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Ingénierie tissulaire des ligaments : Conception d'un bioréacteur et étude des propriétés mécaniques

Abstract : Tissue Engineering aims to fabricate bio-prostheses by regenerating or culture, in vivo or in vitro, tissues or organs. In the in vitro strategy, developing new tools such as bioréactors which allow the culture of cells or tissues under their specific mechanical solicitations is a huge point. Moreover, the last advances of this discipline in regeneration of tissues require new mechanical model allowing their evaluation and comparison to native tissue under physiological loading. Indeed, in order to obtain a good evaluation of their mechanical quality, it is important to be able to applied mechanical solicitations linked to physiological ones. As a first step, a bioreactor of ligament allowing the culture of cells under mechanical solicitations of cyclic traction-torsion was designed and developed. This bioreactor was sized to potentially obtain a bio-prosthesis comparable to native tissue in term of size (4 to 5 cm long). In a second time, a mechanical model was elaborated based on a thermodynamic formalism developed in our laboratory and the observation made on rabbit Achilles tendons. The goals of this model are to improve our knowledge on the mayor structures involved into the mechanical quality of theses tissues and to evaluate and optimise the scaffolds and neo-tissues of substitution
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Cyril Kahn. Ingénierie tissulaire des ligaments : Conception d'un bioréacteur et étude des propriétés mécaniques. Autre. Institut National Polytechnique de Lorraine, 2009. Français. ⟨NNT : 2009INPL010N⟩. ⟨tel-01748711⟩



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