S. A. Adibi and K. Y. , Peptide absorption and hydrolysis, Physiology of the Gastrointestinal Tract. Raven, pp.1073-1095, 1981.

J. M. Anderson, V. Itallie, and C. M. , Tight junctions and the molecular basis for regulation of paracellular permeability, American Journal of Physiology-Gastrointestinal and Liver Physiology, vol.269, issue.4, pp.467-475, 1995.
DOI : 10.1152/ajpgi.1995.269.4.G467

J. M. Anderson, C. M. Van-itallie, M. D. Peterson, B. R. Stevenson, E. A. Carew et al., ZO-1 mRNA and protein expression during tight junction assembly in Caco- 2 cells, The Journal of Cell Biology, vol.109, issue.3, pp.260-267, 1989.
DOI : 10.1083/jcb.109.3.1047

Y. Ando-akatsuka, M. Saitou, T. Hirase, M. Kishi, A. Sakakibara et al., Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues, The Journal of Cell Biology, vol.133, issue.1, pp.43-47, 1996.
DOI : 10.1083/jcb.133.1.43

Y. Aoki, M. Morishita, and K. Takayama, Role of the mucous/glycocalyx layers in insulin permeation across the rat ileal membrane, International Journal of Pharmaceutics, vol.297, issue.1-2, pp.98-109, 2005.
DOI : 10.1016/j.ijpharm.2005.03.004

P. Artursson and R. Borchardt, Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond, Pharmaceutical Research, vol.14, issue.12, pp.1655-1658, 1997.
DOI : 10.1023/A:1012155124489

P. Artursson and K. J. , Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells, Biochemical and Biophysical Research Communications, vol.175, issue.3, 1991.
DOI : 10.1016/0006-291X(91)91647-U

P. Artursson, A. L. Ungell, and J. Lofroth, Selective paracellular permeability in two models of intestinal absorption : cultured monolayers of human intestinal cells and rat intestinal segments, Pharmaceutical Research, vol.10, issue.8, pp.1123-1129, 1993.
DOI : 10.1023/A:1018903931777

P. Artursson, K. Palm, and K. Luthman, Caco-2 monolayers in experimental and theoretical predictions of drug transport, Advanced Drug Delivery Reviews, vol.22, issue.1-2, pp.67-84, 1996.
DOI : 10.1016/S0169-409X(96)00415-2

K. Atisook and M. J. , An oligopeptide permeates intestinal tight junctions at glucose-elicited dilatations, Gastroenterology, vol.100, issue.3, pp.719-743, 1991.
DOI : 10.1016/0016-5085(91)80016-3

P. F. Augustijns and R. T. Brochardt, Transport and metabolism of delta sleep-inducting peptide in cultured human intestinal epithelial cell monolayers, Drug Metabolism and Disposition, vol.23, pp.1372-1378, 1995.

J. P. Bai and G. L. Amidon, Structural specificity of mucosal-cell transport and metabolism of peptide drugs: Implication for oral peptide drug delivery, Pharmaceutical Research, vol.09, issue.8, pp.969-978, 1992.
DOI : 10.1023/A:1015885823793

C. A. Bailey, P. Bryla, and W. M. , The use of the intestinal epithelial cell culture model, Caco-2, in pharmaceutical development, Advanced Drug Delivery Reviews, vol.22, issue.1-2, pp.85-103, 1996.
DOI : 10.1016/S0169-409X(96)00416-4

P. V. Balimane and C. S. , Cell culture-based models for intestinal permeability: A critique, Drug Discovery Today, vol.10, issue.5, pp.335-343, 2005.
DOI : 10.1016/S1359-6446(04)03354-9

K. Barnes, A. J. Turner, and K. A. , Electronmicroscopic immunocytochemistry of pig brain shows that endopeptidase-24.11 is localized in neuronal membranes, Neuroscience Letters, vol.94, issue.1-2, pp.64-69, 1988.
DOI : 10.1016/0304-3940(88)90271-6

L. Barthe, J. Woodley, and G. Houin, Gastrointestinal absorption of drugs: methods and studies, Fundamental & Clinical Pharmacology, vol.105, issue.I, pp.154-168, 1999.
DOI : 10.1016/0016-5085(93)90957-E

L. Barthe, M. Bessouet, J. F. Woodley, and G. Houin, The improved everted gut sac: a simple method to study intestinal P-glycoprotein, International Journal of Pharmaceutics, vol.173, issue.1-2, pp.255-258, 1998.
DOI : 10.1016/S0378-5173(98)00225-7

C. Beata, E. Beaumont, V. Coll, J. Cordel, M. Marion et al., Effect of alpha-casozepine (Zylkene) on anxiety in cats, Journal of Veterinary Behavior: Clinical Applications and Research, vol.2, issue.2, pp.40-46, 2007.
DOI : 10.1016/j.jveb.2007.02.002

C. Beata, E. Beaumont, C. Diaz, M. Marion, N. Marlois et al., 9, Journal of Veterinary Behavior: Clinical Applications and Research, vol.2, issue.3, pp.86-87, 2007.
DOI : 10.1016/j.jveb.2007.04.013

A. Benajiba and M. S. , Purification and Characterization of an Aminopeptidase A from Hog Intestinal Brush-Border Membrane, European Journal of Biochemistry, vol.251, issue.2, pp.381-388, 1980.
DOI : 10.1016/0005-2795(68)90193-1

A. Bernkop-schnürch, The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins, Journal of Controlled Release, vol.52, issue.1-2, pp.1-16, 1998.
DOI : 10.1016/S0168-3659(97)00204-6

R. Berrocal, S. Chanton, M. A. Juillerat, B. Pavillard, J. C. Scherz et al., Tryptic phosphopeptides from whole casein. II. Physicochemical properties related to the solubilization of calcium, Journal of Dairy Research, vol.48, issue.03, pp.335-341, 1989.
DOI : 10.1126/science.128.3322.472

V. Berzinova and I. Oswald, Sleep after a Bedtime Beverage, BMJ, vol.2, issue.5811, pp.431-433, 1972.
DOI : 10.1136/bmj.2.5811.431

S. Beucher, F. Levenez, M. Yvon, and C. T. , Effects of gastric digestive products from casein on CCK release by intestinal cells in rat, The Journal of Nutritional Biochemistry, vol.5, issue.12, pp.578-589, 1994.
DOI : 10.1016/0955-2863(94)90012-4

R. J. Beynon and G. Salvesen, Appendix III. Commercially available protease inhibitors, Proteolytic enzymes, pp.241-249, 1989.

E. Biganzoli, L. A. Cavenaghi, R. Rossi, M. C. Brunati, and N. N. , Use of a Caco-2 cell culture model for the characterization of intestinal absorption of antibiotics, Il Farmaco, vol.54, issue.9, pp.594-599, 1999.
DOI : 10.1016/S0014-827X(99)00069-5

G. Biggio, A. Concas, M. G. Corda, O. Giorgio, E. Sanna et al., Gabaergic and dopaminergic transmission in the rat cerebral cortex: Effect of stress, anxiolytic and anxiogenic drugs, Pharmacology & Therapeutics, vol.48, issue.2, pp.121-142, 1990.
DOI : 10.1016/0163-7258(90)90077-F

X. Boulenc, T. Breul, J. C. Gautier, P. Saudemon, H. Joyeux et al., Sodium lauryl sulphate increases tiludronate paracellular transport using human epithelial caco-2 monolayers, International Journal of Pharmaceutics, vol.123, issue.1, pp.71-83, 1995.
DOI : 10.1016/0378-5173(95)00041-G

M. Bourin and M. Hascoet, The mouse light/dark box test, European Journal of Pharmacology, vol.463, issue.1-3, pp.55-65, 2003.
DOI : 10.1016/S0014-2999(03)01274-3

M. Brandsch, I. Knütter, and L. F. , The intestinal H+/peptide symporter PEPT1: structure???affinity relationships, European Journal of Pharmaceutical Sciences, vol.21, issue.1, pp.53-60, 2004.
DOI : 10.1016/S0928-0987(03)00142-8

V. Brantl, H. Teschemacher, J. Blaesig, A. Henschen, and F. Lottspeich, Opioid activities of ??-casomorphins, Life Sciences, vol.28, issue.17, pp.1903-1909, 1981.
DOI : 10.1016/0024-3205(81)90297-6

V. Brantl, H. Teschemacher, A. Henschen, and F. Lottspeich, -Casomorphins). I. Isolation from Bovine Casein Peptone, Hoppe-Seyler??s Zeitschrift f??r physiologische Chemie, vol.43, issue.2, pp.1211-1227, 1979.
DOI : 10.1016/S0065-3233(08)60022-4

P. S. Burton, R. B. Hill, and C. R. , Metabolism and transport of peptides across the intestinal mucosa, Proc. Int. Symp. Control. Rel. Bioact. Mater, vol.14, pp.6-7, 1987.

B. Burton-freeman, P. Davis, and B. Schneeman, Plasma cholecystokinin is associated with subjective measures of satiety in women, The American Journal of Clinical Nutrition, vol.67, issue.3, pp.659-667, 2002.
DOI : 10.1093/ajcn/67.1.31

I. Caillard and T. D. , Transport of ??-lactoglobulin and ??-lactalbumin in enterocyte-like Caco-2 cells, Reproduction Nutrition Development, vol.35, issue.2, pp.179-188, 1995.
DOI : 10.1051/rnd:19950206

URL : https://hal.archives-ouvertes.fr/hal-00899743

S. Carlson and M. J. , Effects of phlorizin and sodium on glucose-elicited alterations of cell junctions in intestinal epithelia, Am. Physiol. Soc, vol.258, pp.77-85, 1990.

B. Chabance, P. Jollès, C. Izquierdo, E. Mazoyer, C. Francoual et al., Characterization of an antithrombotic peptide from ??-casein in newborn plasma after milk ingestion, British Journal of Nutrition, vol.37, issue.04, pp.583-590, 1995.
DOI : 10.1016/0196-9781(85)90308-0

B. Chabance, P. Mareatu, J. C. Rambaud, D. Migliore-samour, M. Boynard et al., Casein peptide release and passage to the blood in humans during digestion of milk or yogurt, Biochimie, vol.80, issue.2, pp.155-165, 1998.
DOI : 10.1016/S0300-9084(98)80022-9

K. L. Chang, A. Killian, E. Hazum, and C. P. , Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors, Science, vol.212, issue.4490, pp.75-77, 1981.
DOI : 10.1126/science.6259732

I. Chantret and A. Barbat, Différenciation des cellules cancéreuses coliques humaines en culture in vitro Ateliers de formation de l'INSERM No, 1994.

I. Chantret, A. Rodolosse, A. Barbat, E. Dussaulx, E. Brot-laroche et al., Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line Caco-2: evidence for a glucose-dependent negative regulation, J. Cell Sci, vol.107, pp.213-238, 1994.

F. Checler, Neuropeptide-degrading peptidase, Methods in Neurotransmitter and Neuropeptide Res., Part 2, pp.375-418, 1993.

H. Chiba, F. Tani, and M. Yoshikawa, Opioid antagonist peptides derived from ??-casein, Journal of Dairy Research, vol.46, issue.03, pp.363-366, 1989.
DOI : 10.1271/bbb1961.46.1393

S. Chong, S. A. Dando, K. M. Soucek, and R. A. Morrison, In vitro permeability through caco-2 cells is not quantitavely predective of in vivo absorption for prptide-like drugs absorbed via dipeptide transporter system, Pharmaceutical Research, vol.13, issue.1, pp.120-123, 1996.
DOI : 10.1023/A:1016045820933

Z. T. Chowhan and A. A. , Everted Rat Intestinal Sacs as an In Vitro Model for Assessing Absorptivity of New Drugs, Journal of Pharmaceutical Sciences, vol.66, issue.9, pp.1249-1253, 1977.
DOI : 10.1002/jps.2600660911

J. E. Christensen, E. G. Dudley, J. A. Pederson, and J. L. Steele, Peptidases and aminoacid catabolism in lactic acid bacteria, Antonie van Leeuwenhoek, vol.76, issue.1/4, pp.217-246, 1999.
DOI : 10.1023/A:1002001919720

C. D. Swaisgood and H. E. , Bioactive milk peptides: A prospectus, J.Dairy Sci, vol.83, pp.1187-1195, 2000.

R. K. Clauser, P. R. Baker, and A. L. Burlingame, Role of Accurate Mass Measurement (??10 ppm) in Protein Identification Strategies Employing MS or MS/MS and Database Searching, Analytical Chemistry, vol.71, issue.14, pp.2871-2882, 1999.
DOI : 10.1021/ac9810516

N. J. Cogburn, M. G. Donovan, and C. S. Schasteen, Correlation of Caco-2 transport with human oral bioavailability, Journal of Controlled Release, vol.13, issue.2-3, pp.314-315, 1991.
DOI : 10.1016/0168-3659(90)90034-Q

R. A. Conradi, A. R. Hilgers, N. F. Ho, and B. P. , The influence of peptide structure on transport across caco-2 cells. II: Peptide bond modification which results in improved permeability, Pharmaceutical Research, vol.09, issue.3, pp.435-439, 1992.
DOI : 10.1023/A:1015867608405

D. Souza, V. M. Shertzer, H. G. Menon, A. G. , and P. G. , High glucose concentration in isotonic media alters Caco-2 cell permeability, AAPS PharmSci, vol.5, issue.3, pp.1208-1213, 2003.
DOI : 10.1208/ps050324

A. Dalvi and R. J. Rodgers, Behavioral Effects of Diazepam in the Murine Plus-Maze, Pharmacology Biochemistry and Behavior, vol.62, issue.4, pp.727-734, 1999.
DOI : 10.1016/S0091-3057(98)00220-2

A. H. Dantzig and L. Bergin, Carrier-mediated uptake of cephalexin in human intestinal cells, Biochemical and Biophysical Research Communications, vol.155, issue.2, pp.1082-1087, 1988.
DOI : 10.1016/S0006-291X(88)80607-7

A. H. Dantzig, D. C. Duckworth, and T. L. , Transport mechanisms responsible for the absorption of loracarbef, cefixime, and cefuroxime axetil into human intestinal Caco-2 cells, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1191, issue.1, pp.7-13, 1994.
DOI : 10.1016/0005-2736(94)90226-7

A. L. Daugherty and R. J. Mrsny, Transcellular uptake mechanisms of the intestinal epithelial barrier Part one, Pharmaceutical Science & Technology Today, vol.2, issue.4, pp.144-151, 1999.
DOI : 10.1016/S1461-5347(99)00142-X

G. R. Dawson and T. M. , Use of the elevated plus maze in the search for novel anxiolytic agents, Trends in Pharmacological Sciences, vol.16, issue.2, pp.33-36, 1995.
DOI : 10.1016/S0165-6147(00)88973-7

D. Rieux, A. Ragnarsson, E. Gullberg, E. Préat, V. Schneider et al., Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium, European Journal of Pharmaceutical Sciences, vol.25, issue.4-5, pp.455-465, 2005.
DOI : 10.1016/j.ejps.2005.04.015

J. M. Diamond, The epithelial junction : bridge, gate, and fence, Physiologist, vol.20, pp.10-18, 1977.

J. Drewe, G. Fricker, J. Vonderscher, and C. Beglinger, Enteral absorption of octreotide: absorption enhancement by polyoxyethylene-24-cholesterol ether, British Journal of Pharmacology, vol.32, issue.Suppl. 1, pp.298-303, 1993.
DOI : 10.1111/j.2042-7158.1980.tb12863.x

R. H. Erickson, Y. Suzuki, A. Sedlmayer, and Y. Kim, Biosynthesis and degradation of altered immature forms of intestinal dipeptidyl peptidase IV in a rat strain lacking the enzyme, 1992.

A. Ermisch, H. J. Rühle, K. Neubert, B. Hartrodt, and R. Landgraf, H]?Casomorphin-5 Uptake by Eighteen Brain Regions In Vivo, Journal of Neurochemistry, vol.109, issue.7, pp.1229-1233, 1983.
DOI : 10.1038/282623a0

A. S. Fanning, B. J. Jameson, L. A. Jesaitis, and A. J. , The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton, Journal of Biological Chemistry, vol.271, issue.45, pp.1617-1626, 1998.
DOI : 10.1016/0016-5085(95)90605-3

A. M. Fiat and J. P. , Caseins of various origins and biologically active casein peptides and oligosaccharides: Structural and physiological aspects, Molecular and Cellular Biochemistry, vol.12, issue.1, pp.5-30, 1989.
DOI : 10.1271/bbb1961.48.2159

A. M. Fiat, D. Migliore, and J. P. , Biologically active peptides from milk proteins with emphasis on two examples concerning antithrombotic and immunostimulating activities, 1993.

R. J. Fitzgerald, Potential Uses of Caseinophosphopeptides, International Dairy Journal, vol.8, issue.5-6, pp.451-457, 1998.
DOI : 10.1016/S0958-6946(98)00068-5

R. J. Fitzgerald, B. A. Murray, and W. D. , Hypotensive Peptides from Milk Proteins, The Journal of Nutrition, vol.17, issue.4, 2004.
DOI : 10.1093/ajcn/77.2.326

J. M. Fogh and T. Orfeo, Cultured human colon cell lines producting tumors in nude mice, J. Natl. Acad. Sci, vol.59, pp.221-226, 1977.

J. E. Folk and J. Gladner, Cobalt activation of carboxypeptidase A, J. Biol. Chem, vol.235, pp.60-66, 1960.

S. Fosset, G. Fromentin, D. W. Gietzen, M. Dubarry, J. F. Huneau et al., Peptide fragments released from Phe-caseinomacropeptide in vivo in the rat, Peptides, vol.23, issue.10, pp.1773-1781, 2002.
DOI : 10.1016/S0196-9781(02)00134-1

URL : https://hal.archives-ouvertes.fr/hal-00294380

T. C. Freeman, B. S. Bentsen, D. T. Twaites, and N. L. Simmons, H+/Di-tripeptide transporter (PepT1) expression in the rabbit intestine, Pfl???gers Archiv European Journal of Physiology, vol.425, issue.3, pp.394-400, 1995.
DOI : 10.1007/BF00373915

G. Fricker and D. J. , Enteral absorption of octreotide: modulation of intestinal permeability by distinct carbohydrates, J Pharmacol Exp Ther, vol.274, pp.826-832, 1995.

W. Fries and E. Mazzon, A time course of inflammation-associated effects on small intestine tight junction (TJ) proteins, Gastroenterology, vol.124, issue.4, p.317, 2003.
DOI : 10.1016/S0016-5085(03)81596-2

C. Frochot, Étude d'un décapeptide à activité de type benzodiazépine issu d'une protéine du lait bovin, Thèse de l'Institut Polytechnique de Lorraine (INPL), 1998.

J. S. Fruton, A History Of Pepsin And Related Enzymes, The Quarterly Review of Biology, vol.77, issue.2, pp.127-147, 2002.
DOI : 10.1086/340729

J. S. Fruton, The Mechanism of the Catalytic Action of Pepsin and Related Acid Proteinases, Adv. Enzymol. Relat Areas Mol. Biol, vol.129, pp.1-36, 1976.
DOI : 10.1016/0006-291X(74)90626-3

K. Fujita, K. Nakanishi, K. Sobue, T. Ueki, K. Asai et al., Astrocytic gap junction blockage and neuronal Ca2+ oscillation in neuron-astrocyte cocultures in vitro, Neurochemistry International, vol.33, issue.1, pp.41-49, 1998.
DOI : 10.1016/S0197-0186(97)00114-9

M. Furuse, K. Fujita, F. Hiiragi, K. Fujimoto, and T. S. , Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin, The Journal of Cell Biology, vol.110, issue.7, pp.1539-1550, 1998.
DOI : 10.1083/jcb.120.2.477

V. Gagnaire, A. Pierre, D. Mollé, and J. Léonil, Phosphopeptides interacting with colloidal calcium phosphate isolated by tryptic hydrolysis of bovine casein micelles, Journal of Dairy Research, vol.63, issue.03, pp.405-422, 1996.
DOI : 10.1017/S0022029900031927

V. Ganapathy and L. F. , Role of gradient and membrane potential peptide transport in intestinal and renal brush-border membrane vesicules from the rabbit, J. Biol. Pharmacol, vol.151, pp.117-121, 1983.

V. Ganapathy and L. F. , Is intestinal peptide transport energized by electron gradient?, Am. J. Physiol, vol.249, pp.14189-14192, 1985.
DOI : 10.1152/ajpgi.1985.249.2.g153

L. S. Ganjam, W. H. Thornton, R. T. Marshall, and R. S. Macdonald, Antiproliferative Effects of Yogurt Fractions Obtained by Membrane Dialysis on Cultured Mammalian Intestinal Cells, Journal of Dairy Science, vol.80, issue.10, pp.2325-2329, 1997.
DOI : 10.3168/jds.S0022-0302(97)76183-6

A. Gebert, H. J. Rothktter, and R. Pabst, M Cells in Peyer's Patches of the Intestine, Int. Rev. Cyto, vol.167, pp.91-159, 1996.
DOI : 10.1016/S0074-7696(08)61346-7

H. W. Gerber and J. R. , Casein phosphopeptides: Their effect on calcification ofin vitro cultured embryonic rat bone, Calcified Tissue International, vol.98, issue.6, pp.350-357, 1986.
DOI : 10.1016/0005-2795(73)90367-X

M. Gobbetti, F. Mivervini, and R. C. , Angiotensin I-converting-enzymeinhibitory and antimicrobial bioactive peptides, Int. J.Dairy Tech, vol.57, pp.172-188, 2004.
DOI : 10.1111/j.1471-0307.2004.00139.x

E. Grasset, M. Pinto, E. Dussaulx, A. Zweibaum, and D. J. , Epithelial properties of human colonic carcinoma cell line Caco-2: electrical parameters, American Journal of Physiology-Cell Physiology, vol.39, issue.3, pp.260-267, 1984.
DOI : 10.1002/ijc.2910320403

A. C. Gray, I. M. Coupar, and P. J. White, Comparison of opioid receptor distributions in the rat ileum, Life Sciences, vol.78, issue.14, pp.1610-1616, 2006.
DOI : 10.1016/j.lfs.2005.07.048

G. Griebel, C. Belzung, R. Misslin, and E. Vogel, The free-exploratory paradigm, Behavioural Pharmacology, vol.4, issue.6, pp.637-644, 1993.
DOI : 10.1097/00008877-199312000-00009

M. C. Gres, B. Julian, M. Bourrie, V. Meunier, C. Roques et al., Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line, Pharmaceutical Research, vol.15, issue.5, pp.726-733, 1998.
DOI : 10.1023/A:1011919003030

E. Gullberg, M. Leonard, J. Karlsson, A. M. Hopkins, D. Braydn et al., Expression of Specific Markers and Particle Transport in a New Human Intestinal M-Cell Model, Biochemical and Biophysical Research Communications, vol.279, issue.3, pp.808-813, 2000.
DOI : 10.1006/bbrc.2000.4038

J. Guo, Q. Ping, G. Jiang, J. Dong, S. Qi et al., Transport of leuprolide across rat intestine, rabbit intestine and Caco-2 cell monolayer, International Journal of Pharmaceutics, vol.278, issue.2, pp.415-422, 2004.
DOI : 10.1016/j.ijpharm.2004.03.031

B. Hagenbuch and M. P. , The superfamily of organic anion transporting polypeptides, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1609, issue.1, pp.1-18, 2003.
DOI : 10.1016/S0005-2736(02)00633-8

C. Hall, Emotional behavior in the rat. III. The relationship between emotionality and ambulatory activity., Journal of Comparative Psychology, vol.22, issue.3, pp.345-352, 1936.
DOI : 10.1037/h0059253

Y. Hata, M. Yamamoto, M. Ohni, M. Nakajima, Y. Nakamura et al., A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects, The American Journal of Clinical Nutrition, vol.64, issue.5, pp.767-771, 1996.
DOI : 10.1093/ajcn/64.5.767

M. Heyman, A. Crain-denoyelle, S. K. Nath, and D. F. , Quantification of protein transcytosis in the human colon carcinoma cell line CaCo-2, Journal of Cellular Physiology, vol.4, issue.2, pp.391-395, 1990.
DOI : 10.1016/0016-5085(89)90897-4

A. Henschen, F. Lottspeich, V. Brantl, and H. Teschemacher, Novel opioid peptides derived from casein (?-casomorphins). II. Structure of active components from bovine casein peptone, Hoppe-Seyler's Z. Physiol. Chem, vol.360, pp.1217-1241, 1979.

I. J. Hidalgo, T. J. Raub, and R. T. Borchardt, Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability, Gastroenterology, vol.96, issue.2, pp.736-749, 1989.
DOI : 10.1016/S0016-5085(89)80072-1

L. J. Hidalgo and R. T. Brochardt, Transport of bile acids in a human intestinal epithelial cell line, Caco-2, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1035, issue.1, pp.67-103, 1990.
DOI : 10.1016/0304-4165(90)90179-Z

A. Hilgers, R. Conradi, and P. Burton, Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa, Pharmaceutical Research, vol.07, issue.9, pp.902-910, 1990.
DOI : 10.1023/A:1015937605100

M. Hirayama, K. Toyota, G. Yamaguchi, H. Hidaka, and H. Naito, HPLC Analysis of Commercial Casein Phosphopeptides (CPP), Bioscience, Biotechnology, and Biochemistry, vol.56, issue.7, pp.1126-1127, 1992.
DOI : 10.1271/bbb.56.1126

J. H. Hochman, In vitro and in vivo analysis of the mechanism of absorption enhancement by palmitoylcarnitine, J. Pharmacol. Exp. Ther, vol.269, pp.813-822, 1994.

T. P. Hopp and K. R. Et-woods, Prediction of protein antigenic determinants from amino acid sequences., Proceedings of the National Academy of Sciences, vol.78, issue.6, pp.3824-3828, 1981.
DOI : 10.1073/pnas.78.6.3824

S. Howell, A. J. Kenny, and T. A. , A survey of membrane peptidases in two human colonic cell lines, Caco-2 and HT-29, Biochemical Journal, vol.284, issue.2, pp.595-601, 1992.
DOI : 10.1042/bj2840595

C. Huet, C. Sahuquillo-merino, E. Coudrier, and L. D. , Absorptive and mucus-secreting subclones isolated from a multipotent intestinal cell line (HT-29) provide new models for cell polarity and terminal differentiation, The Journal of Cell Biology, vol.105, issue.1, pp.345-57, 1987.
DOI : 10.1083/jcb.105.1.345

J. F. Huneau, C. Erlanson-albertsson, C. Beauvallet, and T. D. , The in vitro intestinal absorption of enterostatin is limited by brush-border membrane peptidases, Regulatory Peptides, vol.54, issue.2-3, pp.495-503, 1994.
DOI : 10.1016/0167-0115(94)90547-9

F. Ingels, S. Deferme, E. Destexhe, M. Oth, G. Van-den-mooter et al., Simulated intestinal fluid as transport medium in the Caco-2 cell culture model, International Journal of Pharmaceutics, vol.232, issue.1-2, pp.83-192, 2002.
DOI : 10.1016/S0378-5173(01)00897-3

T. Isoda, E. Watanabe, M. Haga, S. Haseto, S. Awazu et al., Increase of polypeptide transport by lectin conjugation across rabbit Peyer's patches, European Journal of Pharmaceutics and Biopharmaceutics, vol.44, issue.2, pp.133-136, 1997.
DOI : 10.1016/S0939-6411(97)00079-9

S. Ito, THE ENTERIC SURFACE COAT ON CAT INTESTINAL MICROVILLI, The Journal of Cell Biology, vol.27, issue.3, p.475, 1965.
DOI : 10.1083/jcb.27.3.475

S. Ito, Structure and function of the glycolalyx, Fed. Proc, vol.28, p.12, 1969.

M. Iwan, B. Jarmolowska, K. Bielikowics, E. Kostyra, H. Kostyra et al., Transport of ??-opioid receptor agonists and antagonist peptides across Caco-2 monolayer, Peptides, vol.29, issue.6, pp.1042-1047, 2008.
DOI : 10.1016/j.peptides.2008.01.018

T. C. Jacob, S. J. Moss, and J. R. , GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition, Nature Reviews Neuroscience, vol.23, issue.5, pp.331-343, 2008.
DOI : 10.1006/bbrc.1997.8068

U. Jaehde, R. Masereeuw, D. Boer, A. G. Fricker, G. Nagelkerke et al., Quantification and visualization of the transport of octreotide, a somatostatin analogue, across monolayers of cerebrovascular endothelial cells, Pharmaceutical Research, vol.11, issue.3, pp.442-448, 1994.
DOI : 10.1023/A:1018929508018

Y. Jinsmaa and M. Yoshikawa, Enzymatic release of neocasomorphin and ??-casomorphin from bovine ??-casein, Peptides, vol.20, issue.8, pp.957-962, 1999.
DOI : 10.1016/S0196-9781(99)00088-1

P. Jollès, S. Levy-toledano, A. M. Fiat, C. Soria, D. Gillesen et al., Analogy between fibrinogen and casein. Effect of an undecapeptide isolated from k-casein on platelet function, European Journal of Biochemistry, vol.259, issue.2, pp.379-382, 1986.
DOI : 10.1016/0005-2795(67)90078-5

P. Jollès, M. H. Loucheux-lefèbvre, and A. Henschen, Structural relatedness of??-casein and fibrinogen??-chain, Journal of Molecular Evolution, vol.45, issue.4, pp.271-277, 1978.
DOI : 10.1016/0005-2795(74)90006-3

P. Jollès, F. Parker, F. Floc-'h, D. Migliore, P. Alliel et al., Immunostimulating Substances from Human Casein, Journal of Immunopharmacology, vol.14, issue.3-4, pp.363-369, 1981.
DOI : 10.1016/0022-1759(77)90143-0

P. Jollès, Structural aspects of the milk clotting process. Comparative features with the blood clotting process, Molecular and Cellular Biochemistry, vol.58, issue.2, pp.73-85, 1975.
DOI : 10.1016/0005-2795(70)90288-6

R. J. Kania, N. A. Santiago, and G. G. , Intestinal cell surface peptidase: potential role in protein digestion, Gastroenterology, vol.62, p.768, 1972.

T. T. Kararli, Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals, Biopharmaceutics & Drug Disposition, vol.247, issue.5, pp.351-380, 1995.
DOI : 10.1007/978-1-4684-5344-7_29

G. Antisense-oligonucleotide-to, A ) gamma-2 subnit induces limbic status epilepticus, J. Neurosci. Res, vol.54, pp.863-869

B. Keil, Specificity of proteolysis, 1992.
DOI : 10.1007/978-3-642-48380-6

A. J. Kenny, S. L. Stephenson, and A. J. Turner, Cell surface peptidases, Mammalian ectoenzymes, pp.169-210, 1987.

G. A. Kerchner and L. E. Geary, Studies on the transport of enkephalin-like oligopeptides in rat intestinal mucosa, JPET, vol.226, pp.33-38, 1983.

S. Kernéis, E. Caliot, H. Stubbe, A. Bogdanova, J. P. Kraehenbuhl et al., Molecular studies of the intestinal mucosal barrier physiopathology using cocultures of epithelial and immune cells: a technical update, Microbes and Infection, vol.2, issue.9, pp.1119-1124, 2000.
DOI : 10.1016/S1286-4579(00)01266-1

I. B. Kibangou, S. Bouhallad, G. Henry, F. Bureau, S. Allouche et al., Milk Proteins and Iron Absorption: Contrasting Effects of Different Caseinophosphopeptides, Pediatric Research, vol.356, issue.4, pp.731-733, 2005.
DOI : 10.1042/0264-6021:3560277

URL : https://hal.archives-ouvertes.fr/hal-01453952

A. Kilara, Whey protein functionality, Protein functionality in food systems, 1994.

A. J. Kiliaan, P. R. Saunders, P. B. Bijlsma, M. C. Berin, T. A. Taminiau et al., Stress stimulates transepithelial macromolecular uptake in rat jejunum, American Journal of Physiology-Gastrointestinal and Liver Physiology, vol.70, issue.10, pp.1037-1044, 1998.
DOI : 10.1007/BF01536925

J. H. Kim, D. Desor, Y. T. Kim, W. J. Yoon, K. S. Kim et al., Efficacy of ? s1 -casein hydrolysate on stress-related symptoms in women, Eur. J. Clin. Nutr, 2007.

Y. S. Kim, Y. W. Kim, and M. H. Sleisenger, Studies on the properties of peptide hydrolases in the brush-border and soluble fractions of small intestinal mucosa of rat and man, Biochimica et Biophysica Acta (BBA) - Enzymology, vol.370, issue.1, pp.283-296, 1974.
DOI : 10.1016/0005-2744(74)90053-9

D. D. Kitts and Y. V. Yuan, Caseinophosphopeptides and calcium biovailability, Trends in Food Science & Technology, vol.3, pp.31-35, 1994.
DOI : 10.1016/0924-2244(92)90113-B

G. T. Knipp, D. G. Vander-velde, T. J. Siahaan, and R. T. Borchard, The effect of ?-trun structure on the passive diffusion of peptides across caco-2 cell monolayes, Pharmaceutical Research, vol.14, issue.10, pp.1332-1339, 1997.
DOI : 10.1023/A:1012152117703

D. Kobayashi, T. Nozawa, K. Imai, J. Nezu, A. Tsuji et al., Involvement of Human Organic Anion Transporting Polypeptide OATP-B (SLC21A9) in pH-Dependent Transport across Intestinal Apical Membrane, Journal of Pharmacology and Experimental Therapeutics, vol.306, issue.2, pp.438-445, 2003.
DOI : 10.1124/jpet.103.051300

H. Korhonen and A. Pihlanto, Food-derived Bioactive Peptides - Opportunities for Designing Future Foods, Current Pharmaceutical Design, vol.9, issue.16, pp.1297-1308, 2003.
DOI : 10.2174/1381612033454892

H. Korhonen and A. Pihlanto, Bioactive peptides: Production and functionality, International Dairy Journal, vol.16, issue.9, pp.945-960, 2006.
DOI : 10.1016/j.idairyj.2005.10.012

J. Kovacs-nolan, J. W. Zhang, S. Hayakawa, and Y. Mine, Immunochemical and Structural Analysis of Pepsin-Digested Egg White Ovomucoid, Journal of Agricultural and Food Chemistry, vol.48, issue.12, pp.6261-6266, 2000.
DOI : 10.1021/jf000358e

J. P. Kraehanbuhl and C. M. , EARLY STAGES OF INTESTINAL ABSORPTION OF SPECIFIC ANTIBODIES IN THE NEWBORN: An Ultrastructural, Cytochemical, and Immunological Study in the Pig, Rat, and Rabbit, The Journal of Cell Biology, vol.42, issue.2, pp.345-65, 1969.
DOI : 10.1083/jcb.42.2.345

J. P. Kraehenbuhl and N. M. , Transepithelial transport and mucosal defense: the role of M cells, Trends in Cell Biol, vol.2, pp.134-138, 1992.

G. A. Kullak-ublick, M. G. Ismair, B. Stieger, L. Landmann, R. Huber et al., Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver, Gastroenterology, vol.120, issue.2, pp.525-533, 2001.
DOI : 10.1053/gast.2001.21176

E. Lahov and R. W. , Antibacterial and immunostimulating casein-derived substances from milk: Casecidin, isracidin peptides, Food and Chemical Toxicology, vol.34, issue.1, pp.131-145, 1996.
DOI : 10.1016/0278-6915(95)00097-6

D. A. Laird and H. Drexel, Experimentating with foods and sleep : I. Effects of varying types of foods in offsetting sleep disturbances caused by hunger pangs and gastric distresschildren and adults, J. Am. Diet. Asso, vol.10, pp.89-94, 1934.

P. Langguth, V. Bohner, J. Biber, and M. H. , Metabolism and Transport of the Pentapeptide Metkephamid by Brush-border Membrane Vesicles of Rat Intestine, Journal of Pharmacy and Pharmacology, vol.7, issue.1, pp.34-40, 1994.
DOI : 10.1023/A:1015894617027

P. Langguth, V. Bohner, J. Heizmann, H. P. Merkle, S. Wolffram et al., The challenge of proteolytic enzymes in intestinal peptide delivery, Journal of Controlled Release, vol.46, issue.1-2, pp.39-57, 1997.
DOI : 10.1016/S0168-3659(96)01586-6

A. W. Larhed, P. Artursson, and E. Bjork, The influence of intestinal mucus components on the diffusion of drugs, Pharmaceutical Research, vol.15, issue.1, pp.66-71, 1998.
DOI : 10.1023/A:1011948703571

V. H. Lee, R. D. Traver, and T. M. , Enzymatic barriers to peptide and protein drug delivery, Peptide and Protein Drug Delivery, pp.303-357, 1991.

P. S. Leppert and F. J. , Use of Everted Intestinal Rings forin VitroExamination of Oral Absorption Potential, Journal of Pharmaceutical Sciences, vol.83, issue.7, pp.976-981, 1994.
DOI : 10.1002/jps.2600830712

E. Liang, A. Kabcenell, J. Coleman, J. Robson, R. Ruffles et al., Permeability measurement of macromolecules and assessment of mucosal antigen sampling using in vitro converted M cells, Journal of Pharmacological and Toxicological Methods, vol.46, issue.2, pp.1-9, 2002.
DOI : 10.1016/S1056-8719(02)00163-6

R. G. Lister, The use of a plus-maze to measure anxiety in the mouse, Psychopharmacology, vol.92, issue.2, pp.180-185, 1987.
DOI : 10.1007/BF00177912

S. Loukas, D. Varoucha, C. Zioudrou, R. A. Streaty, and K. W. , Opioid activities and structures of .alpha.-casein-derived exorphins, Biochemistry, vol.22, issue.19, pp.4567-4573, 1983.
DOI : 10.1021/bi00288a034

H. Luddens and K. E. , Biological function of GABAA/benzodiazepine receptor heterogeneity, Journal of Psychiatric Research, vol.29, issue.2, pp.77-94, 1995.
DOI : 10.1016/0022-3956(94)00040-X

S. Lundin and P. Artursson, Absorption of a vasopressin analogue, 1-deamino-8-d-arginine-vasopressin (dDAVP), in a human intestinal epithelial cell line, CaCO-2, International Journal of Pharmaceutics, vol.64, issue.2-3, pp.181-186, 1990.
DOI : 10.1016/0378-5173(90)90267-8

S. Lundin and H. Vilhardt, Absorption of 1-deamino-8-D-arginine vasopressin from different regions of the gastrointestinal tract in rabbits, European Journal of Endocrinology, vol.112, issue.3, pp.457-460, 1986.
DOI : 10.1530/acta.0.1120457

S. Lundin, J. Møss, H. Bundgaard, and P. Artursson, Absorption of thyrotropin-releasing hormone (TRH) and a TRH prodrug in a human intestinal cell line (Caco-2), International Journal of Pharmaceutics, vol.76, issue.3, pp.1-4, 1990.
DOI : 10.1016/0378-5173(91)90282-S

M. Donald and R. L. , Inhibitory synaptic transmission Epilepsy: A Comprehensive Textbook. Philadelphia: Lippincott-Raven Publishers 265?275, 1997.

J. L. Madara and T. J. , Structure and permeability of goblet cell tight junctions in rat small intestine, The Journal of Membrane Biology, vol.5, issue.1, pp.145-157, 1982.
DOI : 10.1113/jphysiol.1972.sp009870

J. L. Madara, Loosening tight junctions. Lessons from the intestine., Journal of Clinical Investigation, vol.83, issue.4, pp.1089-1094, 1989.
DOI : 10.1172/JCI113987

M. Maeno, N. Yamamoto, and T. Takano, Identification of an Antihypertensive Peptide from Casein Hydrolysate Produced by a Proteinase from Lactobacillus helveticus CP790, Journal of Dairy Science, vol.79, issue.8, pp.1316-1321, 1996.
DOI : 10.3168/jds.S0022-0302(96)76487-1

D. D. Maenz, C. Chenu, F. Bellemare, and A. Berteloot, Improved stability of rabbit and rat intestinal brush border membrane vesicles using phospholipase inhibitors, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1069, issue.2, pp.250-258, 1991.
DOI : 10.1016/0005-2736(91)90132-R

S. Maruyama and H. Suzuki, A peptide inhibitor of angiotensin I-converting enzyme in the tryptic hydrolysate of casein, Agr. Biol. Chem, vol.46, pp.1393-1394, 1982.

S. H. Maruyama, H. Mitachi, H. Tanaka, N. Tomizuka, and H. Suzuki, Studies on the Active Site and Antihypertensive Activity of Angiotensin I-Converting Enzyme Inhibitors Derived from Casein, Agricultural and Biological Chemistry, vol.51, issue.6, pp.1581-1586, 1987.
DOI : 10.1080/00021369.1987.10868244

O. Masuda, Y. Nakamura, and T. Takano, Antihypertensive Peptides Are Present in Aorta after Oral Administration of Sour Milk Containing These Peptides to Spontaneously Hypertensive Rats, The Journal of Nutrition, vol.126, issue.12, pp.3036-3068, 1996.
DOI : 10.1093/jn/126.12.3063

D. M. Matthews, Intestinal absorption of peptides, Physiological Reviews, vol.55, issue.4, pp.537-608, 1975.
DOI : 10.1152/physrev.1975.55.4.537

D. M. Matthews and A. S. , Intestinal absorption of peptides, Physiological Reviews, vol.55, issue.4, pp.537-608, 1976.
DOI : 10.1152/physrev.1975.55.4.537

D. M. Matthews and J. W. Payne, Transmembrane Transport of Small Peptides, Curr. Top. Membr. Transp, vol.14, pp.331-425, 1980.
DOI : 10.1016/S0070-2161(08)60119-7

J. L. Maubois and J. Léonil, Peptides du lait ?? activit?? biologique, Le Lait, vol.69, issue.4, pp.245-269, 1989.
DOI : 10.1051/lait:1989420

J. H. Medina, C. Pena, M. Piva, A. C. Paladini, D. Robertis et al., Presence of benzodiazepine-like molecules in mammalian brain and milk, Biochemical and Biophysical Research Communications, vol.152, issue.2, pp.534-539, 1988.
DOI : 10.1016/S0006-291X(88)80070-6

J. H. Medina, C. Pena, M. Piva, C. Wolfman, M. L. De-stein et al., Benzodiazepines in the brain, Molecular Neurobiology, vol.584, issue.4, pp.377-386, 1992.
DOI : 10.1007/978-3-662-02384-6

M. Meisel and H. Frister, Chemical characterization of bioactive peptides from in vivo digests of casein, Journal of Dairy Research, vol.234, issue.03, pp.343-349, 1989.
DOI : 10.1007/BF00473782

H. Meisel, H. B. Andersson, K. Buhl, H. F. Erbersdobler, and E. Schlimme, Heat-induced changes in casein-derived phosphopeptides, Zeitschrift f??r Ern??hrungswissenschaft, vol.369, issue.3, pp.227-232, 1991.
DOI : 10.1515/bchm3.1988.369.2.1275

H. Meisel, Biochemical properties of regulatory peptides derived from mil proteins, Biopolymers, vol.45, issue.2, p.119, 1997.
DOI : 10.4327/jsnfs.45.513

H. Meisel, Biochemical properties of bioactive peptides derived from milk proteins: Potential nutraceuticals for food and pharmaceutical applications, Livestock Production Science, vol.50, issue.1-2, pp.125-138, 1997.
DOI : 10.1016/S0301-6226(97)00083-3

H. Meisel and F. R. , Biofunctional peptides from milk proteins: Mineral binding and cytomodulatory effects, Curr. Pharm. Des, vol.9, pp.1289-1295, 2003.

O. Mellander, The physiological importance of the casein phosphopeptide calcium salts, 1950.

F. Mendy, Fragmentation des protéines laitières, Interview recueillie par J. Rajnchapel- Messaï. Biofutur, vol.24, pp.60-61, 1984.

J. C. Mercier, F. Addeo, and J. P. Pelissier, Structure primaire de la caseine alphasl-bovine. Sequence complete, European Journal of Biochemistry, vol.115, issue.1, pp.41-51, 1971.
DOI : 10.1016/0005-2795(69)90071-3

M. Messaoudi, C. Lefranc-millot, D. Desor, B. Demagny, and L. Bourdon, Effects of a tryptic hydrolysate from bovine milk ??S1???casein on hemodynamic responses in healthy human volunteers facing successive mental and physical stress situations, European Journal of Nutrition, vol.33, issue.2, pp.128-132, 2005.
DOI : 10.1210/jcem-33-1-14

L. Miclo, E. Perrin, A. Driou, V. Papadoupoulos, N. Boujrad et al., -casein with benzodiazepine-like activity, The FASEB Journal, vol.15, issue.10, pp.1780-1782, 2001.
DOI : 10.1096/fj.00-0685fje

D. Migliore-samour, F. Floc-'h, and P. Jollès, Biologically active casein peptides implicated in immunomodulation, Journal of Dairy Research, vol.123, issue.03, pp.357-362, 1989.
DOI : 10.1136/adc.37.194.387

S. Miura, I. S. Song, A. Morita, R. H. Erickson, and K. Y. , Distribution and biosynthesis of aminopeptidase n and dipeptidyl aminopeptidase IV in rat small intestine, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.761, issue.1, pp.66-75, 1983.
DOI : 10.1016/0304-4165(83)90363-X

K. Mostov, G. Apodaca, B. Aroeti, and C. Okamoto, Plasma membrane protein sorting in polarized epithelial cells, The Journal of Cell Biology, vol.116, issue.3, pp.577-583, 1992.
DOI : 10.1083/jcb.116.3.577

H. N. Nellans, (B) Mechanisms of peptide and protein absorption, Advanced Drug Delivery Reviews, vol.7, issue.3, pp.339-364, 1991.
DOI : 10.1016/0169-409X(91)90013-3

M. R. Neutra, A. Frey, and K. J. , Epithelial M Cells: Gateways for Mucosal Infection and Immunization, Cell, vol.86, issue.3, pp.345-348, 1996.
DOI : 10.1016/S0092-8674(00)80106-3

URL : https://doi.org/10.1016/s0092-8674(00)80106-3

E. Nishimura, A. M. Buchan, and C. H. Mcintosh, Autoradiographic Localization of ??- and ??-Type Opioid Receptors in the Gastrointestinal Tract of the Rat and Guinea Pig, Gastroenterology, vol.91, issue.5, pp.1084-1094, 1986.
DOI : 10.1016/S0016-5085(86)80002-6

Y. Niv, J. C. Byrd, . B. Ho-s, R. Dahiya, and K. Y. , Mucin synthesis and secretion in relation to spontaneous differentiation of colon cancer cellsin vitro, International Journal of Cancer, vol.47, issue.1, pp.147-152, 1992.
DOI : 10.1042/bj2670491

M. L. Nurminen, M. Sipola, H. Kaarto, A. Pilhanto-leppälä, K. Piilola et al., ??-Lactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats, Life Sciences, vol.66, issue.16, pp.1535-1543, 2000.
DOI : 10.1016/S0024-3205(00)00471-9

K. Ohinata, S. Sonada, N. Inoue, R. Yamauchi, K. Wada et al., ??-Lactotensin, a neurotensin agonist peptide derived from bovine ??-lactoglobulin, enhances memory consolidation in mice, Peptides, vol.28, issue.7, pp.1470-1474, 2007.
DOI : 10.1016/j.peptides.2007.06.002

F. Ohl, Testing for anxiety, Clinical Neuroscience Research, vol.3, issue.4-5, pp.233-238, 2003.
DOI : 10.1016/S1566-2772(03)00084-7

M. A. Ostuni, K. Marazova, G. Peranzi, B. Vidic, V. Papadopoulos et al., Functional characterization and expression of PBR in rat gastric mucosa: stimulation of chloride secretion by PBR ligands, American Journal of Physiology-Gastrointestinal and Liver Physiology, vol.286, issue.6, pp.1069-1080, 2004.
DOI : 10.1679/aohc.64.449

N. Pantzar, B. R. Weström, A. Luts, and L. S. , Regional Small-Intestinal Permeability in Vitro to Different-Sized Dextrans and Proteins in the Rat, Scandinavian Journal of Gastroenterology, vol.100, issue.3, pp.205-211, 1993.
DOI : 10.1007/BF02209145

V. Papadopoulos, Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function, Endocr.Rev, vol.14, pp.222-240, 1993.

J. R. Pappenheimer, C. E. Dahl, M. L. Karnovsky, and M. J. , Intestinal absorption and excretion of octapeptides composed of D amino acids., Proc. Natl. Acad. Sci, pp.1942-1945, 1994.
DOI : 10.1073/pnas.91.5.1942

F. Parker, D. Migliore-samour, . F. Floc-'h, A. Zerial, G. H. Werner et al., Immunostimulating hexapeptide from human casein: amino acid sequence, synthesis and biological properties, European Journal of Biochemistry, vol.259, issue.3, pp.677-682, 1984.
DOI : 10.1016/0022-1759(77)90143-0

G. M. Pauletti, S. Gangwar, G. T. Knipp, M. M. Nerurkar, F. W. Okumu et al., Structural requirements for intestinal absorption of peptide drugs, Journal of Controlled Release, vol.41, issue.1-2, pp.3-17, 1996.
DOI : 10.1016/0168-3659(96)01352-1

G. M. Pauletti, S. Gangwar, T. J. Siahaan, J. Aubé, and R. T. Borchardt, Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies, Advanced Drug Delivery Reviews, vol.27, issue.2-3, pp.235-256, 1997.
DOI : 10.1016/S0169-409X(97)00045-8

G. M. Pauletti, F. W. Okumu, and R. T. Borchart, Effect of size and charge on the passive diffusion of peptides across Caco-2 cell monolayers via the paracellular pathway, Pharmaceutical Research, vol.14, issue.2, pp.164-168, 1997.
DOI : 10.1023/A:1012040425146

N. L. Pedersen, C. Nagain-domaine, S. Mahe, J. Chariot, C. Roze et al., Caseinomacropeptide specifically stimulates exocrine pancreatic secretion in the anesthetized rat, Peptides, vol.21, issue.10, pp.1527-1535, 2000.
DOI : 10.1016/S0196-9781(00)00307-7

L. Pellegrino, G. Batteli, P. Resmini, P. Ferranti, F. Barone et al., Effects of heat load gradient occurring in moulding on characterization and ripening of Grana Padano, Le Lait, vol.77, issue.2, pp.217-220, 1997.
DOI : 10.1051/lait:1997215

URL : https://hal.archives-ouvertes.fr/hal-00929522

S. Pellow, P. Chopin, S. File, and M. Briley, Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat, Journal of Neuroscience Methods, vol.14, issue.3, pp.149-167, 1985.
DOI : 10.1016/0165-0270(85)90031-7

J. M. Pérès, S. Bouhallab, F. Bureau, J. L. Maubois, P. Arhan et al., Mechanisms of absorption of caseinophosphopeptide bound iron, J. Nutr. Biochem, vol.10, p.2156222, 1999.

M. D. Peterson and M. M. , An in vitro model for the analysis of intestinal brush border assembly. I. Ultrastructural analysis of cell contact-induced brush border assembly in Caco-2BBe cells, J Cell Sci, vol.105, pp.445-460, 1993.

J. P. Pinel and T. D. , The conditioned defensive burying paradigm and behavioral neuroscience Behavioral approaches to brain research, pp.212-234, 1978.

M. Pinto, S. Rabine-leon, . D. Appaym, M. Kedinger, N. Tradou et al., Enterocyte-like differenciation and polarisation of the human colon carcinoma cell line Caco-2 in culture, Biololy. Cell, vol.47, pp.323-330, 1983.

E. Pringault, Towards an in vitro model for microrganism transport and antigen sampling through the epithelial digestive barrier. in "Essenrials of Imnunology, 1996.

Y. S. Quan, T. Fujita, D. Tohara, M. Tsuji, M. Kohyama et al., Transport kinetics of leucine enkephalin across Caco-2 monolayers: Quantitative analysis for contribution of enzymatic and transport barrier, Life Sciences, vol.64, issue.14, pp.1243-1252, 1999.
DOI : 10.1016/S0024-3205(99)00056-9

A. Quirós, A. Dávalos, M. A. Lasunción, M. Ramos, and I. Recio, Bioavailability of the antihypertensive peptide LHLPLP: Transepithelial flux of HLPLP, International Dairy Journal, vol.18, issue.3, pp.279-286, 2008.
DOI : 10.1016/j.idairyj.2007.09.006

A. Richens, New drugs for epilepsy: A rapidly changing scene, Acta Neurologica Scandinavica, vol.3, issue.Suppl 3, pp.65-70, 1992.
DOI : 10.1111/j.1600-0404.1992.tb04473.x

M. B. Roberfroid, What is beneficial for health? The concept of functional food, Food and Chemical Toxicology, vol.37, issue.9-10, pp.1039-1041, 1999.
DOI : 10.1016/S0278-6915(99)00080-0

R. J. Rodgers and A. Dalvi, Anxiety, defence and the elevated plus-maze, Neuroscience & Biobehavioral Reviews, vol.21, issue.6, pp.801-810, 1997.
DOI : 10.1016/S0149-7634(96)00058-9

R. J. Rodgers, B. J. Cao, A. Dalvi, and A. Holmes, Animal models of anxiety: an ethological perspective, Brazilian Journal of Medical and Biological Research, vol.16, issue.3, pp.289-304, 1997.
DOI : 10.1016/S0165-6147(00)89040-9

R. J. Rodgers, J. C. Cole, and C. M. , Anxiogenic-like effects of fluprazine and eltoprazine in the mouse elevated plus-maze, Behavioural Pharmacology, vol.3, issue.6, pp.621-624, 1992.
DOI : 10.1097/00008877-199212000-00009

S. Roufik, S. F. Gauthier, and T. S. , In vitro digestibility of bioactive peptides derived from bovine ??-lactoglobulin, International Dairy Journal, vol.16, issue.4, pp.294-302, 2005.
DOI : 10.1016/j.idairyj.2005.03.010

M. Rousset, The human colon carcinoma cell lines HT-29 and Caco-2: Two in vitro models for the study of intestinal differentiation, Biochimie, vol.68, issue.9, pp.1035-1040, 1985.
DOI : 10.1016/S0300-9084(86)80177-8

A. M. Rowan, P. J. Moughan, M. N. Wilson, K. Maher, T. et al., Comparison of the ileal and faecal digestibility of dietary amino acids in adult humans and evaluation of the pig as a model animal for digestion studies in man, British Journal of Nutrition, vol.43, issue.01, pp.29-42, 1994.
DOI : 10.1016/0308-8146(87)90084-7

W. Rubas and G. G. , Comparison of the permeability characteristics of a human colonic epithelial Caco-2 cell line to colon of rabbit, monkey and dog intestine and human drug absorption, Pharmaceutical Research, vol.10, issue.1, pp.113-121, 1993.
DOI : 10.1023/A:1018937416447

W. Rubas, N. Jezyk, and G. G. , Gastrointestinal lymphatic absorption of peptides and proteins, Advanced Drug Delivery Reviews, vol.7, issue.1, pp.15-69, 1992.
DOI : 10.1016/0169-409X(91)90047-G

G. P. Sachdev and J. S. Fruton, Kinetics of action of pepsin on fluorescent peptide substrates., Proc. Natl. Acad. Sci, pp.3424-3427, 1975.
DOI : 10.1073/pnas.72.9.3424

Y. Sai, M. Kajita, I. Tamai, M. Kamata, J. Wkama et al., Intestinal absorption of fluorescence-derivatized cationic peptide 001-C8-NBD via adsorptive-mediated transcytosis, Bioorganic & Medicinal Chemistry, vol.6, issue.6, pp.841-848, 1998.
DOI : 10.1016/S0968-0896(98)00031-5

M. Samloff and L. W. , Cellular localization of the group II pepsinogens in human stomach and duodenum by immunofluorescence, Gastroenterology, vol.65, pp.36-42, 1973.

J. Santos, P. C. Yang, J. D. Soderholm, M. Benjamin, and M. H. Perdue, Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat, Gut, vol.48, issue.5, pp.630-636, 2000.
DOI : 10.1136/gut.48.5.630

M. Satake, M. Enjoh, Y. Nakamura, T. Takano, Y. Kawamura et al., Transepithelial Transport of the Bioactive Tripeptide, Val-Pro-Pro, in Human Intestinal Caco-2 Cell Monolayers, Bioscience, Biotechnology, and Biochemistry, vol.66, issue.2, pp.378-384, 2002.
DOI : 10.1016/S0070-2161(08)60119-7

F. Saudou, D. A. Amara, A. Dierich, M. Lemeur, S. Ramboz et al., Enhanced aggressive behavior in mice lacking 5-HT1B receptor, Science, vol.265, issue.5180, pp.1875-1878, 1994.
DOI : 10.1126/science.8091214

P. R. Saunders, U. Kosecka, D. M. Mckay, and M. H. Perdue, Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine, American Journal of Physiology-Gastrointestinal and Liver Physiology, vol.267, issue.5, pp.794-799, 1994.
DOI : 10.1152/ajpgi.1994.267.5.G794

V. Schusdziarra, R. Schick, A. De-la-fuente, A. Holland, V. Brantl et al., Effect of ??-Casomorphins on Somatostatin Release in Dogs*, Endocrinology, vol.112, issue.6, pp.1948-1951, 1983.
DOI : 10.1210/endo-112-6-1948

W. C. Shen, J. Wan, and H. Ekrami, (C) Means to enhance penetration, Advanced Drug Delivery Reviews, vol.8, issue.1, pp.93-113, 1992.
DOI : 10.1016/0169-409X(92)90016-J

M. Shimizu, M. Tsunogai, and S. Arai, Transepithelial Transport of Oligopeptides in the Human Intestinal Cell, Caco-2, Peptides, vol.18, issue.5, pp.681-687, 1997.
DOI : 10.1016/S0196-9781(97)00002-8

S. V. Silva and X. Malacata, Caseins as source of bioactive peptides, International Dairy Journal, vol.15, issue.1, pp.1-15, 2005.
DOI : 10.1016/j.idairyj.2004.04.009

E. Smacchi and M. Gobetti, Bioactive peptides in dairy products: synthesis and interaction with proteolytic enzymes, Food Microbiology, vol.17, issue.2, pp.129-141, 2000.
DOI : 10.1006/fmic.1999.0302

J. D. Söderholm and M. H. Perdue, II. Stress and intestinal barrier function, American Journal of Physiology-Gastrointestinal and Liver Physiology, vol.267, issue.1, pp.7-13, 2001.
DOI : 10.1080/725310748

J. D. Söderholm, P. C. Yang, P. Ceponis, A. Vohra, R. Riddell et al., Chronic stress induces mast cell???dependent bacterial adherence and initiates mucosal inflammation in rat intestine, Gastroenterology, vol.123, issue.4, pp.1099-1108, 2002.
DOI : 10.1053/gast.2002.36019

B. R. Stevenson, J. D. Siliciano, M. S. Mooseher, and G. D. , Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia, The Journal of Cell Biology, vol.103, issue.3, pp.755-766, 1986.
DOI : 10.1083/jcb.103.3.755

J. Svedberg, J. De-haas, G. Leimenstoll, F. Paul, and H. Teschemacher, Demonstration of ??-casomorphin immunoreactive materials in in vitro digests of bovine milk and in small intestine contents after bovine milk ingestion in adult humans, Peptides, vol.6, issue.5, pp.825-830, 1985.
DOI : 10.1016/0196-9781(85)90308-0

J. Tauzin, L. Miclo, and G. J. , -casein, FEBS Letters, vol.51, issue.2, pp.369-374, 2002.
DOI : 10.1271/bbb1961.51.2557

T. Terada and K. Inui, (Section A: Molecular, Structural, and Cellular Biology of Drug Transporters) Peptide Transporters: Structure, Function, Regulation and Application for Drug Delivery, Current Drug Metabolism, vol.5, issue.1, pp.85-94, 2004.
DOI : 10.2174/1389200043489153

H. Teschemacher, Opioid Receptor Ligands Derived from Food Proteins, Current Pharmaceutical Design, vol.9, issue.16, pp.1331-1344, 2003.
DOI : 10.2174/1381612033454856

H. Teschemacher, G. Koch, and V. Brantl, Milk protein derived atypical opioid peptides and related compounds with opioid antagonist activity. In ?-Casomorphins and Related Peptides: Recent Developments, pp.3-17, 1994.

D. T. Thwaites, B. H. Hirst, and N. L. Simmons, Passive transepithelial absorption af thyrotropin-releasing-hormone (THR) via a paracellular route in cultured epithelial cell monolayers, Pharmaceutical Research, vol.10, issue.5, pp.674-681, 1993.
DOI : 10.1023/A:1018947430018

S. Tieku and N. M. Hooper, Inhibition of aminopeptidases N, A and W, Biochemical Pharmacology, vol.44, issue.9, pp.1725-1730, 1992.
DOI : 10.1016/0006-2952(92)90065-Q

N. Tobey, W. Heizer, W. Yeh, . Tai-in, . Huang et al., Human Intestinal Brush Border Peptidases, Gastroenterology, vol.88, issue.4, pp.913-926, 1985.
DOI : 10.1016/S0016-5085(85)80008-1

D. Treit, J. P. Pinel, and F. H. , Conditioned defensive burying: A new paradigm for the study of anxiolytic agents, Pharmacology Biochemistry and Behavior, vol.15, issue.4, pp.619-626, 1981.
DOI : 10.1016/0091-3057(81)90219-7

P. Tyrer, A. R. Foxwell, J. Kyd, M. Harvey, P. Sizer et al., Validation and quantitation of an in vitro M-cell model, Biochemical and Biophysical Research Communications, vol.299, issue.3, pp.377-383, 2002.
DOI : 10.1016/S0006-291X(02)02631-1

A. M. Ugolev, L. F. Smirnova, N. N. Iezuitova, N. M. Timofeeva, N. M. Mityushova et al., Distribution of some adsorbed and intrinsic enzymes between the mucosal cells of the rat small intestine and the apical glycocalyx separated from them, FEBS Letters, vol.50, issue.1, pp.35-38, 1979.
DOI : 10.1093/oxfordjournals.jbchem.a130261

H. H. Ussing and K. Zerhan, Active Transport of Sodium as the Source of Electric Current in the Short-circuited Isolated Frog Skin., Acta Physiologica Scandinavica, vol.19, issue.No. 1, pp.110-127, 1951.
DOI : 10.3181/00379727-46-11999P

V. Vermeirssen, B. Deplancke, K. A. Tappenden, J. Van-camp, H. R. Gaskins et al., Intestinal Transport of the Lactokinin Ala-Leu-Pro-Met-His-Ile-Arg through a Caco-2 Bbe Monolayer, Journal of Peptide Science, vol.20, issue.3, pp.95-100, 2002.
DOI : 10.1002/psc.371

V. Vermeirssen, J. Van-camp, and W. Verstraete, Optimisation and validation of an angiotensin-converting enzyme inhibition assay for the screening of bioactive peptides, Journal of Biochemical and Biophysical Methods, vol.51, issue.1, pp.75-87, 2002.
DOI : 10.1016/S0165-022X(02)00006-4

V. Vermeirssen, A. Van-der-bent, J. Van-camp, A. Van-amerongen, and W. Verstraete, A quantitative in silico analysis calculates the angiotensin I converting enzyme (ACE) inhibitory activity in pea and whey protein digests, Biochimie, vol.86, issue.3, pp.231-239, 2004.
DOI : 10.1016/j.biochi.2004.01.003

J. M. Wal, Assessment of allergic potential of (novel) foods, Nahrung/Food, vol.43, issue.3, pp.168-174, 1999.
DOI : 10.1002/(SICI)1521-3803(19990601)43:3<168::AID-FOOD168>3.0.CO;2-R

D. J. Walsh, H. Bernard, B. A. Murray, J. Macdonald, A. K. Pentzien et al., In Vitro Generation and Stability of the Lactokinin ??-Lactoglobulin Fragment (142???148), Journal of Dairy Science, vol.87, issue.11, pp.3845-3857, 2004.
DOI : 10.3168/jds.S0022-0302(04)73524-9

E. Walter and T. Kissel, Heterogeneity in the human intestinal cell line Caco-2 leads to differences in transepithelial transport, European Journal of Pharmaceutical Sciences, vol.3, issue.4, pp.215-230, 1995.
DOI : 10.1016/0928-0987(95)00010-B

R. Weltzin, P. Lucia-landris, P. Michetti, B. N. Fields, J. P. Kraehenbühl et al., Binding and transepithelial transport of immunoglobulins by intestinal M cells: demonstration using monoclonal IgA antibodies against enteric viral proteins, The Journal of Cell Biology, vol.108, issue.5, pp.1673-1685, 1998.
DOI : 10.1083/jcb.108.5.1673

A. Wikman, J. Karlsson, I. Carlstedt, and P. Artursson, A drug absorption model based on the mucus layer producting human intestinal goblet cell line HT29-H, Pharmaceutical Research, vol.10, issue.6, pp.843-852, 1993.
DOI : 10.1023/A:1018905109971

A. Wikman-larhed and P. Artursson, Co-cultures of human intestinal goblet (HT29-H) and absorptive (Caco-2) cells for studies of drug and peptide absorption, European Journal of Pharmaceutical Sciences, vol.3, issue.3, pp.171-183, 1995.
DOI : 10.1016/0928-0987(95)00007-Z

E. S. Wittchens, J. Haskins, and B. R. Stevenson, Protein Interactions at the Tight Junction, Journal of Biological Chemistry, vol.109, issue.49, pp.35179-35185, 1999.
DOI : 10.1083/jcb.138.4.891

J. F. Woodley, Enzymatic barriers for GI peptide and protein delivery, Crit. Rev. Ther. Drug Carr. Syst, vol.11, pp.61-95, 1994.

N. Yamamoto, M. Ejiri, and M. S. , Biogenic Peptides and Their Potential Use, Current Pharmaceutical Design, vol.9, issue.16, pp.1345-1355, 2003.
DOI : 10.2174/1381612033454801

R. Yamauchi, K. Ohinata, and M. Yoshikawa, ??-Lactotensin and neurotensin rapidly reduce serum cholesterol via NT2 receptor, Peptides, vol.24, issue.12, pp.1955-1961, 2003.
DOI : 10.1016/j.peptides.2003.10.003

R. Yamauchi, E. Wada, D. Yamada, M. Yoshikawa, and K. Wada, Effect of ??-lactotensin on acute stress and fear memory, Peptides, vol.27, issue.12, pp.3176-3182, 2006.
DOI : 10.1016/j.peptides.2006.08.009

M. Yoshioka, R. H. Erickson, H. Matsumoto, E. Gum, and Y. S. Kim, Expression of dipeptidyl aminopeptidase IV during enterocytic differentiation of human colon cancer (Caco-2) cells, International Journal of Cancer, vol.122, issue.6, pp.916-921, 1987.
DOI : 10.1016/0304-4165(83)90363-X

Z. M. Zaîr, J. J. Elorant, B. Stieger, and G. A. Kullar-ublick, Pharmacogenetics of OATP, OAT and OCT and PEPT transporters in the intestine, liver and kidney, Future Medecine, vol.9, pp.597-624, 2008.

X. H. Zhou, Overcoming enzymatic and absorption barriers to non-parenterally administered protein and peptide drugs, Journal of Controlled Release, vol.29, issue.3, pp.239-252, 1994.
DOI : 10.1016/0168-3659(94)90071-X

H. D. Zucht, M. Raida, K. Adermann, H. J. Magert, and F. W. , derived peptide exhibits antibacterial activity, FEBS Letters, vol.519, issue.2-3, pp.185-188, 1995.
DOI : 10.1016/0021-9673(90)85160-W

A. Zweibaum, Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture, Biol Cell, vol.47, pp.323-353, 1983.