A. Acakpo, B. Fayomi, and F. Djrolo, Prévalence et étude des facteurs déterminants de l'obésité à Cotonou, Med Afr Noire, vol.47, issue.119, pp.5276-81, 2000.

L. Afmann, K. Lievers, N. Van-der-put, F. Trijbels, and H. Blom, Single nucleotide polymorphisms in the transcobalamin gene: relationship with transcobalamin concentrations and risk for neural tube defects, European Journal of Human Genetics, vol.97, issue.7, pp.433-441, 2002.
DOI : 10.1182/blood.V97.4.1092

S. Ahn, J. Park, C. Lee, C. Lee, S. Kang et al., Association between hepatitis B virus infection and HLA-DR type in Korea, Hepatology, vol.28, issue.6, pp.1371-1373, 2000.
DOI : 10.1046/j.1365-2893.1997.00052.x

N. Akar, E. Akar, and R. Akcay, Effect of methylenetetrahydrofolate reductase 677 C>T, p.1298

A. Almarri and J. Batchelor, HLA and hepatitis B infection, The Lancet, vol.344, issue.8931, pp.1194-1195, 1994.
DOI : 10.1016/S0140-6736(94)90510-X

A. Andersson, L. Brattström, B. Israelsson, A. Isaksson, A. Hamfelt et al., Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status, European Journal of Clinical Investigation, vol.81, issue.2, pp.79-87, 1992.
DOI : 10.1016/S0026-0495(98)90014-2

Y. Matsuzawa, Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell, Circulation, vol.105, pp.2893-98, 2002.

E. Ayoola, Viral hepatitis in Africa Viral hepatitis and liver diseases New York: Liss, pp.161-169, 1988.

L. Bailey and J. Gregory, Polymorphisms of Methylenetetrahydrofolate Reductase and Other Enzymes: Metabolic Significance, Risks and Impact on Folate Requirement, The Journal of Nutrition, vol.16, issue.suppl. 2, pp.919-941, 1999.
DOI : 10.1161/01.ATV.16.7.878

C. Bellia, G. Bivona, C. Scazzone, and M. Ciaccio, Association between homocysteinemia and metabolic syndrome in patients with cardiovascular disease, Ther Clin Risk Manag, vol.3, issue.6, pp.999-1000, 2007.

B. Beutler and A. Cerami, Tumor Necrosis, Cachexia, Shock, and Inflammation: A Common Mediator, Annual Review of Biochemistry, vol.57, issue.1, pp.505-523, 1988.
DOI : 10.1146/annurev.bi.57.070188.002445

J. Berliner, M. Navab, A. Fogelman, J. Frank, L. Demer et al., Atherosclerosis: Basic Mechanisms : Oxidation, Inflammation, and Genetics, Circulation, vol.91, issue.9, pp.2488-96, 1995.
DOI : 10.1161/01.CIR.91.9.2488

Z. Bloomgarden, Definitions of the Insulin Resistance Syndrome: The 1st World Congress on the Insulin Resistance Syndrome, Diabetes Care, vol.27, issue.3, pp.824-854, 2004.
DOI : 10.2337/diacare.27.3.824

B. Blount, M. Mack, C. Wehr, J. Macgregor, R. Hiatt et al., Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage, Proceedings of the National Academy of Sciences, vol.276, issue.23, pp.3290-3295, 1997.
DOI : 10.1001/jama.1996.03540230029031

P. Bosco, R. Gueant-rodriguez, G. Anello, C. Barone, F. Namour et al., Methionine synthase (MTR) 2756 (A?????????G) polymorphism, double heterozygosity methionine synthase 2756 AG/methionine synthase reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having a child with Down syndrome, American Journal of Medical Genetics Part A, vol.62, issue.3
DOI : 10.1086/301825

A. Bostom and L. Lathrop, Hyperhomocysteinemia in end-stage renal disease: Prevalence, etiology, and potential relationship to arteriosclerotic outcomes, Kidney International, vol.52, issue.1, pp.10-20, 1997.
DOI : 10.1038/ki.1997.298

L. Botto and Q. Yang, 5, 10-Methylenetetrahydrofolate Reductase Gene Variants and Congenital Anomalies: A HuGE Review, American Journal of Epidemiology, vol.151, issue.9, pp.862-77, 2000.
DOI : 10.1093/oxfordjournals.aje.a010290

L. Brattstrom, D. Wilcken, J. Ohrvik, and L. Brudin, Common Methylenetetrahydrofolate Reductase Gene Mutation Leads to Hyperhomocysteinemia but Not to Vascular Disease : The Result of a Meta-Analysis, Circulation, vol.98, issue.23, pp.2520-2526, 1998.
DOI : 10.1161/01.CIR.98.23.2520

G. Bray and L. Tartaglia, Medical strategies in the treatment of obesity, Nature, 2000.

C. Bréchot, M. Hadchouel, J. Scotto, M. Fonck, F. Potet et al., State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases., Proceedings of the National Academy of Sciences, vol.78, issue.6, pp.3906-3910, 1981.
DOI : 10.1073/pnas.78.6.3906

A. De-bree, W. Verschuren, and H. Blom, Biological cardiovascular risk factors and plasma homocysteine levels in the general Dutch population, Atherosclerosis, vol.154, issue.2, pp.513-517, 2001.
DOI : 10.1016/S0021-9150(00)00693-6

A. De-bree, W. Verschuren, H. Blom, and D. Kromhout, Association between B vitamin intake and plasma homocysteine concentration in the general Dutch population aged 20???65 y, The American Journal of Clinical Nutrition, vol.53, issue.6, pp.1027-1060, 2001.
DOI : 10.1054/mehy.1998.0791

A. De-bree, W. Verschuren, D. Kromhout, L. Kluijtmans, and H. Blom, Homocysteine Determinants and the Evidence to What Extent Homocysteine Determines the Risk of Coronary Heart Disease, Pharmacological Reviews, vol.54, issue.4, pp.599-618, 2002.
DOI : 10.1124/pr.54.4.599

C. Brown, K. Mckinney, and J. Kaufman, A Common Polymorphism in Methionine Synthase Reductase Increases Risk of Premature Coronary Artery Disease, European Journal of Cardiovascular Risk, vol.7, issue.3, pp.197-200, 2000.
DOI : 10.1177/204748730000700306

K. Boduroglu, Y. Alanay, B. Koldan, and E. Tuncbilek, Methylenetetrahydrofolate reductase enzyme polymorphisms as maternal risk for down syndrome among Turkish women, American Journal of Medical Genetics Part A, vol.275, issue.38
DOI : 10.1074/jbc.M002725200

L. Botto and Q. Yang, 5, 10-Methylenetetrahydrofolate Reductase Gene Variants and Congenital Anomalies: A HuGE Review, American Journal of Epidemiology, vol.151, issue.9, pp.862-877, 2000.
DOI : 10.1093/oxfordjournals.aje.a010290

R. Bowen, B. Wong, and D. Cole, Population-based differences in frequency of the transcobalamin II Pro259Arg polymorphism, Clinical Biochemistry, vol.37, issue.2, pp.128-161, 2004.
DOI : 10.1016/j.clinbiochem.2003.09.001

M. Buysschaert, Actualités dans le domaine de l'insulinothérapie ou les nouvelles insulines en, pp.158-62, 2004.

L. Cardon and L. Palmer, Population stratification and spurious allelic association, The Lancet, vol.361, issue.9357, pp.598-604, 2003.
DOI : 10.1016/S0140-6736(03)12520-2

T. Carlos and J. Harlam, Leukocyte-endothelial adhesion molecules, Blood, vol.84, pp.2068-2101, 1994.

E. Carswell, L. Old, R. Kassel, S. Green, N. Fiore et al., An endotoxin-induced serum factor that causes necrosis of tumors., Proceedings of the National Academy of Sciences, vol.72, issue.9, p.3666, 1975.
DOI : 10.1073/pnas.72.9.3666

E. Cavantes and O. Mutchinick, Defectos de cierre del tubo neural y nutricion materna: estudio multicéntrico en una muestra de la poblacion mexicana (Neural tube defects and maternal nutrition Multicentric study in a Mexican population.) Doctoral dissertation National Autonomous, 1999.

S. Chemaly, C. Chen, and R. Van-zyl, Naturally occurring cobalamins have antimalarial activity, Journal of Inorganic Biochemistry, vol.101, issue.5, pp.764-73, 2007.
DOI : 10.1016/j.jinorgbio.2007.01.006

L. Chen, M. Liu, H. Hwang, L. Chen, J. Korenberg et al., Human Methionine Synthase, Journal of Biological Chemistry, vol.3, issue.6, pp.3628-3662, 1997.
DOI : 10.1073/pnas.76.1.405

P. Chen, R. Poddar, E. Tipa, P. Dibello, C. Moravec et al., Homocysteine metabolism in cardiovascular cells and tissues: implications for hyperhomocysteinemia and cardiovascular disease, Advances in Enzyme Regulation, vol.39, issue.1, pp.93-109, 1999.
DOI : 10.1016/S0065-2571(98)00029-6

P. K. Chiang, Biological Effects of Inhibitors of S-Adenosylhomocysteine Hydrolase, Pharmacology & Therapeutics, vol.77, issue.2, pp.115-149, 1998.
DOI : 10.1016/S0163-7258(97)00089-2

B. Christensen, L. Arbour, P. Tran, D. Leclerc, N. Sabbaghian et al., Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects, American Journal of Medical Genetics, vol.31, issue.2, pp.151-158, 1999.
DOI : 10.1111/j.1471-0528.1994.tb13109.x

I. Clark, N. Hunt, W. Cowden, L. Maxwell, and E. Mackie, Radical mediated damage to parasites and erythrocytes in Plasmodium vinckei infected mice after injection of t-butyl hydroperoxide, Clin Exp Immunol, vol.56, issue.3, pp.524-554, 1984.

S. Clarke, Protein Isoprenylation and Methylation at Carboxyl-Terminal Cysteine Residues, Annual Review of Biochemistry, vol.61, issue.1, p.355, 1992.
DOI : 10.1146/annurev.bi.61.070192.002035

C. Conri, J. Constans, F. Parrot, S. Skopinski, and C. Cipriano, Homocystéinémie : rôle en pathologie vasculaire, pp.737-778, 2000.

P. Coursaget, B. Yvonnet, J. Chotard, P. Vincelot, M. Sarr et al., Age- and sex-related study of hepatitis B virus chronic carrier state in infants from an endemic area (Senegal), Journal of Medical Virology, vol.27, issue.52, pp.1-5, 1987.
DOI : 10.1093/infdis/152.4.817

L. Cranford, Diagnosis, prevention and intervention for the metabolic syndrome, Am J Cardiol, vol.92, pp.35-42, 2003.

M. Deurenberg-yap, S. Chew, and P. Deurenberg, Elevated body fat percentage and cardiovascular risks at low body mass index levels among Singaporean Chinese, Malays and Indians, Obesity Reviews, vol.85, issue.3, pp.209-224, 2002.
DOI : 10.1079/BJN2000251

P. Deurenberg, M. Deurenberg-yap, and S. Guricci, Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationship, Obesity Reviews, vol.53, issue.3, pp.141-147, 2002.
DOI : 10.1038/sj.ijo.0801353

A. Dhur, P. Galan, and S. Hercberg, Folate status and the immune system, Prog Food Nutr Sci, vol.15, pp.43-60, 1991.

G. Dianov, T. Timchenko, O. Sinitsina, A. Kuzminov, O. Medvedev et al., Repair of uracil residues closely spaced on the opposite strands of plasmid DNA results in doublestrand break and deletion formation, Mol Gen Genet, vol.225, pp.448-452, 1991.

H. Dockrell and J. Playfair, Killing of Plasmodium yoelii by enzyme induced products of the oxidative burst, Infect Immun, vol.43, issue.2, pp.451-457, 1984.

M. Doolin, S. Barbaux, M. Mcdonnell, K. Hoess, A. Whitehead et al., Maternal Genetic Effects, Exerted by Genes Involved in Homocysteine Remethylation, Influence the Risk of Spina Bifida, The American Journal of Human Genetics, vol.71, issue.5, pp.1222-1228, 2002.
DOI : 10.1086/344209

T. Egan, J. Combrinck, J. Egan, G. Hearne, H. Marques et al., Fate of haem iron in the malaria parasite Plasmodium falciparum, Biochemical Journal, vol.365, issue.2, pp.343-350, 2002.
DOI : 10.1042/bj20020793

T. Egan, Haemozoin (malaria pigment): a unique crystalline drug target, TARGETS, vol.2, issue.3, pp.115-119, 2003.
DOI : 10.1016/S1477-3627(03)02310-9

O. Erel, A. Kocyigit, S. Avci, N. Aktepe, and V. Bulut, Oxidative Stress and Antioxidative Status of Plasma and Erythrocytes in Patients with Vivax Malaria, Clinical Biochemistry, vol.30, issue.8, pp.631-640, 1997.
DOI : 10.1016/S0009-9120(97)00119-7

S. Esfahani, E. Cogger, and M. Caudill, Heterogeneity in the prevalence of methylenetetrahydrofolate reductase gene polymorphisms in women of different ethnic groups, Journal of the American Dietetic Association, vol.103, issue.2, pp.200-207, 2003.
DOI : 10.1053/jada.2003.50030

E. Ngoa and L. , Obésité en milieu hôtelier : influence du poste de travail sur les métabolismes lipidiques et glucidiques, et sur la pression artérielle de 180 employées des hôtels de Yaoundé au Cameroun, Med Afr Noire, vol.53, issue.3, pp.138-178, 2006.

E. Ngoa, L. Longo, F. , M. Sego, and F. Obésité, hypertension artérielle et diabète dans une population de femmes rurales de l'Ouest du Cameroun, Med Afr Noire, vol.48, issue.10, pp.391-394, 2001.

M. Fasshauer and R. Paschke, Regulation of adipocytokines and insulin resistance, Diabetologia, vol.46, issue.12, pp.1594-603, 2003.
DOI : 10.1007/s00125-003-1228-z

W. Fiers, Tumor necrosis factor Characterization at the molecular, cellular and in vivo level, FEBS Letters, vol.178, issue.2, p.199, 1991.
DOI : 10.1111/j.1432-1033.1988.tb14451.x

E. Ford, W. Giles, and W. Dietz, Prevalence of the Metabolic Syndrome Among US Adults, JAMA, vol.287, issue.3, pp.356-365, 2002.
DOI : 10.1001/jama.287.3.356

R. De-franchis, G. Sebastio, G. Andria, and P. Mastroiacovo, Spina bifida, 677T→C mutation, and role of folate, The Lancet, vol.346, issue.8991-8992, p.1703, 1995.
DOI : 10.1016/S0140-6736(95)92865-0

S. Friso, S. Choi, D. Girelli, J. Mason, G. Dolnikowski et al., A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status, Proceedings of the National Academy of Sciences, vol.115, issue.1, pp.5606-5611, 2002.
DOI : 10.1016/S0304-3835(97)04708-3

P. Frosst, H. Blom, R. Milos, P. Goyette, C. Sheppard et al., A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase, Nature Genetics, vol.11, issue.1, pp.111-114, 1995.
DOI : 10.1203/00006450-197711000-00004

T. Finco and A. Baldwin, Mechanistic aspects of NF-??B regulation: The emerging role of phosphorylation and proteolysis, Immunity, vol.3, issue.3, pp.263-265, 1995.
DOI : 10.1016/1074-7613(95)90112-4

M. Fodinger, W. Horl, and G. Sunder-plassmann, Molecular biology of 5,10- methylenetetrahydrofolate reductase, J Nephrol, vol.13, pp.20-33, 2000.

S. Fried, C. Russell, N. Grauso, and R. Brolin, Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men., Journal of Clinical Investigation, vol.92, issue.5, pp.2191-2199, 1993.
DOI : 10.1172/JCI116821

V. Fuster, Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology [published erratum appears in Circulation 1995 Jan 1;91(1):256], Circulation, vol.90, issue.4, pp.2126-2172, 1994.
DOI : 10.1161/01.CIR.90.4.2126

D. Gaughan, S. Barbaux, and L. Kluijtmans, The human and mouse methylenetetrahydrofolate reductase (MTHFR) genes: genomic organization, mRNA structure and linkage to the CLCN6 gene, Gene, vol.257, issue.2, pp.279-89, 2000.
DOI : 10.1016/S0378-1119(00)00392-9

D. Gaughan, L. Kluijtmans, S. Barbaux, D. Mcmaster, I. Young et al., The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations, Atherosclerosis, vol.157, issue.2, 2001.
DOI : 10.1016/S0021-9150(00)00739-5

J. Geisel, I. Zimbelmann, H. Schorr, J. Knapp, M. Bodis et al., Genetic Defects as Important Factors for Moderate Hyperhomocysteinemia, Clinical Chemistry and Laboratory Medicine, vol.11, issue.8, pp.698-704, 2001.
DOI : 10.1056/NEJM199707243370403

M. Gentilini, Le paludisme dans Médecine Tropicale, pp.91-122, 1990.

J. «. Gilmore, Body mass index and health », Health Reports, vol.11, issue.1, pp.31-43, 1999.

H. Ginsburg and W. Stein, How many functional transport pathways does Plasmodium falciparum induce in the membrane of its host erythrocyte?, Trends in Parasitology, vol.21, issue.3, pp.118-139, 2005.
DOI : 10.1016/j.pt.2005.01.004

J. Guéant and F. Namour, Vitamin B12: Apsorption, mtabolism and deficency. Encyclopedia of, Gastroenterology, pp.619-643, 2003.

J. Guéant, R. Guéant-rodriguez, G. Anello, P. Bosco, L. Brunaud et al., Genetic Determinants of Folate and Vitamin B12 Metabolism: A Common Pathway in Neural Tube Defect and Down Syndrome?, Clinical Chemistry and Laboratory Medicine, vol.51, issue.11, pp.1473-1480, 2003.
DOI : 10.1016/S0140-6736(03)13080-2

J. Guéant, M. Candito, E. Andres, E. Van-obberghen, and J. Nicolas, Familial pernicious anaemia with hyperhomocysteinaemia in recurrent early pregnancy loss, Thromb Haemost, vol.92, pp.1147-1156, 2004.

R. Guéant-rodriguez, C. Rendeli, B. Namour, L. Venuti, A. Romano et al., Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans, Neuroscience Letters, vol.344, issue.3, pp.189-92, 2003.
DOI : 10.1016/S0304-3940(03)00468-3

B. Arrieta, B. Sànchez, A. Romano, B. Herbeth, J. Guilland et al., Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study among Mexican, West African and West European populations, Am J Clin Nutr, vol.83, pp.701-708, 2006.

P. Bosco, C. Romano, H. Arrieta, B. Sànchez, A. Romano et al., Environmental influence on the worldwide prevalence of a 776C > G variant in the transcobalamin gene (TCN2), J Med Genet, vol.44, pp.363-367, 2007.

L. Guidotti, R. Rochford, J. Chung, M. Shapiro, R. Purcell et al., Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection, Science, vol.284, issue.5415, pp.825-829, 1999.
DOI : 10.1126/science.284.5415.825

S. Gulati, P. Baker, Y. Li, B. Fowler, W. Kruger et al., Defects in human methionine synthase in cblG patients, Human Molecular Genetics, vol.5, issue.12, pp.1859-65, 1996.
DOI : 10.1093/hmg/5.12.1859

P. Goyette, A. Pai, R. Milos, P. Frosst, P. Tran et al., Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR), Mammalian Genome, vol.9, issue.8, pp.652-658, 1998.
DOI : 10.1007/s003359900838

P. Grob, W. Jilg, H. Bornhak, G. Gerken, W. Gerlich et al., Serological pattern ?anti-HBc alone?: Report on a workshop, Journal of Medical Virology, vol.70, issue.4, pp.450-455, 2000.
DOI : 10.1111/j.1600-0676.1994.tb00084.x

R. Gross, J. Reid, P. Newberne, B. Burgess, R. Marston et al., Depressed cell-mediated immunity in megaloblastic anemia due to folic acid deficiency, The American Journal of Clinical Nutrition, vol.28, issue.3, pp.225-232, 1975.
DOI : 10.1093/ajcn/28.3.225

N. Hakami, P. Neiman, G. Canellos, and J. Lazeron, Neonatal Megaloblastic Anemia Due to Inherited Transcobalamin II Deficiency in Two Siblings, New England Journal of Medicine, vol.285, issue.21, pp.1163-70, 1971.
DOI : 10.1056/NEJM197111182852103

T. Hassold, L. Burrage, E. Chan, L. Judis, S. Schwartz et al., Maternal Folate Polymorphisms and the Etiology of Human Nondisjunction, The American Journal of Human Genetics, vol.69, issue.2, pp.434-443, 2001.
DOI : 10.1086/321971

C. Hobbs, S. Sherman, P. Yi, S. Hopkins, C. Torfs et al., Polymorphisms in Genes Involved in Folate Metabolism as Maternal Risk Factors for Down Syndrome, The American Journal of Human Genetics, vol.67, issue.3, pp.623-653, 2000.
DOI : 10.1086/303055

M. Hofmann, E. Lalla, Y. Lu, M. Gleason, B. Wolf et al., Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model, Journal of Clinical Investigation, vol.107, issue.6, pp.675-83, 2001.
DOI : 10.1172/JCI10588

T. Höhler, G. Gerken, A. Notghi, R. Lubjuhn, H. Taheri et al., HLA-DRB1*1301 AND *1302 protect against chronic hepatitis B, Journal of Hepatology, vol.26, issue.3, pp.503-507, 1997.
DOI : 10.1016/S0168-8278(97)80414-X

P. Humbert and N. Nguyen, Physiopathologie de l'acanthosis nigricans, Ann Dermatol Vénéréol, vol.125, pp.851-856, 1998.

P. Isolato, G. Wells, and J. Donnelly, Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: an examination of C677T and A1298C mutations, Am J Hum Genet, vol.67, pp.986-90, 2000.

L. Jr, Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: sex differences and correlation with cobalamin and folate concentrations in healthy subjects, Clin Chem, vol.40, pp.873-81, 1994.

R. Rozen, Relation between folate status, a common mutation in methylenetetrahydrofolate reductase and plasma homocysteine concentrations, Circulation, vol.93, pp.7-9, 1996.

C. Jaffiol, M. Rouard, and F. Macari, Résistance à l'insuline : du diagnostic clinique à la génétique moléculaire, Bull Acad Natl Méd, vol.183, pp.1761-75, 1999.

S. James, M. Pogribna, and I. Pogribny, Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome, The American Journal of Clinical Nutrition, vol.56, issue.suppl, pp.495-501, 1999.
DOI : 10.1002/(SICI)1096-9926(199707/08)56:1/2<31::AID-TERA7>3.0.CO;2-4

D. Jahner, H. Stuhlmann, C. Steward, K. Harbers, J. Lo¨hler et al., De novo methylation and expression of retroviral genomes during mouse embryogenesis, Nature, vol.293, issue.5875, pp.623-628, 1982.
DOI : 10.1101/SQB.1978.042.01.108

R. Jayshree, N. Ganguly, A. Sheti, and R. Mahajan, Oxidative metabolic response of peripheral blood monocytes of monkeys during primary and chronic Plasmodium knowlesi infection, APMIS, vol.99, issue.1, pp.245-252, 1992.

D. Jullien, Physiopathologie du syndrome m??tabolique, Annales de Dermatologie et de V??n??r??ologie, vol.135, issue.4, pp.243-251, 2008.
DOI : 10.1016/S0151-9638(08)70542-8

T. Kadowaki and T. Yamauchi, Adiponectin and Adiponectin Receptors, Endocrine Reviews, vol.26, issue.3, pp.439-51, 2005.
DOI : 10.1210/er.2005-0005

URL : https://hal.archives-ouvertes.fr/hal-00174540

K. Kakimi, L. Guidotti, Y. Koezuka, and F. Chisari, Natural Killer T Cell Activation Inhibits Hepatitis B Virus Replication in Vivo, The Journal of Experimental Medicine, vol.163, issue.7, pp.921-930, 2000.
DOI : 10.1016/S0198-8859(98)00098-6

L. Kluijtmans, I. Young, and C. Boreham, Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults, Blood, vol.101, issue.7, pp.2483-2491, 2003.
DOI : 10.1182/blood.V101.7.2483

H. Koo, H. Lee, and Y. Hong, Methylenetetrahydrofolate Reductase TT Genotype as a Predictor of Cardiovascular Risk in Hypertensive Adolescents, Pediatric Cardiology, vol.177, issue.1, pp.136-177, 2008.
DOI : 10.1161/01.ATV.16.7.878

K. Kumar, V. Govindaiah, S. Naushad, R. Devi, and A. Jyothy, Plasma homocysteine levels correlated to interactions between folate status and methylene tetrahydrofolate reductase gene mutation in women with unexplained recurrent pregnancy loss, Journal of Obstetrics and Gynaecology, vol.23, issue.1, pp.55-63, 2003.
DOI : 10.1080/0144361021000043263

L. Kushi, E. Lenart, and W. Willett, Health implications of Mediterranean diets in light of contemporary knowledge. 1. Plant foods and dairy products, The American Journal of Clinical Nutrition, vol.61, issue.6, pp.1407-1422, 1995.
DOI : 10.1093/ajcn/61.6.1407S

D. Leclerc, E. Campeau, P. Goyette, C. Adjalla, B. Christensen et al., Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders, Human Molecular Genetics, vol.5, issue.12, pp.1867-74, 1996.
DOI : 10.1093/hmg/5.12.1867

F. Legros, M. Danis, and E. Noireau, Caractéristiques épidémiologiques du paludisme d'importation en France métropolitaine (CNRMI : données 1999-2000) Bull Centre National de Référence des maladies d'Importation, pp.16-17, 2002.

O. Levander and A. Ager, Malarial parasites and antioxidant nutrients, Parasitology, vol.3, issue.S1, pp.95-106, 1993.
DOI : 10.1016/S0960-894X(00)80177-8

G. Lewis, K. Uffelman, L. Szeto, B. Weller, and G. Steiner, Effects of Acute Hyperinsulinemia on VLDL Triglyceride and VLDL ApoB Production in Normal Weight and Obese Individuals, Diabetes, vol.42, issue.6, pp.833-875, 1993.
DOI : 10.2337/diab.42.6.833

Y. Liao, A. Hutto, and S. Kwon, Critical Evaluation of Adult Treatment Panel III Criteria in Identifying Insulin Resistance With Dyslipidemia, Diabetes Care, vol.27, issue.4, pp.978-83, 2004.
DOI : 10.2337/diacare.27.4.978

D. Liao, X. Yang, and H. Wang, Abstract, Clinical Chemical Laboratory Medicine, vol.263, issue.12, pp.1652-1661, 2007.
DOI : 10.1038/353265a0

A. Lissak, A. Sharon, O. Fruchter, A. Kassel, J. Sanderovitz et al., Polymorphism for mutation of cytosine to thymine at location 677 in the methylenetetrahydrofolate reductase gene is associated with recurrent early fetal loss, American Journal of Obstetrics and Gynecology, vol.181, issue.1, pp.126-156, 1999.
DOI : 10.1016/S0002-9378(99)70447-3

Y. Li, S. Gulati, P. Baker, L. Brody, R. Banerjee et al., Cloning, mapping and RNA analysis of the human methionine synthase gene, Human Molecular Genetics, vol.5, issue.12, pp.1851-1859, 1996.
DOI : 10.1093/hmg/5.12.1851

Y. Li, R. Schartz, I. Waddel, B. Holloway, and M. Reid, Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-??B activation in response to tumor necrosis factor ??, The FASEB Journal, vol.12, issue.10, pp.871-80, 1998.
DOI : 10.1164/ajrccm/145.6.1350

. Loetscher, Y. Pan, H. Lahm, R. Gentz, M. Brockhaus et al., Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor, Cell, vol.61, issue.2, p.351, 1990.
DOI : 10.1016/0092-8674(90)90815-V

A. Lok, E. Heathcote, and J. Hoofnagle, Management of hepatitis B: 2000???Summary of a workshop, Gastroenterology, vol.120, issue.7, pp.1828-1853, 2001.
DOI : 10.1053/gast.2001.24839

L. Lombard, M. Augustyn, and B. Ascott-evans, The metabolic syndrome: pathogenesis, clinical features and management, Cardiovasc J S Afr, vol.13, issue.4, pp.181-187, 2002.

R. Malmström, C. Packard, M. Caslake, D. Bedford, P. Stewart et al., Effects of insulin and acipimox on VLDL1 and VLDL2 apolipoprotein B production in normal subjects, Diabetes, vol.47, issue.5, pp.779-87, 1998.
DOI : 10.2337/diabetes.47.5.779

D. Malvy, F. Djossou, R. Thiebaut, L. Bras, and M. , Plasmodies-Malaria. Formes cliniques et diagnostic dans Encyclopédie médico-chirurgicale, pp.507-527, 2000.

E. Mayer, D. Jacobsen, and K. Robinson, Homocysteine and coronary atherosclerosis, Journal of the American College of Cardiology, vol.27, issue.3, pp.517-544, 1996.
DOI : 10.1016/0735-1097(95)00508-0

URL : https://doi.org/10.1016/0735-1097(95)00508-0

A. Mc-caddon, K. Blennow, P. Hudson, B. Regland, and D. Hill, Transcobalamin polymorphism and homocysteine, Blood, vol.98, issue.12, pp.3497-3506, 2001.
DOI : 10.1182/blood.V98.12.3497

M. Cully, K. Wilson, and R. , Homocysteine theory of arteriosclerosis, Atherosclerosis, vol.22, pp.15-27, 1975.

M. Quillan, B. Beilby, J. Nidorf, M. Thompson, P. et al., Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening The Perth Carotid Ultrasound Disease Assessment Study (CUDAS), Circulation, vol.99, pp.2383-2391, 1999.

M. Medina and M. Amores-sanchez, Genetic Basis of Hyperhomocysteinemia, Molecular Genetics and Metabolism, vol.71, issue.3, pp.478-80, 2000.
DOI : 10.1006/mgme.2000.3080

L. Mikael, J. Genest, . Jr, and R. Rozen, Elevated Homocysteine Reduces Apolipoprotein A-I Expression in Hyperhomocysteinemic Mice and in Males with Coronary Artery Disease Circ Res, pp.564-571, 2006.

J. Miller, M. Ramos, M. Garrod, M. Flynn, and R. Green, Transcobalamin II 775G>C polymorphism and indices of vitamin B12 status in healthy older adults, Blood, vol.100, issue.2, pp.718-738, 2002.
DOI : 10.1182/blood-2002-01-0209

S. Miner, J. Evrovski, and D. Cole, Clinical chemistry and molecular biology of homocysteine metabolism: An update, Clinical Biochemistry, vol.30, issue.3, pp.189-201, 1997.
DOI : 10.1016/S0009-9120(96)00172-5

V. Mohamed-ali, J. Pinkney, and S. Coppack, Adipose tissue as an endocrine and paracrine organ, International Journal of Obesity, vol.22, issue.12, pp.1145-58, 1998.
DOI : 10.1038/sj.ijo.0800770

K. Mohan, N. Ganguly, M. Dubey, and R. Mahajan, Oxidative damage of erythrocytes infected with Plasmodium falciparum, Annals of Hematology, vol.193, issue.Suppl, pp.131-135, 1992.
DOI : 10.1017/S003118200008598X

D. Morrow and P. Ridker, C-REACTIVE PROTEIN, INFLAMMATION, AND CORONARY RISK, Medical Clinics of North America, vol.84, issue.1, pp.149-61, 2000.
DOI : 10.1016/S0025-7125(05)70211-X

T. Mutabingwa, A. Nzila, and E. Mberu, Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania, The Lancet, vol.358, issue.9289, pp.1218-1241, 2001.
DOI : 10.1016/S0140-6736(01)06344-9

C. Mylonas and D. Kouretas, Lipid peroxidation and tissue damage, In Vivo, vol.13, issue.3, pp.295-309, 1999.

M. Nakanishi, A. Iwata, C. Yatome, and Y. Kitade, Purification and Properties of Recombinant Plasmodium falciparum S-Adenosyl-L-Homocysteine Hydrolase, Journal of Biochemistry, vol.129, issue.1, pp.101-106, 2001.
DOI : 10.1093/oxfordjournals.jbchem.a002819

F. Namour, M. Guy, I. Aimone-gastin, M. De-nonancourt, N. Mrabet et al., Isoelectrofocusing Phenotype and Relative Concentration of Transcobalamin II Isoproteins Related to the Codon 259 Arg/Pro Polymorphism, Biochemical and Biophysical Research Communications, vol.251, issue.3, pp.769-74, 1998.
DOI : 10.1006/bbrc.1998.9463

URL : https://hal.archives-ouvertes.fr/tel-01747259

N. Diaye and M. , Obésité en Afrique : définitions et épidémiologie, J Afr Hepato Gastroenterol, vol.1, pp.71-76, 2007.

W. Nelen, E. Steegers, T. Eskes, and H. Blom, Genetic risk factor for unexplained recurrent early pregnancy loss, The Lancet, vol.350, issue.9081, p.861, 1997.
DOI : 10.1016/S0140-6736(97)24038-9

J. Ninomiya, L. 'italien, G. Criqui, and M. , Association of the Metabolic Syndrome with history of myocardial infarction and stroke in the Third National Health and Nutritional Examination Survey Circulation, pp.42-48, 2004.

T. Nobutada, N. Masayuki, K. Yoshio, S. Katsura, Y. Saori et al., Crystal Structure of S-Adenosyl-L-Homocysteine Hydrolase from the Human Malaria Parasite Plasmodium falciparum, J. Mol. Biol, vol.343, pp.1007-1017, 2004.

A. Nzila, S. Ward, K. Marsh, P. Sims, and J. Hyde, Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy, Trends in Parasitology, vol.21, issue.6
DOI : 10.1016/j.pt.2005.04.002

A. Nzila, S. Ward, K. Marsh, P. Sims, and J. Hyde, Comparative folate metabolism in humans and malaria parasites (part II): activities as yet untargeted or specific to Plasmodium, Trends in Parasitology, vol.21, issue.7, 2005.
DOI : 10.1016/j.pt.2005.05.008

A. Nzila, The past, present and future of antifolates in the treatment of Plasmodium falciparum infection, Journal of Antimicrobial Chemotherapy, vol.57, issue.6, pp.1043-54, 2006.
DOI : 10.1093/jac/dkl104

O. Leary, V. Parle-mcdermott, A. Molloy, and A. , MTRR and MTHFR polymorphism: Link to Down syndrome?, American Journal of Medical Genetics, vol.67, issue.2, pp.151-55, 2002.
DOI : 10.1006/mgme.1999.2879

P. Olliaro and D. Goldberg, The Plasmodium digestive Vacuole: Metabolic Headquarters and Choice Drug Target, Parasitology Today, vol.11, issue.8, pp.294-301, 1995.
DOI : 10.1016/0169-4758(95)80042-5

M. Takahashi, T. Nakamura, S. Yamashita, T. Funahashi, and Y. Matsuzawa, Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin, Circulation, vol.100, pp.2473-2479, 1999.

C. Pallaud, C. Stranieri, C. Sass, G. Siest, F. Pignatti et al., Candidate Gene Polymorphism in Cardiovascular Disease: A Comparative Study of Frequencies between a French and an Italian Population, Clinical Chemistry and Laboratory Medicine, vol.33, issue.2, pp.146-54, 2001.
DOI : 10.1016/S0009-9120(98)00077-0

C. Papapetrou, S. Lynch, J. Burn, and Y. Edwards, Methylenetetrahydrofolate reductase and neural tube defects, The Lancet, vol.348, issue.9019, p.58, 1996.
DOI : 10.1016/S0140-6736(05)64382-6

A. Pascot, I. Lemieux, and D. Prud-'homme, Reduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity, J Lipid Res, vol.42, pp.2007-2021, 2001.

G. Pepe, C. Vanegas, O. Giusti, B. Brunelli, T. Marcucci et al., Heterogeneity in World Distribution of the Thermolabile C677T Mutation in 5,10-Methylenetetrahydrofolate Reductase, The American Journal of Human Genetics, vol.63, issue.3, pp.917-937, 1998.
DOI : 10.1086/302015

R. Poddar, N. Sivasubramanian, P. Dibello, K. Robinson, and D. Jacobsen, Homocysteine Induces Expression and Secretion of Monocyte Chemoattractant Protein-1 and Interleukin-8 in Human Aortic Endothelial Cells : Implications for Vascular Disease, Circulation, vol.103, issue.22, pp.2717-2740, 2001.
DOI : 10.1161/01.CIR.103.22.2717

M. Poulliot, J. Despres, and S. Lemieux, Waist circumference and abdominal sagittal diameter: Best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women, The American Journal of Cardiology, vol.73, issue.7, pp.460-468, 1994.
DOI : 10.1016/0002-9149(94)90676-9

N. Postma, E. Mommers, W. Eling, and J. Zuidema, Oxidative stress in malaria; implications for prevention and therapy, Pharmacy World and Science, vol.39, issue.2, pp.121-130, 1996.
DOI : 10.3181/00379727-184-42461

N. Van-der-put, R. Steegers-theunissen, and P. Frosst, Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida, The Lancet, vol.346, issue.8982, pp.1070-1071, 1995.
DOI : 10.1016/S0140-6736(95)91743-8

E. Quinlivan, J. Mcpartlin, and H. Mcnulty, Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease, The Lancet, vol.359, issue.9302, pp.227-235, 2002.
DOI : 10.1016/S0140-6736(02)07439-1

F. Ratter, C. Gabner, V. Shatrov, and V. Lehmann, Modulation of tumor necrosis factor-??-mediated cytotoxicity by changes of the cellular methylation state: mechanism and in vivo relevance, International Immunology, vol.11, issue.4, pp.519-546, 1999.
DOI : 10.1016/S0092-8674(00)81377-X

F. Retief, C. Gottlieb, and V. Herbert, Mechanism of vitamin B12 uptake by erythocytes., Journal of Clinical Investigation, vol.45, issue.12, pp.1907-1915, 1966.
DOI : 10.1172/JCI105495

K. Rexrode, V. Carey, and C. Hennekens, Abdominal Adiposity and Coronary Heart Disease in Women, JAMA, vol.280, issue.21, pp.1843-1851, 1998.
DOI : 10.1001/jama.280.21.1843

A. Rinaldi, Fighting malaria at the crossroads, EMBO reports, vol.81, issue.9, pp.847-851, 2004.
DOI : 10.1136/bmj.328.7448.1086

K. Robertson and R. Ambinder, Methylation of the Epstein-Barr virus genome in normal lymphocytes, Blood, vol.90, pp.4480-4484, 1997.

K. Robinson, E. Mayer, D. Miller, R. Green, F. Van-lente et al., Hyperhomocysteinemia and Low Pyridoxal Phosphate : Common and Independent Reversible Risk Factors for Coronary Artery Disease, Circulation, vol.92, issue.10, pp.2825-2855, 1995.
DOI : 10.1161/01.CIR.92.10.2825

E. Rogers, S. Chen, and A. Chan, Folate Deficiency and Plasma Homocysteine during Increased Oxidative Stress, New England Journal of Medicine, vol.357, issue.4, pp.421-423, 2007.
DOI : 10.1056/NEJMc066569

URL : http://www.nejm.org/doi/pdf/10.1056/NEJMc066569

D. Rosenblatt, Folate and homocysteine metabolism and gene polymorphisms in the etiology of Down syndrome, The American Journal of Clinical Nutrition, vol.70, issue.4, pp.429-459, 1999.
DOI : 10.1038/ng0595-111

D. Rosenblatt and W. Fenton, Inherited disorders of folate and cobalamin transport and metabolism The metabolic and molecular bases of inherited disease, pp.3897-933, 2001.

N. Rosenberg, M. Murata, and Y. Ikeda, The Frequent 5,10-Methylenetetrahydrofolate Reductase C677T Polymorphism Is Associated with a Common Haplotype in Whites, Japanese, and Africans, The American Journal of Human Genetics, vol.70, issue.3, pp.758-62, 2002.
DOI : 10.1086/338932

R. Ross, Atherosclerosis ??? An Inflammatory Disease, New England Journal of Medicine, vol.340, issue.2, pp.115-141, 1999.
DOI : 10.1056/NEJM199901143400207

J. Roth, . Goebeler, S. Ludwing, L. Wagner, K. Kilian et al., Homocysteine inhibits tumor necrosis factor-induced activation of endothelium via modulation of nuclear factor-??b activity, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1540, issue.2, pp.154-65, 2001.
DOI : 10.1016/S0167-4889(01)00130-6

A. Sadewa, R. Sutomo, C. Hayashi, M. Lee, and H. Ayaki, The C677T mutation in the methylenetetrahydrofolate reductase gene among the Indonesian Javanese population, Kobe J Med Sci, vol.48, pp.5-6137, 2002.

D. Sandoval and S. Davis, Leptin, Journal of Diabetes and its Complications, vol.17, issue.2, pp.108-113, 2003.
DOI : 10.1016/S1056-8727(02)00167-8

M. Schachter, Insulin resistance in patients with polycystic ovary syndrome is associated with elevated plasma homocysteine, Human Reproduction, vol.18, issue.4, pp.721-728, 2003.
DOI : 10.1093/humrep/deg190

K. Schultz-osthoff, A. Bakker, B. Vanhaesebroeck, R. Beyaert, W. Jacob et al., Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions

J. Scott and D. Weir, Folic acid, homocysteine and one-carbon metabolism: a review of the essential biochemistry, J Cardiovasc Risk, vol.5, pp.223-230, 1998.

B. Seetharam, ), Annual Review of Nutrition, vol.19, issue.1, pp.173-95, 1999.
DOI : 10.1146/annurev.nutr.19.1.173

J. Selhub, P. Jaques, P. Wilson, D. Rush, and I. Rosenberg, Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population, JAMA: The Journal of the American Medical Association, vol.270, issue.22, pp.2693-2701, 1993.
DOI : 10.1001/jama.1993.03510220049033

S. Semiz, S. Rota, O. Özdemir, A. Ozdemir, and B. Kaptanoglu, Are C-reactive protein and homocysteine cardiovascular risk factors in obese children and adolescents? Pediat Int, pp.419-442, 2008.

A. Senok, E. Nelson, K. Li, and S. Oppenheimer, Thalassaemia trait, red blood cell age and oxidant stress: effects on Plasmodium falciparum growth and sensitivity to artemisinin, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.83, issue.5, pp.585-594, 1997.
DOI : 10.1172/JCI113910

G. Shaw, R. Rosen, R. Finnel, C. Wasserman, and E. Lammer, Maternal Vitamin Use, Genetic Variation of Infant Methylenetetrahydrofolate Reducatase, and Risk for spina Bifida, American Journal of Epidemiology, vol.148, issue.1, pp.30-37, 1998.
DOI : 10.1093/oxfordjournals.aje.a009555

D. Shields, P. Kirke, and J. Mills, The ???Thermolabile??? Variant of Methylenetetrahydrofolate Reductase and Neural Tube Defects: An Evaluation of Genetic Risk and the Relative Importance of the Genotypes of the Embryo and the Mother, The American Journal of Human Genetics, vol.64, issue.4, pp.1045-55, 1999.
DOI : 10.1086/302310

A. Shuldiner, R. Yang, and D. Gong, Resistin, Obesity, and Insulin Resistance ??? The Emerging Role of the Adipocyte as an Endocrine Organ, New England Journal of Medicine, vol.345, issue.18, pp.1345-1351, 2001.
DOI : 10.1056/NEJM200111013451814

C. Sibley, J. Hyde, and P. Sims, Pyrimethamine???sulfadoxine resistance in Plasmodium falciparum: what next?, Trends in Parasitology, vol.17, issue.12, pp.582-590, 2001.
DOI : 10.1016/S1471-4922(01)02085-2

J. Simpore, S. Pignatelli, S. Barlati, M. Malaguarnera, and S. Musumeci, Plasma homocysteine concentrations in a healthy population living in Burkina Faso, Current Therapeutic Research, vol.61, issue.9, pp.659-68, 2000.
DOI : 10.1016/S0011-393X(00)88018-2

J. Smith, M. Al-amri, A. Sniderman, and K. Cianflone, Leptin and adiponectin in relation to body fat percentage, waist to hip ratio and the apoB/apoAI ratio in Asian Indian and Caucasian men and women, Nutrition & Metabolism, vol.3, issue.1, p.18, 2006.
DOI : 10.1186/1743-7075-3-18

R. W. Snow, C. A. Guerra, A. M. Noor, H. Y. Myint, and S. I. Hay, The global distribution of clinical episodes of Plasmodium falciparum malaria, Nature, vol.3, issue.7030, pp.214-221, 2005.
DOI : 10.1038/nrmicro1069

A. Sow and M. Ndiaye, Fassa H Aspects cliniques et biologiques de l'obésité au Sénégal, à propos de 318 cas, Med Afr Noire, vol.33, issue.3, pp.243-50, 1986.

K. Stegmann, A. Ziegler, E. Ngo, N. Kohlschmidt, B. Schroter et al., Linkage disequilibrium of MTHFR genotypes 677C/T-1298A/C in the German population and association studies in probands with neural tube defects(NTD), American Journal of Medical Genetics, vol.88, issue.1, pp.23-32, 1999.
DOI : 10.1038/bjc.1997.191

L. Stuppia, V. Gatta, and A. Gaspari, C677T mutation in the 5,10-MTHFR gene and risk of Down syndrome in Italy, European Journal of Human Genetics, vol.346, issue.6, pp.388-90, 2002.
DOI : 10.1016/S0140-6736(95)92865-0

P. Suffys, R. Beyaert, F. Van-roy, and W. Fiers, Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism, Biochemical and Biophysical Research Communications, vol.149, issue.2, p.735, 1987.
DOI : 10.1016/0006-291X(87)90429-3

A. Sumner, The relationship of body fat to metabolic disease: Influence of sex and ethnicity, Gender Medicine, vol.5, issue.4
DOI : 10.1016/j.genm.2008.11.003

L. Brody, Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population, Birth Defects Res A Clin Mol Teratol, vol.73, pp.239-283, 2005.

M. Taskinen, J. Kahri, V. Koivisto, J. Shepherd, and C. Packard, Metabolism of HDL apolipoprotein A-I and A-II in Type 1 (insulin-dependent) diabetes mellitus, Diabetologia, vol.86, issue.Suppl 2, pp.347-56, 1992.
DOI : 10.2337/diab.32.1.75

B. L. Tekwani and L. A. Walker, Targeting the Hemozoin Synthesis Pathway for New Antimalarial Drug Discovery: Technologies for In Vitro &#946;-Hematin Formation Assay, Combinatorial Chemistry & High Throughput Screening, vol.8, issue.1, pp.63-79, 2005.
DOI : 10.2174/1386207053328101

I. Terruzzi, P. Senesi, I. Fermo, G. Lattuada, and L. Luzi, Are genetic variants of the methyl group metabolism enzymes risk factors predisposing to obesity?, Journal of Endocrinological Investigation, vol.55, issue.8A, pp.747-53, 2007.
DOI : 10.1258/0007142991902646

C. Thio, M. Carrington, D. Marti, S. O-'brien, D. Vlahov et al., Class II HLA Alleles and Hepatitis B Virus Persistence in African Americans, The Journal of Infectious Diseases, vol.179, issue.4, pp.1004-1010, 1999.
DOI : 10.1086/314684

D. Thurnham and R. Singkamani, The acute phase response and vitamin A status in malaria, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.35, issue.2
DOI : 10.1111/j.1753-4887.1977.tb06554.x

P. Trayhurn and I. Wood, Adipokines: inflammation and the pleiotropic role of white adipose tissue, British Journal of Nutrition, vol.14, issue.03, pp.347-55, 2004.
DOI : 10.1073/pnas.162349799

A. Turrini, A. Saba, D. Perrone, E. Cialfa, D. Amicis et al., Food consumption patterns in Italy: the INN-CA Study 1994???1996, European Journal of Clinical Nutrition, vol.55, issue.7, pp.571-88, 1994.
DOI : 10.1038/sj.ejcn.1601185

J. Ubbink, A. Christianson, and M. Bester, Folate status, homocysteine metabolism, and methylene tetrahydrofolate reductase genotype in rural south african blacks with a history of pregnancy complicated by neural tube defects, Metabolism, vol.48, issue.2, pp.269-74, 1999.
DOI : 10.1016/S0026-0495(99)90046-X

P. Ueland and H. Refsum, Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease and drug therapy, J Lab Clin Med, vol.144, pp.450-73, 1989.

P. Ueland, H. Refsum, and L. Brattström, Plasma homocysteine and cardiovascular disease

F. Jr and R. Ed, Atherosclerotic cardiovascular disease. Marcel Dekker, Inc. hemostasis, and endothelial function, pp.183-236, 1992.

P. Ueland, H. Refsum, S. Stabler, M. Malinow, A. Andersson et al., Total homocysteine in plasma or serum: methods and clinical applications, Clin Chem, vol.39, pp.1764-79, 1993.

P. Ueland, S. Hustad, J. Schneede, H. Refsum, and S. Vollset, Biological and clinical implications of the MTHFR C677T polymorphism, Trends in Pharmacological Sciences, vol.22, issue.4, pp.195-201, 2001.
DOI : 10.1016/S0165-6147(00)01675-8

W. Fiers and P. Vandenabeele, Inhibition of caspases increase the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor, J. Exp. Med, vol.187, p.1477, 1998.

J. Virtanen, S. Voutilainen, and G. Alfthan, Homocysteine as a risk factor for CVD mortality in men with other CVD risk factors: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study, Journal of Internal Medicine, vol.98, issue.3, pp.255-261, 2005.
DOI : 10.1002/(SICI)1096-8628(19991008)86:4<380::AID-AJMG13>3.0.CO;2-9

L. M. Corcoran, T. R. Burkot, and R. Carter, Genetic analysis of the human malaria parasite Plasmodium falciparum, Science, vol.236, pp.1661-1666, 1987.

G. Wang and O. , Homocysteine stimulates the expression of monocyte chemoattractant protein-1 receptor (CCR2) in human monocytes: possible involvement of oxygen free radicals, Biochemical Journal, vol.357, issue.1, pp.233-273, 2001.
DOI : 10.1042/bj3570233

G. Wang, Y. Siow, and O. , Homocysteine induces monocyte chemoattractant protein-1

S. Wang, C. Lengeler, T. Smith, P. Vounatsou, M. Akogbeto et al., Rapid Urban Malaria Appraisal (RUMA) IV: epidemiology of urban malaria in, Malaria Journal, vol.5, issue.1, pp.45-54, 2006.
DOI : 10.1186/1475-2875-5-45

D. Warhurst, A molecular marker for chloroquine-resistant falciparum malaria N Engl

J. Webber, Energy balance in obesity, Proceedings of the Nutrition Society, vol.62, issue.02, pp.539-582, 2003.
DOI : 10.1056/NEJM198802253180802

T. Wellems, Chloroquine Resistance and the Search for a Replacement Antimalarial Drug, Science, vol.40, issue.5591, pp.124-130, 2002.
DOI : 10.1021/jm9902180

J. M. Whaun, G. A. Miura, N. D. Brown, R. K. Gordon, and P. K. Chiang, Antimalaria activity of neplanocin Awith perturbations in the metabolism of purines, polyamines and Sadenosylmethionine, J Pharmacol Expt Ther, vol.236, pp.277-83, 1986.

A. Whitehead, P. Gallagher, and J. Mills, A genetic defect in 5,10-methylenetetrahydrofolate reductase in neural tube defects, QJM, vol.88, pp.763-769, 1995.

A. Wilson, D. Leclerc, F. Saberi, E. Campeau, H. Hwang et al., Functionally Null Mutations in Patients with the cblG-Variant Form of Methionine Synthase Deficiency, The American Journal of Human Genetics, vol.63, issue.2, pp.409-423, 1998.
DOI : 10.1086/301976

A. Wilson, R. Platt, Q. Wu, D. Leclerc, B. Christensen et al., A Common Variant in Methionine Synthase Reductase Combined with Low Cobalamin (Vitamin B12) Increases Risk for Spina Bifida, Molecular Genetics and Metabolism, vol.67, issue.4, pp.317-340, 1999.
DOI : 10.1006/mgme.1999.2879

G. Yamamoto, A. Horibe, H. Mabuchi, H. Kita, T. Matsuzawa et al., Analysis of serum lipid levels in Japanese men and women according to body mass index. Increase in risk of atherosclerosis in postmenopausal women, Atherosclerosis, vol.143, issue.1, pp.55-73, 1999.
DOI : 10.1016/S0021-9150(98)00275-5

M. Yamanishi, M. Vlasie, and R. Banerjee, Adenosyltransferase: an enzyme and an escort for coenzyme B12?, Trends in Biochemical Sciences, vol.30, issue.6, pp.304-312, 2005.
DOI : 10.1016/j.tibs.2005.04.008

T. Yamauchi, J. Kamon, Y. Minokoshi, Y. Ito, H. Waki et al., Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMPactivated protein kinase, Nat Med, issue.8, pp.1288-95, 2002.
URL : https://hal.archives-ouvertes.fr/hal-00174612

L. Yvan-charvet, P. Even, and M. Bloch-faure, Deletion of the Angiotensin Type 2 Receptor (AT2R) Reduces Adipose Cell Size and Protects From Diet-Induced Obesity and Insulin Resistance, Diabetes, vol.54, issue.4, pp.991-1000, 2005.
DOI : 10.2337/diabetes.54.4.991

B. Yoffe, D. Burns, H. Bhatt, and B. Combes, Extrahepatic hepatitis B virus DNA sequences in patients with acute hepatitis B infection, Hepatology, vol.8, issue.2, pp.187-192, 1990.
DOI : 10.7326/0003-4819-100-1-43

Y. Zhang, M. Zhang, T. Niu, X. Xu, G. Zhu et al., D919G polymorphism of methionine synthase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients, Journal of Human Genetics, vol.49, issue.6, pp.296-301, 2004.
DOI : 10.1007/s10038-004-0149-0

H. Zetterberg, B. Regland, and M. Palmér, The transcobalamin codon 259 polymorphism influences the risk of human spontaneous abortion, Human Reproduction, vol.17, issue.12, pp.3033-3039, 2002.
DOI : 10.1093/humrep/17.12.3033

H. Zetterberg, A. Zafiropoulos, D. Spandidos, L. Rymo, and K. Blennow, Gene-gene interaction between fetal MTHFR 677C>T and transcobalamin 776C>G polymorphisms in human spontaneous abortion, Human Reproduction, vol.18, issue.9, pp.1948-50, 2003.
DOI : 10.1093/humrep/deg375

H. Zetterberg, Methylenetetrahydrofolate reductase and transcobalamin genetic polymorphisms in human spontaneous abortion: biological and clinical implications, Reproductive Biology and Endocrinology, vol.2, issue.1, p.7, 2004.
DOI : 10.1186/1477-7827-2-7

J. Zhou, J. Moller, M. Ritskes-hoitinga, M. Larsen, R. Austin et al., Effects of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoE-deficient mice, Atherosclerosis, vol.168, issue.2
DOI : 10.1016/S0021-9150(03)00138-2

S. Zhou, L. Tang, H. Sheng, and Y. Wang, Malaria situation in the People's Republic of China

A. Zieske, G. Malcom, and J. Strong, NATURAL HISTORY AND RISK FACTORS OF ATHEROSCLEROSIS IN CHILDREN AND YOUTH: THE PDAY STUDY, Pediatric Pathology & Molecular Medicine, vol.21, issue.2, pp.213-220, 2002.
DOI : 10.1080/pdp.21.2.213.237