R. Boumiza, A. Debard, and G. Monneret, The basophil activation test by flow cytometry: recent developments in clinical studies, standardization and emerging perspectives

S. Erdmann, N. Heussen, S. Moll-slodowy, H. Merk, and B. Sachs, CD63 expression on basophils as a tool for the diagnosis of pollen-associated food allergy: sensitivity and specificity, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.53, issue.5, pp.607-621, 2003.
DOI : 10.1111/j.1398-9995.1998.tb04940.x

W. Stevens, Flow-assisted quantification of in vitro activated basophils in the diagnosis of wasp venom allergy and follow-up of wasp venom immunotherapy, Cytometry B Clin Cytom, pp.28-33, 2005.

B. Bohle, B. Zwolfer, A. Heratizadeh, B. Jahn-schmid, Y. Antonia et al., Cooking birch pollen???related food: Divergent consequences for IgE- and T cell???mediated reactivity in vitro and in vivo, Journal of Allergy and Clinical Immunology, vol.118, issue.1
DOI : 10.1016/j.jaci.2006.03.011

D. Ebo, J. Sainte-laudy, C. Bridts, C. Mertens, M. Hagendorens et al., Flow-assisted allergy diagnosis: current applications and future perspectives, Allergy, vol.94, issue.1, pp.1028-1067, 2006.
DOI : 10.1016/j.jaci.2005.04.042

R. Valenta and D. Kraft, Recombinant allergens: from production and characterization to diagnosis, treatment, and prevention of allergy, Methods, vol.32, issue.3, pp.207-215, 2004.
DOI : 10.1016/j.ymeth.2003.08.001

. B. Cudowska and M. Kaczmarski, Diagnostic value of birch recombinant allergens

B. Ballmer-weber, A. Wangorsch, B. Bohle, S. Kaul, T. Kundig et al., Component-resolved in vitro diagnosis in carrot allergy: Does the use of recombinant carrot allergens improve the reliability of the diagnostic procedure?, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.33, issue.7, pp.970-978, 2005.
DOI : 10.1111/j.1365-2222.2004.1939.x

A. Diaz-perales and . Sanz, Recombinant Pru p 3 and natural Pru p 3, a major peach allergen, show equivalent immunologic reactivity: A new tool for the diagnosis of fruit allergy, Journal of Allergy and Clinical Immunology, vol.111, issue.3, pp.628-661, 2003.
DOI : 10.1067/mai.2003.75

. B. Cudowska and M. Kaczmarski, Immunoblotting in the diagnosis of cross-reactivity in children allergic to birch, Rocz Akad Med Bialymst, vol.50, pp.268-73, 2005.

W. Shreffler, K. Beyer, T. Chu, A. Burks, and H. Sampson, Microarray immunoassay: Association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes, Journal of Allergy and Clinical Immunology, vol.113, issue.4, pp.776-82, 2004.
DOI : 10.1016/j.jaci.2003.12.588

S. Erdmann, B. Sachs, A. Schmidt, H. Merk, O. Scheiner et al., In vitro Analysis of Birch-Pollen-Associated Food Allergy by Use of Recombinant Allergens in the Basophil Activation Test, International Archives of Allergy and Immunology, vol.104, issue.3, pp.230-238, 2005.
DOI : 10.1067/mai.2000.108711

J. Kleine-tebbe and S. Erdmann, Diagnostic Tests Based on Human Basophils: Potentials, Pitfalls and Perspectives, International Archives of Allergy and Immunology, vol.52, issue.1, pp.79-90, 2006.
DOI : 10.1034/j.1398-9995.2002.13423.x

M. Sanz, M. Garcia-aviles, A. Batar, M. Anda, B. Garcia et al., Basophil Activation Test and specific IgE measurements using a panel of recombinant natural rubber latex allergens to determine the latex allergen sensitization profile in children, Pediatric Allergy and Immunology, vol.1, issue.4, pp.148-56, 2006.
DOI : 10.1111/j.1398-9995.2004.00400.x

E. Apostolou, K. Deckert, R. Puy, A. Sandrini, M. De-leon et al., Anaphylaxis to GelofusineR confirmed by in vitro basophil activation test: a case series*, Anaesthesia, vol.173, issue.3, pp.264-272, 2006.
DOI : 10.1111/j.1365-2044.2004.04086.x

M. Shields, R. Mirakhur, A. Crockard, and J. Edgar, The use of basophil activation to diagnose allergy to GelofusineR, Anaesthesia, vol.44, issue.7, pp.716-723, 2006.
DOI : 10.1111/j.1398-9995.1989.tb04215.x

R. Asero and B. Ballmer-weber, IgE-Mediated food allergy diagnosis: Current status and new perspectives, Molecular Nutrition & Food Research, vol.59, issue.1, pp.135-182, 2007.
DOI : 10.1016/S0031-3955(16)38845-9

P. Valent, A. Hauswirth, S. Natter, W. Sperr, H. Buhring et al., Assays for measuring in vitro basophil activation induced by recombinant allergens, Methods, vol.32, issue.3, pp.265-70, 2004.
DOI : 10.1016/j.ymeth.2003.08.006

G. Palmer, D. Dibbern, A. Burks, G. Bannon, S. Bock et al., Comparative potency of Ara h 1 and Ara h 2 in immunochemical and functional assays of allergenicity, Clinical Immunology, vol.115, issue.3, pp.302-314, 2005.
DOI : 10.1016/j.clim.2005.02.011

C. Kepley, L. Youssef, R. Andrews, B. Wilson, and J. Olivier, Syk deficiency in nonreleaser basophils????????????, Journal of Allergy and Clinical Immunology, vol.104, issue.2, pp.279-284, 1999.
DOI : 10.1016/S0091-6749(99)70367-2

R. Valenta and D. Kraft, Recombinant allergen molecules: tools to study effector cell activation, Immunological Reviews, vol.179, issue.1, pp.119-127, 2001.
DOI : 10.1034/j.1600-065X.2001.790112.x

J. Lidholm and B. Ballmer-weber, Component-resolved diagnostics in food allergy, Current Opinion in Allergy and Clinical Immunology, vol.6, issue.3
DOI : 10.1097/01.all.0000225166.90768.d6

A. Reuter, J. Lidholm, K. Andersson, J. Ostling, M. Lundberg et al., A critical assessment of allergen component-based in vitro diagnosis in cherry allergy across Europe, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.9, issue.6
DOI : 10.1002/pmic.200400874

T. Kleber-janke and R. Crameri, Patient-tailored cloning of allergens by phage display: Peanut (Arachis hypogaea) profilin, a food allergen derived from a rare mRNA, Journal of Chromatography B: Biomedical Sciences and Applications, vol.756, issue.1-2
DOI : 10.1016/S0378-4347(01)00088-3

M. Willerroider, H. Fuchs, B. Ballmer-weber, M. Focke, M. Susani et al., Cloning and Molecular and Immunological Characterisation of Two New Food Allergens, Cap a 2 and Lyc e 1, Profilins from Bell Pepper <i>(Capsicum annuum)</i> and Tomato <i>(Lycopersicon esculentum)</i>, International Archives of Allergy and Immunology, vol.131, issue.4, pp.245-255, 2003.
DOI : 10.1159/000072136

D. Mittag, J. Akkerdaas, B. Ballmer-weber, L. Vogel, M. Wensing et al., Ara h 8, a Bet v 1???homologous allergen from peanut, is a major allergen in patients with combined birch pollen and peanut allergy, Journal of Allergy and Clinical Immunology, vol.114, issue.6, pp.1410-1417, 2004.
DOI : 10.1016/j.jaci.2004.09.014

N. Abuaf, B. Rajoely, E. Ghazouani, D. Levy, C. Pecquet et al., Validation of flow cytometry assay detecting in vitro basophil activation for the diagnosis of muscle relaxant allergy, J Allergy Clin Immunol, vol.105, pp.411-418, 1999.

N. Abuaf, B. Rajoely, H. Gaouar, C. Pecquet, and F. Leynadier, Contribution de la cytométrie en flux au diagnostic d'une allergie. Rev franc allergologie Immuno clin, pp.37-44, 2004.
DOI : 10.1016/j.allerg.2003.10.001

M. Akdis, K. Blaser, A. Cezmi, and C. Akdis, T Regulatory Cells in Allergy, J Allergy Clin Immunol, issue.5, pp.116-961, 2005.
DOI : 10.1159/000090279

T. Maitani, Profile analysis and immunoglobulin E reactivity of wheat protein hydrolysates. Int Arch Allery Immunol, pp.36-42, 2006.

T. Asensio, Novel plant pathogenesis-related protein family involved in food allergy, Journal of Allergy and Clinical Immunology, vol.114, issue.4, pp.896-905, 2004.
DOI : 10.1016/j.jaci.2004.06.014

R. Asero, IgE-Mediated food allergy diagnosis: Current status and new perspectives, Molecular Nutrition & Food Research, vol.59, issue.1
DOI : 10.1016/S0031-3955(16)38845-9

C. Astier, M. Morisset, O. Roitel, F. Codreanu, S. Jacquenet et al., Predictive value of skin prick tests using recombinant allergens for diagnosis of peanut allergy, Journal of Allergy and Clinical Immunology, vol.118, issue.1, pp.250-256, 2006.
DOI : 10.1016/j.jaci.2006.04.053

J. D. Astwood, A. Silvanovich, and G. Bannon, Vicilins: A case study in allergen pedigrees, Journal of Allergy and Clinical Immunology, vol.110, issue.1, pp.26-33, 2002.
DOI : 10.1067/mai.2002.125690

R. Bacchetta, S. Gregori, and M. Roncarolo, CD4+ regulatory T cells: Mechanisms of induction and effector function, Autoimmunity Reviews, vol.4, issue.8, pp.491-406, 2005.
DOI : 10.1016/j.autrev.2005.04.005

B. Ballmer-weber, A. Wangorsch, B. Bohle, S. Kaul, G. Kündig et al., Component-resolved in vitro diagnosis in carrot allergy: Does the use of recombinant carrot allergens improve the reliability of the diagnostic procedure?, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.33, issue.7, pp.970-978, 2005.
DOI : 10.1111/j.1365-2222.2004.1939.x

G. Bannon, T. Fu, I. Kimber, and D. Hinton, Protein digestibility and relevance to allergenicity. Environmental Health Perpect, pp.1122-1124, 2003.
DOI : 10.1289/ehp.5812

URL : http://europepmc.org/articles/pmc1241561?pdf=render

L. Bloedon, S. Balikai, . Sc, J. Berlin, D. Rader et al., Flaxseed and Cardiovascular Risk Factors: Results from a Double Blind, Randomized, Controlled Clinical Trial, Journal of the American College of Nutrition, vol.134, issue.1, pp.65-74, 2008.
DOI : 10.1179/rer.2000.5.1.45

R. Boumiza, G. Monneret, M. Forissiert, J. Savoye, M. Gutowski et al., Marked improvement of the basophil activation test by detecting CD203c instead of CD63, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.35, issue.2
DOI : 10.1159/000057747

R. Boumiza, A. Debard, and G. Monneret, The basophils activation test by flow cytometry: recent developments in clinical studies, standardization and emerging perpectives, Clinical and Molecular Allergy, vol.3, issue.1, p.9, 2005.
DOI : 10.1186/1476-7961-3-9

H. Breiteneder, Can any protein become an allergen? Revue française d'allergologie et d'immunologie clinique, pp.135-138, 2008.

H. Breiteneder and E. Mills, Plant food allergens???structural and functional aspects of allergenicity, Biotechnology Advances, vol.23, issue.6, pp.395-399, 2005.
DOI : 10.1016/j.biotechadv.2005.05.004

M. Chapman, A. Pomés, H. Breiteneder, and F. Ferreira, Nomenclature and structural biology of??allergens, Journal of Allergy and Clinical Immunology, vol.119, issue.2, pp.414-420, 2007.
DOI : 10.1016/j.jaci.2006.11.001

M. Chehade and L. Mayer, Oral tolerance and its relation to food hypersensitivities, Journal of Allergy and Clinical Immunology, vol.115, issue.1, pp.3-12, 2005.
DOI : 10.1016/j.jaci.2004.11.008

S. Chung, C. Butts, S. Maleki, and E. Champagne, Linking Peanut Allergenicity to the Processes of Maturation, Curing, and Roasting, Journal of Agricultural and Food Chemistry, vol.51, issue.15, pp.4273-4277, 2003.
DOI : 10.1021/jf021212d

R. Crevel, Industrial dimensions of food allergy, Proceedings of the Nutrition Society, vol.51, issue.04, pp.470-474, 2005.
DOI : 10.1136/thx.51.7.670

R. W. Crevel, Risk assessment for food allergy - the industry viewpoint, Allergy, vol.100, issue.s67, pp.94-101, 2001.
DOI : 10.1016/S0091-6749(97)70161-1

P. J. Davis, C. M. Smales, and D. C. James, How can thermal processing modify the antigenicity of proteins? Allergy, pp.56-60, 2001.

A. M. De-la-barca, A. Wall, and J. A. Lopez-diaz, Allergenicity, trypsin inhibitor activity and nutritive quality of enzymatically modified soy proteins, Int J Food Sci Nutr, issue.3, pp.56-203, 2005.

A. De-weck, M. Sanz, P. Gamboa, W. Aberer, J. Bienvenu et al., Diagnostic Tests Based on Human Basophils: More Potentials and Perspectives than Pitfalls, International Archives of Allergy and Immunology, vol.50, issue.3, pp.177-189, 2008.
DOI : 10.1007/BF03361072

C. Dirks, M. Pedersen, M. Platzer, C. Bindslev-jensen, P. Skov et al., Does absorption across the buccal mucosa explain early onset of food-induced allergic systemic reactions? Allergy Clin Immunol, pp.1321-1324, 2005.

G. Docena, P. Rozenfeld, R. Fernandez, and C. Fossati, tests, Allergy, vol.20, issue.2, pp.83-91, 2002.
DOI : 10.1111/j.1365-2222.1990.tb02798.x

S. Dreborg, Skin test in diagnosis of food allergy. Allergy Proc, pp.251-255, 1991.

M. Dube, Effect of technological processing on the allergenicity of mangoes (Mangifera indica L.), J Agric Food Chem, issue.12, pp.52-3938, 2004.

J. Dunwell, A. Purvis, and S. Khuri, Cupins : the most functionally divers protein superfamily? Phytochemistry, pp.7-17, 2004.

D. Ebo, B. Lechkar, A. Schuerwegh, C. Bridts, D. Clerk et al., Validation of a two-color flow cytometric assay detecting in vitro basophil activation for the diagnosis of IgE-mediated natural rubber latex allergy, Allergy, vol.107, issue.8, pp.706-712, 2002.
DOI : 10.1067/mai.2001.115139

D. Ebo, M. Hagendorens, C. Bridts, A. Schuerwegh, D. Clerck et al., Flow cytometric analysis of in vitro activated basophils, specific IgE and skin tests in the diagnosis of pollen-associated food allergy, Cytometry Part B: Clinical Cytometry, vol.108, issue.1, pp.28-33, 2005.
DOI : 10.1002/cyto.b.20042

D. Ebo, J. Sainte-laudy, C. Bridts, C. Mertens, M. Hagendorens et al., Flow-assisted allergy diagnosis: current applications and future perspectives, Allergy, vol.94, issue.1, pp.1028-1039, 2006.
DOI : 10.1016/j.jaci.2005.04.042

B. Ehn, T. Allmere, E. Telemo, U. Bengtsson, and B. Ekstrand, Modification of IgE binding to beta-lactoglobulin by fermentation and proteolysis of cow's milk, J Agric Food Chem, issue.9, pp.533743-3748, 2005.

A. Fiocchi, Clinical tolerance of processed foods, Annals of Allergy, Asthma & Immunology, vol.93, issue.5, pp.38-46, 2004.
DOI : 10.1016/S1081-1206(10)61731-0

A. Fiocchi, P. Restani, E. Riva, G. Mirri, I. Santini et al., Heat treatment modifies the allergenicity of beef and bovine serum albumin, Allergy, vol.89, issue.8, pp.798-802, 1998.
DOI : 10.1080/07315724.1997.10718701

K. Fötisch, F. Altmann, D. Haustein, and S. Vieths, Involvement of Carbohydrate Epitopes in the IgE Response of Celery???Allergic Patients, International Archives of Allergy and Immunology, vol.120, issue.1, pp.30-42, 1999.
DOI : 10.1159/000024217

F. Gay-crosier, G. Schreiber, and C. Hauser, Anaphylaxis from Inulin in Vegetables and Processed Food, New England Journal of Medicine, vol.342, issue.18, p.3421372, 2000.
DOI : 10.1056/NEJM200005043421814

P. Gruber, W. Becker, and T. Hofman, ), Its Major Epitopes, and Peanut Agglutinin, Journal of Agricultural and Food Chemistry, vol.53, issue.6, pp.2289-2296, 2005.
DOI : 10.1021/jf048398w

V. Gutierrez-gomez, C. Fournier, C. Vilain, A. Just, N. Wallaert et al., Réactions anaphylactiques induites par l'inuline. Rev Franc Allerg Immunol clin, pp.493-495, 2005.

K. Hansen, B. Ballmer-weber, D. Lüttkopf, P. Skov, B. Wüthrich et al., Roasted hazelnuts - allergenic activity evaluated by double-blind, placebo-controlled food challenge, Allergy, vol.111, issue.2, pp.727-736, 2003.
DOI : 10.1034/j.1398-9995.2002.1o3319.x

D. Hermans, Aspects cliniques de l'allergie alimentaire du jeune enfant. Louvain médical, pp.214-219, 2005.

W. Howell, S. Turner, J. Hourihane, T. Dean, and J. Warner, HLA class II DRB1, DQB1 and DPB1 genotypic associations with peanut allergy: evidence from a family-based and case-control study, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.98, issue.2, pp.156-162, 1998.
DOI : 10.1016/S0091-6749(96)70228-2

U. Jappe, M. Raulf-heimsoth, M. Hoffmann, G. Burow, C. Hübsch-müller et al., In vitro hymenoptera venom allergy diagnosis: improved by screening for cross-reactive carbohydrate determinants and reciprocal inhibition, Allergy, vol.17, issue.1, pp.1220-1229, 2006.
DOI : 10.1067/mai.2003.173

M. Jutel, M. Akdis, K. Blaser, and C. Akdis, Mechanisms of allergen specific immunotherapy - T-cell tolerance and more, Allergy, vol.165, issue.37, pp.796-807, 2006.
DOI : 10.1016/S0952-7915(98)80082-4

J. Kleine-tebbe, S. Erdmann, E. Knol, D. Macglashan, L. Poulsen et al., Diagnostic Tests Based on Human Basophils: Potentials, Pitfalls and Perspectives, International Archives of Allergy and Immunology, vol.52, issue.1, pp.79-80, 2006.
DOI : 10.1034/j.1398-9995.2002.13423.x

M. Kobayashi, Y. Hashimoto, S. Taniuchi, and . Tanabes, Degradation of wheat allergen in japanese soy sauce, Int J Mol Med, vol.13, issue.6, pp.821-827, 2004.

R. Kopper, N. Odum, M. Sen, R. Helm, J. Stanley et al., Peanut Protein Allergens: The Effect of Roasting on Solubility and Allergenicity, International Archives of Allergy and Immunology, vol.169, issue.1, pp.16-22, 2005.
DOI : 10.1016/S0091-6749(03)01719-6

C. Lambert, L. Guilloux, C. Dzviga, C. Gourgaud-massias, and C. Genin, Flow cytometry versus histamine release analysis of in vitro basophil degranulation in allergy to Hymenoptera venom, Cytometry, vol.51, issue.1, pp.13-19, 2003.
DOI : 10.1002/jlb.51.4.386

F. Lamblin, . Hano-c, O. Fliniaux, F. Mesnard, M. Fliniaux et al., Int??r??t des lignanes dans la pr??vention et le traitement de cancers, m??decine/sciences, vol.24, issue.5, pp.511-520, 2008.
DOI : 10.1051/medsci/2008245511

H. Lee, E. Keum, S. Lee, D. Sung, D. Chung et al., Allergenicity of Proteolytic Hydrolysates of the Soybean 11S Globulin, Journal of Food Science, vol.33, issue.2, pp.168-172, 2007.
DOI : 10.1016/j.jaci.2003.12.588

S. Lehrer and G. Reese, Recombinant Proteins in Newly Developed Foods: Identification of Allergenic Activity, International Archives of Allergy and Immunology, vol.113, issue.1-3, pp.122-124, 1997.
DOI : 10.1159/000237523

S. B. Lehrer and G. A. Bannon, Risks of allergic reactions to biotech proteins in foods: perception and reality, Allergy, vol.103, issue.5, pp.60-559, 2005.
DOI : 10.1159/000065172

F. León, M. Rodríguez, and M. Cuevas, The major allergen of linseed. Allergy, 2002.

G. Macfarlane, H. Steed, and S. Macfarlane, Bacterial metabolism and health-related effects of galacto-oligosaccahrides and other prebiotic, J appl microbiol, vol.104, pp.305-344, 2008.

H. Malandain and F. Lavaud, Allergénicité des protéines de défense végétale. Revue française d'allergologie et d'immunologie clinique, pp.469-475, 2004.

H. Malandain, IgE-reactive carbohydrate epitopes--classification, cross-reactivity, and clinical impact, Allerg Immunol, vol.37, pp.122-130, 2005.

S. Maleki, S. Chung, E. Champagne, and J. Raufman, The effects of roasting on the allergenic properties of peanut proteins, Journal of Allergy and Clinical Immunology, vol.106, issue.4, pp.763-771, 2000.
DOI : 10.1067/mai.2000.109620

S. J. Maleki, Food processing: effects on allergenicity, Current Opinion in Allergy and Clinical Immunology, vol.4, issue.3, pp.241-246, 2004.
DOI : 10.1097/00130832-200406000-00018

A. Mari, IgE to Cross-Reactive Carbohydrate Determinants: Analysis of the Distribution and Appraisal of the in vivo and in vitro Reactivity, International Archives of Allergy and Immunology, vol.129, issue.4, pp.286-95, 2002.
DOI : 10.1159/000067591

T. Matsuda, T. Matsubara, and S. Hino, Immunogenic and allergenic potentials of natural and recombinant innocuous proteins, Journal of Bioscience and Bioengineering, vol.101, issue.3, pp.203-214, 2006.
DOI : 10.1263/jbb.101.203

C. Meredith, Allergenic potential of novel foods, Proceedings of the Nutrition Society, vol.43, issue.04, pp.487-90, 2005.
DOI : 10.1016/S0140-6736(94)90234-8

D. D. Metcalfe, Assessment of the allergenic potential of foods derived from genetically engineered crop plants*, Critical Reviews in Food Science and Nutrition, vol.250, issue.sup001, pp.165-86, 1996.
DOI : 10.1002/elps.1150090603

E. Mills, A. Mackie, P. Burney, K. Beyer, L. Frewer et al., The prevalence, cost and basis of food allergy across Europe. allergy, pp.717-722, 2007.

L. Mondoulet, E. Paty, M. Drumare, S. Ah-leung, P. Scheinmann et al., Influence of Thermal Processing on the Allergenicity of Peanut Proteins, Journal of Agricultural and Food Chemistry, vol.53, issue.11, pp.53-4547, 2005.
DOI : 10.1021/jf050091p

D. A. Moneret-vautrin, Modifications of allergenicity linked to food technologies, Allerg Immunol, vol.30, issue.1, pp.9-13, 1998.

D. Moneret-vautrin, G. Kanny, and M. Morisset, Les allergies alimentaires de l'enfant et de l'adulte, 2006.

D. A. Moneret-vautrin, Epidémiologie de l'allergie alimentaire. Rev franc allerg immunol clin, pp.171-178, 2008.

G. Monneret, Y. Benoit, A. Gutowski, M. Topenot, I. Bienvenu et al., Monitoring of Basophil Activation Using CD63 and CCR3 in Allergy to Muscle Relaxant Drugs, Clinical Immunology, vol.102, issue.2, pp.192-199, 2002.
DOI : 10.1006/clim.2001.5156

M. Morisset, F. Codreanu, C. Astier, R. Olivier, S. Jacquenet et al., Int??r??t des allerg??nes recombinants dans le diagnostic de l???allergie alimentaire, Revue Fran??aise d'Allergologie et d'Immunologie Clinique, vol.48, issue.3, pp.242-245, 2008.
DOI : 10.1016/j.allerg.2008.01.029

N. Nieuwenhuizen and A. Lopata, Fighting Food Allergy: Current Approaches, Annals of the New York Academy of Sciences, vol.1056, issue.1, pp.30-45, 2005.
DOI : 10.1196/annals.1352.003

A. Nowak-wegrzyn and H. A. Sampson, Adverse Reactions to Foods, Medical Clinics of North America, vol.90, issue.1, pp.97-127, 2006.
DOI : 10.1016/j.mcna.2005.08.012

S. Oehlschlager, Food allergy???towards predictive testing for novel foods, Food Additives and Contaminants, vol.8, issue.12, pp.1099-107, 2001.
DOI : 10.1016/S0140-6736(94)90234-8

A. Patade, L. Devareddy, E. Lucas, K. Korlagunta, B. Daggy et al., Flaxseed Reduces Total and LDL Cholesterol Concentrations in Native American Postmenopausal Women, Journal of Women's Health, vol.17, issue.3, pp.17-355, 2008.
DOI : 10.1089/jwh.2007.0359

G. Pauli, C. Metz-favre, and J. Fontaine, Allergènes recombinants croisant avec les allergènes de pollen, Rev Franç Allerg Immunol, vol.46, pp.153-157, 2006.

E. Peñas, P. Restani, C. Ballabio, G. Préstamo, A. Fiocchi et al., Evaluation of the Residual Antigenicity of Dairy Whey Hydrolysates Obtained by Combination of Enzymatic Hydrolysis and High-Pressure Treatment, Journal of Food Protection, vol.50, issue.7, pp.1707-1719, 2006.
DOI : 10.1016/S0091-6749(95)70056-0

I. Platz, M. Binder, A. Marxer, G. Lischka, P. Valent et al., Hymenoptera-Venom-Induced Upregulation of the Basophil Activation Marker Ecto-Nucleotide Pyrophosphatase/Phosphodiesterase 3 in Sensitized Individuals, International Archives of Allergy and Immunology, vol.126, issue.4, pp.335-342, 2001.
DOI : 10.1159/000049531

R. E. Poms and E. Anklam, Effects of chemical, physical, and technological processes on the nature of food allergens, J AOAC Int, vol.87, issue.6, pp.1466-74, 2004.

L. Poulsen, In search of a new paradigm: mechanisms of sensitization and elicitation of food allergy*, Allergy, vol.81, issue.5, pp.549-558, 2005.
DOI : 10.1016/0091-6749(92)90080-L

C. Prussin and D. Metcalfe, 4. IgE, mast cells, basophils, and eosinophils, Journal of Allergy and Clinical Immunology, vol.111, issue.2, pp.486-494, 2003.
DOI : 10.1067/mai.2003.120

C. Radauer and H. Breiteneder, Evolutionary biology of plant food allergens, Journal of Allergy and Clinical Immunology, vol.120, issue.3, pp.518-525, 2007.
DOI : 10.1016/j.jaci.2007.07.024

F. Régnier, A. Lhuissier, and S. Gojard, Sociologie de l'alimentation. Collection Repères, 2006.

A. Reuter, J. Lidholm, K. Andersson, J. Östling, M. Lundberg et al., A critical assessment of allergen component-based in vitro diagnosis in cherry allergy across Europe, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.9, issue.6, pp.815-823, 2006.
DOI : 10.1002/pmic.200400874

S. Romagnani, Immunologic influences on allergy and the TH1/TH2 balance, Journal of Allergy and Clinical Immunology, vol.113, issue.3, pp.395-400, 2004.
DOI : 10.1016/j.jaci.2003.11.025

S. Romagnani, Regulatory T cells: which role in the pathogenesis and treatment of allergic disorders?, Allergy, vol.360, issue.Suppl., pp.3-14, 2006.
DOI : 10.1172/JCI18246

S. Romagnani, Regulation of the T cell response, Clinical & Experimental Allergy, vol.71, issue.11, pp.1357-1366, 2006.
DOI : 10.1172/JCI28508

R. Rona, T. Keil, C. Summers, D. Gislason, L. Zuidmeer et al., The prevalence of food allergy: A meta-analysis, Journal of Allergy and Clinical Immunology, vol.120, issue.3, pp.638-646, 2007.
DOI : 10.1016/j.jaci.2007.05.026

A. Rosendal and . Barkholt, Detection of Potentially Allergenic Material in 12 Hydrolyzed Milk Formulas, Journal of Dairy Science, vol.83, issue.10, pp.2200-2210, 2000.
DOI : 10.3168/jds.S0022-0302(00)75103-4

J. Saintelaudy, A. Sabbah, M. Drouet, M. Lauret, and M. Loiry, Diagnosis of venom allergy by flow cytometry. Correlation with clinical history, skin tests, specific IgE, histamine and leukotriene C4 release, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.90, issue.8, pp.1166-1171, 2000.
DOI : 10.1159/000235070

C. Sanchez and F. S. , Conséquences des traitements thermiques et de la formulation sur la structure et l'allergénicité des protéines alimentaires. Rev franc allergologie immunol clin, pp.13-20, 2003.
DOI : 10.1016/s0335-7457(02)00003-5

A. Sancho, N. Rigby, L. Zuidmeer, R. Asero, G. Mistrello et al., The effect of thermal processing on the Ige reativity of the non-specific lipid transfer protein from apple, pp.1262-1268, 2005.

B. Seabourn, O. Chung, P. Seib, and P. Mathewson, Determination of Secondary Structural Changes in Gluten Proteins during Mixing Using Fourier Transform Horizontal Attenuated Total Reflectance Spectroscopy, Journal of Agricultural and Food Chemistry, vol.56, issue.11, pp.4236-4243, 2008.
DOI : 10.1021/jf703569b

S. H. Sicherer and H. A. Sampson, Food allergy, J Allergy Clin Immunol, vol.9, issue.1172, 2006.
URL : https://hal.archives-ouvertes.fr/hal-01262509

S. Steckelbroeck, B. Ballmer-weber, and S. Vieths, Potential, pitfalls, and prospects of food allergy diagnostics with recombinant allergens or synthetic sequential epitopes, Journal of Allergy and Clinical Immunology, vol.121, issue.6, pp.1323-1330, 2008.
DOI : 10.1016/j.jaci.2008.04.008

J. Steinke, S. Rich, and L. Borish, 5. Genetics of allergic disease, Journal of Allergy and Clinical Immunology, vol.121, issue.2, pp.384-387, 2008.
DOI : 10.1016/j.jaci.2007.07.029

URL : https://hal.archives-ouvertes.fr/in2p3-00024132

P. Sudheer, J. Hall, G. Read, A. Rowbottom, and P. Williams, Flow cytometric investigation of per-anesthesic anaphylaxis using CD63 and CD 203c, Anaesthesia, vol.60, pp.2516-256, 2005.

S. L. Taylor, Review of the development of methodology for evaluating the human allergenic potential of novel proteins, Molecular Nutrition & Food Research, vol.37, issue.7, pp.50-604, 2006.
DOI : 10.1002/mnfr.200500275

S. L. Taylor and S. L. Hefle, Will genetically modified foods be allergenic?, Journal of Allergy and Clinical Immunology, vol.107, issue.5, pp.765-71, 2001.
DOI : 10.1067/mai.2001.114241

K. Thomas, C. Herouet-guicheney, G. Ladics, G. Bannon, A. Cockburn et al., Evaluating the effect of food processing on the potential human allergenicity of novel proteins: International workshop report, Food and Chemical Toxicology, vol.45, issue.7, pp.1116-1122, 2007.
DOI : 10.1016/j.fct.2006.12.016

H. Tsuji, N. Okada, R. Yamanishi, N. Bando, M. Kimoto et al., Bd 30K, a Major Soybean Allergen, in Soybean Products by a Sandwich Enzyme-linked Immunosorbent Assay, Bioscience, Biotechnology, and Biochemistry, vol.59, issue.1, pp.150-151, 1995.
DOI : 10.1271/bbb.59.150

E. Untersmayr and E. Jensen-jarolim, Mechanisms of type I food allergy, Pharmacology & Therapeutics, vol.112, issue.3, pp.787-798, 2006.
DOI : 10.1016/j.pharmthera.2006.06.004

P. Valent, A. Hauswirth, S. Natter, W. Sperr, H. Bürhing et al., Assays for measuring in vitro basophil activation induced by recombinant allergens, Methods, vol.32, issue.3, pp.265-270, 2004.
DOI : 10.1016/j.ymeth.2003.08.006

E. Van-boxtel, V. Broek, L. Koppelman, S. Gruppen, and H. , Legumin allergens from peanuts and soybeans: Effects of denaturation and aggregation on allergenicity, Mol nutr foods res, pp.52-674, 2008.
DOI : 10.4049/jimmunol.169.2.882

M. Van-der-veen, R. Van-ree, R. Aalberse, J. Akkerdaas, S. Koppelman et al., Poor biologic activity of cross-reactive IgE directed to carbohydrate determinants of glycoproteins, Journal of Allergy and Clinical Immunology, vol.100, issue.3, pp.327-361, 1997.
DOI : 10.1016/S0091-6749(97)70245-8

M. Van-de-weert, P. Haris, W. Hennink, and D. Crommelin, Fourier Transform Infrared Spectrometric Analysis of Protein Conformation: Effect of Sampling Method and Stress Factors, Analytical Biochemistry, vol.297, issue.2, pp.160-169, 2001.
DOI : 10.1006/abio.2001.5337

. Van-ree, The CREATE Project: Development of Certified Reference Materials for Allergenic Products and Validation of Methods for Their Quantification, Allergy, vol.63, pp.310-326, 2008.
DOI : 10.1007/978-3-642-31609-8_9

S. Vieths, Factors influencing the quality of food extracts for in vitro and in vivo diagnosis, Allergy, issue.53, pp.65-71, 1946.

S. Vieths, S. Scheurer, and B. Ballmer-weber, Current Understanding of Cross-Reactivity of Food Allergens and Pollen, Annals of the New York Academy of Sciences, vol.103, issue.1, pp.47-68, 2002.
DOI : 10.1111/j.1398-9995.1998.tb04965.x

H. Vila, K. Beyer, K. Järvinen, P. Chatchatee, L. Bardina et al., Role of conformational and linear epitopes in the achievement of tolerance in cow's milk allergy, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.24, issue.4, pp.1599-1606, 2001.
DOI : 10.1203/00006450-198808000-00012

V. Mutius and E. , Allergies, infections and the hygiene hypothesis ??? The epidemiological evidence, Immunobiology, vol.212, issue.6, pp.433-439, 2007.
DOI : 10.1016/j.imbio.2007.03.002

J. Wal, Thermal processing and allergenicity of foods, Allergy, vol.51, issue.8, pp.727-729, 2003.
DOI : 10.1067/mai.2002.129235

J. Wal, Allergies alimentaires??: m??canismes physiopathologiques, identification des allerg??nes alimentaires, Nutrition Clinique et M??tabolisme, vol.18, issue.1, pp.15-19, 2004.
DOI : 10.1016/j.nupar.2004.01.008

R. Yamanishi, H. Tsuji, N. Bando, Y. Nadaoka, K. Nishikawa et al., Reduction of the Allergenicity of Soybean by Treatment with Proteases., Journal of Nutritional Science and Vitaminology, vol.42, issue.6, pp.581-587, 1996.
DOI : 10.3177/jnsv.42.581

W. Zhang, X. Wang, Y. Liu, H. Tian, B. Flickinger et al., Effects of Dietary Flaxseed Lignan Extract on Symptoms of Benign Prostatic Hyperplasia, Journal of Medicinal Food, vol.11, issue.2, 2008.
DOI : 10.1089/jmf.2007.602

J. Zhu, H. Yamane, J. Cote-sierra, L. Guo, and W. Paul, GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors, Cell Research, vol.307, issue.1, pp.3-10, 2006.
DOI : 10.1126/science.1103336

R. 1. Dziarski, R. Gupta, and D. , Peptidoglycan recognition in innate immunity, Journal of Endotoxin Research, vol.101, issue.5, pp.304-314, 2005.
DOI : 10.1182/blood-2002-07-2319

J. Huang, L. Wu, D. Yalda, Y. Adkins, S. Kelleher et al., Expression of functional recombinant human lysozyme in transgenic rice cell culture, Bajaj-Elliott M. Innate immune defence in the human gastrointestinal tract, pp.229-268, 2002.
DOI : 10.1023/A:1015663706259

R. Lodovina and V. Jouja, Influence of oral lysozyme administration on serum immunoglobulin and intestinal secretory IgA levels in infants, Mol Immunol Acta Pediatr Scand, vol.42, issue.66, pp.903-12709, 1977.

B. Lonnerdal, N. Zavaleta, D. Figueroa, J. Rivera, J. Sanchez et al., Expression of human milk proteins in plants Efficacy of rice-based oral rehydration solution containing recombinant lactoferrin and lysozyme in Peruvian children with acute diarrhea, J Am Coll Nutr J Pediatr Gastroenterol Nutr, vol.21, issue.44, pp.218-21258, 2002.

D. Metcalfe, J. Astwood, R. Townsend, H. Sampson, S. Taylor et al., Assessment of the allergenic potential of foods derived from genetically engineered crop plants Commission CA Guideline for the conduct of food safety assessment of foods derived from recombinant-DNA plants. Annex on the assessment of possible allergenicity34 Joint FAO/WHO Food Standard Programme 25 th session 30-06 5 07 2003 Appendix III and IV: 47-60. 9. Goodman RE, Hefle SL, Taylor Sl, van Ree R. Assessing genetically modified crops to minimize the risk of increased food allergy: a review Moneret-Vautrin DA.Transgenic plants: what we do and don't know about the risks of allergenicity, Crit Rev Food Sci Nutr Alinorm Int Arch Allergy Immunol Rev Fr Allergol Immunol Clin, vol.36, issue.46, pp.165-86153, 1996.

R. Aalberse, Assessment of sequence homology and cross-reactivity, Toxicology and Applied Pharmacology, vol.207, issue.2
DOI : 10.1016/j.taap.2005.01.021

E. Holen, S. Elsayed, S. Frémont, G. Kanny, J. Nicolas et al., Characterization of four major allergens of hen egg-white by IEF/SDS-PAGE combined with electrophoretic transfer and IgE-immunoautoradiography Prevalence of lysozyme sensitization in an egg-allergic population Detection of four distinct groups of hen egg allergens binding IgE in the sera of children with egg allergy New occupational allergen in a pharmaceutical industry: serratial peptidase and lysozyme chloride, Toxicol Appl Pharmacol Int Arch Allergy Appl Immunol Allergy Allergol Immunopathol Ann Allergy Asthma Immunol, vol.207, issue.78, pp.149-51136, 1990.

C. Leser, A. Hartmann, G. Praml, and B. Wuthrich, The "egg-egg" syndrome: occupational respiratory allergy to airborne egg proteins with consecutive ingestive egg allergy in the bakery and confectionery industry, Clin Exp Allergy J Investig Allergol Clin Immunol, vol.28, issue.11, pp.478-8589, 1998.

M. Nieto, J. Miguel, J. Cuesta, J. Sastre, F. Rance et al., Egg white proteins as inhalant allergens associated with baker's asthma Dreborg S. Diagnosis of food allergy: tests in vivo and in vitro Food allergy to peanuts in Franceevaluation of 142 observations, Allergy Pediatr Allergy Immunol Clin Exp Allergy, vol.58, issue.28, pp.616-2024, 1998.

B. Aabin, L. Poulsen, K. Ebbehoj, A. Norgaard, H. Frokiaer et al., Enzyme immunoassay for hen egg white lysozyme used as a food additive Specific IgE antibody titers to hen's egg white lysozyme in allergic children to egg Concentration of egg white lysozyme in the serum of healthy subjects after oral administration Acute exercise induces gastrointestinal leakage of allergen in lysozyme-sensitized mice Holen E, Elsayed S. Specific T cell lines for ovalbumin, ovomucoid, lysozyme and two OA synthetic epitopes, generated from egg allergic patients' PBMC Contribution of conformational stability of hen lysozyme to induction of type 2 T-helper immune responses Comparative studies on antigenicity and allergenicity of native and denatured egg white proteins Immunodominance of conformation-dependent B-cell epitopes of protein antigens Lonnerdal B. Recombinant human milk proteins Assays for measuring in vitro basophil activation induced by recombinant allergens In vitro analysis of birch-pollen associated food allergy by use of recombinant allergens in the basophil activation test Multiple food allergy: a possible diagnosis in breastfed infants An eye witness perspective of the changing patterns of food allergy Sensitization to human milk, Int Arch Allergy Immunol J Assoc Off Anal Chem Arerugi Clin Exp Pharmacol Eur J Appl Physiol Clin Exp Allergy Immunology J Agric Food Chem Biochem Biophys Res Commun Nestle Nutr Workshop Ser Pediatr Program Methods Erdmann SM Int Arch Allergy Immunol Acta Paediatr Eur J Gastroenterol Hepatol Clin exp Allergy, vol.109, issue.38, pp.50-7502, 1991.