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\Y est classique Après une introduction générale le mt!illoue se décompose en deux parties majeures: UIl ap<!rçu historique du sujet çt les travaux personnels du candidat ,
Les raies et les conceplS majeurs sont correctement abordés. Cependant:, on peut regretter que son analyse soit dirigée sur la limioe intérieure de l'autorégulation et que l'analyse intellectuelle de la limite supérieure (ce qui se passe lors d'une hypertension aiguë) ne soit ni traitée ni assimilée ,
el -BP 5229 -14074 CI\.EN CedèX rd. 02 31 4702 30 -fox; 0231 470222 -E-mail: Ma<.:Kènzic@<.:ycerol.l.fr ,
pu démontrer grâce aux mesures classiques que la mélaranine diminue le débit sanguin cérébral de base, augmente le débit cérébro-vasculai.re hypercapnique et dimio.ue la limite inférieure de l'auto-régulation cérébrale. Ces études ont été publiées dans l'American]oumal of Physiology. La. seule critiqlle que l'on puisse émettre SUI la présentation de cet aspect de ses recherches est que les résultats sant présentés en pourcentage et ,
1ieur REGRIGNY concerne les eft"ets direcLS de la mélatomne sur le calibre des artérioles pie-mèrie.cnes. La mélatonine induit une vasOCOllstriction des petits vaisseaux d'envù"on 40 J.lIll. Cet effet n'est pas une fonction de la dose ad.mi.aistrée et peut être supprimée par }'administrcUion d'un antagoniste relativement sélectifpar les récepleurs mélatoninergiqucs. Par contre, cette étude, qui est soumise au]ournal of CardiovasCll]ar Pharmacology: ne peut mettre en é ... idence un effet direct de la mélatonine sur le débit sanguin cérébral de base ,