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50 III.5.3)a) Généralités sur la synthèse indolique de, p.51 ,
107 V.3. ESSAI A PARTIR DE LA 5, 107 V.2. ESSAI AU DEPART DU 2, pp.8-11 ,
118 VI.1. Synthèse du 2-cyclohexylidènemalononitrile 93 118 VI.2. Synthèse de la 3-chloro-4 119 VI.3. Synthèse de la 3-chloro-4-carboxamide-5 121 VI.5. Synthèse du 2-cyclohexylidènecyanoacétate de méthyle 98, -tétrahydroisoquinoléine 94 ... 120 VI.4. Synthèse du 2-cyclohexylidènecyanoacétate d'éthyle 97, p.132, 1992. ,
136 VII.3, 139 VII.3.2) Nouvelle synthèse du, pp.12-12 ,
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32 (type B, synthèse indolique de Fischer ,
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1873 -1971 : intercalation entre les paires de bases de l'ADN 156 -1981 et 1983 : bioactivation et formation d'espèces réactives alkylantes 157, 158 -1982 : inhibition de la topoisomérase II, pp.159-2005, 1976. ,
la manière dont un dérivé d'ellipticine précis agit pour donner son effet antitumoral n'est pas connue avec précision ,
Figure 5) est plus actif que l'ellipticine elle-même 163 et que l'acétate de son dérivé quaternisé par un groupement méthyle sur la position 1 (céliptium 16, Figure 5) a été utilisé jadis comme médicament anticancéreux, pp.162-171 ,
ensemble sur les synthèses d'ellipticines, voyons à présent ce qui a initié notre projet. Il s'agit plus particulièrement des recherches du groupe de Bisagni qui a travaillé intensément sur le sujet de, 1975. ,
méthyl-9-hydroxyellipticinium) 16 développé par Le Pecq et coll., 164, 165 utilisé comme médicament en France dans les années plusieurs autres molécules (18 à 20 Figure 5) synthétisées par l'équipe de Bisagni ont révélé d'importantes 156, FEBS Letters, vol.166, issue.17, pp.167-321, 1971. ,
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40 mg Rendement : 85% Aspect : solide jaune pâle R f : 0 ,
01 g Rendement : 4% Aspect : solide rose pâle R f : 0 ,
0 g Rendement : 52% Aspect : solide marron R f : 0 ,
70 mg Rendement : 51% Aspect : solide rose pâle R f : 0, p.45 ,
141 (calculée : 306,116) N H HN VIII.8. Synthèse du 13-méthyl-12,13-dihydro-7H-indolo[2',3':3,4]cyclopenta[1,2-a]carbazole REFERENCES BIBLIOGRAPHIQUES F. Wöhler, Ann. Phys. Chem, vol.306, issue.12, p.253 ,
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