨tel-01746387⟩

Share

Metrics

Record views

71

Files downloads

129