Synthèse et fonctionnalisation d'exo-glycals : Application à la préparation d'anti-tumoraux

Abstract : The objective of this work consists in the synthesis and functionnalization of exo-glycals toward potential anti-cancer compounds. On the one hand, the transformation of easily accessible exo-glycals to more elaborated ones using palladium cross-coupling reaction has been performed and offered a new route to disubstituted exo-glycals. The hydrogenation of these compounds gave original C-glycosides. On the other hand, the new functionnal exo-glycals have been developped to prepare biologically active compounds. Analogs of phenstatin have been obtained and tested for their cellular growth inhibition. Furthermore, a C-glycoside has been used as a scaffold for peptidomimetics synthesis against the tumor angiogenesis process.
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Alexandre Novoa. Synthèse et fonctionnalisation d'exo-glycals : Application à la préparation d'anti-tumoraux. Autre. Université Henri Poincaré - Nancy 1, 2010. Français. ⟨NNT : 2010NAN10006⟩. ⟨tel-01748215⟩

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