. Est-ce-qu, un traitement chronique à la mélatonine peut améliorer les capacités d'autorégulation du DSC d'animaux âgés? (Chapitre II-5)

I. Adams, . Brierley, R. Connor, and C. S. Et-treips, THE EFFECTS OF SYSTEMIC HYPOTENSION UPON THE HUMAN BRAIN. CLINICAL AND NEUROPATHOLOGICAL OBSERVATIONS IN 11 CASES, Brain, vol.89, issue.2, pp.235-267, 1966.
DOI : 10.1093/brain/89.2.235

A. Alperovitch, I. Mas, B. Doyon, and P. Et-myquel, Mortality from Stroke in France 1968???1982, Neuroepidemiology, vol.5, issue.2, pp.80-87, 1986.
DOI : 10.1159/000110817

F. Anton-tay, Melatonin: effects on brain function, Adv Biochem Psychopharmacol, pp.315-324, 1974.

S. L. Archer, . Huang, V. Hampl, D. P. Nelson, . Shultz et al., Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase., Proceedings of the National Academy of Sciences, vol.91, issue.16, pp.7583-7587, 1994.
DOI : 10.1073/pnas.91.16.7583

. Arendt, Melatonin: A New Probe in Psychiatric Investigation?, British Journal of Psychiatry, vol.155, issue.05, pp.585-590, 1989.
DOI : 10.1192/S0007125000018055

. Arendt, . Borbley, . Aa, C. Franey, and . Wright, The effects of chronic, small doses of melatonin given in the late afternoon on fatigue in man: A preliminary study, Neuroscience Letters, vol.45, issue.3, pp.317-321, 1984.
DOI : 10.1016/0304-3940(84)90245-3

W. M. Armstead, Hypotension dilates pial arteries by KATP and Kca channel activation, Brain Research, vol.816, issue.1, pp.158-164, 1999.
DOI : 10.1016/S0006-8993(98)01146-9

M. Asano, . Masuzawa, and T. Et-matsuda, Functional role of charybodotoxinsensitive K+ channels in the resting state of cerebral, coronary and mesenteric arteries in the dog, J Pharmacol Exp Pharmacol, vol.267, pp.1277-1285, 1993.

L. M. Auer and N. Et-ishiyama, Pial Vascular Behavior during Bilateral and Contralateral Cervical Sympathetic Stimulation, Journal of Cerebral Blood Flow & Metabolism, vol.5, issue.3, pp.298-304, 1986.
DOI : 10.1038/jcbfm.1982.12

URL : http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1986.52

L. M. Auer and M. Et-mokry, Effect of topical nimodipine versus its ethanol-containing vehicle on cat pial arteries, Stroke, vol.17, issue.2, pp.225-228, 1986.
DOI : 10.1161/01.STR.17.2.225

K. Aukland, B. F. Bower, and R. W. Et-berliner, Measurement of Local Blood Flow with Hydrogen Gas, Circulation Research, vol.14, issue.2, pp.164-187, 1964.
DOI : 10.1161/01.RES.14.2.164

T. Bar, Morphometric evaluation of capillaries in different laminae of rat cerebral cortex by autonomic image analysis: changes during development and aging, Adv Neurol, vol.20, pp.1-9, 1978.

D. I. Barry, S. Strandgaard, D. I. Graham, O. Braendstrup, U. Svendsen et al., Cerebral Blood Flow in Rats with Renal and Spontaneous Hypertension: Resetting of the Lower Limit of Autoregulation, Journal of Cerebral Blood Flow & Metabolism, vol.57, issue.3, pp.347-353, 1982.
DOI : 10.1161/01.CIR.53.4.720

G. L. Baumbach, Effects of Increased Pulse Pressure on Cerebral Arterioles, Hypertension, vol.27, issue.2, 1996.
DOI : 10.1161/01.HYP.27.2.159

G. L. Baumbach and D. D. Et-heistad, Adaptive changes in cerebral blood vessels during chronic hypertension, Journal of Hypertension, vol.9, issue.11, pp.987-991, 1991.
DOI : 10.1097/00004872-199111000-00002

G. L. Baumbach, J. Siems, and D. D. Et-heistad, Effects of local reduction in pressure on distensibility and composition of cerebral arterioles, Circulation Research, vol.68, issue.2, pp.338-351, 1991.
DOI : 10.1161/01.RES.68.2.338

G. L. Baumbach, F. B. Dobrin, M. N. Hart, and D. D. Et-heistad, Mechanics of cerebral arterioles in hypertensive rats, Circulation Research, vol.62, issue.1, pp.56-64, 1988.
DOI : 10.1161/01.RES.62.1.56

G. L. Baumbach, J. Walmsley, and M. N. Hart, Composition and mechanics of cerebral arterioles in hypertensive rats, Am J Pathol, vol.133, pp.464-471, 1988.

W. M. Bayliss, On the local reaction of the arterial wall to changes of internaI pressure, 1902.

G. Benitez-king, L. Huerto-delgadillo, and F. Et-anton-tay, Binding of3H-melatonin to calmodulin, L~fe Sci, vol.53, pp.201-207, 1993.

R. Berne, The role of adenosine in the regulation of coronary blood flow, Circulation Research, vol.47, issue.6, pp.807-813, 1980.
DOI : 10.1161/01.RES.47.6.807

C. E. Beyer, J. Steketee, and D. Et-saphier, Antioxidant properties of melatonin???an emerging mystery, Biochemical Pharmacology, vol.56, issue.10, pp.1265-1272, 1998.
DOI : 10.1016/S0006-2952(98)00180-4

J. Booker and . Et-hellekson, Prevalence of seasonaÎ affective disorder in Alaska, 1992.

H. Bosman, I. C. Dormehl, N. Hugo, I. F. Redelinghuys, and . Et-theron, The effect of intravenous administration of melatonin on cardiovascular parameters of the baboon (Papio ursinus), J Pineal Res, issue.1, pp.179-181, 1991.

D. M. Bowen, A. N. Et-davidson, T. Bartus, and S. Et-gershon, Can the pathophysiology of dementia lead to rational therapy ? ln Treatment Development Strategies for Alzheimer 's Disease, pp.36-66, 1986.

J. Brayden and M. T. Et-nelson, Regulation of arterial tone by activation of calcium-dependent potassium channels, Science, vol.256, issue.5056, pp.532-535, 1992.
DOI : 10.1126/science.1373909

L. Bray-des-boscs, . Lartaud, F. Muller, . Atkinson, and C. Et-capdeville, Effects of the Angiotensin I Converting Enzyme Inhibitor Perindopril on Cerebral Blood Flow in Awake Hypertensive Rats, American Journal of Hypertension, vol.4, issue.3_Pt_2, pp.246-252, 1991.
DOI : 10.1093/ajh/4.3.246S

J. Brian, . Jr, F. M. Faraci, and D. D. Et-heistad, RECENT INSIGHTS INTO THE REGULATION OF CEREBRAL CIRCULATION, Clinical and Experimental Pharmacology and Physiology, vol.76, issue.13, pp.449-457, 1996.
DOI : 10.1161/01.RES.76.6.1057

J. Brun, B. Claustrat, P. Saddier, and G. Et-chazot, Nocturnal melatonin excretion is decreased in patients with migraine without aura attacks associated with menses. Cephalgia, pp.136-139, 1995.

J. E. Buchanan and J. W. Et-phillis, The role of nitric oxide in the regulation of cerebral blood flow, Brain Research, vol.610, issue.2, pp.248-255, 1993.
DOI : 10.1016/0006-8993(93)91408-K

M. Buresova, M. Dvorakova, P. Zvolsky, and . Iiinerova, Early morning bright light phase advances the human circadian pacemaker within one day, Neuroscience Letters, vol.121, issue.1-2, pp.47-50, 1991.
DOI : 10.1016/0304-3940(91)90646-B

D. Busija and . Heistad, Factors involved in the physiological regulation of the cerebral circulation, Rev. Physiol, Biochem Pharmacol, vol.10, issue.0, pp.161-211, 1984.
DOI : 10.1007/BFb0027696

S. Capsoni, B. M. Stankov, and F. Et-fraschini, Reduction of regional cerebral blood flow by melatonin in young rats NeuroReport, pp.1346-1348, 1996.

S. Capsoni, M. Viswanathan, D. Oliveira, A. M. Et-saavedra, and J. M. , Characterization of melatonin receptors and signal transduction system in rat arteries forming the circle of Willis., Endocrinology, vol.135, issue.1, pp.373-378, 1994.
DOI : 10.1210/endo.135.1.8013371

R. Carneiro, O. Tofoletto, J. Cipolla-neto, and R. Et-markus, Modulation of sympathetic neurotransmission by melatonin, European Journal of Pharmacology, vol.257, issue.1-2, pp.73-77, 1994.
DOI : 10.1016/0014-2999(94)90696-3

J. Cervos-navarro, H. Gertz, and V. Et-frydl, Cerebral blood vessel changes in old people, Mechanisms of Ageing and Development, vol.39, issue.3, pp.223-231, 1987.
DOI : 10.1016/0047-6374(87)90062-5

J. M. Chillon and G. Et-baumbach, Effects of an Angiotensin-Converting Enzyme Inhibitor and a ??-Blocker on Cerebral Arterioles in Rats, Hypertension, vol.33, issue.3, pp.856-891, 1999.
DOI : 10.1161/01.HYP.33.3.856

J. M. Chillon, O. Régrigny, 1. Lartaud-idjouadiene, P. Delagrange, E. Scalbert et al., Melatonin constricts rat cerebral arterioles in vivo by blocking Ca 2 + -activated K+ (BKCa) channels, BrU J Pharmacol, vol.126, p.34, 1999.

. Chillon, G. L. Baumbach, K. A. Welch, L. R. Capian, D. Reis et al., Autoregulation of Cerebral Blood Flow, Primer on Cerebrovascular Diseases, pp.51-54, 1997.
DOI : 10.1016/B978-012743170-3.50014-5

L. Chillon, S. Ghoneim, and G. L. Et-baumbach, Effects of Chronic Nitric Oxide Synthase Inhibition on Cerebral Arterioles in Rats, Hypertension, vol.30, issue.5, pp.1097-1104, 1997.
DOI : 10.1161/01.HYP.30.5.1097

L. Chillon, D. D. Heistad, and G. L. Et-baumbach, Effects of Endothelin Receptor Inhibition on Cerebral Arterioles in Hypertensive Rats, Hypertension, vol.27, issue.3, pp.794-798, 1996.
DOI : 10.1161/01.HYP.27.3.794

B. Claustrat, M. Geoffriau, . Brun, and G. Et-chazot, La mélatonine: de l'hormone au médicament?, Pathol Biol, vol.44, pp.645-653, 1996.

M. Cohen, D. Roselle, B. Chabner, T. Schmidt, and M. Et-lippman, Evidence for a cytoplasmic melatonin receptor, Nature, vol.193, issue.5674, pp.894-895, 1978.
DOI : 10.1083/jcb.70.2.261

R. H. Cox, Effects of age on the mechanical properties of rat carotid artery, American Journal of Physiology-Heart and Circulatory Physiology, vol.233, issue.2, pp.256-263, 1977.
DOI : 10.1152/ajpheart.1977.233.2.H256

T. Coyle and P. Et-puttfarcken, Oxidative stress, glutamate, and neurodegenerative disorders, Science, vol.262, issue.5134, pp.689-695, 1993.
DOI : 10.1126/science.7901908

H. Cramer, . Rudolph, V. Consbruck, . Et-kendel, E. Costa et al., On the effects ofmelatonin on sleep and behaviour on man, Advances in Biochemical Psychopharmacology, pp.187-191, 1974.

M. Daffertshofer and M. Et-hennerici, Cerebrovascular regulation and vasoneuronal coupling, Journal of Clinical Ultrasound, vol.110, issue.2, pp.125-138, 1995.
DOI : 10.1161/01.STR.23.1.9

D. Dawson and N. Et-encel, Melatonin and sleep in humans, Journal of Pineal Research, vol.5, issue.1, pp.1-12, 1993.
DOI : 10.1126/science.227056

D. Jong, G. I. Farkas, E. Stienstra, E. M. Plass, I. M. Keijser et al., Cerebral hypoperfusion yields capillary damage in the hippocampal CA1 area that correlates with spatial memory impairment, Neuroscience, vol.91, issue.1, pp.203-210, 1999.
DOI : 10.1016/S0306-4522(98)00659-9

L. De-la-torre, Critical threshold cerebral hypoperfusion causes Alzheimer's disease?, Acta Neuropathologica, vol.98, issue.1, 1999.
DOI : 10.1007/s004010051044

M. J. Duncan, . Takahashi, and M. L. Dubocovich, I]Iodomelatonin Binding Sites in Djungarian Hamster Brain*, Endocrinology, vol.125, issue.2, pp.1011-1018, 1989.
DOI : 10.1210/endo-125-2-1011

M. J. Duncan, . Takahashi, and M. L. Dubocovich, I]Iodomelatonin Binding Sites in Hamster Brain Membranes: Pharmacological Characteristics and Regional Distribution*, Endocrinology, vol.122, issue.5, pp.1825-1833, 1988.
DOI : 10.1210/endo-122-5-1825

C. Durlach-misteli and . Et-van-ree, Dopamine and melatonin in the nucleus accumbens may be implicated in the mode of action of antidepressant drugs, European Journal of Pharmacology, vol.217, issue.1, pp.15-21, 1992.
DOI : 10.1016/0014-2999(92)90505-X

L. Edvinsson and E. T. Et-mac-kenzie, Amine mechanisms in the cerebral circulation, 1976.

B. K. Evans, R. Mason, and V. Et-wilson, Evidence for direct vasoconstrictor activity of melatonin in ?pressurized? segments of isolated caudal artery from juvenile rats, Naunyn-Schmiedeberg's Archives of Pharmacology, vol.346, issue.3, pp.362-365, 1992.
DOI : 10.1007/BF00173553

F. M. Faraci and K. R. Et-breeske, Nitric oxide mediates vasodilatation in response to activation of N- methyl-D-aspartate receptors in brain, Circulation Research, vol.72, issue.2, pp.476-480, 1993.
DOI : 10.1161/01.RES.72.2.476

F. M. Faraci, Role of nitric oxide in regulation of basilar artery tone in vivo, American Journal of Physiology-Heart and Circulatory Physiology, vol.259, issue.4, pp.216-221, 1990.
DOI : 10.1152/ajpheart.1990.259.4.H1216

F. M. Faraci and D. D. Et-heistad, Regulation of large cerebral arteries and cerebral microvascular pressure, Circulation Research, vol.66, issue.1, pp.8-17, 1990.
DOI : 10.1161/01.RES.66.1.8

F. M. Faraci, Effects of endothelin and vasopressin on cerebral blood vessels, American Journal of Physiology-Heart and Circulatory Physiology, vol.257, issue.3, pp.799-803, 1989.
DOI : 10.1152/ajpheart.1989.257.3.H799

F. M. Faraci, G. L. Baumbach, and D. D. Et-heistad, Myogenic mechanisms in the cerebral circulation, J Hypertens, vol.7, pp.61-64, 1989.

E. Ferrari, F. Magri, D. Dori, G. Migliorati, T. Nescis et al., Neuroendocrine Correlates of the Aging Brain in Humans, Neuroendocrinology, vol.61, issue.4, pp.464-470, 1995.
DOI : 10.1159/000126869

M. Fevre-montagne, La mélatonine. la Presse Médicale, pp.1659-1663, 1985.

T. Finkel, Myocyte hypertrophy: the long and winding RhoA???d, Journal of Clinical Investigation, vol.103, issue.12, pp.1619-1620, 1999.
DOI : 10.1172/JCI7459

B. Folkow, Description of the myogenic hypothesis, Circ Res, vol.15, pp.279-287, 1964.

K. Fujii, D. D. Heistad, and F. M. Et-faraci, Flow-mediated dilatation of the basilar artery in vivo, Circulation Research, vol.69, issue.3, pp.69697-705, 1991.
DOI : 10.1161/01.RES.69.3.697

K. Fujii, D. D. Heistad, and F. M. Et-faraci, Role of the basilar artery in regulation of blood flow to the brain stem in rats, Stroke, vol.22, issue.6, pp.763-767, 1991.
DOI : 10.1161/01.STR.22.6.763

. Garcia-roldan and . Bevan, Augmentation of endothelium-independent flow constriction in pial arteries at high intravascular pressures., Hypertension, vol.17, issue.6_Pt_2, pp.870-874, 1991.
DOI : 10.1161/01.HYP.17.6.870

G. G. Geary, D. N. Krause, and S. P. Et-duckles, Melatonin directly constricts rat cerebral arteries through modulation of potassium channels, American Journal of Physiology-Heart and Circulatory Physiology, vol.273, issue.3, pp.530-536, 1997.
DOI : 10.1152/ajpheart.1997.273.3.H1530

E. V. Golanov, K. A. Et-reis-welch, L. R. Capian, D. Reis, B. K. Siesjô et al., Oxygen and Cerebral Blood Flow, Cerebrovascular Diseases, pp.58-60, 1997.
DOI : 10.1016/B978-012743170-3.50016-9

B. D. Goldman, The physiology ofmelatonin in mammals, Pineal Research Reviews, pp.145-182, 1983.

L. Greenberg, B. Weiss, and E. Et-cantor, beta-Adrenergic receptors in aged rat brain: reduced number and capacity of pineal gland to develop supersensitivity, Science, vol.201, issue.4350, pp.61-63, 1978.
DOI : 10.1126/science.208145

L. Guerrero, M. I. Pablos, G. G. Ortiz, M. T. Agapito, and . Reiter, NOCTURNAL DECREASES IN NITRIC OXIDE AND CYCLIC GMP CONTENTS IN THE CHICK BRAIN AND THEIR PREVENTION BY LIGHT, Neurochemistry International, vol.29, issue.4, pp.417-421, 1996.
DOI : 10.1016/0197-0186(95)00162-X

M. A. Hadju, D. D. Heistad, J. Siems, and G. L. Et-baumbach, Effects of aging on mechanics and composition of cerebral arterioles in rats, Circ Res, vol.66, pp.1747-1754, 1990.

E. Haggendal and B. Et-johansson, EFFECTS OF ARTERIAL CARBON DIOXIDE TENSION AND OXYGEN SATURATION ON CEREBRAL BLOOD FLOW AUTOREGULATION IN DOGS, Acta Physiologica Scandinavica, vol.23, issue.Suppl. I, pp.27-53, 1965.
DOI : 10.1001/archneurpsyc.1930.02220120002001

L. Haining, M. D. Turner, and R. Et-pantall, Measurement of Local Cerebral Blood Flow in the Unanesthetized Rat Using a Hydrogen Clearance Method, Circulation Research, vol.23, issue.2, pp.313-324, 1968.
DOI : 10.1161/01.RES.23.2.313

L. Hardebo and L. Et-edvindsson, Adenine compounds: cerebrovascular effects in vitro with reference to their possible involvement in migraine, Stroke, vol.10, issue.1, pp.58-62, 1979.
DOI : 10.1161/01.STR.10.1.58

D. R. Harder, C. Sanchez-ferrer, K. Kauser, W. Stekiel, and G. M. Et-rubanyi, Pressure releases a transferable endothelial contractile factor in cat cerebral arteries, Circulation Research, vol.65, issue.1, pp.193-198, 1989.
DOI : 10.1161/01.RES.65.1.193

D. Harder, Pressure-induced myogenic activation of cat cerebral arteries is dependent on intact endothelium, Circulation Research, vol.60, issue.1, pp.102-107, 1987.
DOI : 10.1161/01.RES.60.1.102

R. Harlow, Influence of the Pineal Gland and Melatonin on Blood Flow and Evaporative Water Loss During Heat Stress in Rats, Journal of Pineal Research, vol.45, issue.8, pp.147-159, 1987.
DOI : 10.1016/0024-3205(67)90043-4

S. L. Harper and H. G. Et-bohlen, Microvascular adaptation in the cerebral cortex of adult spontaneously hypertensive rats, Hypertension, vol.6, issue.3, pp.408-419, 1984.
DOI : 10.1161/01.HYP.6.3.408

D. D. Heistad, M. L. Marcus, D. Piegors, and M. L. Armstrong, Regulation of cerebral blood flow in atherosclerotic monkeys, American Journal of Physiology-Heart and Circulatory Physiology, vol.239, issue.4, pp.539-544, 1980.
DOI : 10.1152/ajpheart.1980.239.4.H539

D. D. Heistad, M. L. Marcus, and F. M. Et-abboud, Role of Large Arteries in Regulation of Cerebral Blood Flow in Dogs, Journal of Clinical Investigation, vol.62, issue.4, pp.761-768, 1978.
DOI : 10.1172/JCI109187

. Hernandez, . Ml, R. W. Brennan, and G. S. Et-bowman, Cerebral blood flow autoregulation in the rat Stroke, pp.150-155, 1978.

M. Holland, . Langton, . Pd, N. B. Standen, and . Et-boyle, Effects of the BKCa channel activator, NS1619, on rat cerebral artery smooth muscle, British Journal of Pharmacology, vol.439, issue.1, pp.119-129, 1996.
DOI : 10.1113/jphysiol.1991.sp018691

K. Hong, S. E. Yoo, S. S. Yu, . Lee, and B. Y. Et-rhim, Pharmacological coupling and functionnal role for CGRP receptors in the vasodilation of rat pial arterioles, Am J Physiol, vol.270, pp.317-323, 1996.

K. Hongo, T. Nakagomi, N. F. Kassel, T. Sasaki, M. Lehman et al., Effects of aging and hypertension on endothelium-dependent vascular relaxation in rat carotid artery, Stroke, vol.19, issue.7, pp.892-897, 1988.
DOI : 10.1161/01.STR.19.7.892

W. Humbert and P. Et-pévet, The pineal gland of the aging rat: Calcium localization and variation in the number of pinealocytes, Journal of Pineal Research, vol.3, issue.1, pp.32-40, 1995.
DOI : 10.1016/S0140-6736(76)92781-1

W. Humbert and P. Et-pévet, Calcium content and concretions of pineal glands of young and old rats, Cell and Tissue Research, vol.193, issue.3, pp.593-596, 1991.
DOI : 10.1007/BF00327294

P. D. Hum, R. I. Et-traystman, K. A. Welch, L. R. Capian, D. Reis et al., Overview of cerebrovascular hemodynamics, Cerebrovaseular Diseases, pp.42-44, 1997.

C. Iadecola, Does nitric oxide mediate the increases in cerebral blood flow elicited by hypercapnia?, Proceedings of the National Academy of Sciences, vol.89, issue.9, pp.3913-3916, 1992.
DOI : 10.1073/pnas.89.9.3913

N. Ishimura, K. Kitaguchi, . Tatsumi, and H. Et-furuya, Nitric Oxide Involvement in Hypoxic Dilation of Pial Arteries in the Cat, Anesthesiology, vol.85, issue.6, pp.1350-1356, 1996.
DOI : 10.1097/00000542-199612000-00016

I. Committee, Classification c.b.t.I.c.o.r.n.a.d, The IUPHAR COmpendium ofReceptor Characterization and Classification, pp.188-193, 1998.

Z. Jiang, C. Nelson, and C. Et-allen, Melatonin activates an outward current and inhibits Ih in rat suprachiasmatic nucleus neurons, Brain Research, vol.687, issue.1-2, pp.125-132, 1995.
DOI : 10.1016/0006-8993(95)00478-9

R. Jockers, L. Petit, and I. Et-lacroix, Novel isoforms of Mellc melatonin receptor modulating intracellular cyclic guano sine 3',5'-monophophate level, Mol Endoerinol, 1997.

B. Johansson, Myogenic tone and reactivity: definitions based on muscle physiology, J Hypertens, vol.7, pp.5-8, 1989.

P. C. Johnson, Autoregulation of blood flow, Circulation Research, vol.59, issue.5, pp.483-495, 1986.
DOI : 10.1161/01.RES.59.5.483

S. Jones, B. Bose, . Furlan, . Friel, . Ht et al., CO 2 reactivity and heterogeneity of cerebral blood flow in ischemic, border zone, and normal cortex, P. et Little, lR Am J Physiol, vol.257, pp.473-482, 1989.

E. Kilic, Y. Ozdemir, H. Bolay, . Kelestimur, and T. Et-dalkara, Pinealectomy aggravates and melatonin administration attenuates brain dommages in focal ischemia, J Cereb Blood Flow Metab, vol.26, pp.1713-1723, 1999.

T. Kitazono, F. M. Faraci, . Taguchi, and D. D. Et-heistad, Role of Potassium Channels in Cerebral Blood Vessels, Stroke, vol.26, issue.9, pp.1713-1723, 1995.
DOI : 10.1161/01.STR.26.9.1713

T. Kitazono, D. D. Heistad, and F. M. Et-faraci, Role of ATP sensitive K+ channels in CGRP induced dilatation ofbasilar artery in vivo, Am J Physiol, vol.265, pp.677-681, 1993.

B. Klein, W. Kuschinsky, H. Schrock, and F. Et-vetterlein, Interdependency of local capillary density, blood flow, and metabolism in rat brains, American Journal of Physiology-Heart and Circulatory Physiology, vol.251, issue.6, pp.1333-1340, 1986.
DOI : 10.1152/ajpheart.1986.251.6.H1333

D. C. Klein and R. Moore, Pineal N-acetyltransferase and hydroxyindole-O-methyl-transferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus, Brain Research, vol.174, issue.2, pp.245-262, 1979.
DOI : 10.1016/0006-8993(79)90848-5

M. Kobari, Y. Fukuuchi, M. Tomita, N. Tanahashi, and H. Et-takeda, Role of nitric oxide in regulation of cerebral microvascular tone and autoregulation of cerebral blood flow in cats, Brain Research, vol.667, issue.2, pp.255-262, 1994.
DOI : 10.1016/0006-8993(94)91503-2

H. A. Kontos, E. P. Wei, R. Navari, L. Levasseur, W. I. Rosenblum et al., J (1978a) Responses of cerebral arteries and arterioles to acute hypotension and hypertension, Am J Physlol, vol.234, pp.371-383

H. A. Kontos, E. P. Wei, . Raper, W. I. Rosenblum, R. Navari et al., Role of tissue hypoxia in local regulation of cerebral microcirculation, American Journal of Physiology-Heart and Circulatory Physiology, vol.234, issue.5, pp.582-591, 1978.
DOI : 10.1152/ajpheart.1978.234.5.H582

H. Kontos, E. P. Wei, A. Raper, and . Patterson, Local mechanism of C02 action on cat pial arterioles, Stroke, vol.8, pp.227-229, 1977.

D. N. Krause, V. E. Barrios, and S. P. Et-duckles, Melatonin receptors mediate potentiation of contractile responses to adrenergic nerve stimulation in rat caudal artery, European Journal of Pharmacology, vol.276, issue.3, pp.207-213, 1995.
DOI : 10.1016/0014-2999(95)00028-J

D. N. Krause and M. L. Et-dubocovich, Melatonin Receptors, Annual Review of Pharmacology and Toxicology, vol.31, issue.1, pp.549-568, 1991.
DOI : 10.1146/annurev.pa.31.040191.003001

D. N. Krause and M. L. Et-dubocovich, Regulatory sites in the melatonin system of mammals, Trends in Neurosciences, vol.13, issue.11, pp.464-470, 1990.
DOI : 10.1016/0166-2236(90)90100-O

A. Laflamme, L. Wu, S. Foucart, and . Et-de-champlain, Impaired basal sympathetic tone and alphal-adrenergic responsiveness in association with the hypotensive effect of melatonin in spontaneously hypertensive rats, Am.J Hypert, pp.219-229, 1998.

L. Laitinen, M. Viswanathan, O. Vakkuri, and . Saavedra, Differentiai regulation of the rat melatonin receptors: selective age-associated decline and lack of melatonin-induced changes, Endocrinology, vol.130, pp.2139-2144, 1992.

N. A. Lassen, Cerebral Blood Flow and Oxygen Consumption in Man, Physiological Reviews, vol.39, issue.2, pp.183-238, 1959.
DOI : 10.1152/physrev.1959.39.2.183

N. Laudignon, K. Beharry, E. Farri, and . Et-aranda, The Role of Adenosine in the Vascular Adaptation of Neonatal Cerebral Blood Flow during Hypotension, Journal of Cerebral Blood Flow & Metabolism, vol.239, issue.3, pp.424-431, 1991.
DOI : 10.1002/ana.410120506

W. S. Lee, Y. Kwon, S. S. Yu, B. Y. Rhim, and K. W. Hong, Disturbances III autoregulatory responses ofrat pial arteries by sulfonylureas, Life Sei, vol.52, pp.1527-1534, 1993.

T. S. Leeson, C. R. Leeson, . Etpaparo, and . Aa, InAtlasofHystologie, 1988.

A. Lewy, S. Ahmed, J. M. Latham-jackson, and R. L. Et-sack, Melatonin Shifts Human Orcadian Rhythms According to a Phase-Response Curve, Chronobiology International, vol.52, issue.5, pp.380-392, 1992.
DOI : 10.1159/000125573

A. J. Lewy, T. A. Wehr, F. K. Goodwin, D. A. Newsome, and S. P. Et-markey, Light suppresses melatonin secretion in humans, Science, vol.210, issue.4475, pp.1267-1269, 1980.
DOI : 10.1126/science.7434030

A. Lewy, . Tetsuo, and S. P. Et-markey, PINEALECTOMY ABOLISHES PLASMA MELATONIN IN THE RAT, The Journal of Clinical Endocrinology & Metabolism, vol.50, issue.1, pp.204-205, 1979.
DOI : 10.1210/jcem-50-1-204

P. Lissoni, F. Morabito, G. Esposti, D. Esposti, G. Ripamonti et al., A study on the thymus-pineal axis: interactions between thymic hormones and melatonin secretion, Acta Med Auxol, vol.20, pp.35-39, 1988.

C. Liu, D. R. Weaver, . Jin, L. P. Shearman, R. L. Pieschi et al., Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian dock. ne/mm, pp.91-102, 1997.

L. M. Machesky and . Hall, Rho: a connection between membrane receptor signalling and the cytoskeleton, Trends in Cell Biology, vol.6, issue.8, pp.304-310, 1996.
DOI : 10.1016/0962-8924(96)10026-X

G. Maestroni and . Lm, The immunoneuroendocrine role of melatonin, Journal of Pineal Research, vol.10, issue.1, pp.1-10, 1993.
DOI : 10.1089/jir.1990.10.403

G. J. Maestroni, . Conti, and W. Et-pierpaoli, Pineal Melatonin, Its Fundamental Immunoregulatory Role in Aging and Cancer, Annals of the New York Academy of Sciences, vol.68, issue.1 Neuroimmunomo, pp.140-148, 1988.
DOI : 10.1007/978-1-4899-0557-4_4

Y. Magata, H. Saji, S. R. Choi, K. Tajima, T. Takagaki et al., Noninvasive Measurement of Cerebral Blood Flow and Glucose Metabolic Rate in the Rat with High-Resolution Animal Positron Emission Tomography(PET): A Novel in Vivo Approach for Assessing Drug Action in the Brains of Small Animals., Biological & Pharmaceutical Bulletin, vol.18, issue.5, pp.753-756, 1995.
DOI : 10.1248/bpb.18.753

C. D. Mahle, G. D. Goggins, and F. D. Et-yocca, Melatonin modulates vascular tone in rat anterior cerebral artery, Neuroscience, vol.21, p.183, 1995.
DOI : 10.1177/074873049701200626

M. T. Martin, F. Azpiroz, and . Malagelada, Melatonin and the gastrointestinal tract, IR, 1998.

E. Masoro, Minireview: Food Restriction in Rodents: An Evaluation of Its Role in the Study of Aging, Journal of Gerontology, vol.43, issue.3, pp.59-64, 1988.
DOI : 10.1093/geronj/43.3.B59

W. G. Mayhan and F. M. Et-faraci, Responses of cerebral arterioles in diabetic rats to activation of ATP-sensitive potassium channels, American Journal of Physiology-Heart and Circulatory Physiology, vol.265, issue.1, pp.52-57, 1993.
DOI : 10.1152/ajpheart.1993.265.1.H152

W. G. Mayhan, F. M. Faraci, G. L. Baumbach, and D. D. Et-heistad, Effects of aging on responses of cerebral arterioles, American Journal of Physiology-Heart and Circulatory Physiology, vol.258, issue.4, pp.138-143, 1990.
DOI : 10.1152/ajpheart.1990.258.4.H1138

L. Mayo, R. Sainz, H. Uria, . Antolin, M. M. Esteban et al., Inhibition of cell proliferation: A mechanism likely to mediate the prevention of neuronal cell death by melatonin, Journal of Pineal Research, vol.6, issue.1, pp.12-18, 1998.
DOI : 10.1111/j.1471-4159.1992.tb08880.x

A. Mcarthur, M. U. Gilette, and R. A. Et-prosser, Melatonin directly resets the rat suprachiasmatic circadian clock in vitro, Brain Research, vol.565, issue.1, pp.158-161, 1990.
DOI : 10.1016/0006-8993(91)91748-P

S. Mellander, Functional aspects of myogenic vascular control, J Hypertens, vol.7, pp.21-30, 1989.

L. Miguez, . Martin, and M. Et-aldegunde, Effects of single doses and daily melatonin treatments on serotonin metabolism in rat brain regions, Journal of Pineal Research, vol.7, issue.4, pp.170-176, 1994.
DOI : 10.1007/BF01923669

E. Molinari, P. E. North, and M. L. Et-dubocovich, 2-[125I]Iodo-5-methoxycarbonylamino-N-acetyltryptamine: a selective radioligand for the characterization of melatonin ML2 binding sites, European Journal of Pharmacology, vol.301, issue.1-3, pp.159-168, 1996.
DOI : 10.1016/0014-2999(95)00870-5

P. G. Morgan, !. Barret, P. Howell, H. Et-hel1iwell, and R. , Melatonin receptors: Localization, molecular pharmacology and physiological significance, Neurochemistry International, vol.24, issue.2, pp.101-146, 1994.
DOI : 10.1016/0197-0186(94)90100-7

P. Morgan, W. Lawson, G. Davidson, and H. Howell, MELATONIN INHIBITS CYCLIC AMP PRODUCTION IN CULTURED OVINE PARS TUBERALIS CELLS, Journal of Molecular Endocrinology, vol.3, issue.2, pp.5-8, 1989.
DOI : 10.1677/jme.0.003R005

E. Capdeville, Perindopril resets the lower limit of cerebral blood flow autoregulation in awake renovascular hypertensive rats, Eur J Pharmacol, vol.183, p.1308, 1990.

S. Nagasawa, H. Handa, A. Okumura, Y. Naruo, K. Moritake et al., Mechanical properties of human cerebral arteries. Part 1: effects of age and vascular smooth muscle activation, Surg Neurol, vol.12, pp.297-304, 1979.

E. Nathan and Q. Et-xie, Regulation of biosynthesis of nitric oxide, J Biol Chem, vol.269, pp.13725-13728, 1994.

E. S. Nelson, . Marino, and E. N. Et-allen, Melatonin receptors activate heteromeric G-protein coupled Kir3 channels, NeuroReport, vol.7, issue.3, pp.717-720, 1996.
DOI : 10.1097/00001756-199602290-00009

G. M. Nemecek, S. Coughlin, R. Handley, D. Moskowitz, and M. , Stimulation of aortic smooth muscle ceIl mitogenesis by serotonin, Proceedings ~f the National Academy of, pp.674-678, 1986.

. Oelsen, E. Munch, . Moldt, and . Drejer, Selective activation of Ca2+ -dependent K+ channels by novel benzimidazolone, European Journal of Pharmacology, vol.251, issue.1, pp.53-59, 1994.
DOI : 10.1016/0014-2999(94)90442-1

G. Osol and W. Et-halpern, Myogenic properties of cerebral blood vessels from normotensive and hypertensive rats, American Journal of Physiology-Heart and Circulatory Physiology, vol.249, issue.5, pp.914-921, 1985.
DOI : 10.1152/ajpheart.1985.249.5.H914

L. Pantoni and . Garcia, Pathogenesis of Leukoaraiosis : A Review, Stroke, vol.28, issue.3, pp.652-659, 1997.
DOI : 10.1161/01.STR.28.3.652

B. A. Pappas, J. De-la-torre, . Davidson, M. Keyes, and T. Et-fortin, Chronic reduction of cerebral blood flow in the adult rat: late-emerging CA1 cell loss and memory dysfunction, Brain Research, vol.708, issue.1-2, pp.50-58, 1996.
DOI : 10.1016/0006-8993(95)01267-2

W. M. Pardridge, Blood-Brain Barrier Transport Mechanisms In Cerebrovascular, 1997.

P. Pasqualetti, G. Natali, . Casale, and D. Colantonio, Epidemiological chronorisk of stroke, Acta Neurologica Scandinavica, vol.69, issue.9, pp.71-74, 1990.
DOI : 10.1042/cs0690369

U. Passant, . Warkentin, L. S-"-l\iiinthon, . Faldt, and L. Et-edvinsson, Cortical blood flow during head-up postural change in subjects with orthostatic hypotension, Clinical Autonomic Research, vol.105, issue.5, pp.311-318, 1993.
DOI : 10.1161/01.STR.11.4.342

O. B. Paulson and G. Et-waldemar, Inhibition of the renin angiotensin system and the autoregulation of cerebral circulation, Coronary and Cerebrovascular F:ffects of, 1990.

A. Peters, S. L. Palay, and R. Webster, The Fine Sstructure of the Nervous System: Neurons and their Sllpporting Cells, 1991.

C. Pieri, M. Marra, F. Moroni, R. Recchioni, and F. Et-marcheselli, Melatonin: A peroxyl radical scavenger more effective than vitamin E, Life Sciences, vol.55, issue.15, pp.271-276, 1996.
DOI : 10.1016/0024-3205(94)00666-0

P. T. Ram, T. Kiefer, M. Silverman, . Song, G. M. Brown et al., Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors, Molecular and Cellular Endocrinology, vol.141, issue.1-2, 1998.
DOI : 10.1016/S0303-7207(98)00095-1

O. Régrigny, J. Atkinson, C. Capdeville-atkinson, . Liminana, and . Et-chillon, Effect of Lovastatin on Cerebral Circulation in Spontaneously Hypertensive Rats, Hypertension, vol.35, issue.5, pp.1105-1110, 2000.
DOI : 10.1161/01.HYP.35.5.1105

O. Régrigny, P. Delagrange, E. Scalbert, and . Lartaud-idjouadiene, Effects of melatonin on rat pial arteriolar diameter in vivo, Atkinson, l et Chillon, lM. Brit J Pharmacol, vol.1, issue.127, pp.1666-1670, 1999.

O. Régrigny, P. Delagrange, E. Scalbert, . Atkinson, and . Et-lartaud-idjouadiene, Melatonin improves cerebral circulation security margin in rats, American Journal of Physiology-Heart and Circulatory Physiology, vol.22, issue.7, pp.139-144, 1998.
DOI : 10.1136/bmj.1.6171.1117

R. Reiter, Antioxidant Actions of Melatonin, Adv Pharmacol, vol.38, pp.103-117, 1997.
DOI : 10.1016/S1054-3589(08)60981-3

R. Reiter, M. !. Pablos, T. Agapito, and . Et-guerrero, Melatonin in the Context of the Free Radical Theory of Aging, Annals of the New York Academy of Sciences, vol.786, issue.1 Near-Earth Ob, pp.362-378, 1996.
DOI : 10.1111/j.1749-6632.1996.tb39077.x

R. Reiter, Oxygen radical detoxification processes during agmg: the functional importance of melatonin, Aging, vol.7, pp.340-351, 1995.

R. Reiter, Pineal function during aging: attenuation of the melatonin rhythm and its neurobiological consequences, Acta Nel/rohiol Exp (Warsz), vol.54, pp.31-39, 1994.

G. Rosenberg, K. M. Awelch, L. R. Capian, D. Reis, B. K. Siesjo et al., CSF, Cerebrovascular Diseases, pp.29-33, 1997.
DOI : 10.1016/B978-012743170-3.50009-1

L. Roth, . Rabin, and K. Et-agnello, Melatonin suppression of PC12 cell growth and death, Brain Research, vol.768, issue.1-2, pp.63-70, 1997.
DOI : 10.1016/S0006-8993(97)00549-0

R. Sack, . Lewy, D. L. Erb, W. M. Vollner, and C. M. Et-singer, Human Melatonin Production Decreases With Age, Journal of Pineal Research, vol.24, issue.4, pp.379-388, 1986.
DOI : 10.1016/0165-1781(79)90028-3

N. Satake, H. Oe, T. Sa\vada, and S. Shibata, The mode of vasorelaxing action of melatonin in rabbit aorta, General Pharmacology: The Vascular System, vol.22, issue.2, pp.219-221
DOI : 10.1016/0306-3623(91)90435-9

N. Satake, H. Oe, and S. Shibata, Vasorelaxing action of melatonin in rat isolated aorta; possible endothelium dependent relaxation, General Pharmacology: The Vascular System, vol.22, issue.6, pp.1127-1133, 1991.
DOI : 10.1016/0306-3623(91)90589-X

E. Scwerynek, B. Poeggeler, D. Melchiorri, and R. Reiter, H2O2 induced lipid peroxidation in rat brain homogenates is greatly reduced by melatonin, Neuroscience Letters, vol.195, issue.3, pp.203-205, 1995.
DOI : 10.1016/0304-3940(95)11803-5

T. M. Seasholtz, M. Majumdar, D. D. Kaplan, and I. Et-brown, Rho and Rho Kinase Mediate Thrombin-Stimulated Vascular Smooth Muscle Cell DNA Synthesis and Migration, Circulation Research, vol.84, issue.10, pp.1186-1193, 1999.
DOI : 10.1161/01.RES.84.10.1186

P. Semple, Angiotensin II in the Rat, Endocrinology, vol.107, issue.3, pp.771-773, 1980.
DOI : 10.1210/endo-107-3-771

H. M. Shapiro, D. D. Stromberg, D. R. Lee, and C. A. Et-wiederhielm, Dynamic pressures in the pial arterial microcirculation, American Journal of Physiology-Legacy Content, vol.221, issue.1, pp.279-283, 1971.
DOI : 10.1152/ajplegacy.1971.221.1.279

S. Shibata, V. Cassone, and R. Y. Et-moore, Effects of melatonin on neuronal activity in the rat suprachiasmatic nucleus in vitro, Neuroscience Letters, vol.97, issue.1-2, pp.140-144, 1989.
DOI : 10.1016/0304-3940(89)90153-5

S. Shibata, N. Satake, T. Takagi, and H. Et-usui, Vasorelaxing action of melatonin in rabbit basilar artery, General Pharmacology: The Vascular System, vol.20, issue.5, pp.677-680
DOI : 10.1016/0306-3623(89)90106-7

E. Shohami and . Sidi, in Autoregulation, Journal of Cerebral Blood Flow & Metabolism, vol.245, issue.1, pp.107-109, 1984.
DOI : 10.1161/01.STR.13.4.494

A. Shuaib, Alteration of blood pressure regulation and cerebrovascular disorders in the elderly, Cerebrovasc Brain Metab Rev, vol.4, pp.329-345, 1992.

D. Skene, B. Vivien-roels, D. L. Sparks, . Hunsaker, P. Pévet et al., Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease, Brain Research, vol.528, issue.1, pp.170-174, 1990.
DOI : 10.1016/0006-8993(90)90214-V

E. Skinh0j and S. Strandgaard, Patohgenesis ofhypertensive encephalopathy, Lancet, pp.461-462, 1973.

1. Skoog, Status of Risk Factors for Vascular Dementia, Neuroepidemiology, vol.17, issue.1, pp.2-9, 1998.
DOI : 10.1159/000026147

1. Skoog, The relationship between blood pressure and dementia: a review, Biomedicine & Pharmacotherapy, vol.51, issue.9, pp.367-375, 1997.
DOI : 10.1016/S0753-3322(97)89428-0

A. Slominski and D. Pruski, Melatonin Inhibits Proliferation and Melanogenesis in Rodent Melanoma Cells, Experimental Cell Research, vol.206, issue.2, pp.189-194, 1993.
DOI : 10.1006/excr.1993.1137

L. Sokoloff, K. A. Welch, L. Capian, D. J. Reis, . Siesjb et al., Anatomy of Cerebral Circulation, Cerebrovascular Diseases, pp.3-5, 1997.
DOI : 10.1016/B978-012743170-3.50002-9

S. Strandgaard, . Olesen, E. Skinhoj, and N. A. Et-lassen, Autoregulation of Brain Circulation in Severe Arterial Hypertension, BMJ, vol.1, issue.5852, pp.507-510, 1973.
DOI : 10.1136/bmj.1.5852.507

D. Sugden, H. Pickering, M. T. Teh, and P. J. Garratt, Melatonin receptor pharmacology: toward subtype specificity, Biology of the Cell, vol.89, issue.8, pp.531-537, 1998.
DOI : 10.1016/S0248-4900(98)80009-9

Y. J. Suzuki, H. J. Forman, and . Et-sevanian, Oxidants as Stimulators of Signal Transduction, Free Radical Biology and Medicine, vol.22, issue.1-2, pp.269-285
DOI : 10.1016/S0891-5849(96)00275-4

Y. Tagashira, M. Matsuda, K. A. Welch, E. Chabi, and . Meyer, Effects of cyclic AMP and dibutyryl cyclic AMP on cerebral hemodynamics and metabolism in the baboon, Journal of Neurosurgery, vol.15, issue.4, pp.484-493, 1977.
DOI : 10.1016/0014-2999(71)90176-2

H. Taguchi, D. D. Heistad, . Kitazono, and F. M. Et-faraci, Dilatation of Cerebral Arterioles in Response to Activation of Adenylate Cyclase Is Dependent on Activation of Ca2+-Dependent K+ Channels, Circulation Research, vol.76, issue.6, pp.1057-1062, 1995.
DOI : 10.1161/01.RES.76.6.1057

S. Takahashi, M. Cook, . Jehle, . Kennedy, and L. Sokoloff, Preservation of autoregulatory cerebral vasodilator responses to hypotension after inhibition of nitric oxide synthesis, Brain Research, vol.678, issue.1-2, pp.21-28, 1995.
DOI : 10.1016/0006-8993(95)00129-E

D. Tan, R. Reiter, L. D. Chen, B. Poeggeler, L. Manchester et al., Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole, Carcinogenesis, vol.15, issue.2, pp.215-218, 1994.
DOI : 10.1093/carcin/15.2.215

D. Tan, B. Poeggeler, L. E. Manchester, and R. Et-reiter, Melatonin: a potent, endogenous hydroxyl radical scavenger, J Endoer, vol.1, pp.57-60, 1993.

K. Tanaka, Y. Fukuuchi, S. Gomi, B. Mihara, T. Shirai et al., Inhibition of nitric oxide synthesis impairs autoregulation of local cerebral blood flow in the rat, NeuroReport, vol.4, issue.3, pp.267-270, 1993.
DOI : 10.1097/00001756-199303000-00010

K. Tanaka, F. Gotoh, S. Gomi, S. Takashima, B. Mihara et al., Inhibition of nitric oxide synthesis induces a significant reduction in local cerebral blood flow in the rat, Neuroscience Letters, vol.127, issue.1, pp.129-132, 1991.
DOI : 10.1016/0304-3940(91)90911-C

T. K. Tatemachi and . Mohr, Migraine and stroke In Stroke: Pathophysiology, Diagnosis and Management, pp.761-785, 1992.

K. Ting, W. Dunn, D. Davies, D. Sugden, P. Delagrange et al., Studies on the vasoconstrictor action of melatonin and putative melatonin receptor ligands in the tail artery of juvenile Wistar rats, British Journal of Pharmacology, vol.296, issue.7, pp.1299-1306, 1997.
DOI : 10.1111/j.1476-5381.1991.tb12527.x

Y. Touitou, B. Selmaoui, and . Zhao, Mélatonine et rythmes biologiques: quelques aspects en physiopathologies humaines, Z.Y Ann. Pharmaceutiques Françaises, vol.54, pp.241-250, 1996.

Y. Touitou, M. Fevre, M. Lagoguey, A. Carayon, A. Bogdan et al., AGE- AND MENTAL HEALTH-RELATED CIRCADIAN RHYTHMS OF PLASMA LEVELS OF MELATONIN, PROLACTIN, LUTEINIZING HORMONE AND FOLLICLE-STIMULATING HORMONE IN MAN, Journal of Endocrinology, vol.91, issue.3, pp.467-475, 1981.
DOI : 10.1677/joe.0.0910467

K. Toyoda, K. Fujii, Y. Takata, S. Ibayashi, M. Fujikawa et al., Effect of Aging on Regulation of Brain Stem Circulation During Hypotension, Journal of Cerebral Blood Flow & Metabolism, vol.1, issue.17, pp.680-685, 1997.
DOI : 10.1136/bmj.1.6171.1117

K. Toyoda, K. Fujii, Y. Takata, S. Ibayashi, T. Kitazono et al., Age-Related Changes in Response of Brain Stem Vessels to Opening of ATP-Sensitive Potassium Channels, Stroke, vol.28, issue.1, pp.171-175, 1997.
DOI : 10.1161/01.STR.28.1.171

K. Toyoda, K. Fujii, S. Ibayashi, S. Sadoshima, and M. Et-fujishima, Changes in arterioles, arteries, and local perfusion of the brain stem during hemorrhagic hypertension, American Journal of Physiology-Heart and Circulatory Physiology, vol.270, issue.4, pp.1350-1354, 1996.
DOI : 10.1152/ajpheart.1996.270.4.H1350

H. Van-aken and . Et-van-hemelrijck, Influence ofanesthesia on cerebral blood flow and cerebral metabolism: an overview, Agressologie, vol.32, pp.303-306, 1991.

C. Atkinson, Melatonin potentiates the contractile response to noradrenaline without modifYing intracellular calcium mobilisation in the perfused rat tail artery, Brit J Pharmacol, vol.122, p.97, 1997.

. Vanecek, Cellular Mechanisms of Melatonin Action, Physiological Reviews, vol.252, issue.3, pp.687-721, 1998.
DOI : 10.1146/annurev.bb.23.060194.003045

M. Viswanathan, . Laitinen, and . Saavedra, Vascular Melatonin Receptors, Neurosignals, vol.2, issue.4, pp.221-227, 1993.
DOI : 10.1159/000109495

M. Viswanathan, . Laitinen, and . Saavedra, Expression of melatonin receptors in arteries involved in thermoregulation., Proceedings of the National Academy of Sciences, vol.87, issue.16, pp.6200-6203, 1990.
DOI : 10.1073/pnas.87.16.6200

P. A. Vitte, . Brun, P. Lestage, B. Claustrat, and P. Et-bobillier, The effects of melatonin and pinealectomy upon local cerebral glucose utilization in awake unrestrained rats are restricted to a few specific regions, Brain Research, vol.489, issue.2, pp.273-282, 1989.
DOI : 10.1016/0006-8993(89)90860-3

B. C. Voordouw, R. Euser, R. E. Verdonk, B. T. Alberda, D. Jong et al., Melatonin and melatonin-progestin combinations alter pituitary-ovarian fllnction in women and can inhibit ovulation, J Clin Endocr, vol.74, pp.107-117, 1992.

M. Wahl, Local Chemical, Neural, and Humoral Regulation of Cerebrovascular Resistance Vessels, Journal of Cardiovascular Pharmacology, vol.7, pp.36-46, 1985.
DOI : 10.1097/00005344-198500073-00005

G. Waldemar, Acute Sympathetic Denervation Does Not Eliminate the Effect of Angiotensin Converting Enzyme Inhibition on CBF Autoregulation in Spontaneously Hypertensive Rats, Journal of Cerebral Blood Flow & Metabolism, vol.37, issue.1, pp.43-47, 1990.
DOI : 10.1097/00004872-198903000-00010

G. Waldemar and O. B. Et-paulson, Angiotensin converting enzyme inhibition and cerebral circulation-a review., British Journal of Clinical Pharmacology, vol.438, issue.Suppl 1, pp.177-182, 1989.
DOI : 10.1016/0006-8993(88)91318-2

H. Wang and T. Et-ng, Hypotensive Activity of the Pineal Indoleamine Hormones Melatonin, 5-Methoxytryptophol and 5-Methoxytryptamine, Pharmacology & Toxicology, vol.86, issue.3, pp.125-128, 2000.
DOI : 10.1034/j.1600-0773.2000.pto860306.x

Q. Wang, O. B. Paulson, and N. A. Et-lassen, Is autoregulation of cerebral blood flow in rats influenced by nitro-l-arginine, a blocker of the synthesis of nitric oxide?, Acta Physiologica Scandinavica, vol.6, issue.suppl. 1, pp.297-298, 1992.
DOI : 10.1161/01.RES.60.1.102

L. B. Weekley, Effects of melatonin on pulmonary and coronary vessels are exerted through perivascular nerves, Clinical Autonomic Research, vol.59, issue.suppl, pp.45-47, 1993.
DOI : 10.1161/01.CIR.59.5.938

E. P. Wei and H. Et-kontos, Responses of cerebral arterioles to increased venous pressure, American Journal of Physiology-Heart and Circulatory Physiology, vol.243, issue.3, pp.442-447, 1982.
DOI : 10.1152/ajpheart.1982.243.3.H442

E. P. Wei, H. Kontos, and . Patterson, Dependence of pial arteriolar response to hypercapnia on vessel size, American Journal of Physiology-Heart and Circulatory Physiology, vol.238, issue.5, pp.697-703, 1980.
DOI : 10.1152/ajpheart.1980.238.5.H697

H. R. Winn, . Rubio, and R. Et-berne, Brain adenosine production in the rat during 60 seconds of ischemia, Circulation Research, vol.45, issue.4, pp.486-492, 1979.
DOI : 10.1161/01.RES.45.4.486

K. Witte and R. Et-lemmer, Free-running Rhythms in Blood Pressure and Heart Rate in Normotensive and Transgenic Hypertensive Rats, Chronobiology International, vol.235, issue.4, pp.237-247, 1995.
DOI : 10.1016/0031-9384(83)90061-6

L. Wollner, S. T. Maccarthy, N. D. Soper, and D. Macy, Failure of cerebral autoregulation as a cause ofbrain dysfunction in the elderly, BrU J Pharmacol, pp.1117-1118, 1979.

S. N. Young, Melatonin, sleep, aging, and the health protection branch, J P.~ychiatry Neurosci, vol.21, pp.161-164, 1996.

Z. Zhang, . Inserra, . Pt, R. Liang, S. Ardestani et al., Melatonin, Immune Modulation and Aging, Autoimmunity, vol.5, issue.1, pp.43-53, 1997.
DOI : 10.1016/0024-3205(91)90454-J

M. Zito, G. Parati, S. Omboni, . Cervone, L. Ulian et al., Effect of ageing on blood pressure variability, J Hypertens, vol.9, pp.328-329, 1991.

M. Zuber and J. L. Et-mas, Epidémiologie des accidents vasculaires cérébraux, pp.13-24, 1993.

R. La-thèse-de-monsieur, \Y est classique Après une introduction générale le mt!illoue se décompose en deux parties majeures: UIl ap<!rçu historique du sujet çt les travaux personnels du candidat

. Dlabord, Les raies et les conceplS majeurs sont correctement abordés. Cependant:, on peut regretter que son analyse soit dirigée sur la limioe intérieure de l'autorégulation et que l'analyse intellectuelle de la limite supérieure (ce qui se passe lors d'une hypertension aiguë) ne soit ni traitée ni assimilée

C. Ceoire and H. , el -BP 5229 -14074 CI\.EN CedèX rd. 02 31 4702 30 -fox; 0231 470222 -E-mail: Ma<.:Kènzic@<.:ycerol.l.fr

L. Dans-le-premier-chapin-'e and . Canclidilt, pu démontrer grâce aux mesures classiques que la mélaranine diminue le débit sanguin cérébral de base, augmente le débit cérébro-vasculai.re hypercapnique et dimio.ue la limite inférieure de l'auto-régulation cérébrale. Ces études ont été publiées dans l'American]oumal of Physiology. La. seule critiqlle que l'on puisse émettre SUI la présentation de cet aspect de ses recherches est que les résultats sant présentés en pourcentage et

. Le-deuxième-chapitre-des-travaux-personnels-de-mon, 1ieur REGRIGNY concerne les eft"ets direcLS de la mélatomne sur le calibre des artérioles pie-mèrie.cnes. La mélatonine induit une vasOCOllstriction des petits vaisseaux d'envù"on 40 J.lIll. Cet effet n'est pas une fonction de la dose ad.mi.aistrée et peut être supprimée par }'administrcUion d'un antagoniste relativement sélectifpar les récepleurs mélatoninergiqucs. Par contre, cette étude, qui est soumise au]ournal of CardiovasCll]ar Pharmacology: ne peut mettre en é ... idence un effet direct de la mélatonine sur le débit sanguin cérébral de base