Inactivation of the sodium channel. II. Gating current experiments, The Journal of General Physiology, vol.70, issue.5, pp.567-590, 1977. ,
DOI : 10.1085/jgp.70.5.567
Changes in Local S4 Environment Provide a Voltage-sensing Mechanism for Mammalian Hyperpolarization???activated HCN Channels, The Journal of General Physiology, vol.115, issue.1, pp.5-19, 2004. ,
DOI : 10.1007/s004240050253
A microscopic view of ion conduction trough the potassium channel, Proc. Natl. Acad. Sci. USA, pp.8644-8648, 2003. ,
The Voltage Sensor in Voltage-Dependent Ion Channels, Physiological Reviews, vol.24, issue.2, pp.555-592, 2000. ,
DOI : 10.1085/jgp.110.2.101
Inactivation of the sodium channel. I. Sodium current experiments, The Journal of General Physiology, vol.70, issue.5, pp.549-566, 1977. ,
DOI : 10.1085/jgp.70.5.549
Molecular Movement of the voltage sensor in a potassium channel, Gen. Physiol, issue.1, 2003. ,
Exploring the origin of the ion selectivity of the KcsA potassium channel, Proteins, vol.53, pp.412-426, 2003. ,
Discrete-state theory in nerve impulse modelling, Riv. Biol, vol.96, pp.261-270, 2003. ,
Ion channels: structural bioinfonnatics and modelling, Hum. Mol. Genet, vol.Il, pp.2425-2433, 2002. ,
Molecular mechanisms of gating and drug block of sodium channels, Novartis Found Symp, vol.241, pp.206-232, 2002. ,
Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy, Nature, vol.35, issue.6763, pp.813-817, 1999. ,
DOI : 10.1152/physrev.2000.80.2.555
Tracking Voltage-dependent Conformational Changes in Skeletal Muscle Sodium Channel during Activation, The Journal of General Physiology, vol.22, issue.3, pp.629-645, 2002. ,
DOI : 10.1016/S0006-3495(91)82186-5
A unique role for the S4 segment of domain 4 in the inactivation of sodium channels, The Journal of General Physiology, vol.108, issue.6, pp.549-556, 1996. ,
DOI : 10.1085/jgp.108.6.549
Potassium channel structures, Nature Reviews Neuroscience, vol.385, issue.2, pp.115-121, 2002. ,
DOI : 10.1038/385272a0
Recent advances in ion channel research, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1565, issue.2, pp.267-286, 2002. ,
DOI : 10.1016/S0005-2736(02)00574-6
Answers and Questions from the KvAP Structures, Neuron, vol.39, issue.3, pp.395-400, 2003. ,
DOI : 10.1016/S0896-6273(03)00472-0
The Birth of a Channel, Neuron, vol.40, issue.2, pp.265-276, 2003. ,
DOI : 10.1016/S0896-6273(03)00506-3
Ion channel structures: a review of recent progress, Curr. Opin. Drug. Discov. Devel, vol.6, pp.611-619, 2003. ,
Potassium Channel, Ions, and Water: Simulation Studies Based on the High Resolution X-Ray Structure of KcsA, Biophysical Journal, vol.85, issue.5, pp.2787-2800, 2003. ,
DOI : 10.1016/S0006-3495(03)74702-X
The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity, Science, vol.280, issue.5360, pp.69-77, 1998. ,
DOI : 10.1126/science.280.5360.69
Evolutionary Relationship between K+ Channels and Symporters, Biophysical Journal, vol.77, issue.2, pp.775-788, 1999. ,
DOI : 10.1016/S0006-3495(99)76931-6
On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel, Biophysical Journal, vol.71, issue.6, pp.3110-3125, 1996. ,
DOI : 10.1016/S0006-3495(96)79505-X
Inactivation and secondary structure in the D4/S4-5 region of the SKMl sodium channel, J. Gen. Physiol, vol.11, pp.703-710, 1998. ,
The Orientation and Molecular Movement of a K+ Channel Voltage-Sensing Domain, Neuron, vol.40, issue.3, pp.515-525, 2003. ,
DOI : 10.1016/S0896-6273(03)00646-9
Primary structure of the adult human skeletal muscle voltage-dependent sodium channel, Annals of Neurology, vol.260, issue.2, pp.131-137, 1992. ,
DOI : 10.1007/978-1-4757-1361-9_11
Molecular modeling of ion channels: structural predictions, Current Opinion in Chemical Biology, vol.7, issue.1, pp.150-156, 2003. ,
DOI : 10.1016/S1367-5931(02)00012-1
Diversity of Mammalian Voltage-Gated Sodium Channels, Annals of the New York Academy of Sciences, vol.2, issue.1 MOLECULAR AND, 1999. ,
DOI : 10.1097/00001756-199708180-00025
On Mutations that Uncouple Sodium Channel Activation from Inactivation, Biophysical Journal, vol.76, issue.5, pp.2553-2559, 1999. ,
DOI : 10.1016/S0006-3495(99)77408-4
URL : https://doi.org/10.1016/s0006-3495(99)77408-4
The selectivity of scorpion alpha-toxins for sodium channels subtypes is determined by subtle variations at the interacting surface, Toxicon, vol.4, pp.25-28, 2003. ,
Calcium channel characteristics conferred on the sodium channel by single mutations, Nature, vol.356, issue.6368, pp.441-443, 1992. ,
DOI : 10.1038/356441a0
Ionic channels of excitable membranes, 1992. ,
A quantitative description of membrane current and its application to conduction and excitation in nerve, The Journal of Physiology, vol.117, issue.4, pp.500-544, 1952. ,
DOI : 10.1113/jphysiol.1952.sp004764
KcsA closed and open: modelling and simulation studies, European Biophysics Journal, vol.33, issue.3, 2003. ,
DOI : 10.1007/s00249-003-0355-2
Occurrence of type 3 sodium channel peptide toxins in two species of sea anemones (Dofleinia armata and Entacmaea ramsayi), Toxicon, vol.41, issue.5, pp.637-639, 2003. ,
DOI : 10.1016/S0041-0101(02)00368-9
Conversation between voltage sensors and gates of Ion channels, Biochemistry, vol.39, pp.15653-15658, 2000. ,
VMD: Visual molecular dynamics, Journal of Molecular Graphics, vol.14, issue.1, pp.33-38, 1996. ,
DOI : 10.1016/0263-7855(96)00018-5
Infromation theory for system engineers, 1970. ,
Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel, Nature, vol.353, issue.6339, pp.86-90, 1991. ,
DOI : 10.1038/353086a0
Auxiliary subunits of voltage-gated ion channels, Neuron, vol.12, issue.6, pp.1183-1194, 1994. ,
DOI : 10.1016/0896-6273(94)90436-7
The open pore conformation of potassium channels, Nature, vol.11, issue.6888, pp.523-526, 2002. ,
DOI : 10.1002/prot.340110407
X-ray structure of a voltage-dependent K+ channel, Nature, vol.22, issue.6935, pp.33-41, 2003. ,
DOI : 10.1093/nar/22.22.4673
The principle of gating charge movement in a voltage-dependent K+ channel, Nature, vol.19, issue.6935, pp.42-48, 2003. ,
DOI : 10.1016/S0896-6273(00)80422-5
Structural determinants of ion selectivity in brain calcium channel, FEBS Letters, vol.13, issue.2, pp.145-148, 1993. ,
DOI : 10.1016/0166-2236(90)90160-C
Predicting transmembrane protein topology with a hidden markov model: application to complete genomes11Edited by F. Cohen, Journal of Molecular Biology, vol.305, issue.3, pp.567-580, 2001. ,
DOI : 10.1006/jmbi.2000.4315
Neurological disorders caused by inherited ion-channel mutations, The Lancet Neurology, vol.1, issue.3, pp.157-166, 2002. ,
DOI : 10.1016/S1474-4422(02)00071-6
Atomic Proximity between S4 Segment and Pore Domain in Shaker Potassium Channels, Neuron, vol.39, issue.3, pp.467-481, 2003. ,
DOI : 10.1016/S0896-6273(03)00468-9
Interaction between Extracellular Hanatoxin and the Resting Conformation of the Voltage-Sensor Paddle in Kv Channels, Neuron, vol.40, issue.3, pp.527-536, 2003. ,
DOI : 10.1016/S0896-6273(03)00636-6
Determination of the subunit stoichiometry of a voltage-activated potassium channel, Nature, vol.350, issue.6315, pp.232-235, 1991. ,
DOI : 10.1038/350232a0
Sodium channel toxins and neurotransmitter release, Neurochemical Research, vol.28, issue.10, pp.1607-1611, 2003. ,
DOI : 10.1023/A:1025643030044
Negatively charged residues adjacent to IFM motif in the DilI-DIV linker of hNa(V)1.4 differentially affect slow inactivation. FEBS LeU, pp.163-169, 2003. ,
DifferentiaI contribution by conserved glutamate residues to an ion selectivity site in the l.rtype Ca++ channel pore. FEBS LeU, pp.265-269, 1994. ,
Changes in sodium channel gating produced by point mutations in a cytoplasmic linker, Science, vol.250, issue.4981, pp.688-691, 1990. ,
DOI : 10.1126/science.2173138
Cardiac Sodium Channel Diseases, Clinical Chemistry and Laboratory Medicine, vol.12, issue.4, pp.439-444, 2003. ,
DOI : 10.1126/science.1073569
Evidence for Intersubunit Interactions between S4 and S5 Transmembrane Segments of the Shaker Potassium Channel, Journal of Biological Chemistry, vol.80, issue.31, pp.29079-29085, 2003. ,
DOI : 10.1006/jsbi.1998.3962
Structure and structure-function relationships of sea anemone proteins that interact with the sodium channel, Toxicon, vol.29, issue.9, pp.1051-1084, 1991. ,
DOI : 10.1016/0041-0101(91)90205-6
Amino acid sequence required for fast Na+-channel inactivation: charge neutralization and deletions in the III-IV linker, Proc. Nat!. Acad. Sci. USA, pp.10905-10909, 1992. ,
Demonstration of Sodium and Potassium Conductance Changes during a Nerve Action Potential, Nature, vol.22, issue.5234, pp.747-748, 1970. ,
DOI : 10.1113/jphysiol.1969.sp008778
Theoretical and computational models of ion channels, Current Opinion in Structural Biology, vol.12, issue.2, pp.182-189, 2002. ,
DOI : 10.1016/S0959-440X(02)00307-X
Introduction: Molecular diversity of Ion Channels and Cell Function, Annals of the New York Academy of Sciences, vol.6, issue.1 MOLECULAR AND, 1999. ,
DOI : 10.1016/0896-6273(94)90441-3
Potassium channels: structures, models, simulations, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1565, issue.2, pp.294-307, 2002. ,
DOI : 10.1016/S0005-2736(02)00576-X
Potassium Channels, The Journal of General Physiology, vol.69, issue.2, pp.313-342, 1998. ,
DOI : 10.1016/S0006-3495(90)82623-0
Pfam: A comprehensive database of protein domain families based on seed alignments, Proteins: Structure, Function, and Genetics, vol.183, issue.3, pp.405-420, 1997. ,
DOI : 10.1016/0076-6879(90)83031-4
SCORPION, a molecular database of scorpion toxins, Toxicon, vol.40, issue.1, pp.23-31, 2002. ,
DOI : 10.1016/S0041-0101(01)00182-9
Bioinformatics for venom and toxin sciences, Briefings in Bioinformatics, vol.4, issue.1, pp.53-62, 2003. ,
DOI : 10.1093/bib/4.1.53
Role of an S4-S5 linker in sodium channel inactivation probed by mutagenesis and a peptide blocker, The Journal of General Physiology, vol.108, issue.2, pp.89-104, 1996. ,
DOI : 10.1085/jgp.108.2.89
Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila, Science, vol.237, issue.4816, pp.770-775, 1987. ,
DOI : 10.1126/science.2441471
A mutation in the pore of the sodium channel alters gating, Biophysical Journal, vol.68, issue.5, pp.1814-1827, 1995. ,
DOI : 10.1016/S0006-3495(95)80358-9
Identification of an intracellular peptide segment involved in sodium channel inactivation, Science, vol.241, issue.4873, pp.1658-1661, 1988. ,
DOI : 10.1126/science.2458625
Sequence and genomic structure of the human adult skeletal muscle sodium channel ?? subunit gene on 17q, Biochemical and Biophysical Research Communications, vol.182, issue.2, pp.794-801, 1992. ,
DOI : 10.1016/0006-291X(92)91802-W
A cluster ofhydrophobic amino acid residues required for fast Na-channel inactivation, Proc. Nat!. Acad. Sei. USA, pp.10910-10914, 1992. ,
Molecular determinants of Ca2+ selectivity and ion
permeation in L-type Ca2+ channels, Nature, vol.366, issue.6451, pp.158-161, 1993. ,
DOI : 10.1038/366158a0
Molecular Basis of Charge Movement in Voltage-Gated Sodium Channels, Neuron, vol.16, issue.1, pp.113-122, 1996. ,
DOI : 10.1016/S0896-6273(00)80028-8
The voltage-gated potassium channels and their relatives, Nature, vol.276, issue.6902, pp.35-42, 2002. ,
DOI : 10.1016/S0092-8674(00)81635-9
Potassium channel receptor site for the inactivation gate and quatemary amine inhibitors, Nature, vol.411, issue.6838, pp.657-661, 2001. ,
DOI : 10.1038/35079500
Molecular dynamics with coupling to an external bath, The Journal of Chemical Physics, vol.15, issue.8, pp.3684-3690, 1984. ,
DOI : 10.1039/fs9821700055
The Protein Data Bank, Thanki, H. Weissig, 1. D. Westbrook, and C. Zardecki, pp.899-907, 2002. ,
DOI : 10.1107/S0907444902003451
Structure comparison and alignment, Methods Biochem Anal, vol.44, pp.321-337, 2003. ,
CHARMM: A program for macromolecular energy, minimization, and dynamics calculations, Journal of Computational Chemistry, vol.I, issue.2, pp.187-217, 1983. ,
DOI : 10.1145/321796.321811
Theory and simulation The control and timescale of structure and reactivity in biological systems: from peptide folding to cellular networks, Current Opinion in Structural Biology, vol.13, issue.2, pp.143-145, 2003. ,
DOI : 10.1016/S0959-440X(03)00042-3
The Role and Perspective of Ab Initio Molecular Dynamics in the Study of Biological Systems, Accounts of Chemical Research, vol.35, issue.6, pp.455-464, 2002. ,
DOI : 10.1021/ar010018u
Protein folding in the landscape perspective: Chevron plots and non-arrhenius kinetics, Proteins: Structure, Function, and Genetics, vol.2, issue.1, pp.2-33, 1998. ,
DOI : 10.1016/S1359-0278(97)00067-9
FlexE: efficient molecular docking considering protein structure variations1 1Edited by J. Thornton, Journal of Molecular Biology, vol.308, issue.2, pp.377-395, 2001. ,
DOI : 10.1006/jmbi.2001.4551
H Residual Dipolar Couplings Using Conjoined Rigid Body/Torsion Angle Dynamics, Journal of the American Chemical Society, vol.125, issue.10, pp.2902-2912, 2003. ,
DOI : 10.1021/ja028893d
A second generation force field for the simulation of proteins, nucleic acids, and organic molecules, J Am. Chem. Soc, vol.117, issue.1, pp.5179-5197, 1995. ,
Molecular Dynamics Simulations of the Protein Unfolding/Folding Reaction, Accounts of Chemical Research, vol.35, issue.6, pp.422-429, 2002. ,
DOI : 10.1021/ar0100834
) method for Ewald sums in large systems, The Journal of Chemical Physics, vol.9, issue.12, pp.10089-10092, 1993. ,
DOI : 10.1126/science.2548279
Structural contributions for themostability of a new endo-l,4-beta-xylanase from the fungus Humicola grisea, Internet Electron. J Mol. Des, vol.2, pp.835-851, 2003. ,
Long Time Dynamics of Complex Systems, Accounts of Chemical Research, vol.35, issue.6, pp.396-403, 2002. ,
DOI : 10.1021/ar010021d
A smooth particle mesh Ewald method, The Journal of Chemical Physics, vol.100, issue.19, pp.8577-8593, 1995. ,
DOI : 10.1063/1.470043
Understanding Molecular Simulation, Computers in Physics, vol.11, issue.4, 1996. ,
DOI : 10.1063/1.4822570
Folding simulations of a threedimensional protein model with a nonspecific hydrophobie energy function, Phys. Rev. E, vol.64, pp.1-5, 2001. ,
Structural genomics: Computational methods for structure analysis, Protein Science, vol.95, issue.9, pp.1813-1821, 2003. ,
DOI : 10.1073/pnas.95.26.15189
Molecular dynamics simulations, Current Opinion in Structural Biology, vol.12, issue.2, pp.190-196, 2002. ,
DOI : 10.1016/S0959-440X(02)00308-1
Computational approaches to study protein unfolding: Hen egg white lysozyme as a case study, Proteins: Structure, Function, and Genetics, vol.6, issue.3, pp.196-213, 1995. ,
DOI : 10.1007/978-94-015-7658-1_21
GROMACS 3.0: a package for molecular simulation and trajectory analysis, Journal of Molecular Modeling, vol.7, issue.8, pp.306-317, 2001. ,
DOI : 10.1007/s008940100045
All-atom empirical potential :s of proteins, J Phys. Chem. B, vol.1, 1998. ,
Explicit reversible Phys, pp.1117-1157, 1996. ,
Specificity of charge-carrying residues in the voltage sensor of potassium channels, J; Gen. Physio1, vol.123, pp.205-216, 2004. ,
Essential dynamics of proteins, Proteins: Structure, Function, and Genetics, vol.158, issue.4, pp.412-425, 1993. ,
DOI : 10.1002/prot.340170408
Ion permeation mechanism of the potassium channel, Nature, vol.23, issue.6780, pp.881-884, 2000. ,
DOI : 10.1016/0021-9991(77)90098-5
Ion channel gating: insights via molecular simulations, FEBS Letters, vol.14, issue.1, pp.85-90, 2003. ,
DOI : 10.1016/S0263-7855(97)00009-X
Changes in Local S4 Environment Provide a Voltage-sensing Mechanism for Mammalian Hyperpolarization???activated HCN Channels, The Journal of General Physiology, vol.115, issue.1, pp.5-19, 2004. ,
DOI : 10.1007/s004240050253
Molecular Dynamics of the KcsA K+ Channel in a Bilayer Membrane, Biophysical Journal, vol.78, issue.6, pp.2900-2917, 2000. ,
DOI : 10.1016/S0006-3495(00)76831-7
A microscopie view of ion conduction trough the potassium channel, Proc. Nat!. Acad. Sei. USA, pp.8644-8648, 2003. ,
The Voltage Sensor in Voltage-Dependent Ion Channels, Physiological Reviews, vol.24, issue.2, pp.555-592, 2000. ,
DOI : 10.1085/jgp.110.2.101
Voltage Sensor Movements, The Journal of General Physiology, vol.82, issue.4, pp.465-473, 2002. ,
DOI : 10.1007/s004240050253
Shake, rattle or roll?, Nature, vol.291, issue.6974, pp.499-500, 2004. ,
DOI : 10.1006/jmbi.1999.3027
Molecular movement of the voltage sensor in a potassium channel, J. Gen. Physiol, 2003. ,
Molecular Dynamics Simulations of a K Channel Model:?? Sensitivity to Changes in Ions, Waters, and Membrane Environment, The Journal of Physical Chemistry B, vol.106, issue.17, pp.4543-4551, 2002. ,
DOI : 10.1021/jp0129986
Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy, Nature, vol.35, issue.6763, pp.813-817, 1999. ,
DOI : 10.1152/physrev.2000.80.2.555
Potassium channel structures, Nature Reviews Neuroscience, vol.385, issue.2, pp.115-121, 2002. ,
DOI : 10.1038/385272a0
Recent advances in ion channel research, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1565, issue.2, pp.267-286, 2002. ,
DOI : 10.1016/S0005-2736(02)00574-6
Answers and Questions from the KvAP Structures, Neuron, vol.39, issue.3, pp.395-400, 2003. ,
DOI : 10.1016/S0896-6273(03)00472-0
Multiple sequence alignment with hierarchical clustering, Nucleic Acids Research, vol.16, issue.22, pp.10881-10890, 1988. ,
DOI : 10.1093/nar/16.22.10881
) method for Ewald sums in large systems, The Journal of Chemical Physics, vol.9, issue.12, pp.10089-10092, 1993. ,
DOI : 10.1126/science.2548279
An extended sampling of the configurational space of RPr from E. coli, Proteins: Struct. Funct. Genet, pp.314-322, 1996. ,
Blocker protection in the pore of a voltage-gated K+ channel
and its structural implications, Nature, vol.385, issue.6767, pp.321-325, 2000. ,
DOI : 10.1038/385272a0
Ion channel structures: a review of recent progress, Curr. Opin. Drug. Discov. Devel, vol.6, pp.611-619, 2003. ,
Potassium Channel, Ions, and Water: Simulation Studies Based on the High Resolution X-Ray Structure of KcsA, Biophysical Journal, vol.85, issue.5, pp.2787-2800, 2003. ,
DOI : 10.1016/S0006-3495(03)74702-X
The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity, Science, vol.280, issue.5360, pp.69-77, 1998. ,
DOI : 10.1126/science.280.5360.69
Analysis of membrane and surface protein sequences with the hydrophobic moment plot, Journal of Molecular Biology, vol.179, issue.1, pp.125-142, 1984. ,
DOI : 10.1016/0022-2836(84)90309-7
SERF: A Program for Accessible Surface Area Calculations, Journal of Molecular Graphics and Modelling, vol.15, issue.4, pp.238-244, 1997. ,
DOI : 10.1016/S1093-3263(97)00082-X
Knowledge-based protein secondary structure assignment, Proteins: Structure, Function, and Genetics, vol.206, issue.4, pp.566-579, 1995. ,
DOI : 10.1107/S0108768191012363
The Orientation and Molecular Movement of a K+ Channel Voltage-Sensing Domain, Neuron, vol.40, issue.3, pp.515-525, 2003. ,
DOI : 10.1016/S0896-6273(03)00646-9
Water As A Structural Element In A Channel: Gating In The Kcsa Channel, And Implications For Voltage- Gated Ion Channels, Journal of Biomolecular Structure and Dynamics, vol.80, issue.4, pp.725-730, 2002. ,
DOI : 10.1016/S0896-6273(00)80422-5
Convergence of sampling in protein simulations, Physical Review E, vol.35, issue.3, pp.1-10, 2002. ,
DOI : 10.1002/(SICI)1097-0134(19990515)35:3<283::AID-PROT2>3.0.CO;2-R
Ionie channels of excitable membranes, 1992. ,
A quantitative description of membrane current and its application to conduction and excitation in nerve, The Journal of Physiology, vol.117, issue.4, pp.500-544, 1952. ,
DOI : 10.1113/jphysiol.1952.sp004764
Channel, The Journal of General Physiology, vol.70, issue.1, pp.51-58, 2000. ,
DOI : 10.1017/S0033583598003448
URL : https://hal.archives-ouvertes.fr/in2p3-00113952
Projection of monte carlo and molecular dynamics trajectories onto the normal mode axes: Human lysozyme, Proteins: Structure, Function, and Genetics, vol.209, issue.2, pp.106-116, 1991. ,
DOI : 10.1002/prot.340100204
Conversation between voltage sensors and gates of ion channels, Biochemistry, vol.39, pp.15653-15658, 2000. ,
Collective motions in proteins: A covariance analysis of atomic fluctuations in molecular dynamics and normal mode simulations, Proteins: Structure, Function, and Genetics, vol.82, issue.3, pp.205-217, 1991. ,
DOI : 10.1107/S0567740875002415
Longer time steps for molecular dynamics, The Journal of Chemical Physics, vol.110, issue.20, pp.9853-9864, 1999. ,
DOI : 10.1145/229473.229474
Potassium channels and their evolving gates, Nature, vol.371, issue.6493, pp.119-122, 1994. ,
DOI : 10.1038/371119a0
CLONED POTASSIUM CHANNELS FROM EUKARYOTES AND PROKARYOTES, Annual Review of Neuroscience, vol.20, issue.1, pp.91-123, 1997. ,
DOI : 10.1146/annurev.neuro.20.1.91
The open pore conformation of potassium channels, Nature, vol.11, issue.6888, pp.523-526, 2002. ,
DOI : 10.1002/prot.340110407
X-ray structure of a voltage-dependent K+ channel, Nature, vol.22, issue.6935, pp.33-41, 2003. ,
DOI : 10.1093/nar/22.22.4673
The principle of gating charge movement in a voltage-dependent K+ channel, Nature, vol.19, issue.6935, pp.42-48, 2003. ,
DOI : 10.1016/S0896-6273(00)80422-5
Comparison of simple potential functions for simulating liquid water, The Journal of Chemical Physics, vol.79, issue.2, pp.926-935, 1983. ,
DOI : 10.1016/0009-2614(80)85344-9
Namd2: Greater sca1ability for paralle1 mo1ecu1ar dynamics, J Comput. Phys, vol.1, issue.151, pp.283-312, 1999. ,
K+ channels 1acking the 'tetramerization' domain: implications for pore structure, Nat. Struct. Biol, vol.6, pp.1122-1125, 1999. ,
Bacterial ion channels and their eukaryotic homologues, BioEssays, vol.371, issue.12, pp.1148-1158, 2001. ,
DOI : 10.1038/371119a0
Crystal structure of the tetramerization domain of the Shaker potassium channel, Nature, vol.11, issue.6679, pp.945-948, 1998. ,
DOI : 10.1002/prot.340110407
Predicting transmembrane protein topology with a hidden markov model: application to complete genomes11Edited by F. Cohen, Journal of Molecular Biology, vol.305, issue.3, pp.567-580, 2001. ,
DOI : 10.1006/jmbi.2000.4315
Atomic Proximity between S4 Segment and Pore Domain in Shaker Potassium Channels, Neuron, vol.39, issue.3, pp.467-481, 2003. ,
DOI : 10.1016/S0896-6273(03)00468-9
Transmembrane Movement of the Shaker K+ Channel S4, Neuron, vol.16, issue.2, pp.387-397, 1996. ,
DOI : 10.1016/S0896-6273(00)80056-2
Interaction between Extracellular Hanatoxin and the Resting Conformation of the Voltage-Sensor Paddle in Kv Channels, Neuron, vol.40, issue.3, pp.527-536, 2003. ,
DOI : 10.1016/S0896-6273(03)00636-6
Channel, The Journal of General Physiology, vol.8, issue.1, pp.33-49, 2000. ,
DOI : 10.1126/science.2122520
Gating modifier toxins revea1 a conserved structural motif in vo1tage-gated calcium and potassium channe1s, Proc. Natl. Acad Sei. USA, pp.8585-8589, 1998. ,
Channel, The Journal of General Physiology, vol.14, issue.6, pp.673-684, 2000. ,
DOI : 10.1007/s004240050253
Helical Structure of the Cooh Terminus of S3 and Its Contribution to the Gating Modifier Toxin Receptor in Voltage-Gated Ion Channels, The Journal of General Physiology, vol.76, issue.3, pp.205-217, 2001. ,
DOI : 10.1017/S0033583598003448
Ion conduction pore is conserved among potassium channels, Nature, vol.243, issue.6858, pp.809-813, 2001. ,
DOI : 10.1126/science.2493160
Computational modelling of the open-state Kv1.5 ion channel block by bupivacaine, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1652, issue.1, pp.35-51, 2003. ,
DOI : 10.1016/j.bbapap.2003.08.006
1. Evanseck, M. 1. Field, S. Fischer, 1, Prodhom, W. E. Reiher nI, B. Roux, M ,
URL : https://hal.archives-ouvertes.fr/hal-01212246
All-atom empirical potential for molecular modeling and dynamics studies ofproteins, J Phys. Chem. B, vol.1, issue.102, pp.3586-3616, 1998. ,
Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor, Science, vol.245, issue.4924, pp.1382-1385, 1989. ,
DOI : 10.1126/science.2476850
Role of K+ channels in pulmonary hypertension, Vascular Pharmacology, vol.38, issue.1, pp.25-33, 2002. ,
DOI : 10.1016/S1537-1891(02)00123-4
Independence and Cooperativity in Rearrangements of a Potassium Channel Voltage Sensor Revealed by Single Subunit Fluorescence, The Journal of General Physiology, vol.8, issue.3, pp.257-268, 2000. ,
DOI : 10.1085/jgp.112.4.457
1.4 differentially affect slow inactivation, FEBS Letters, vol.277, issue.2-3, pp.163-169, 2003. ,
DOI : 10.1074/jbc.M205661200
URL : https://hal.archives-ouvertes.fr/hal-01579189
Global and local motions in ribonuclease A: a molecular dynamics study, Biopolymers, vol.65, pp.274-283, 2002. ,
An Escherichia coli homologue of eukaryiotic potassium channel proteins, Proc. Natl. Acad. Sei. USA, pp.3510-3514, 1994. ,
Channel, The Journal of General Physiology, vol.6, issue.3, pp.415-423, 1999. ,
DOI : 10.1126/science.2122520
Evidence for Intersubunit Interactions between S4 and S5 Transmembrane Segments of the Shaker Potassium Channel, Journal of Biological Chemistry, vol.80, issue.31, pp.29079-29085, 2003. ,
DOI : 10.1006/jsbi.1998.3962
Structural Rearrangements Underlying K+-Channel Activation Gating, Science, vol.285, issue.5424, pp.73-78, 1999. ,
DOI : 10.1126/science.285.5424.73
Mutation of conserved negatively charged residues in the S2 and S3 transmembrane segments of a mammalian K+ channel selectively modulates channel gating., Proc. Nat. Acad. Sei, pp.9422-9426, 1995. ,
DOI : 10.1073/pnas.92.20.9422
Membrane protein folding and oligomerization: the twostage model, Biochemistry, vol.2721, pp.4031-4037, 1990. ,
Influence of the membrane potential on the free energy of an intrinsic protein, Biophysical Journal, vol.73, issue.6, pp.2980-2989, 1997. ,
DOI : 10.1016/S0006-3495(97)78327-9
Theoretical and computational models of ion channels, Current Opinion in Structural Biology, vol.12, issue.2, pp.182-189, 2002. ,
DOI : 10.1016/S0959-440X(02)00307-X
Functional analysis of an archaebacterial voltage-dependent K+ channel, Nature, vol.62, issue.6928, pp.180-185, 2003. ,
DOI : 10.1124/mol.62.1.48
The voltage-sensitive sodium channel is a bell-shaped molecule with several cavities, Nature, vol.409, issue.6823, pp.1047-1051, 2001. ,
DOI : 10.1038/35059098
Activation of Shaker potassium channels. Ill. An activation gating model for wild-type and V2 mutant channel, J Gen. Physiol, pp.313-342, 1998. ,
Voltage-Sensing Residues in the S2 and S4 Segments of the Shaker K+ Channel, Neuron, vol.16, issue.6, pp.1159-1167, 1996. ,
DOI : 10.1016/S0896-6273(00)80142-7
Fast gating in the Shaker K+ channel and the energy landscape of activation, Proc. Natl. Acad. Sei, pp.7611-7615, 2003. ,
DOI : 10.1038/nature01580
The pore dimensions of gramicidin A, Biophysical Journal, vol.65, issue.6, pp.1109-1126, 1993. ,
DOI : 10.1016/S0006-3495(93)81293-1
Three-dimensional structure of a vo1tage-gated potassium channel at 2.5 nm reso1ution, Structure (Camb.), vol.9, pp.215-220, 2001. ,
Channel, The Journal of General Physiology, vol.74, issue.5, pp.469-490, 2001. ,
DOI : 10.1007/s004240050253
A proton pore in a potassium channel voltage sensor reveals a focused electric field, Nature, vol.33, issue.6974, pp.548-553, 2004. ,
DOI : 10.1021/bi00188a012
Voltage-Dependent Proton Transport by the Voltage Sensor of the Shaker K+ Channel, Neuron, vol.19, issue.6, pp.1319-1327, 1997. ,
DOI : 10.1016/S0896-6273(00)80422-5
Calculation of the dielectric permettivity profile for a nonuniform system: application to a lipid bilayer simulation, J Chem. Phys, vol.118, pp.3401-3412, 2003. ,
An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula, Neuron, vol.15, issue.4, pp.941-949, 1995. ,
DOI : 10.1016/0896-6273(95)90184-1
Hanatoxin Modifies the Gating of a Voltage-Dependent K+ Channel through Multiple Binding Sites, Neuron, vol.18, issue.4, pp.665-673, 1997. ,
DOI : 10.1016/S0896-6273(00)80306-2
Mapping the Receptor Site for Hanatoxin, a Gating Modifier of Voltage-Dependent K+ Channels, Neuron, vol.18, issue.4, pp.675-682, 1997. ,
DOI : 10.1016/S0896-6273(00)80307-4
Solution structure of hanatoxin l, a gating modifier of voltage-dependent potassium channels: common surface features of gating modifier toxins, J Mol. Biol, vol.1, issue.297, pp.771-780, 2000. ,
Voltage-Dependent Insertion of Alamethicin at Phospholipid/Water and Octane/Water Interfaces, Biophysical Journal, vol.80, issue.1, pp.331-346, 2001. ,
DOI : 10.1016/S0006-3495(01)76018-3
Analysis and Evaluation of Channel Models: Simulations of Alamethicin, Biophysical Journal, vol.83, issue.5, pp.2393-2407, 2002. ,
DOI : 10.1016/S0006-3495(02)75253-3
Electrostatic interactions between transmembrane segments mediate folding of Shaker K+ channel subunits, Biophysical Journal, vol.72, issue.4, pp.1489-1500, 1997. ,
DOI : 10.1016/S0006-3495(97)78797-6
Channels, Journal of Biological Chemistry, vol.80, issue.21, pp.18994-19000, 2002. ,
DOI : 10.1038/35101535
Principles governing amino acid composition of integral membrane proteins: application to topology prediction 1 1Edited by J. Thornton, Journal of Molecular Biology, vol.283, issue.2, pp.489-506, 1998. ,
DOI : 10.1006/jmbi.1998.2107
Hydrophobic docking: A proposed enhancement to molecular recognition techniques, Proteins: Structure, Function, and Genetics, vol.193, issue.4, pp.320-329, 1994. ,
DOI : 10.1080/07391102.1992.10507954
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges, Nature, vol.38, issue.6985, pp.864-868, 2004. ,
DOI : 10.1021/bi9914457
Molecular Basis of Charge Movement in Voltage-Gated Sodium Channels, Neuron, vol.16, issue.1, pp.113-122, 1996. ,
DOI : 10.1016/S0896-6273(00)80028-8
The voltage-gated potassium channels and their relatives, Nature, vol.276, issue.6902, pp.35-42, 2002. ,
DOI : 10.1016/S0092-8674(00)81635-9
Potassium channel receptor site for the inactivation gate and quatemary amine inbibitors, Nature, vol.411, issue.6838, pp.657-661, 2001. ,
DOI : 10.1038/35079500
démontrent, en réalité, une convergence évolutive pour le mécanisme d'action de ces toxines (Winterfield and Swartz, 2000) Les caractéristiques du complexe moléculaire formé par le canal Shaker B et l'hanatoxine, rapportées ici, peuvent correspondre à des propriétés générales pour un mécanisme d'action conservé des toxines sur les canaux ioniques sensibles à la tension, 1998. ,
Essential dynamics of proteins, Proteins: Structure, Function, and Genetics, vol.158, issue.4, pp.412-425, 1993. ,
DOI : 10.1002/prot.340170408
Changes in Local S4 Environment Provide a Voltage-sensing Mechanism for Mammalian Hyperpolarization???activated HCN Channels, The Journal of General Physiology, vol.115, issue.1, pp.5-19, 2004. ,
DOI : 10.1007/s004240050253
Mechanism of action of neurotoxins on the inactivation of voltage-gated sodium channels, CR Seances Soc. Biol. Fil, vol.192, pp.409-436, 1998. ,
The Voltage Sensor in Voltage-Dependent Ion Channels, Physiological Reviews, vol.24, issue.2, pp.555-592, 2000. ,
DOI : 10.1085/jgp.110.2.101
Molecular Movement of the voltage sensor in a potassium channel, J Gen. Physiol, 2003. ,
Discrete-state theory in nerve impulse modelling, Riv. Biol, vol.96, pp.261-270, 2003. ,
Molecular mechanisms of gating and drug block of sodium channels, Novartis Found Symp, vol.241, pp.206-232, 2002. ,
Potassium channel structures, Nature Reviews Neuroscience, vol.385, issue.2, pp.115-121, 2002. ,
DOI : 10.1038/385272a0
Ion channel structures: a review of recent progress, Curr. Opin. Drug. Discov. Devel, vol.6, pp.611-619, 2003. ,
Potassium Channel, Ions, and Water: Simulation Studies Based on the High Resolution X-Ray Structure of KcsA, Biophysical Journal, vol.85, issue.5, pp.2787-2800, 2003. ,
DOI : 10.1016/S0006-3495(03)74702-X
Evolutionary Relationship between K+ Channels and Symporters, Biophysical Journal, vol.77, issue.2, pp.775-788, 1999. ,
DOI : 10.1016/S0006-3495(99)76931-6
The Orientation and Molecular Movement of a K+ Channel Voltage-Sensing Domain, Neuron, vol.40, issue.3, pp.515-525, 2003. ,
DOI : 10.1016/S0896-6273(03)00646-9
Structure of the BgK-Kv1.1 Complex Based on Distance Restraints Identified by Double Mutant Cycles, Journal of Biological Chemistry, vol.8, issue.40, pp.37406-37413, 2002. ,
DOI : 10.1016/0896-6273(95)90104-3
The selectivity of scorpion ??-toxins for sodium channel subtypes is determined by subtle variations at the interacting surface, Toxicon, vol.41, issue.2, pp.125-128, 2003. ,
DOI : 10.1016/S0041-0101(02)00294-5
Occurrence of type 3 sodium channel peptide toxins in two species of sea anemones (Dofleinia armata and Entacmaea ramsayi), Toxicon, vol.41, issue.5, pp.637-639, 2003. ,
DOI : 10.1016/S0041-0101(02)00368-9
Conversation between voltage sensors and gates of Ion channels, Biochemistry, vol.39, pp.15653-15658, 2000. ,
X-ray structure of a voltage-dependent K+ channel, Nature, vol.22, issue.6935, pp.33-41, 2003. ,
DOI : 10.1093/nar/22.22.4673
The principle of gating charge movement in a voltage-dependent K+ channel, Nature, vol.19, issue.6935, pp.42-48, 2003. ,
DOI : 10.1016/S0896-6273(00)80422-5
Atomic Proximity between S4 Segment and Pore Domain in Shaker Potassium Channels, Neuron, vol.39, issue.3, pp.467-481, 2003. ,
DOI : 10.1016/S0896-6273(03)00468-9
BmKK4, a novel toxin from the venom of Asian scorpion Buthus martensi Karsch, inhibits potassium currents in rat hippocampal neurons in vitro, Toxicon, vol.42, issue.2, pp.199-205, 2003. ,
DOI : 10.1016/S0041-0101(03)00136-3
Gating modifier toxins reveal a conserved structural motif in voltage-gated calcium and potassium channels, Proc. Natl. Acad. Sei. USA, pp.8585-8589, 1998. ,
Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor, Science, vol.245, issue.4924, pp.1382-1385, 1989. ,
DOI : 10.1126/science.2476850
Sodium channel toxins and neurotransmitter release, Neurochemical Research, vol.28, issue.10, pp.1607-1611, 2003. ,
DOI : 10.1023/A:1025643030044
Evidence for Intersubunit Interactions between S4 and S5 Transmembrane Segments of the Shaker Potassium Channel, Journal of Biological Chemistry, vol.80, issue.31, pp.29079-29085, 2003. ,
DOI : 10.1006/jsbi.1998.3962
Structure and structure-function relationships of sea anemone proteins that interact with the sodium channel, Toxicon, vol.29, issue.9, pp.1051-1052, 1991. ,
DOI : 10.1016/0041-0101(91)90205-6
Three-Dimensional Structure in Solution of the Polypeptide Cardiac Stimulant Anthopleurin-A, Biochemistry, vol.34, issue.11, pp.3782-3794, 1995. ,
DOI : 10.1021/bi00011a036
Novel interactions between K+ channels and scorpion toxins, Trends in Pharmacological Sciences, vol.24, issue.5, pp.222-227, 2003. ,
DOI : 10.1016/S0165-6147(03)00080-4
Introduction: Molecular diversity of Ion Channels and Cell Function, Annals of the New York Academy of Sciences, vol.6, issue.1 MOLECULAR AND, 1999. ,
DOI : 10.1016/0896-6273(94)90441-3
Functional analysis of an archaebacterial voltage-dependent K+ channel, Nature, vol.62, issue.6928, pp.180-185, 2003. ,
DOI : 10.1124/mol.62.1.48
Purification, sequence, and pharmacological properties of sea anemone toxins from Radianthus paumotensis. A new class of sea anemone toxins acting on the sodium channel, Biochemistry, vol.24, issue.14, pp.3554-3561, 1985. ,
DOI : 10.1021/bi00335a025
SCORPION, a molecular database of scorpion toxins, Toxicon, vol.40, issue.1, pp.23-31, 2002. ,
DOI : 10.1016/S0041-0101(01)00182-9
An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula, Neuron, vol.15, issue.4, pp.941-949, 1995. ,
DOI : 10.1016/0896-6273(95)90184-1
Solution structure of hanatoxin1, a gating modifier of voltage-dependent K+ channels: common surface features of gating modifier toxins, Journal of Molecular Biology, vol.297, issue.3, pp.771-780, 2000. ,
DOI : 10.1006/jmbi.2000.3609
Bioinformatics for venom and toxin sciences, Briefings in Bioinformatics, vol.4, issue.1, pp.53-62, 2003. ,
DOI : 10.1093/bib/4.1.53
Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins, Cellular Signalling, vol.15, issue.2, pp.151-159, 2003. ,
DOI : 10.1016/S0898-6568(02)00085-2
A Hot Spot for the Interaction of Gating Modifier Toxins with Voltage-Dependent Ion Channels, The Journal of General Physiology, vol.266, issue.5, pp.637-644, 2000. ,
DOI : 10.1021/bi00211a022
The voltage-gated potassium channels and their relatives, Nature, vol.276, issue.6902, pp.35-42, 2002. ,
DOI : 10.1016/S0092-8674(00)81635-9