N. Brown and L. Condreay, Identification and characterization of mutations in hepatitis B virus resistant to lamivudine, Lamivudine Clinical Investigation Group, 1998.

Z. Andrade, J. Lesborde, P. Ravisse, R. Parana, A. Prata et al., Fulminant hepatitis with microvascular steatosis (a histologic comparison of cases occurring in Brazil ?Labrea hepatitis? and in Central Africa?Bangui hepatitis), 1992.

P. Arauz-ruiz, H. Norder, K. Visoná, and L. Magnius, Genotype F prevails in HBV infected patients of Hispanic origin in Central America and may carry the precore stop mutant, Journal of Medical Virology, vol.176, issue.4, pp.305-312, 1997.
DOI : 10.1016/B978-0-12-255850-4.50010-X

P. Arauz-ruiz, H. Norder, B. Robertson, and L. Magnius, Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America, Journal of General Virology, vol.41, issue.8, pp.2059-2073, 2002.
DOI : 10.1172/JCI115500

W. Bancroft, F. Mundon, and P. Russel, Detection of additional antigenic determinants of hepatitis B antigen, J. Immunol, vol.109, pp.842-848, 1972.

T. Baumert, S. Rogers, K. Hasegawn, and T. Liang, Two core promotor mutations identified in a hepatitis B virus strain associated with fulminant hepatitis result in enhanced viral replication., Journal of Clinical Investigation, vol.98, issue.10, pp.2268-2276, 1996.
DOI : 10.1172/JCI119037

P. Opolon and M. Gentilini, Efficacy of lamivudine on replication of hepatitis B virus in HIV-infected patients, Lancet, vol.345, pp.396-397, 1995.

R. Beasley, C. Trepo, C. Stevens, and W. Szmuness, THE e ANTIGEN AND VERTICAL TRANSMISSION OF HEPATITIS B SURFACE ANTIGEN, American Journal of Epidemiology, vol.105, issue.2, pp.94-98, 1977.
DOI : 10.1093/oxfordjournals.aje.a112370

R. Beasley, C. Lin, L. Hwang, and C. Chien, Hepatocellular carcinoma and hepatitis B virus : a prospective study of 22 707 men in Taiwan, Lancet, vol.II, pp.1129-1133, 1981.

B. Blumberg, H. Alter, and S. Vinisch, A " new " antigen in leukaemia sera, J. Amer, 1965.

S. Bowyer, L. Van-staden, M. Kew, and J. Sim, A unique segment of the hepatitis B virus group A genotype identified in isolates from South Africa., Journal of General Virology, vol.78, issue.7, pp.1719-1729, 1997.
DOI : 10.1099/0022-1317-78-7-1719

S. Bowyer and J. Sim, Relationships within and between genotypes of hepatitis B virus at points across the genome: footprints of recombination in certain isolates, Journal of General Virology, vol.41, issue.2, pp.379-392, 2000.
DOI : 10.1002/(SICI)1096-9071(199906)58:2<111::AID-JMV2>3.0.CO;2-B

K. Breiner, S. Urban, and H. Schaller, Carboxypeptidase D (gp 180), a Golgiresident protein, functions in the attachment and entry of avian hepatitis B viruses, J, 1998.

M. Abate, P. Manzini, and M. Capalbo, Hepatitis B virus unable to secrete " e " antigen and response to interferon in chronic hepatitis B, Gastroenterology, vol.105, issue.3, pp.845-850, 1993.

V. Bruss and D. Ganem, The role of envelope proteins in hepatitis B virus assembly., Proc. Nat. Acad. Sci, pp.1059-1063, 1991.
DOI : 10.1073/pnas.88.3.1059

V. Bruss, E. Ganem, K. Vieluf, and G. Wunderlich, Functions of the Large Hepatitis B Virus Surface Protein in Viral Particle Morphogenesis, Intervirology, vol.39, issue.1-2, pp.23-31, 1996.
DOI : 10.1159/000150471

M. Buendia, Genetics of hepatocellular carcinoma, Seminars in Cancer Biology, vol.10, issue.3, pp.185-200, 2000.
DOI : 10.1006/scbi.2000.0319

W. Carman, A. Zanetti, P. Karayiannis, J. Waters, G. Manzillo et al., Vaccine-induced escape mutant of hepatitis B virus, The Lancet, vol.336, issue.8711, pp.325-329, 1990.
DOI : 10.1016/0140-6736(90)91874-A

S. Chang, H. Netter, M. Bruns, R. Schneider, K. Frölich et al., A New Avian Hepadnavirus Infecting Snow Geese (Anser caerulescens) Produces a Significant Fraction of Virions Containing Single-Stranded DNA, Virology, vol.262, issue.1, pp.39-54, 1999.
DOI : 10.1006/viro.1999.9844

Y. Miyano, H. Koike, M. Kobayashi, I. Koida, Y. Arase et al., Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy, Hepatology, vol.27, pp.1711-1716, 1998.

B. Chen, P. Chen, G. Jow, E. Sablon, C. Liu et al., High prevalence of mixed genotype infections in hepatitis B virus infected intravenous drug users, Journal of Medical Virology, vol.61, issue.4, pp.536-542, 2004.
DOI : 10.1099/0022-1317-81-1-67

C. Chen, L. Wang, S. Lu, M. Wu, S. You et al., Elevated aflatoxin exposure and increased risk of hepatocellular carcinoma Hepatology, pp.38-42, 1996.

C. Chen, M. Yu, and Y. Liaw, Epidemiological characteristics and risk factors of hepatocellular carcinoma, Journal of Gastroenterology and Hepatology, vol.90, issue.9-10, pp.9-10, 1997.
DOI : 10.1056/NEJM199306243282501

P. Chirillo, S. Pagano, G. Natoli, P. Puri, V. Burgio et al., The hepatitis B virus X gene induces p53-mediated programmed cell death, Proc. Nat. Acad Sci, pp.8162-8167, 1997.
DOI : 10.1016/S0959-437X(96)90004-0

C. Confavreux, S. Suissa, P. Saddier, V. Bourdes, and S. Vukusic, For the Vaccination in Multiple Study Group Vaccinations and the risk of replease in multiple sclerosis, 2001.

A. Courouce and J. Pillonel, Estimation of risk of virus transmission in hepatitis B and C and human retrovirus via transfusion of labile blood derivatives, 1996.

C. Cui, J. Shi, L. Hui, H. Xi, . Zhuoma et al., The dominant hepatitis B virus genotype identified in Tibet is a C/D hybrid, Journal of General Virology, vol.4, issue.11, pp.2773-2777, 2002.
DOI : 10.1099/0022-1317-82-4-883

D. Dane, C. Cameron, and M. Briggs, VIRUS-LIKE PARTICLES IN SERUM OF PATIENTS WITH AUSTRALIA-ANTIGEN-ASSOCIATED HEPATITIS, The Lancet, vol.295, issue.7649, pp.695-698, 1970.
DOI : 10.1016/S0140-6736(70)90926-8

D. Franchis, R. Hadengue, A. Lau, G. Lavanchy, D. Lok et al., Consensus statement (long version), EASL International Consensus Conference on Hepatitis B. 13, 2002.

F. Degos, P. Marcellin, and J. Benhamou, Treatment of chronic active hepatitis caused by hepatitis B virus infection, Gastroenterol. Clin. Biol, vol.12, issue.11, pp.845-854, 1988.

A. Dejean, C. Lugassy, S. Zafrani, P. Tiollais, and C. Brechot, Detection of Hepatitis B Virus DNA in Pancreas, Kidney and Skin of Two Human Carriers of the Virus, Journal of General Virology, vol.65, issue.3, pp.651-655, 1984.
DOI : 10.1099/0022-1317-65-3-651

S. Gardner, D. Gray, and E. Schiff, Histological outcome during long-term lamivudine therapy, Gastroenterology, vol.124, pp.105-117, 2003.

H. Doerr and W. Gerlich, Medizinische Virologie Verlag : Thieme Stuttgart, 2002.

W. Edmunds, G. Medley, D. Nokes, O. Callaghan, C. Whittle et al., Epidemiological patterns of hepatitis B virus (HBV) in highly endemic areasr, Epidemiology and Infection, vol.65, issue.02, pp.313-325, 1996.
DOI : 10.1080/02724936.1986.11748448

P. Farci, T. Roskams, L. Chessa, G. Peddis, A. Mazzoleni et al., Long-term benefit of interferon ?? therapy of chronic hepatitis D: regression of advanced hepatic fibrosis, Gastroenterology, vol.126, issue.7, pp.1740-1749, 2004.
DOI : 10.1053/j.gastro.2004.03.017

P. Farci, A. Mandas, A. Coiana, M. Lai, V. Desmet et al., Treatment of Chronic Hepatitis D with Interferon Alfa-2a, New England Journal of Medicine, vol.330, issue.2, pp.88-94, 1994.
DOI : 10.1056/NEJM199401133300202

G. Fattovich, Natural History and Prognosis of Hepatitis B, Seminars in Liver Disease, vol.23, issue.1, pp.47-58, 2003.
DOI : 10.1055/s-2003-37590

L. Fiume, M. Cerenzia, F. Bonino, C. Busi, A. Mattioli et al., INHIBITION OF HEPATITIS B VIRUS REPLICATION BY VIDARABINE MONOPHOSPHATE CONJUGATED WITH LACTOSAMINATED SERUM ALBUMIN, The Lancet, vol.332, issue.8601, pp.13-15, 1988.
DOI : 10.1016/S0140-6736(88)92946-7

E. Flodgren, S. Bengtsson, M. Knutsson, E. Strebkova, A. Kidd et al., Recent high incidence of fulminant hepatitis in Samara, Russia : molecular analysis of prevailing hepatitis B and D virus strains, J. Clin, 2000.

M. Sakaki, Y. Okochi, K. Nakajima, and E. , Gly 145 to Arg substitution in HBs antigen of immune escape mutant of hepatitis B virus, Biochem. Biophys. Res. Commun, vol.184, pp.1152-1157, 1992.

S. Akplogan, N. Yoshihara, R. Ueda, and M. Mizokami, Distribution of HBV genotypes among HBV carriers in Benin : phylogenetic analysis and virological characteristics of HBV genotype E, World J. Gastroenterol, vol.11, pp.6410-6415, 2005.

F. Galibert, E. Mandart, F. Fitoussi, P. Tiollais, and P. Charnay, Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli, Nature, vol.5, issue.5733, pp.646-650, 1979.
DOI : 10.1016/0092-8674(78)90070-3

N. Hawajri, P. Deny, M. Beaugrand, and E. Gordien, Significance of hepatitis B virus genotypes A to E in a cohort of patients with chronic hepatitis B in the Seine Saint Denis District of Paris (France), J Med Virol, vol.78, pp.335-340, 2006.

W. Gerlich, X. Lu, and K. Heermann, Studies on the attachment and penetration of hepatitis B virus, Journal of Hepatology, vol.17, pp.10-14, 1993.
DOI : 10.1016/S0168-8278(05)80417-9

D. Glebe, M. Aliakbari, P. Krass, E. Knoop, K. Valerius et al., Pre-S1 antigen-dependent infection of Tupaia hepatocyte cultures with human hepatitis B virus, 2003.

C. Trepo and C. Guguen-guillouzo, Infection of a human hepatoma cell line by hepatitis B virus, Proc. Nat. Acad. Sci. USA, pp.15655-15660, 2002.

S. Günther, L. Fischer, I. Pult, M. Sterneck, and W. H. , Naturally Occurring Variants of Hepatitis B Virus, Adv. Virus. Res, vol.52, pp.25-137, 1999.
DOI : 10.1016/S0065-3527(08)60298-5

S. Hadziyannis, N. Tassopoulos, E. Heathcote, T. Chang, G. Kitis et al., Adefovir Dipivoxil for the Treatment of Hepatitis B e Antigen???Negative Chronic Hepatitis B, New England Journal of Medicine, vol.348, issue.9, pp.800-807, 2003.
DOI : 10.1056/NEJMoa021812

S. Hadziyannis, N. Tassopoulos, E. Heathcote, T. Chang, G. Kitis et al., Long-Term Therapy with Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B, The Adefovir dipivoxil 438 study group, pp.2673-2681, 2005.
DOI : 10.1056/NEJMoa042957

C. Hannoun, H. Norder, and M. Lindh, An aberrant genotype revealed in recombinant hepatitis B virus strains from Vietnam, Journal of General Virology, vol.81, issue.9, pp.2267-2272, 2000.
DOI : 10.1099/0022-1317-81-1-67

C. Hannoun, K. Krogsgaard, P. Horal, and M. Lindh, Genotype Mixtures of Hepatitis B Virus in Patients Treated with Interferon, The Journal of Infectious Diseases, vol.186, issue.6, pp.752-759, 2002.
DOI : 10.1086/342599

C. Hannoun, A. Soderstrom, G. Norkrans, and M. Lindh, Phylogeny of African complete genomes reveals a West African genotype A subtype of hepatitis B virus and relatedness between Somali and Asian A1 sequences, Journal of General Virology, vol.86, issue.8, pp.2163-2167, 2005.
DOI : 10.1099/vir.0.80972-0

T. Harrison, E. Hopes, C. Oon, A. Zanetti, and A. Zuckerman, Independent emergence of a vaccine-induced escape mutant of hepatitis B virus, Journal of Hepatology, vol.13, pp.105-107, 1991.
DOI : 10.1016/0168-8278(91)90037-C

F. Hughson, Structural characterization of viral fusion proteins, Current Biology, vol.5, issue.3, pp.265-274, 1995.
DOI : 10.1016/S0960-9822(95)00057-1

N. Trebi, S. Aidoo, D. Ofori-adjei, T. Sata, H. Ushijima et al., Characteristics of hepatitis B virus in Ghana : full length genome sequences indicate the endemicity of genotype E in West Africa, J. Med. Virol, vol.78, pp.178-184, 2006.

C. Simon, T. So, G. Gerken, D. Man, R. Niesters et al., HBV 99-01 Study Group, and Rotterdam Foundation for Liver Research. Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B : a randomised trial, Lancet, vol.365, pp.123-129, 2005.

M. Kann, A. Bischof, and W. Gerlich, In vitro model for the nuclear transport of the hepadnavirus genome, J. Virol, vol.71, pp.1310-1316, 1997.

J. Kao, N. Wu, P. Chen, M. Lai, and D. Chen, Hepatitis B genotypes and the response to interferon therapy, Journal of Hepatology, vol.33, issue.6, pp.998-1002, 2000.
DOI : 10.1016/S0168-8278(00)80135-X

H. Kao, P. Chen, M. Lai, and D. Chen, Genotypes and Clinical Phenotypes of Hepatitis B Virus in Patients with Chronic Hepatitis B Virus Infection, Journal of Clinical Microbiology, vol.40, issue.4, pp.1207-1209, 2002.
DOI : 10.1128/JCM.40.4.1207-1209.2002

M. Mizokami, Characteristics of hepatitis B virus isolates of genotype G and their phylogenetic differences from the other six genotypes (A through F), J. Virol, vol.76, pp.6131-6137, 2002.

K. Kidd-ljunggren, Y. Miyakawa, and A. Kidd, Genetic variability in hepatitis B viruses, Journal of General Virology, vol.357, issue.6, pp.1267-1280, 2002.
DOI : 10.1016/S0140-6736(00)04219-7

C. Kim, K. Koike, I. Saito, T. Miyamura, and G. Jay, HBx gene of hepatitis B virus induces liver cancer in transgenic mice, Nature, vol.351, issue.6324, pp.317-320, 1991.
DOI : 10.1038/351317a0

G. Kimbi, A. Kramvis, and M. Kew, Distinctive sequence characteristics of subgenotype A1 isolates of hepatitis B virus from South Africa, Journal of General Virology, vol.85, issue.5, pp.1211-1220, 2004.
DOI : 10.1099/vir.0.19749-0

T. Koibuchi, A. Hitani, T. Nakamura, N. Nojiri, K. Nakajima et al., Predominance of genotype A HBV in an HBV-HIV-1 dually positive population compared with an HIV-1-negative counterpart in Japan, Journal of Medical Virology, vol.58, issue.4, pp.435-440, 2001.
DOI : 10.1002/(SICI)1096-9071(199906)58:2<105::AID-JMV1>3.0.CO;2-3

J. Korenman, B. Baker, J. Waggoner, J. Everhart, D. Bisceglie et al., Long-Term Remission of Chronic Hepatitis B after Alpha-Interferon Therapy, Annals of Internal Medicine, vol.114, issue.8, pp.629-634, 1991.
DOI : 10.7326/0003-4819-114-8-629

A. Kramvis, L. Weitzmann, W. Owiredu, and M. Kew, Analysis of the complete genome of subgroup A??? hepatitis B virus isolates from South Africa, Journal of General Virology, vol.82, issue.4, 2002.
DOI : 10.1099/0022-1317-82-4-893

F. Kurbanov, Y. Tanaka, K. Fujiwara, F. Sugauchi, D. Mbanya et al., A new subtype (subgenotype) Ac (A3) of hepatitis B virus and recombination between genotypes A and E in Cameroon, Journal of General Virology, vol.86, issue.7, pp.2047-2056, 2005.
DOI : 10.1099/vir.0.80922-0

K. Kuroki, P. Cheung, L. Marion, and D. Ganem, A cell surface protein that binds avian hepatitis B virus particles, J. Virol, vol.68, pp.2091-2096, 1994.

K. Kuroki, F. Eng, T. Ishikawa, C. Turck, F. Harada et al., gp180, a Host Cell Glycoprotein That Binds Duck Hepatitis B Virus Particles, Is Encoded by a Member of the Carboxypeptidase Gene Family, Journal of Biological Chemistry, vol.264, issue.25, pp.15022-15028, 1995.
DOI : 10.1016/0022-2836(82)90515-0

K. Lacombe, J. Gozlan, P. Boelle, L. Serfaty, F. Zoulim et al., Long-term hepatitis B virus dynamics in HIV???hepatitis B virus-co-infected patients treated with tenofovir disoproxil fumarate, AIDS, vol.19, issue.9, pp.907-915, 2005.
DOI : 10.1097/01.aids.0000171404.07995.5c

C. Lai, C. Ching, A. Tung, E. Li, J. Young et al., Lamivudine is effective in suppressing hepatitis B virus DNA in Chinese hepatitis B surface antigen carriers: A placebo-controlled trial, Hepatology, vol.25, issue.1, pp.241-244, 1997.
DOI : 10.1002/hep.510250144

R. Wilber, R. Zink, A. Cross, R. Colonno, and L. Fernandes, BEHoLD AI463027 Study Group. Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B, N. Engl. J. Med, vol.354, pp.1011-1020, 2006.

D. Lau, E. Doo, Y. Park, D. Kleiner, P. Schmid et al., Lamivudine for chronic delta hepatitis, Hepatology, vol.50, issue.2, pp.546-549, 1999.
DOI : 10.1002/hep.510300217

URL : http://onlinelibrary.wiley.com/doi/10.1002/hep.510300217/pdf

L. Bouvier and G. , The Heterogeneity of Australia Antigen, Journal of Infectious Diseases, vol.123, issue.6, pp.671-675, 1971.
DOI : 10.1093/infdis/123.6.671

J. Lefrère, Les virus transmissibles par le sang, 1996.

Y. Liaw, J. Sung, W. Chow, G. Farrell, C. Lee et al., Lamivudine for Patients with Chronic Hepatitis B and Advanced Liver Disease, New England Journal of Medicine, vol.351, issue.15, pp.1521-1531, 2004.
DOI : 10.1056/NEJMoa033364

M. Lindh, C. Hannoun, A. Dhillon, G. Norkrans, and P. Horal, Core Promoter Mutations and Genotypes in Relation to Viral Replication and Liver Damage in East Asian Hepatitis B Virus Carriers, The Journal of Infectious Diseases, vol.179, issue.4, pp.775-7821, 1999.
DOI : 10.1086/314688

A. Lok, E. Heathcote, and J. Hoofnagle, Summary of a workshop, Management of hepatitis B Gastroenterology, vol.120, pp.1828-1853, 2001.

X. Lu, Block Timothy. Study of the early steps of the hepatitis B virus life cycle, 2004.

L. Magnius and H. Norder, Subtypes, Genotypes and Molecular Epidemiology of the Hepatitis B Virus as Reflected by Sequence Variability of the S-Gene, Intervirology, vol.38, issue.1-2, pp.24-34, 1995.
DOI : 10.1159/000150411

«. Mammette and A. , » : Virologie Médicale, Collection AZAY, p.562, 2002.

Z. Goodman, M. Wulfsohn, S. Xiong, J. Fry, and C. Brosgart, The Adefovir Dipivoxil 437

S. Group, Adefovir dipivoxil for the treatment of hepatitis B e antigenpositive chronic hepatitis B, N. Engl. J. Med, vol.348, pp.808-816, 2003.

P. Marion, L. S. Oshiro, D. Regnery, G. Scullard, and W. S. Robinson, A virus in Beechey ground squirrels that is related to hepatitis B virus of humans., Proceedings of the National Academy of Sciences, vol.77, issue.5, pp.2941-2945, 1980.
DOI : 10.1073/pnas.77.5.2941

F. Martinson, K. Weigle, R. Royce, D. Weber, C. Suchindran et al., Risk Factors for Horizontal Transmission of Hepatitis B Virus in a Rural District in Ghana, American Journal of Epidemiology, vol.147, issue.5, pp.478-487, 1998.
DOI : 10.1093/oxfordjournals.aje.a009474

W. S. Mason, G. Seal, and J. Summers, Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus, J. Virol, vol.36, pp.829-836, 1980.

V. Mathet, M. Cuestas, V. Ruiz, M. Minassian, C. Rivero et al., Detection of Hepatitis B Virus (HBV) Genotype E Carried--Even in the Presence of High Titers of Anti-HBs Antibodies--by an Argentinean Patient of African Descent Who Had Received Vaccination against HBV, Journal of Clinical Microbiology, vol.44, issue.9, 2006.
DOI : 10.1128/JCM.00866-06

P. Maupas, A. Goudeau, P. Drucker, J. Bagros, and P. , IMMUNISATION AGAINST HEPATITIS B IN MAN, The Lancet, vol.307, issue.7974, pp.1367-1370, 1976.
DOI : 10.1016/S0140-6736(76)93023-3

C. Mayerat, A. Mantegani, and P. Frei, Does hepatitis B virus (HBV) genotype influence the clinical outcome of HBV infection?, Journal of Viral Hepatitis, vol.6, issue.4, pp.299-304, 1999.
DOI : 10.1136/gut.19.11.1022

A. Faou and C. Muller, Low genetic diversity despite hyperendemicity of hepatitis B virus genotype E throughout West Africa, J Infect Dis, vol.190, pp.400-408, 2004.

. Paterlini-bréchot, Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas, Gut, vol.54, pp.1162-1168, 2005.

M. Nassal, M. Junker-niepmann, and H. Schaller, Translational inactivation of RNA function: Discrimination against a subset of genomic transcripts during HBV nucleocapsid assembly, Cell, vol.63, issue.6, pp.1357-1363, 1990.
DOI : 10.1016/0092-8674(90)90431-D

H. Norder, A. Couroucé, and L. Magnius, Molecular basis of hepatitis B virus serotype variations within the four major subtypes, Journal of General Virology, vol.73, issue.12, pp.3141-3145, 1992.
DOI : 10.1099/0022-1317-73-12-3141

H. Norder, B. Hammas, S. Lee, K. Bile, A. Couroucé et al., Genetic relatedness of hepatitis B viral strains of diverse geographical origin and natural variations in the primary structure of the surface antigen, Journal of General Virology, vol.74, issue.7, pp.1341-1348, 1993.
DOI : 10.1099/0022-1317-74-7-1341

H. Norder, A. Couroucé, and L. Magnius, Complete Genomes, Phylogenetic Relatedness, and Structural Proteins of Six Strains of the Hepatitis B Virus, Four of Which Represent Two New Genotypes, Virology, vol.198, issue.2, pp.489-503, 1994.
DOI : 10.1006/viro.1994.1060

B. Robertson, S. Locarnini, and L. Magnius, Genetic diversity of hepatitis B virus strains derived worldwide : genotypes, subgenotypes, and HBsAg subtypes, Intervirology, vol.47, pp.289-309, 2004.

C. Muller, Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa, J Med Virol, vol.65, pp.463-469, 2001.

A. Faou and C. Muller, Phylogenetic analysis of the precore/core gene of hepatitis B virus genotypes E and A in West Africa : new subtypes, mixed infections and recombinations, J Gen Virol, vol.87, pp.1163-1173, 2006.

H. Okamoto, M. Imai, F. Tsuda, T. Tanaka, Y. Miyakawa et al., Point mutation in the S gene of hepatitis B virus for a d/y or w/r subtypic change in two blood donors carrying a surface antigen of compound subtype adyr or adwr, J.Virol, vol.61, pp.3030-3040, 1987.

H. Okamoto, K. Yano, Y. Nozaki, A. Matsui, H. Miyazaki et al., Mutations within the S Gene of Hepatitis B Virus Transmitted from Mothers to Babies Immunized with Hepatitis B Immune Globulin and Vaccine, Pediatric Research, vol.32, issue.3, pp.264-268, 1992.
DOI : 10.1203/00006450-199209000-00002

N. Paran, B. Geiger, and Y. Shaul, HBV infection of cell culture: evidence for multivalent and cooperative attachment, The EMBO Journal, vol.20, issue.16, pp.4443-4453, 2001.
DOI : 10.1093/emboj/20.16.4443

K. Murray, HEPATITIS B VIRUS GENES AND THEIR EXPRESSION IN E. COLI, Biochemical Society Transactions, vol.9, issue.2, pp.575-579, 1979.
DOI : 10.1042/bst009098pa

P. Paterlini, K. Poussin, M. Kew, D. Franco, and C. Bréchot, Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma, Hepatology, vol.21, pp.313-321, 1995.

J. Pawlotsky, L. Belec, G. Gresenguet, L. Deforges, M. Bouvier et al., High prevalence of hepatitis B, C, and E markers in young sexually active adults from The Central African Republic, Journal of Medical Virology, vol.344, issue.3, pp.269-272, 1995.
DOI : 10.1093/clinids/14.4.961

R. Perrillo, F. Regenstein, M. Peters, K. Deschryver-kecskemeti, C. Bodicky et al., Prednisone Withdrawal Followed by Recombinant Alpha Interferon in the Treatment of Chronic Type B Hepatitis, Annals of Internal Medicine, vol.109, issue.2, pp.95-100, 1988.
DOI : 10.7326/0003-4819-109-2-95

R. Perrillo, E. Schiff, G. Davis, H. Bodenheimer, L. Jr et al., A randomized, controlled trial of interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. The Hepatitis Interventional Therapy Group, N. Engl. J, 1990.

P. Pontisso, M. Ruvoletto, W. Gerlich, K. Heermann, R. Bardini et al., Identification of an attachment site for human liver plasma membranes on hepatitis B virus particles, Virology, vol.173, issue.2, pp.522-530, 1989.
DOI : 10.1016/0042-6822(89)90564-3

A. Prince, An antigen detected in the blood during the incubation period of serum hepatitis., Proc. Natl. Acad. Sci. USA, pp.814-821, 1968.
DOI : 10.1073/pnas.60.3.814

M. Rizzetto, M. Canese, S. Aricò, O. Crivelli, C. Trepo et al., Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers., Gut, vol.18, issue.12, pp.997-1003, 1977.
DOI : 10.1136/gut.18.12.997

M. Rizzetto, J. Shih, and J. Gerin, The hepatitis B virus-associated delta antigen: isolation from liver, development of solid-phase radioimmunoassays for delta antigen and anti-delta and partial characterization of delta antigen, J. Immunol, vol.125, pp.318-324, 1980.

X. Ren, G. Luo, Z. Xie, L. Zhou, X. Kong et al., Inhibition of multiple gene expression and virus replication of HBV by stable RNA interference in 2.2.15 cells, Journal of Hepatology, vol.44, issue.4, 2006.
DOI : 10.1016/j.jhep.2005.10.029

R. Ross, J. Yuan, M. Yu, G. Wogan, G. Qian et al., Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma, The Lancet, vol.339, issue.8799, pp.943-946, 1992.
DOI : 10.1016/0140-6736(92)91528-G

M. Rossner, Hepatitis B virus X-gene product: A promiscuous transcriptional activator, Journal of Medical Virology, vol.6, issue.2, pp.101-117, 1992.
DOI : 10.1016/B978-0-12-255850-4.50010-X

R. Schirmbeck, W. Bohm, K. Ando, F. Chisari, and J. Reimann, Nucleic acid vaccination primes hepatitis B virus surface antigen-specific cytotoxic T lymphocytes in nonresponder mice, J. Virol, vol.69, pp.5929-5934, 1995.

C. Seeger and W. Mason, Hepatitis B Virus Biology, Microbiology and Molecular Biology Reviews, vol.64, issue.1, pp.51-68, 2000.
DOI : 10.1128/MMBR.64.1.51-68.2000

D. Sitterlin, P. Tiollais, and C. Transy, Le rôle de la protéine virale X dans le cycle infectieux des hépadnavirus de mammifères, Virologie, vol.4, pp.217-227, 2000.

R. Sprengel, F. Kaleta, and W. H. , Isolation and characterization of a hepatitis B virus endemic in herons, J. Virol, vol.62, pp.3832-3839, 1988.

R. Ueda, Hepatitis B virus infection among residents of a nursing home for the Elderly : seroepidemiological study and molecular evolutionary analysis, J. Med. Virol, vol.62, pp.456-462, 2000.

F. Sugauchi, E. Orito, T. Ichida, H. Kato, H. Sakugawa et al., Hepatitis B Virus of Genotype B with or without Recombination with Genotype C over the Precore Region plus the Core Gene, Journal of Virology, vol.76, issue.12, pp.5985-5992, 2002.
DOI : 10.1128/JVI.76.12.5985-5992.2002

F. Sugauchi, E. Orito, H. Kato, S. Suzuki, S. Kawakita et al., Genotype, serotype, and phylogenetic characterization of the complete genome sequence of hepatitis B virus isolates from Malawian chronic carriers of the virus, Journal of Medical Virology, vol.87, issue.1, pp.33-40, 2003.
DOI : 10.1016/S0166-0934(00)00153-1

J. Summers, J. Smolec, and R. Snyder, A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks., Proc. Natl. Acad. Sci. USA, pp.4533-4537, 1978.
DOI : 10.1073/pnas.75.9.4533

L. Stuyver, D. Grent, S. Van-geyt, C. Zoulim, F. Fried et al., A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness, Journal of General Virology, vol.65, issue.1, pp.67-74, 2000.
DOI : 10.1016/0166-0934(91)90004-J

S. Suzuki, F. Sugauchi, E. Orito, H. Kato, S. Usuda et al., Distribution of hepatitis B virus (HBV) genotypes among HBV carriers in the cote d'Ivoire: Complete genome sequence and phylogenetic relatedness of HBV genotype E, Journal of Medical Virology, vol.87, issue.4, pp.459-465, 2003.
DOI : 10.1016/S0166-0934(00)00153-1

W. Szmuness, Hepatocellular carcinoma and the hepatitis B virus : evidence for a causal association, Prog. Med. Virol, vol.24, pp.40-69, 1978.

W. Szmuness, Large-scale efficacy trials of hepatitis B vaccines in the USA: Baseline data and protocols, Journal of Medical Virology, vol.227, issue.4, pp.327-340, 1979.
DOI : 10.7326/0003-4819-83-4-489

S. Mishiro, The precore/core promoter mutant (T1762A 1764) of hepatitis B virus : clinical significance and easy method for detection, J. Gen. Virol, vol.76, pp.3159-3164, 1995.

O. Terradillos, O. Billet, C. Renard, R. Levy, T. Molina et al., The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice, Oncogene, vol.14, issue.4, pp.395-404, 1997.
DOI : 10.1038/sj.onc.1200850

V. Thibault, Y. Benhamou, C. Seguret, M. Bochet, C. Katlama et al., Mutations Associated with Resistance to Lamivudine in Patients Coinfected with HBV and Human Immunodeficiency Virus, Hepatitis B Virus (HBV). J. Clin. Microbiol, vol.37, pp.3013-3016, 1999.

F. Tiné, A. Liberati, A. Craxi, P. Almasio, and L. Pagliaro, Interferon treatment in patients with chronic hepatitis B: A meta-analysis of the published literature, Journal of Hepatology, vol.18, issue.2, pp.154-162, 1993.
DOI : 10.1016/S0168-8278(05)80241-7

P. Tiollais, C. Pourcel, and A. Dejean, The hepatitis B virus, Nature, vol.191, issue.6037, pp.489-495, 1985.
DOI : 10.1001/jama.1965.03080070025007

P. Tiollais, Le virus de l'hépatite B. Un exemple d'application médicale du génie génétique, Ann. Biol. Clin, vol.59, pp.173-175, 2001.

S. Tong, J. Li, and J. Wands, Carboxypeptidase D is an avian hepatitis B virus receptor, J. Virol, vol.73, pp.8696-8702, 1999.

J. Sommadossi and H. Thomas, A line probe assay for hepatitis B virus genotypes In Therapy for viral hepatitis, pp.139-145, 1998.

V. Venard, D. Corsaro, C. Kajzer, J. Bronowicki, L. Faou et al., Hepatitis B virus X gene variability in French-born patients with chronic hepatitis and hepatocellular carcinoma, Journal of Medical Virology, vol.68, issue.2, pp.177-184, 2000.
DOI : 10.1007/BF02253575

J. Wang, X. Chenivesse, B. Henglein, and C. Brechot, Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma, Nature, vol.343, issue.6258, pp.555-557, 1990.
DOI : 10.1038/343555a0

B. Weber, Recent developments in the diagnosis and monitoring of HBV infection and role of the genetic variability of the S gene, Expert Review of Molecular Diagnostics, vol.30, issue.1, pp.75-91, 2005.
DOI : 10.1002/hep.510300508

Y. Wei, J. Etiemble, G. Fourel, L. Vitvitski-trepo, and M. Buendia, Hepadna virus integration generates virus-cell cotranscripts carrying 3??? truncated X genes in human and woodchuck liver tumors, Journal of Medical Virology, vol.3, issue.1, pp.82-90, 1995.
DOI : 10.1128/MCB.7.1.545

K. Weinberger, T. Bauer, S. Bohm, and W. Jilg, High genetic variability of the group-specific a-determinant of hepatitis B virus surface antigen (HBsAg) and the corresponding fragment of the viral polymerase in chronic virus carriers lacking detectable HBsAg in serum, Journal of General Virology, vol.29, issue.5, pp.1165-1174, 2000.
DOI : 10.1016/S0168-8278(98)80191-8

B. Weiser, D. Ganem, C. Seeger, and H. Varmus, Closed circular viral DNA and asymmetrical heterogeneous forms in livers from animals infected with ground squirrel hepatitis virus, J. Virol, vol.48, pp.1-9, 1983.

X. Xiong, C. Flores, H. Yang, J. Toole, and C. Gibbs, Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovirin vitro, Hepatology, vol.34, issue.4, pp.1669-1673, 1998.
DOI : 10.1002/hep.510280629

K. Yamamoto, M. Horikita, F. Tsuda, K. Itoh, Y. Akahane et al., Naturally occurring escape mutant of hepatitis B ANNEXES : PUBLICATIONS Central African Republic is part of the West-African hepatitis B virus genotype E crescent, J Clin Virol, vol.40, issue.1, pp.31-37, 1994.

?. Bekondi, C. Olinger, C. Talarmin, A. Boua, N. Muller et al., Characterization of Hepatitis B virus strains from The Central African Republic: preliminary results. Accepté et sous presse dans, Pathologie Biologie, Ref.: Ms, pp.7-00146

?. Bekondi, C. Bernede, C. Passone, N. Minssart, P. Kamalo et al., Primary and opportunistic pathogens associated with meningitis in adults in Bangui, Central African Republic, in relation to human immunodeficiency virus serostatus, International Journal of Infectious Diseases, vol.10, issue.5
DOI : 10.1016/j.ijid.2005.07.004

?. Mihaila-amrouche, L. Bekondi, C. Kappe, Y. Bouvet, A. Bercion et al., First reported cases of Streptococcus pyogenes meningitis in Central African Republic

?. Tuyet, D. Yassibanda, S. , N. Thi, P. Koyenede et al., Enteropathogenic Escherichia coli O157 in Bangui and N'Goila, Central African Republic: A brief report, Am. J. Trop. Med. Hyg, vol.75, pp.513-515, 2006.

?. Mossoro, C. Glaziou, P. Yassibanda, S. , N. Thi et al., Chronic Diarrhea, Hemorrhagic Colitis, and Hemolytic-Uremic Syndrome Associated with HEp-2 Adherent Escherichia coli in Adults Infected with Human Immunodeficiency Virus in Bangui, Central African Republic, Journal of Clinical Microbiology, vol.40, issue.8, pp.3086-3088, 2002.
DOI : 10.1128/JCM.40.8.3086-3088.2002

L. Des, A. Soumis, . Publication, S. Ndala, N. Komas et al., Age of acquisition of Hepatitis B infection in children in a region of high prevalence

?. Ricai, 27 ème Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse : Session virologie 6 ?7 Décembre, 2007.

?. Ricai, 27 ème Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse : Session VIH et autres viroses 6 ? 7 Décembre, 2007.

D. De-virologie-systématique, Institut Pasteur de Paris