Autonomic dysfunction in the ICU patient, Current Opinion in Critical Care, vol.7, issue.5, pp.314-322, 2001. ,
DOI : 10.1097/00075198-200110000-00002
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference, SIS International Sepsis Definitions Conference, pp.1250-1256, 2001. ,
DOI : 10.1097/01.CCM.0000050454.01978.3B
Conférence de consensus, pp.418-419, 2006. ,
Immunomodulation and sepsis -Impact of the microorganisms, pp.182-191, 2003. ,
Molecular mechanisms involved in the pathogenesis of septic shock. Archives of Medical Research, pp.465-479, 2004. ,
Endotoxemia in Human Septic Shock, Chest, vol.99, issue.1, pp.169-175, 1991. ,
DOI : 10.1378/chest.99.1.169
The Cardiovascular Response of Normal Humans to the Administration of Endotoxin, New England Journal of Medicine, vol.321, issue.5, pp.280-287, 1989. ,
DOI : 10.1056/NEJM198908033210503
Effects of cGMP on calcium handling in ATP-stimulated rat resistance arteries, American Journal of Physiology-Heart and Circulatory Physiology, vol.268, issue.3, pp.1223-1231, 1995. ,
DOI : 10.1152/ajpheart.1995.268.3.H1223
LPS-induced TNF-alpha release from and apoptosis in rat cardiomyocytes: obligatory role for CD14 in mediating the LPS response, J Mol Cell Cardiol, issue.12, pp.302761-2775, 1998. ,
Lipopolysaccharide Internalization Activates Endotoxin-Dependent Signal Transduction in Cardiomyocytes, Circulation Research, vol.88, issue.5, pp.491-498180, 1995. ,
DOI : 10.1161/01.RES.88.5.491
NF-??B activation as a pathological mechanism of septic shock and inflammation, American Journal of Physiology-Lung Cellular and Molecular Physiology, vol.290, issue.4, pp.622-645125, 2002. ,
DOI : 10.1152/ajpgi.00431.2002
Toll like receptor, inflammatory response and sepsis. Réanimation, pp.167-175, 2004. ,
Stress molecules in sepsis and systemic inflammatory response syndrome, FEBS Letters, vol.7, issue.19, pp.5813723-3733, 2007. ,
DOI : 10.1016/S1473-3099(07)70052-X
Hypoxia increases production of interleukin-1 and tumor necrosis factor by human mononuclear cells AR: Sensitization to lipopolysaccharide in mice with asymptomatic viral infection: role of T cell-dependent production of interferon-gamma, Cytokine J Infect Dis, vol.3, issue.1761, pp.189-194151, 1991. ,
Relevance of tumour necrosis factor-alpha and interleukin-1-alpha in the pathogenesis of hypoxia-related organ failure, Eur J Anaesthesiol CYCLOOXYGENASES: Structural, Cellular, and Molecular Biology. Annual Review of Biochemistry, vol.10, issue.691, pp.273-285145, 1993. ,
Biosynthesis of nitric oxide from l-arginine, Biochemical Pharmacology, vol.38, issue.11, pp.1709-1715, 1989. ,
DOI : 10.1016/0006-2952(89)90403-6
Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock, Proceedings of the National Academy of Sciences, vol.62, issue.5, pp.979753-9758, 2000. ,
DOI : 10.1172/JCI118469
Oxidation and Nitration of Catecholamines by Nitrogen Oxides Derived from Nitric Oxide, Nitric Oxide, vol.1, issue.3, pp.234-243, 1997. ,
DOI : 10.1006/niox.1997.0123
Bioactive 6-Nitronorepinephrine Identified in Mammalian Brain, Journal of Biological Chemistry, vol.98, issue.23, pp.27113561-13565, 1996. ,
DOI : 10.1007/BF00229111
Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock, British Journal of Pharmacology, vol.26, issue.114 ,
DOI : 10.1093/cvr/26.1.48
Norepinephrine in septic patients--friend or foe? Journal of Clinical Anesthesia Clutter WE, Cryer PE: Plasma dose-response studies with noradrenaline and adrenaline in man, Prog Biochem Pharmacol, vol.15, issue.17, pp.154-15884, 1980. ,
Gut and muscle tissue PO2 in endotoxemic dogs during shock and resuscitation, Journal of Applied Physiology, vol.76, issue.2, pp.793-800, 1994. ,
DOI : 10.1152/jappl.1994.76.2.793
Microcirculatory oxygenation and shunting in sepsis and shock, Critical Care Medicine, vol.27, issue.7, pp.1369-1377, 1999. ,
DOI : 10.1097/00003246-199907000-00031
Splanchnic and total body oxygen consumption differences in septic and injured patients, Surgery, vol.101, issue.1, pp.69-80, 1987. ,
Dependency Exist in Critically Ill Septic Patients?, American Journal of Respiratory and Critical Care Medicine, vol.62, issue.4, pp.1219-1225, 1998. ,
DOI : 10.1007/BF00254516
Loss of microvascular negative charges accompanied by interstitial edema in septic rats' heart, Circ Shock, vol.36, issue.1, pp.45-56, 1992. ,
Myocardial energy metabolism and morphology in a canine model of sepsis Structure-function relationships in the septic rat heart, Am J Physiol Am J Respir Crit Care Med, vol.266, issue.1565, pp.1473-1482, 1994. ,
Leukocytes and decreased left-ventricular contractility during endotoxemia in rabbits., American Journal of Respiratory and Critical Care Medicine, vol.155, issue.6, pp.1977-1983, 1997. ,
DOI : 10.1164/ajrccm.155.6.9196105
Sepsis/septic shock, Critical Care Medicine, vol.24, issue.6, pp.1072-1078, 1996. ,
DOI : 10.1097/00003246-199606000-00031
M: Physiopathologie de la défaillance cardiaque Springer 2005:51-71. 79. Rudiger A, Singer M: Mechanisms of sepsis-induced cardiac dysfunction, Crit Care Med, vol.35, issue.6, pp.1599-1608, 2007. ,
DOI : 10.1007/2-287-27496-0_3
Cardiac and splenic norepinephrine turnover during septic peritonitis, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol.250, issue.5, pp.892-897, 1986. ,
DOI : 10.1152/ajpregu.1986.250.5.R892
HYPER- AND HYPOCARDIODYNAMIC STATES ARE ASSOCIATED WITH EXTERNALIZATION AND INTERNALIZATION, RESPECTIVELY, OF ??-ADRENERGIC RECEPTORS IN RAT HEART DURING SEPSIS, Shock, vol.7, issue.5, pp.318-323, 1997. ,
DOI : 10.1097/00024382-199705000-00002
Initial externalization followed by internalization of betaadrenergic receptors in rat heart during sepsis, Am J Physiol, vol.270, issue.1 2, pp.254-263, 1996. ,
Functional recovery after embolic stroke in rodents by activated protein C, Annals of Neurology, vol.280, issue.3, pp.474-477, 2005. ,
DOI : 10.1161/01.CIR.103.13.1799
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective, Nature Medicine, vol.102, issue.3, pp.338-342, 2003. ,
DOI : 10.1172/JCI2029
Activated Protein C Prevents Endotoxin-Induced Hypotension in Rats by Inhibiting Excessive Production of Nitric Oxide, Circulation, vol.104, issue.10, pp.1171-1175, 2001. ,
DOI : 10.1161/hc3501.093799
Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia*, Critical Care Medicine, vol.32, issue.4, pp.1011-1017, 2004. ,
DOI : 10.1097/01.CCM.0000120058.88975.42
Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model, Critical Care Medicine, vol.33, issue.2, pp.368-372, 2005. ,
DOI : 10.1097/01.CCM.0000153415.04995.88
Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis, Blood, vol.104, issue.13, pp.1043878-3885, 2004. ,
DOI : 10.1182/blood-2004-06-2140
Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats, Blood, vol.87, issue.2, pp.642-647, 1996. ,
Inhibition of coagulation and inflammation by activated protein C or antithrombin reduces intestinal ischemia/reperfusion injury in rats, Critical Care Medicine, vol.32, issue.6, pp.321375-1383, 2004. ,
DOI : 10.1097/01.CCM.0000128567.57761.E9
The effect of activated protein C on experimental acute necrotizing pancreatitis, Critical Care, vol.9, issue.3, pp.184-190, 2005. ,
DOI : 10.1186/cc3485
Protease-activated Receptor-1 Signaling by Activated Protein C in Cytokine-perturbed Endothelial Cells Is Distinct from Thrombin Signaling, Journal of Biological Chemistry, vol.12, issue.20, pp.19808-19814, 2005. ,
DOI : 10.1038/nm0402-349
Gene Expression Profiling of Inflamed Human Endothelial Cells and Influence of Activated Protein C, Circulation, vol.110, issue.18, pp.2903-2909, 2004. ,
DOI : 10.1161/01.CIR.0000146344.49689.BB
The up-regulation of IL- 6 and IL-8 in human endothelial cells by activated protein C, J Immunol, issue.5, pp.1612567-2573, 1998. ,
Stabilization of monocyte chemoattractant protein- 1-mRNA by activated protein C, Thromb Haemost, vol.89, issue.1, pp.149-160, 2003. ,
Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line, British Journal of Haematology, vol.73, issue.1, pp.130-134, 2000. ,
DOI : 10.1074/jbc.272.28.17795
Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis, Journal of Biological Chemistry, vol.95, issue.14, pp.27611199-11203, 2001. ,
DOI : 10.1093/glycob/4.2.221
Expression and function of the endothelial protein C receptor in human neutrophils, Blood, vol.102, issue.4, pp.1499-1505, 2003. ,
DOI : 10.1182/blood-2002-12-3880
Activated protein C increases sensitivity to vasoconstriction in rabbit Escherichia coli endotoxin-induced shock, Critical Care, vol.10, issue.2, p.47, 2006. ,
DOI : 10.1186/cc4858
URL : https://hal.archives-ouvertes.fr/inserm-00081194
Architecture of the vessel wall. Handbook of physiology. Section II: the Cardiovascular System II: Vascular Smooth Muscle, Bohr DF, pp.1-32, 1980. ,
The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume, Proceedings of the National Academy of Sciences, vol.12, issue.3, pp.207-214, 1926. ,
DOI : 10.1073/pnas.12.3.207
Uber kreislaufregulatorische Vorgäne an den grossen Arterien bei der Muskelarbeit. Plugers Arch, pp.743-748, 1933. ,
Vascular Caliber, Cardiology, vol.60, issue.1, pp.4-49, 1975. ,
DOI : 10.1159/000169701
Negative Feedback Mechanisms in the Architecture and Function of the Connective and Cardiovascular Tissues, Perspectives in Biology and Medicine, vol.13, issue.4, pp.507-527, 1970. ,
DOI : 10.1353/pbm.1970.0054
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine, Nature, vol.265, issue.5789, pp.373-376, 1980. ,
DOI : 10.1161/01.RES.34.3.317
Flow-mediated endothelial mechanotransduction, Physiological Reviews, vol.75, issue.3, pp.519-560, 1995. ,
DOI : 10.1152/physrev.1995.75.3.519
Moyen d'étude des artéres de résistance Livre Biologie et pathologie du coeur et des vaisseaux, pp.419-426, 2002. ,
Septic shock, The Lancet, vol.365, issue.9453, pp.63-78, 2005. ,
DOI : 10.1016/S0140-6736(04)17667-8
URL : https://hal.archives-ouvertes.fr/hal-01414960
Pathophysiology of Sepsis, The American Journal of Pathology, vol.170, issue.5, pp.1435-1444, 2007. ,
DOI : 10.2353/ajpath.2007.060872
Mechanisms of sepsis-induced cardiac dysfunction, Critical Care Medicine, vol.35, issue.6, pp.1599-1608, 2007. ,
DOI : 10.1097/01.CCM.0000266683.64081.02
Nitric Oxide and Peroxynitrite in Health and Disease, Physiological Reviews, vol.87, issue.1, pp.315-424, 2007. ,
DOI : 10.1089/152308601750100443
MYOCARDIAL STRUCTURAL CHANGES IN LONG-TERM HUMAN SEVERE SEPSIS/SEPTIC SHOCK MAY BE RESPONSIBLE FOR CARDIAC DYSFUNCTION, Shock, vol.27, issue.1, pp.10-18, 2007. ,
DOI : 10.1097/01.shk.0000235141.05528.47
Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis, New England Journal of Medicine, vol.344, issue.10, pp.699-709, 2001. ,
DOI : 10.1056/NEJM200103083441001
The cytoprotective protein C pathway, Blood, vol.109, issue.8, pp.3161-3172, 2007. ,
DOI : 10.1182/blood-2006-09-003004
The endothelial protein C receptor, Current Opinion in Hematology, vol.13, issue.5, pp.382-385, 2006. ,
DOI : 10.1097/01.moh.0000239712.93662.35
Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis, Journal of Biological Chemistry, vol.95, issue.14, pp.11199-11203, 2001. ,
DOI : 10.1093/glycob/4.2.221
Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line, British Journal of Haematology, vol.73, issue.1, pp.130-134, 2000. ,
DOI : 10.1074/jbc.272.28.17795
Influence of drotrecogin alpha (activated) infusion on the variation of Bax/Bcl-2 and Bax/Bcl-xl ratios in circulating mononuclear cells: A cohort study in septic shock patients, Critical Care Medicine, vol.35, issue.1, 2006. ,
DOI : 10.1097/01.CCM.0000251133.26979.F4
Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation Bench-to-bedside review: The role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury):239. 14. Regnault V, Levy B. Recombinant activated protein C in sepsis: endothelium protection or endothelium therapy?, ):103. 15. Favory R, pp.319-325899, 2005. ,
Activated Protein C Prevents Endotoxin-Induced Hypotension in Rats by Inhibiting Excessive Production of Nitric Oxide, Circulation, vol.104, issue.10, pp.1171-1175, 2001. ,
DOI : 10.1161/hc3501.093799
Beneficial effects of recombinant human activated protein C in a ewe model of septic shock* Rapid and beneficial hemodynamic effects of activated protein C in septic shock patients Infiltration of inflammatory cells plays an important role in matrix metalloproteinase expression and activation in the heart during sepsis, Crit Care Med Intensive Care Med Am J Pathol, vol.31169, issue.205, pp.1573-15761567, 2005. ,
Acute actions and novel targets of matrix metalloproteinases in the heart and vasculature Peroxynitrite decomposition catalysts prevent myocardial dysfunction and inflammation in endotoxemic rats, Br J Pharmacol J Am Coll Cardiol, vol.2243, issue.12, pp.2348-2358, 2004. ,
Protection against endotoxic shock as a consequence of reduced nitrosative stress in MLCK210-null mice Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis, Am J Pathol Circ Res, vol.17082, issue.2412, pp.439-4461298, 1998. ,
Comparative effects of early versus delayed use of norepinephrine in resuscitated endotoxic shock The cytoprotective protein C pathway Activated Protein C ameliorates LPS-induced acute kidney injury and down-regulates renal iNOS and Angiotensin 2, Crit Care Med Blood Am J Physiol Renal Physiol Crit Care, vol.351099, issue.28, pp.1736-17403161, 2005. ,
The Pathogenesis of Vasodilatory Shock, New England Journal of Medicine, vol.345, issue.8, pp.588-595, 2001. ,
DOI : 10.1056/NEJMra002709
Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock, British Journal of Pharmacology, vol.26, issue.114, pp.786-792, 1993. ,
DOI : 10.1093/cvr/26.1.48
The reaction of no with superoxide Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice, Free Radic Res Commun Shock, vol.1817, issue.324, pp.195-199286, 1993. ,
Activated protein C improves survival in severe sepsis patients with elevated troponin, Intensive Care Medicine, vol.353, issue.12, pp.2122-2128, 2007. ,
DOI : 10.1007/s00134-007-0816-7
Sepsis and the Heart, Circulation, vol.116, issue.7, pp.793-802, 2007. ,
DOI : 10.1161/CIRCULATIONAHA.106.678359
Nitric oxide and cardiac function Endotoxin-induced contractile dysfunction in guinea pig hearts is not mediated by nitric oxide Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis Superoxide activates mitochondrial uncoupling proteins al. Association between mitochondrial dysfunction and severity and outcome of septic shock, Life Sci Am J Physiol Pt Cardiovasc Res Nature Lancet, vol.8126864415360, issue.3868679328, pp.779-793, 1995. ,
Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation, Blood, vol.95, issue.12, pp.3781-3787, 2000. ,
Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia*, Critical Care Medicine, vol.32, issue.4, pp.1011-1017, 2004. ,
DOI : 10.1097/01.CCM.0000120058.88975.42
Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly Matrix metalloproteinase activities are altered in the heart and plasma during endotoxemia, Circ Res Crit Care Med, vol.9032, issue.436, pp.251-2621332, 2002. ,
Near-infrared fluorescent imaging of matrix metalloproteinase activity after myocardial infarction Complexity of inducible nitric oxide synthase: cellular source determines benefit versus toxicity Expression and function of the endothelial protein C receptor in human neutrophils al. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C, Circulation Circulation Blood Kerschen EJ J Exp Med, vol.111108102204, issue.4710, pp.1800-18051107, 2003. ,
The promise of protein C Evaluation of endotoxin models for the study of sepsis Hemodynamic instability in sepsis: bedside assessment by Doppler echocardiography Early goal-directed therapy in the treatment of severe sepsis and septic shock, Blood Cells Mol Dis Shock Am J Respir Crit Care Med N Engl J Med, vol.3624168345, issue.4911, pp.211-2161270, 2001. ,
The Pathogenesis of Vasodilatory Shock, New England Journal of Medicine, vol.345, issue.8, pp.588-595, 2001. ,
DOI : 10.1056/NEJMra002709
Management of Sepsis, New England Journal of Medicine, vol.355, issue.16, pp.1699-1713, 2006. ,
DOI : 10.1056/NEJMra043632
Physiology of the endothelium, British Journal of Anaesthesia, vol.93, issue.1, pp.105-118, 2004. ,
DOI : 10.1093/bja/aeh163
The cytoprotective protein C pathway, Blood, vol.109, issue.8, pp.3161-72, 2007. ,
DOI : 10.1182/blood-2006-09-003004
Molecular basis of endothelial dysfunction in sepsis, Cardiovascular Research, vol.60, issue.1, pp.49-57, 2003. ,
DOI : 10.1016/S0008-6363(03)00397-3
Pulmonary endothelium in acute lung injury: from basic science to the critically ill, Intensive Care Med, vol.30, pp.1702-1714, 2004. ,
Overproduction of nitric oxide in pathophysiology of blood vessels, Biochemistry (Mosc), vol.63, pp.826-832, 1998. ,
Temporal variation in endotoxin-induced vascular hyporeactivity in a rat mesenteric artery organ culture model, British Journal of Pharmacology, vol.12, issue.3, pp.351-360, 2001. ,
DOI : 10.1111/j.1476-5381.1995.tb13343.x
Induction of Nitric Oxide Synthase and Dual Effects of Nitric Oxide and Cyclooxygenase Products in Regulation of Arterial Contraction in Human Septic Shock, Circulation, vol.100, issue.2, pp.107-112, 1999. ,
DOI : 10.1161/01.CIR.100.2.107
Activated protein C and sepsis, Frontiers in Bioscience, vol.11, issue.1, pp.676-98, 2006. ,
DOI : 10.2741/1827
Activated protein C improves LPS-induced cardiovascular dysfunction by decreasing tissular inflammation and oxidative stress, Crit Care Med, 2008. ,
ACTIVATED PROTEIN C SUPPRESSES ADRENOMEDULLIN AND AMELIORATES LIPOPOLYSACCHARIDE-INDUCED HYPOTENSION, Shock, vol.28, issue.4, pp.468-76, 2007. ,
DOI : 10.1097/SHK.0b013e3180487f09
Endotoxemia and sepsis mortality reduction by non-anticoagulant???activated protein C, The Journal of Experimental Medicine, vol.66, issue.10, pp.2439-2448, 2007. ,
DOI : 10.1097/01.shk.0000126906.52367.dd
Leukocyte and endothelial cell interactions in sepsis: Relevance of the protein C pathway, Critical Care Medicine, vol.32, issue.Supplement, pp.280-86, 2004. ,
DOI : 10.1097/01.CCM.0000128037.72072.22
Phenotypic Heterogeneity of the Endothelium: II. Representative Vascular Beds, Circulation Research, vol.100, issue.2 ,
DOI : 10.1161/01.RES.0000255690.03436.ae
Human Serum Albumin Improves Arterial Dysfunction during Early Resuscitation in Mouse Endotoxic Model via Reduced Oxidative and Nitrosative Stresses, The American Journal of Pathology, vol.171, issue.6 ,
DOI : 10.2353/ajpath.2007.070316
URL : https://hal.archives-ouvertes.fr/hal-00207826
Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis, Journal of Biological Chemistry, vol.95, issue.14, pp.11199-11203, 2001. ,
DOI : 10.1093/glycob/4.2.221
Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line, British Journal of Haematology, vol.73, issue.1, pp.130-134, 2000. ,
DOI : 10.1074/jbc.272.28.17795
Influence of drotrecogin alpha (activated) infusion on the variation of Bax/Bcl-2 and Bax/Bcl-xl ratios in circulating mononuclear cells: A cohort study in septic shock patients, Critical Care Medicine, vol.35, issue.1, pp.69-75, 2007. ,
DOI : 10.1097/01.CCM.0000251133.26979.F4
Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation, Thrombosis Research, vol.115, issue.4 ,
DOI : 10.1016/j.thromres.2004.09.011
Bench-to-bedside review: The role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury, Critical Care, vol.10, issue.6, p.239, 2006. ,
DOI : 10.1186/cc5099
Recombinant activated protein C in sepsis: endothelium protection or endothelium therapy? Crit Care, p.103, 2007. ,
The endothelial protein C receptor, Current Opinion in Hematology, vol.13, issue.5, pp.382-385, 2006. ,
DOI : 10.1097/01.moh.0000239712.93662.35
Cardiovascular protective role for activated protein C during endotoxemia in rats, Intensive Care Medicine, vol.95, issue.6, pp.899-905, 2006. ,
DOI : 10.1056/NEJM198908033210503
Beneficial effects of recombinant human activated protein C in a ewe model of septic shock*, Critical Care Medicine, vol.35, issue.11, pp.2594-600, 2007. ,
DOI : 10.1097/01.CCM.0000287590.55294.40
Rapid and beneficial hemodynamic effects of activated protein C in septic shock patients, Intensive Care Medicine, vol.33, issue.11, pp.1573-1576, 2005. ,
DOI : 10.1007/s00134-003-1731-1
Endogenous nitric oxide: physiology, pathology and clinical relevance, European Journal of Clinical Investigation, vol.8, issue.4, pp.361-74, 1991. ,
DOI : 10.1097/00000441-189305000-00001
Life history of eNOS: Partners and pathways, Cardiovascular Research, vol.75, issue.2, pp.247-60, 2007. ,
DOI : 10.1016/j.cardiores.2007.03.023
Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice, The FASEB Journal, vol.17, issue.6, pp.773-778, 2003. ,
DOI : 10.1096/fj.02-0668fje
Phosphorylation of Endothelial Nitric-Oxide Synthase Is Diminished in Mesenteric Arteries from Septic Rabbits Depending on the Altered Phosphatidylinositol 3-Kinase/Akt Pathway: Reversal Effect of Fluvastatin Therapy, Journal of Pharmacology and Experimental Therapeutics, vol.319, issue.3 ,
DOI : 10.1124/jpet.106.109785
Recombinant human activated protein C upregulates cyclooxygenase-2 expression in endothelial cells via binding to endothelial cell protein C receptor and activation of protease-activated receptor-1, Thrombosis and Haemostasis, vol.93, issue.4, pp.743-50, 2005. ,
DOI : 10.1160/TH04-08-0511
The Transcription Factor NF-??B and the Regulation of Vascular Cell Function, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.20, issue.11, pp.83-91, 2000. ,
DOI : 10.1161/01.ATV.20.11.e83
Nuclear factor-kappaB and its role in sepsis-associated organ failure ,
Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock, Critical Care, vol.12, issue.2, p.35, 2008. ,
DOI : 10.1186/cc6814
Prognostic value of the dobutamine test in patients with sepsis syndrome and normal lactate values, Critical Care Medicine, vol.21, issue.12, pp.1868-1875, 1993. ,
DOI : 10.1097/00003246-199312000-00014
A prospective study of the use of a dobutamine stress test to identify outcome in patients with sepsis, severe sepsis, or septic shock, Critical Care Medicine, vol.27, issue.11, pp.2361-2366, 1999. ,
DOI : 10.1097/00003246-199911000-00007
Heterogeneity and prediction of hemodynamic responses to dobutamine in patients with septic shock, Critical Care Medicine, vol.34, issue.9, pp.2392-2398, 2006. ,
DOI : 10.1097/01.CCM.0000233871.52553.CD
The Pathogenesis of Vasodilatory Shock, New England Journal of Medicine, vol.345, issue.8, pp.588-595, 2001. ,
DOI : 10.1056/NEJMra002709
Nitric Oxide and Peroxynitrite in Health and Disease, Physiological Reviews, vol.87, issue.1, pp.315-424, 2007. ,
DOI : 10.1089/152308601750100443
Cardiovascular response to dopamine and early prediction of outcome in septic shock: A prospective multiple-center study*, Critical Care Medicine, vol.33, issue.10, pp.2172-2177, 2005. ,
DOI : 10.1097/01.CCM.0000181297.14319.3C
Relation between muscle Na+K+ ATPase activity and raised lactate concentrations in septic shock: a prospective study, The Lancet, vol.365, issue.9462, pp.871-875, 2005. ,
DOI : 10.1016/S0140-6736(05)71045-X
Increased aerobic glycolysis through beta-2 stimulation is a common mechanism involved in lactate formation during shock states, Shock, 2008. ,
Low exogenous lactate clearance as an early predictor of mortality in normolactatemic critically ill septic patients, Critical Care Medicine, vol.31, issue.3, pp.705-710, 2003. ,
DOI : 10.1097/01.CCM.0000045561.85810.45
Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis, New England Journal of Medicine, vol.344, issue.10, pp.699-709, 2001. ,
DOI : 10.1056/NEJM200103083441001
Rapid and beneficial hemodynamic effects of activated protein C in septic shock patients, Intensive Care Medicine, vol.33, issue.11, pp.1573-1579, 2005. ,
DOI : 10.1007/s00134-003-1731-1
Effects of Drotrecogin Alfa (Activated) in Human Endotoxemia, Shock, vol.21, issue.3, pp.222-231, 2004. ,
DOI : 10.1097/01.shk.0000116778.27924.79
Recombinant human activated protein C (rhAPC; drotrecogin alfa [activated]) has minimal effect on markers of coagulation, fibrinolysis, and inflammation in acute human endotoxemia, Blood, vol.102, issue.6, pp.2093-2101, 2003. ,
DOI : 10.1182/blood-2003-02-0416
Activated Protein C Prevents Endotoxin-Induced Hypotension in Rats by Inhibiting Excessive Production of Nitric Oxide, Circulation, vol.104, issue.10, pp.1171-1176, 2001. ,
DOI : 10.1161/hc3501.093799
Cardiovascular protective role for activated protein C during endotoxemia in rats, Intensive Care Medicine, vol.95, issue.6, pp.899-905, 2006. ,
DOI : 10.1056/NEJM198908033210503
Hemodynamic effects of activated protein C, Intensive Care Medicine, vol.32, p.74, 2006. ,
Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis, Blood, vol.104, issue.13, pp.3878-85, 2004. ,
DOI : 10.1182/blood-2004-06-2140
Effects of Recombinant Human Activated Protein C in Human Models of Endotoxin Administration, Proceedings of the American Thoracic Society, vol.2, issue.3, pp.243-250, 2005. ,
DOI : 10.1513/pats.200501-004AC
Regulation of Blood Coagulation by the Protein C Anticoagulant Pathway: Novel Insights Into Structure-Function Relationships and Molecular Recognition, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.25, issue.7, pp.1311-1331, 2005. ,
DOI : 10.1161/01.ATV.0000168421.13467.82
New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated), Critical Care, vol.9, issue.Suppl 4, pp.38-45, 2005. ,
DOI : 10.1186/cc3747
The anticoagulant protein C pathway, FEBS Letters, vol.276, issue.15, pp.3310-3316, 2005. ,
DOI : 10.1074/jbc.M006541200
Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation, Blood, vol.95, pp.3781-3788, 2000. ,
Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia*, Critical Care Medicine, vol.32, issue.4, pp.1011-1018, 2004. ,
DOI : 10.1097/01.CCM.0000120058.88975.42
Activated Protein C Induces Endothelial Cell Proliferation by Mitogen-Activated Protein Kinase Activation In Vitro and Angiogenesis In Vivo, Circulation Research, vol.95, issue.1, pp.34-41, 2004. ,
DOI : 10.1161/01.RES.0000133680.87668.FA
Activated protein C reduces stress-induced gastric mucosal injury in rats by inhibiting the endothelial cell injury, Journal of Thrombosis and Haemostasis, vol.95, issue.2, pp.313-333, 2004. ,
DOI : 10.1023/A:1012779530004
Innate immune recognition by stimulatory immunoreceptors, Curr Opin Immunol, vol.15, pp.37-44, 2003. ,
A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells, Proceedings of the National Academy of Sciences, vol.272, issue.11, pp.5261-5267, 1997. ,
DOI : 10.1074/jbc.272.11.7320
NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily, The Journal of Experimental Medicine, vol.159, issue.5, pp.787-96, 1999. ,
DOI : 10.1002/eji.1830270313
Cutting Edge: Signal-Regulatory Protein ??1 Is a DAP12-Associated Activating Receptor Expressed in Myeloid Cells, The Journal of Immunology, vol.164, issue.1, pp.9-12, 2000. ,
DOI : 10.4049/jimmunol.164.1.9
Cutting Edge: Inflammatory Responses Can Be Triggered by TREM-1, a Novel Receptor Expressed on Neutrophils and Monocytes, The Journal of Immunology, vol.164, issue.10, pp.4991-4996, 2000. ,
DOI : 10.4049/jimmunol.164.10.4991
Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family, European Journal of Immunology, vol.126, issue.3 ,
DOI : 10.1016/0003-2697(82)90118-X
TREM-1 amplifies inflammation and is a crucial mediator of septic shock, Nature, vol.410, issue.6832, pp.1103-1110, 2001. ,
DOI : 10.1038/35074114
TREM???1 (Triggering Receptor Expressed on Myeloid Cells): A New Player in Acute Inflammatory Responses, The Journal of Infectious Diseases, vol.21, issue.s2, pp.397-401, 2003. ,
DOI : 10.1182/blood-2002-02-0523
A Role for Triggering Receptor Expressed on Myeloid Cells-1 in Host Defense During the Early-Induced and Adaptive Phases of the Immune Response, The Journal of Immunology, vol.170, issue.7, pp.3812-3820, 2003. ,
DOI : 10.4049/jimmunol.170.7.3812
Triggering Receptor Expressed on Myeloid Cells-1 in Neutrophil Inflammatory Responses: Differential Regulation of Activation and Survival, The Journal of Immunology, vol.172, issue.8, pp.4956-63, 2004. ,
DOI : 10.4049/jimmunol.172.8.4956
Cutting Edge: Expression Patterns of Surface and Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Human Endotoxemia, The Journal of Immunology, vol.173, issue.12, pp.7131-7135, 2004. ,
DOI : 10.4049/jimmunol.173.12.7131
A Soluble Form of the Triggering Receptor Expressed on Myeloid Cells-1 Modulates the Inflammatory Response in Murine Sepsis, The Journal of Experimental Medicine, vol.10, issue.11, pp.1419-1445, 2004. ,
DOI : 10.7326/0003-4819-141-1-200407060-00009
Soluble Triggering Receptor Expressed on Myeloid Cells and the Diagnosis of Pneumonia, New England Journal of Medicine, vol.350, issue.5, pp.451-459, 2004. ,
DOI : 10.1056/NEJMoa031544
Serial changes in soluble TREM-1 Pathway Modulation during Pneumonia ? JID) ? 983 triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia, Intensive Care Med, vol.194, issue.31, pp.1495-500, 2005. ,
Triggering receptor expressed on myeloid cells: role in the diagnosis of lung infections, European Respiratory Journal, vol.24, issue.2, pp.247-50, 2004. ,
DOI : 10.1183/09031936.04.00014204
Surfactant protein A differentially regulates peripheral and inflammatory neutrophil chemotaxis, American Journal of Physiology-Lung Cellular and Molecular Physiology, vol.264, issue.1, pp.140-147, 2003. ,
DOI : 10.1152/ajplung.1993.264.4.L338
Chronic pneumonia with Pseudomonas aeruginosa and impaired alveolar fluid clearance, Respiratory Research, vol.116, issue.1, p.17, 2005. ,
DOI : 10.1378/chest.116.1.157
Alveolar Fibrin Formation Caused by Enhanced Procoagulant and Depressed Fibrinolytic Capacities in Severe Pneumonia, American Journal of Respiratory and Critical Care Medicine, vol.151, issue.2, pp.454-62, 2000. ,
DOI : 10.1016/0140-6736(93)92004-D
Bronchoalveolar coagulation and fibrinolysis in endotoxemia and pneumonia, Critical Care Medicine, vol.31, issue.Supplement, pp.238-280, 2003. ,
DOI : 10.1097/01.CCM.0000057849.53689.65
Modulation of Hepatic Granulomatous Responses by Transgene Expression of DAP12 or TREM-1-Ig Molecules, The American Journal of Pathology, vol.162, issue.4, pp.1191-201, 2003. ,
DOI : 10.1016/S0002-9440(10)63915-6
DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis, The Journal of Experimental Medicine, vol.10, issue.3, pp.363-372, 2005. ,
DOI : 10.1021/ac026136s
URL : http://jem.rupress.org/content/jem/202/3/363.full.pdf
Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12, Nature Immunology, vol.19, issue.6, pp.579-86, 2005. ,
DOI : 10.1016/S0022-1759(98)00204-X
Intrapulmonary, Adenovirus-Mediated Overexpression of KARAP/DAP12 Enhances Fungal Clearance during Invasive Aspergillosis, Infection and Immunity, vol.73, issue.12, pp.8402-8408, 2005. ,
DOI : 10.1128/IAI.73.12.8402-8406.2005
Antibody-mediated bacterial clearance from the lower respiratory tract of mice requires complement component C3, European Journal of Immunology, vol.34, issue.1, pp.184-93, 2004. ,
DOI : 10.1002/eji.200324234
Two-Way Interactions Between Inflammation and Coagulation, Trends in Cardiovascular Medicine, vol.15, issue.7, pp.254-263, 2005. ,
DOI : 10.1016/j.tcm.2005.07.004