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Influence de la variabilité de la mesure des bactéries de l'air sur l'évaluation du risque infectieux : exemple de la légionellose

Abstract : The aim of our study was to develop a quantitative microbiological risk assessment involving the respiratory pathway. We chose the example of Legionnaires'disease, on the basis of two types of exposure : when taking a shower and being outside in the vicinity of a cooling tower. We collected suitable data in international scientific literature, which allowed us to integrate individual susceptibility factors such as sex, age or smoking habits in our calculations. We established a dose-response relationship by fitting the results of an animal exposure experiment to different models used in microbiological foodborne or waterborne risk assesment.We used a probabilistic approach based on Monte Carlo simulations for risk characterization. "Legionella" concentrations of 2 CFU.m[exponent -3] in the air near showers and 0,02 CFU.m[exponent -3] near cooling towers amount to an annual risk estimate of 10[exponent -5]. Taking the exposure measurement variability into account does not change our risk estimation for concentrations above 100 CFU.m[exponent -3], but it decreases for lowest ones, which probably are more frequently encountered in the case of "Legionella" exposure.
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Theses
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http://docnum.univ-lorraine.fr/prive/SCD_T_2003_0008_AMBROISE.pdf
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https://hal.univ-lorraine.fr/tel-01746788
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Submitted on : Thursday, March 29, 2018 - 10:44:51 AM
Last modification on : Wednesday, October 14, 2020 - 4:08:40 AM

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Denis Ambroise. Influence de la variabilité de la mesure des bactéries de l'air sur l'évaluation du risque infectieux : exemple de la légionellose. Biochimie, Biologie Moléculaire. Université Henri Poincaré - Nancy 1, 2003. Français. ⟨NNT : 2003NAN10008⟩. ⟨tel-01746788⟩

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