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Étude des mécanismes régissant l'efficacité photodynamique sélective de l'Héxylaminolévulinate-Protoporphyrine IX dans le traitement du cancer de la vessie : Application dans le cadre de la prévention de ses récidives

Abstract : Photodynamic therapy (PDT) is a treatment modality based on the cytotoxic effect occurring on target tissues by interaction of a photosensitizer with light in the presence of oxygen. The aim of this study was to optimise PDT for treatment and prevention of recurrence of bladder cancer. The study was performed in vivo. PDT was performed with Hexvix® a precursor of the photosentitizer protoporphyrin IX (PpIX). First, we executed a mechanistic analysis of differential PDT effects according to Hexvix® concentration. 8 or 16 mM induced diametrically opposed photodynamic effects. PDT efficacy is depends on the mitochondrial localization of PpIX and its concentration and leads to pro-apoptotic damages. Second, PDT was performed in a rat model mimicking post fluorescence guided TUR. The amount of viable tumor cell within the bladder lumen significantly decreased with PDT and resulted in a significant reduction of tumor implantation
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https://hal.univ-lorraine.fr/tel-01748506
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Saoussen Berrahmoune. Étude des mécanismes régissant l'efficacité photodynamique sélective de l'Héxylaminolévulinate-Protoporphyrine IX dans le traitement du cancer de la vessie : Application dans le cadre de la prévention de ses récidives. Autre. Université Henri Poincaré - Nancy 1, 2009. Français. ⟨NNT : 2009NAN10012⟩. ⟨tel-01748506⟩

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