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une molécule exclusivement associée à l'obésité. L'avancement des connaissances a mis en évidence des rôles multiples dans d'autres mécanismes physio-pathologiques et particulièrement ceux de l'inflammation. La présente étude a voulu démontrer la présence de l'ARNm de la leptine dans les globules blancs mononucléaires (PBMCs), et quantifier l ,
expression de la leptine ont été significativement associés d'une façon négative avec la pression artérielle systolique (PAS) et diastolique (PAD) (p=0.03, p=0.003 respectivement) Une analyse de régression multiple a montré que les taux d'ARNm de la leptine pouvaient expliquer 11% de la variation de la PAS (p=0.007) et de la variation de la PAD (p=0.003). Ces pourcentages n'ont pas été altérés après l'introduction de l ,
nous décrivons pour la première fois l'expression de la leptine dans les PBMCs humains de sujets supposés sains. Les associations trouvées avec la pression artérielle ,
Sophie Visvikis-Siest Clin Endocrinol (Oxf) in press La visfatine est une adipokine ayant des rôles dans les mécanismes inflammatoires mais son implication dans l'inflammation associée à l'adiposité/obésité n'a pas été encore étudiée. Nous avons ciblé l'étude des relations de la visfatine avec les marqueurs d'inflammation et l, IMC) dans les globules blancs mononucléaires (PBMCs), un type de cellules lié aux mécanismes inflammatoires ,