. Min, Le plasma est recueilli et stocké à -80°C jusqu'au jour de l'analyse pour la détermination de l'activité plasmatique de l'enzyme de conversion (AEC; Ryan et coll, 1977.

. Ainsi, enzyme de conversion (mmoVml/min) est basé sur la mesure de la libération de His-Leu à partir de CBZ après dérivation fluorescente (O-phtaldialdéhyde). 2

. Cardio-vasculaire, Faculté de Pharmacie, Nancy) d'après une technique déjà décrite par Thorin et Atkinson (1994), basée sur l'extraction des catécholamines en présence d'alumine activée. Une partie du plasma recueilli précédemment

. Ml-de-tampon-tris, HCl2 M (pH 8,6 ; Merck) Les échantillons sont placés sur un mélangeur rotatif à 4°C pendant 15 min pour permettre l'adsorption des catécholamines sur l'alumine. L'alumine récupérée est ensuite lavée trois fois avec 2 ml d'eau tridistillée à 4°C, p.3

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