HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Theses

Influence de la variabilité de la mesure des bactéries de l'air sur l'évaluation du risque infectieux : exemple de la légionellose

Abstract : The aim of our study was to develop a quantitative microbiological risk assessment involving the respiratory pathway. We chose the example of Legionnaires'disease, on the basis of two types of exposure : when taking a shower and being outside in the vicinity of a cooling tower. We collected suitable data in international scientific literature, which allowed us to integrate individual susceptibility factors such as sex, age or smoking habits in our calculations. We established a dose-response relationship by fitting the results of an animal exposure experiment to different models used in microbiological foodborne or waterborne risk assesment.We used a probabilistic approach based on Monte Carlo simulations for risk characterization. "Legionella" concentrations of 2 CFU.m[exponent -3] in the air near showers and 0,02 CFU.m[exponent -3] near cooling towers amount to an annual risk estimate of 10[exponent -5]. Taking the exposure measurement variability into account does not change our risk estimation for concentrations above 100 CFU.m[exponent -3], but it decreases for lowest ones, which probably are more frequently encountered in the case of "Legionella" exposure.
Complete list of metadata

https://hal.univ-lorraine.fr/tel-01746788
Contributor : Thèses Ul Connect in order to contact the contributor
Submitted on : Thursday, March 29, 2018 - 10:44:51 AM
Last modification on : Wednesday, October 14, 2020 - 4:08:40 AM

Links full text

Identifiers

  • HAL Id : tel-01746788, version 1

Collections

Citation

Denis Ambroise. Influence de la variabilité de la mesure des bactéries de l'air sur l'évaluation du risque infectieux : exemple de la légionellose. Biochimie, Biologie Moléculaire. Université Henri Poincaré - Nancy 1, 2003. Français. ⟨NNT : 2003NAN10008⟩. ⟨tel-01746788⟩

Share

Metrics

Record views

8