Blood Pressure and the Global Burden of Cardiovascular Disease, Clinical and Experimental Hypertension, vol.4, issue.1, pp.5-6543, 1999. ,
DOI : 10.1111/j.1467-842X.1997.tb01779.x
Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization References (1) The biology of vascular endothelial growth factor Multiplexed discovery of sequence polymorphisms using base-specific cleavage and MALDI-TOF MS, Endocr Rev. Nucleic Acids Res, vol.1833, pp.4-25, 1997. ,
Highly Parallel SNP Genotyping, Cold Spring Harbor Symposia on Quantitative Biology, vol.32, issue.0, pp.69-78, 2003. ,
DOI : 10.1038/nbt0402-353
GWAF: an R package for genome-wide association analyses with family data, Bioinformatics, vol.73, issue.Suppl. 1, pp.580-581, 2009. ,
DOI : 10.1093/biomet/73.1.13
The relationship of VEGF polymorphisms with serum VEGF levels and progression-free survival in patients with epithelial ovarian cancer, Gynecologic Oncology, vol.117, issue.1, pp.109-116, 2010. ,
DOI : 10.1016/j.ygyno.2009.11.011
Vascular endothelial growth factor gene polymorphisms and serum levels in Beh??et???s disease, Tissue Antigens, vol.30, issue.6, pp.581-587, 2008. ,
DOI : 10.1042/cs0940395
Genotypes and haplotypes of the VEGF gene are associated with higher mortality and lower VEGF plasma levels in patients with ARDS, Thorax, vol.62, issue.8, pp.718-722, 2007. ,
DOI : 10.1136/thx.2006.069393
The role of vascular endothelial growth factor (VEGF) in inflammatory bowel disease, Inflammatory Bowel Diseases, vol.46, issue.9, pp.870-878, 2006. ,
DOI : 10.1093/rheumatology/kei013
A common 936 C/T gene polymorphism of vascular endothelial growth factor is associated with decreased breast cancer risk, International Journal of Cancer, vol.22, issue.4, pp.468-471, 2003. ,
DOI : 10.1161/01.ATV.0000026801.56080.14
A Common Polymorphism in the 5'-Untranslated Region of the VEGF Gene Is Associated With Diabetic Retinopathy in Type 2 Diabetes, Diabetes, vol.51, issue.5, pp.1635-1639, 2002. ,
DOI : 10.2337/diabetes.51.5.1635
A Common 936 C/T Mutation in the Gene for Vascular Endothelial Growth Factor Is Associated with Vascular Endothelial Growth Factor Plasma Levels, Journal of Vascular Research, vol.37, issue.6 ,
DOI : 10.1159/000054076
Local and genetic determinants of vascular endothelial growth factor expression in advanced proliferative diabetic retinopathy ,
mRNA Expression and Susceptibility to Sporadic Colon Cancer, DNA and Cell Biology, vol.27, issue.10, pp.569-574, 2008. ,
DOI : 10.1089/dna.2008.0756
Vascular endothelial growth factor polymorphisms endometriosis: their influence on vascular endothelial growth factor expression Peripheral blood mononuclear cells (PBMCs): a possible model for studying cardiovascular biology systems, Fertil Steril. Visvikis-Siest S Clin Chem Lab Med, vol.9245, issue.43, pp.1214-12201154, 2007. ,
The Carboxyl-terminal Domain(111165) of Vascular Endothelial Growth Factor Is Critical for Its Mitogenic Potency, Journal of Biological Chemistry, vol.11, issue.13, pp.7788-7795, 1996. ,
DOI : 10.1074/jbc.270.13.7717
FOG-2, a Cofactor for GATA Transcription Factors, Is Essential for Heart Morphogenesis and Development of Coronary Vessels from Epicardium, Cell, vol.101, issue.7, pp.729-739, 2000. ,
DOI : 10.1016/S0092-8674(00)80885-5
Critical Role for GATA3 in Mediating Tie2 Expression and Function in Large Vessel Endothelial Cells, Journal of Biological Chemistry, vol.87, issue.42, pp.29109-29124, 2009. ,
DOI : 10.1161/01.RES.87.1.19
Anomalien der Koronararterien Teil I: Aktuelle Erkenntnisse aus der Embryologie, Zeitschrift f??r Kardiologie, vol.219, issue.12, pp.929-937, 2004. ,
DOI : 10.1161/01.CIR.75.1.255
Genomic response of hypoxic M??ller cells involves the very low density lipoprotein receptor as part of an angiogenic network, Experimental Eye Research, vol.88, issue.5, pp.928-937, 2009. ,
DOI : 10.1016/j.exer.2008.11.037
Platelet: transporter of vascular endothelial growth factor, Clin Cancer Res, vol.3, pp.2187-2190, 1997. ,
The Framingham Study An Epidemiological Approach to Coronary Heart Disease, Circulation, vol.34, issue.4, pp.553-555, 1966. ,
DOI : 10.1161/01.CIR.34.4.553
The framingham offspring study. Design and preliminary data, Preventive Medicine, vol.4, issue.4, pp.518-525, 1975. ,
DOI : 10.1016/0091-7435(75)90037-7
The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: Design, Recruitment, and Initial Examination, American Journal of Epidemiology, vol.165, issue.11, pp.1328-1335, 2007. ,
DOI : 10.1093/aje/kwm021
The STANISLAS Cohort: a 10-year follow-up of supposed healthy families. Gene-environment interactions, reference values and evaluation of biomarkers in prevention of cardiovascular diseases, Clinical Chemistry and Laboratory Medicine, vol.55, issue.6, pp.733-747, 2008. ,
DOI : 10.1080/15287390490514895
Objectives, Design and Recruitment of a Familial and Longitudinal Cohort for Studying Gene-Environment Interactions in the Field of Cardiovascular Risk: The Stanislas Cohort, Clinical Chemistry and Laboratory Medicine, vol.35, issue.1, pp.35-42, 1998. ,
DOI : 10.1016/0009-8981(91)90106-M
A comparison of three different methods to evaluate endothelium-dependent vasodilation in the elderly, the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study ,
Development of a High-Throughput Automated Analyzer Using Biochip Array Technology, Clinical Chemistry, vol.51, issue.7, pp.1165-1176, 2005. ,
DOI : 10.1373/clinchem.2005.049429
Highly Parallel SNP Genotyping, Cold Spring Harbor Symposia on Quantitative Biology, vol.32, issue.0, pp.69-78, 2003. ,
DOI : 10.1038/nbt0402-353
Principal components analysis corrects for stratification in genome-wide association studies, Nature Genetics, vol.15, issue.8, pp.904-909, 2006. ,
DOI : 10.1111/j.1469-1809.1949.tb02451.x
Population Structure and Eigenanalysis, PLoS Genetics, vol.15, issue.12, p.190, 2006. ,
DOI : 1088-9051(2005)015[1576:CACSOH]2.0.CO;2
Diagnosis and management of the metabolic syndrome, Current Opinion in Cardiology, vol.21, issue.1, pp.2735-2752, 2005. ,
DOI : 10.1097/01.hco.0000200416.65370.a0
GWAF: an R package for genome-wide association analyses with family data, Bioinformatics, vol.73, issue.Suppl. 1, pp.580-581 ,
DOI : 10.1093/biomet/73.1.13
Decomposition of metabolic network into functional modules based on the global connectivity structure of reaction graph, Bioinformatics, vol.20, issue.12, pp.1870-1876, 2004. ,
DOI : 10.1093/bioinformatics/bth167
Collection and Storage of Human Blood Cells for mRNA Expression Profiling: A 15-Month Stability Study, Clinical Chemistry, vol.51, issue.7, pp.1250-1252, 2005. ,
DOI : 10.1373/clinchem.2005.048546
Quantification of VEGF Isoforms and VEGFR Transcripts by qRT-PCR and Their Significance in Acute Myeloid Leukemia, The International Journal of Biological Markers, vol.102, issue.1, pp.22-31, 2009. ,
DOI : 10.1182/blood-2002-10-2998
Factors regulating circulating vascular endothelial growth factor (VEGF): Association with bone mineral density (BMD) in post-menopausal osteoporosis, Cytokine, vol.46, issue.3, pp.376-381, 2009. ,
DOI : 10.1016/j.cyto.2009.03.012
Relationship Between Vascular Endothelial Growth Factor + 936 Genotype and Plasma/Epithelial Lining Fluid Vascular Endothelial Growth Factor Protein Levels in Patients With and at Risk for ARDS, Chest, vol.136, issue.2, pp.457-464, 2009. ,
DOI : 10.1378/chest.09-0383
Genetic polymorphisms in the vascular endothelial growth factor gene and breast cancer risk. The Austrian ???tumor of breast tissue: incidence, genetics, and environmental risk factors??? study, Breast Cancer Research and Treatment, vol.103, issue.2, pp.297-304, 2008. ,
DOI : 10.1007/s10549-007-9655-z
Low serum VEGF levels are associated with Alzheimer's disease, Acta Neurologica Scandinavica, vol.31, issue.1, pp.56-58, 2007. ,
DOI : 10.1016/S0197-4580(03)00111-8
Heritability for Plasma VEGF Concentration in the Stanislas Family Study, Annals of Human Genetics, vol.266, issue.1, pp.54-63, 2007. ,
DOI : 10.1161/hc0902.104718
The relationship of VEGF polymorphisms with serum VEGF levels and progression-free survival in patients with epithelial ovarian cancer, Gynecologic Oncology, vol.117, issue.1, pp.109-116 ,
DOI : 10.1016/j.ygyno.2009.11.011
Vascular endothelial growth factor gene polymorphisms and serum levels in Beh??et???s disease, Tissue Antigens, vol.30, issue.6, pp.581-587, 2008. ,
DOI : 10.1042/cs0940395
Genotypes and haplotypes of the VEGF gene are associated with higher mortality and lower VEGF plasma levels in patients with ARDS, Thorax, vol.62, issue.8, pp.718-722, 2007. ,
DOI : 10.1136/thx.2006.069393
The role of vascular endothelial growth factor (VEGF) in inflammatory bowel disease, Inflammatory Bowel Diseases, vol.46, issue.9, pp.870-878, 2006. ,
DOI : 10.1093/rheumatology/kei013
A common 936 C/T gene polymorphism of vascular endothelial growth factor is associated with decreased breast cancer risk, International Journal of Cancer, vol.22, issue.4 ,
DOI : 10.1161/01.ATV.0000026801.56080.14
A Common Polymorphism in the 5'-Untranslated Region of the VEGF Gene Is Associated With Diabetic Retinopathy in Type 2 Diabetes, Diabetes, vol.51, issue.5, pp.1635-1639, 2002. ,
DOI : 10.2337/diabetes.51.5.1635
A Common 936 C/T Mutation in the Gene for Vascular Endothelial Growth Factor Is Associated with Vascular Endothelial Growth Factor Plasma Levels, Journal of Vascular Research, vol.37, issue.6, pp.443-448, 2000. ,
DOI : 10.1159/000054076
Adhesion molecules and their role in vascular disease, American Journal of Hypertension, vol.14, issue.11, 2001. ,
DOI : 10.1016/S0895-7061(01)02069-6
Vascular Adhesion Molecules in Atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.27, issue.11, pp.2292-301, 2007. ,
DOI : 10.1161/ATVBAHA.107.149179
Atherosclerosis: current pathogenesis and therapeutic options, Nature Medicine, vol.147, issue.11, pp.1410-1432, 2011. ,
DOI : 10.1161/ATVBAHA.109.202671
Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy, Journal of Clinical Oncology, vol.20, issue.21, pp.4368-80, 2002. ,
DOI : 10.1200/JCO.2002.10.088
The biology of VEGF and its receptors, Nature Medicine, vol.99, issue.21, pp.669-76, 2003. ,
DOI : 10.1073/pnas.152324099
VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2, Journal of Cell Science, vol.116, issue.4, pp.665-74, 2003. ,
DOI : 10.1242/jcs.00286
Identification of cis- and trans-Acting Genetic Variants Explaining Up to Half the Variation in Circulating Vascular Endothelial Growth Factor Levels, Circulation Research, vol.109, issue.5, pp.554-63, 2011. ,
DOI : 10.1161/CIRCRESAHA.111.243790
The STANISLAS Cohort: a 10-year follow-up of supposed healthy families. Gene-environment interactions, reference values and evaluation of biomarkers in prevention of cardiovascular diseases, Clinical Chemistry and Laboratory Medicine, vol.55, issue.6, pp.733-780, 2008. ,
DOI : 10.1080/15287390490514895
Development of a High-Throughput Automated Analyzer Using Biochip Array Technology, Clinical Chemistry, vol.51, issue.7, pp.1165-76, 2005. ,
DOI : 10.1373/clinchem.2005.049429
Collection and Storage of Human Blood Cells for mRNA Expression Profiling: A 15-Month Stability Study, Clinical Chemistry, vol.51, issue.7, pp.1250-1252, 2005. ,
DOI : 10.1373/clinchem.2005.048546
Multiplexed discovery of sequence polymorphisms using base-specific cleavage and MALDI-TOF MS, Nucleic Acids Research, vol.33, issue.4, p.38, 2005. ,
DOI : 10.1093/nar/gni038
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses, The American Journal of Human Genetics, vol.81, issue.3, pp.559-75, 2007. ,
DOI : 10.1086/519795
Vascular Endothelial Growth Factor Expression of Intercellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule 1 (VCAM-1), and E-selectin through Nuclear Factor-??B Activation in Endothelial Cells, Journal of Biological Chemistry, vol.9, issue.10, pp.2767614-2767634, 2001. ,
DOI : 10.1038/sj.mn.7300155
Junctional Adhesion Molecule-C Is a Soluble Mediator of Angiogenesis, The Journal of Immunology, vol.185, issue.3, pp.1777-85, 2010. ,
DOI : 10.4049/jimmunol.1000556
Angiogenesis mediated by soluble forms of E-selectin and vascular cell
adhesion molecule-1, Nature, vol.376, issue.6540, pp.517-526, 1995. ,
DOI : 10.1038/376517a0
Insights into the Molecular Basis of Leukocyte Tethering and Rolling Revealed by Structures of P- and E-Selectin Bound to SLeX and PSGL-1, Cell, vol.103, issue.3, pp.467-79, 2000. ,
DOI : 10.1016/S0092-8674(00)00138-0
Regulation of Membrane Metalloproteolytic Cleavage of L-selectin (CD62L) by the Epidermal Growth Factor Domain, Journal of Biological Chemistry, vol.267, issue.33, 2001. ,
DOI : 10.1073/pnas.96.7.3922
Heritability for Plasma VEGF Concentration in the Stanislas Family Study, Annals of Human Genetics, vol.266, issue.1, pp.54-63, 2007. ,
DOI : 10.1161/hc0902.104718
Molecular Insights and Therapeutic Targets for Diabetic Endothelial Dysfunction, Circulation, vol.120, issue.13, pp.1266-86, 2009. ,
DOI : 10.1161/CIRCULATIONAHA.108.835223
URL : http://circ.ahajournals.org/content/circulationaha/120/13/1266.full.pdf
Peripheral blood gene expression profiling for cardiovascular disease assessment, Genomic Medicine, vol.39, issue.3-4, pp.3-4105, 2007. ,
DOI : 10.1161/hy0302.104670
Peripheral blood mononuclear cells (PBMCs): a possible model for studying cardiovascular biology systems, Clinical Chemical Laboratory Medicine, vol.32, issue.9, pp.1154-68, 2007. ,
DOI : 10.2337/diabetes.53.7.1857
Activation in vitro of NF-??B" by phosphorylation of its inhibitor I??B", Nature, vol.344, issue.6267, pp.678-82, 1990. ,
DOI : 10.1038/344678a0
Inhibition of nuclear factor-kappa B nuclear localization reduces human E-selectin expression and the systemic inflammatory response, Circulation, pp.98-282, 1998. ,
Transcriptional Regulation of the Intercellular Adhesion Molecule-1 Gene by Inflammatory Cytokines in Human Endothelial Cells, Journal of Biological Chemistry, vol.13, issue.2, pp.933-976, 1995. ,
DOI : 10.1128/MCB.13.11.7180
Inhibition of endothelial cell activation by adenovirus-mediated expression of I kappa B alpha, an inhibitor of the transcription factor NF-kappa B, Journal of Experimental Medicine, vol.183, issue.3, pp.1013-1035, 1996. ,
DOI : 10.1084/jem.183.3.1013
NF-?B activation in human prostate cancer: Important mediator or epiphenomenon?, Journal of Cellular Biochemistry, vol.1, issue.1, pp.100-117, 2004. ,
DOI : 10.1016/S1097-2765(00)80066-0
Vascular endothelial growth factor production is regulated by gene polymorphisms, Iran J Immunol, vol.6, issue.3, pp.119-148, 2009. ,
Hypoxia-Inducible Factor-1 as Regulator of Angiogenesis in Rheumatoid Arthritis - Therapeutic Implications, Current Medicinal Chemistry, vol.17, issue.3, pp.254-63, 2010. ,
DOI : 10.2174/092986710790149783
Placenta growth factor (PlGF) induces vascular endothelial growth factor (VEGF) secretion from mononuclear cells and is co-expressed with VEGF in synovial fluid, Clinical and Experimental Immunology, vol.8, issue.1, pp.182-190, 2000. ,
DOI : 10.1006/cimm.1995.9978
Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor alpha and interleukin-1 in rheumatoid arthritis, Arthritis Rheum, issue.467, pp.411258-65, 1998. ,
Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis., Molecular and Cellular Biology, vol.17, issue.7, pp.4015-4038, 1997. ,
DOI : 10.1128/MCB.17.7.4015
The Human Placenta Remodels the Uterus by Using a Combination of Molecules That Govern Vasculogenesis or Leukocyte Extravasation, Annals of the New York Academy of Sciences, vol.40, issue.1, 2003. ,
DOI : 10.1016/S0002-9440(10)62567-9
Signaling Functions of L-selectin, Journal of Biological Chemistry, vol.269, issue.25, pp.15403-15414, 1995. ,
DOI : 10.1006/bbrc.1994.1819
Vascular endothelial growth factor VEGF189 induces human neutrophil chemotaxis in extravascular tissue via an autocrine amplification mechanism, Laboratory Investigation, vol.101, issue.4, pp.502-514, 2004. ,
DOI : 10.1111/j.1471-0528.1994.tb13690.x
Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells, American Journal of Physiology-Cell Physiology, vol.296, issue.4, pp.821-827, 2009. ,
DOI : 10.1161/01.HYP.0000138688.78906.6b
, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix, Journal of Biological Chemistry, vol.302, issue.11, pp.2727151-2727159, 1997. ,
DOI : 10.3109/08977199509003209
Quantification of VEGF Isoforms and VEGFR Transcripts by qRT-PCR and Their Significance in Acute Myeloid Leukemia, The International Journal of Biological Markers, vol.102, issue.1, pp.22-31, 2009. ,
DOI : 10.1182/blood-2002-10-2998
Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance, Atherosclerosis, vol.208, issue.2, pp.512-519, 2010. ,
DOI : 10.1016/j.atherosclerosis.2009.07.045
Metabolic Syndrome: A Multiplex Cardiovascular Risk Factor, The Journal of Clinical Endocrinology & Metabolism, vol.92, issue.2, pp.399-404, 2007. ,
DOI : 10.1210/jc.2006-0513
The metabolic syndrome, The Lancet, vol.365, issue.9468, pp.1415-1443, 2005. ,
DOI : 10.1016/S0140-6736(05)66378-7
Metabolic syndrome: Definition, pathophysiology, and mechanisms, American Heart Journal, vol.149, issue.1, pp.33-45, 2005. ,
DOI : 10.1016/j.ahj.2004.07.013
The cellular and signaling networks linking the immune system and metabolism in disease, Nature Medicine, vol.152, issue.3, pp.363-74, 2012. ,
DOI : 10.2337/db10-1278
Disruption of HIF-1alpha in hepatocytes impairs glucose metabolism in diet-induced obesity mice ,
The Metabolic Syndrome, Endocrine Reviews, vol.29, issue.7, pp.777-822, 2008. ,
DOI : 10.1210/er.2008-0024
Hypercholesterolemia reduces collateral artery growth more dominantly than 261 ,
Vascular Endothelial Growth Factor: Basic Science and Clinical Progress, Endocrine Reviews, vol.25, issue.4 ,
DOI : 10.1210/er.2003-0027
Angiogenesis modulates adipogenesis and obesity, Journal of Clinical Investigation, vol.117, issue.9, pp.2362-2370, 2007. ,
DOI : 10.1172/JCI32239
Identification of cis- and trans-Acting Genetic Variants Explaining Up to Half the Variation in Circulating Vascular Endothelial Growth Factor Levels, Circulation Research, vol.109, issue.5, pp.554-63, 2011. ,
DOI : 10.1161/CIRCRESAHA.111.243790
Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance, Diabetes, vol.61, issue.7, 2012. ,
DOI : 10.2337/db11-0832
Circulating Levels of Endothelial Progenitor Cell Mobilizing Factors in the Metabolic Syndrome, The American Journal of Cardiology, vol.106, issue.11, pp.1606-1614, 2010. ,
DOI : 10.1016/j.amjcard.2010.07.039
The contribution of omental adipose tissue to adipokine concentrations in patients with the metabolic syndrome, Clinical & Investigative Medicine, vol.30, issue.5, pp.192-199, 2007. ,
DOI : 10.25011/cim.v30i5.2895
Vascular endothelial growth factor, its soluble receptor, and hepatocyte growth factor, p.262 ,
A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium, Diabetes, vol.60, issue.4, pp.1329-1368, 2011. ,
DOI : 10.2337/db10-1011
A Genome-Wide Association Study of the Metabolic Syndrome in Indian Asian Men, PLoS ONE, vol.41, issue.1, p.11961, 2010. ,
DOI : 10.1371/journal.pone.0011961.s010
Metabolic syndrome-related composite factors over 5 years in the STANISLAS family study: genetic heritability and common environmental influences, Clin Chim Acta, vol.411, pp.11-12833, 2010. ,
High Prevalence of Metabolic Syndrome in Iran in Comparison with France: What Are the Components That Explain This?, Metabolic Syndrome and Related Disorders, vol.10, issue.3, pp.181-189, 2012. ,
DOI : 10.1089/met.2011.0097
Metabolic syndrome: Its prevalence and relationship to socio-economic parameters in an Iranian population, Nutrition, Metabolism and Cardiovascular Diseases, vol.18, issue.3, pp.11-12, 2008. ,
DOI : 10.1016/j.numecd.2007.07.005
Multiplexed discovery of sequence polymorphisms using base-specific cleavage and MALDI-TOF MS, Nucleic Acids Research, vol.33, issue.4, p.38, 2005. ,
DOI : 10.1093/nar/gni038
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses, The American Journal of Human Genetics, vol.81, issue.3, pp.559-75, 2007. ,
DOI : 10.1086/519795
A navigator for human genome epidemiology, Nature Genetics, vol.38, issue.2, pp.124-129, 2008. ,
DOI : 10.1038/ng0208-124
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits, Proceedings of the National Academy of Sciences, vol.40, issue.3, pp.9362-9369, 2009. ,
DOI : 10.1038/ng.91
The National Cholesterol Education Program-Adult Treatment Panel III, International Diabetes Federation, and World Health Organization Definitions of the Metabolic Syndrome as Predictors of Incident Cardiovascular Disease and Diabetes, Diabetes Care, vol.30, issue.1, pp.8-13, 2007. ,
DOI : 10.2337/dc06-1414
Impaired Revascularization in a Mouse Model of Type 2 Diabetes Is Associated With Dysregulation of a Complex Angiogenic-Regulatory Network, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.25, issue.8, pp.1603-1612, 2005. ,
DOI : 10.1161/01.ATV.0000171994.89106.ca
Abdominal Obesity and the Metabolic Syndrome: Contribution to Global Cardiometabolic Risk, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.28, issue.6 ,
DOI : 10.1161/ATVBAHA.107.159228
URL : http://atvb.ahajournals.org/content/atvbaha/28/6/1039.full.pdf
Plasma vascular endothelial growth factor and its receptor Flt-1 in patients with hyperlipidemia and atherosclerosis and the effects of fluvastatin or fenofibrate, The American Journal of Cardiology, vol.87, issue.10, pp.1160-1163, 2001. ,
DOI : 10.1016/S0002-9149(01)01486-2
The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients, Diabetes Research and Clinical Practice, vol.81, issue.1, pp.56-60, 2008. ,
DOI : 10.1016/j.diabres.2008.02.006
Risk of Alzheimer's disease is associated with a very low-density lipoprotein receptor genotype in northern Ireland, American Journal of Medical Genetics, vol.100, issue.2, pp.140-144, 1999. ,
DOI : 10.1007/s004390050488
The atherogenic lipoprotein Lp(a) is internalized and degraded in a process mediated by the VLDL receptor., Journal of Clinical Investigation, vol.100, issue.9, pp.2170-81, 1997. ,
DOI : 10.1172/JCI119753
The Very Low-density Lipoprotein (VLDL) Receptor: Characterization and Functions as a Peripheral Lipoprotein Receptor, Journal of Atherosclerosis and Thrombosis, vol.11, issue.4, pp.200-208, 2004. ,
DOI : 10.5551/jat.11.200
Protection From Obesity in Mice Lacking the VLDL Receptor, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.21, issue.9, pp.1488-93, 2001. ,
DOI : 10.1161/hq0901.095147
The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction, Journal of Clinical Investigation, vol.121, issue.7, pp.2625-2665, 2011. ,
DOI : 10.1172/JCI43068DS1
Glucose deprivation accelerates VLDL receptor-mediated TG-rich lipoprotein uptake by AMPK activation in skeletal muscle cells, Biochemical and Biophysical Research Communications, vol.368, issue.3, pp.716-738, 2008. ,
DOI : 10.1016/j.bbrc.2008.01.154
Human triglyceride-rich lipoproteins impair glucose metabolism and insulin signalling in L6 skeletal muscle cells independently of non-esterified fatty acid levels, Diabetologia, vol.5, issue.Suppl 1, pp.756-66, 2005. ,
DOI : 10.1007/s00125-005-1684-8
Mitochondrial dysfunction and insulin resistance from the outside in: extracellular matrix, the cytoskeleton, and mitochondria, American Journal of Physiology-Endocrinology and Metabolism, vol.2, issue.5, pp.749-755, 2011. ,
DOI : 10.1039/b701483j
Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family, Cardiovascular Research, vol.49, issue.3, pp.568-81, 2001. ,
DOI : 10.1016/S0008-6363(00)00268-6
Induction of mitochondrial uncoupling enhances VEGF(120) but reduces MCP-1 ,
Effect of Insulin Deprivation on Muscle Mitochondrial ATP Production and Gene Transcript Levels in Type 1 Diabetic Subjects, Diabetes, vol.56, issue.11, pp.2683-2692, 2007. ,
DOI : 10.2337/db07-0378
Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome ,
Heart of the matter: Coronary dysfunction in metabolic syndrome, Journal of Molecular and Cellular Cardiology, vol.52, issue.4, pp.848-56, 2012. ,
DOI : 10.1016/j.yjmcc.2011.06.025
Contribution of voltage-dependent K+ channels to metabolic control of coronary blood flow, Journal of Molecular and Cellular Cardiology, vol.52, issue.4, pp.912-921, 2012. ,
DOI : 10.1016/j.yjmcc.2011.07.004
Channels in Pancreatic ??-Cells Enhances Glucose-dependent Insulin Secretion, Journal of Biological Chemistry, vol.1283, issue.47, pp.44938-44983, 2002. ,
DOI : 10.1016/0079-6107(89)90013-8
Role of VEGF-A in Pancreatic Beta Cells, Endocrine Journal, vol.57, issue.3, pp.185-91, 2010. ,
DOI : 10.1507/endocrj.K09E-035
Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes, American Journal of Physiology-Renal Physiology, vol.60, issue.6, pp.1263-1273, 2003. ,
DOI : 10.1042/cs0970303
URL : http://ajprenal.physiology.org/content/ajprenal/284/6/F1263.full.pdf
Acyl-CoA esters modulate intracellular Ca2+ handling by permeabilized clonal pancreatic beta-cells, J Biol Chem, vol.267, issue.28, pp.19840-19845, 1992. ,
Molecular and metabolic mechanisms of insulin resistance and ??-cell failure in type 2 diabetes, Nature Reviews Molecular Cell Biology, vol.132, issue.3, pp.193-205, 2008. ,
DOI : 10.1172/JCI200422230
channels regulate the duration of reactive hyperemia in the canine coronary circulation, American Journal of Physiology-Heart and Circulatory Physiology, vol.294, issue.5, pp.2371-2381, 2008. ,
DOI : 10.1073/pnas.93.19.10489
Molecular mechanisms and clinical applications of angiogenesis, Nature, vol.464, issue.7347, pp.298-307, 2011. ,
DOI : 10.1038/nature08889
Vascular Endothelial Growth Factors, Journal of the American College of Cardiology, vol.49, issue.10, pp.1015-1026, 2007. ,
DOI : 10.1016/j.jacc.2006.09.053
Anti-Vascular Endothelial Growth Factor Therapies and Cardiovascular Toxicity: What Are the Important Clinical Markers to Target?, The Oncologist, vol.15, issue.2, pp.130-141, 2010. ,
DOI : 10.1634/theoncologist.2009-0252
Vascular endothelial growth factor and soluble P-selectin in acute and chronic congestive heart failure, The American Journal of Cardiology, vol.90, issue.11, pp.1258-1260, 2002. ,
DOI : 10.1016/S0002-9149(02)02848-5
Expression of vascular endothelial growth factor in patients with acute myocardial infarction, J Am Coll Cardiol, vol.35, pp.968-973, 2000. ,
Serial Measurement of Vascular Endothelial Growth Factor and Transforming Growth Factor-??1 in Serum of Patients With Acute Ischemic Stroke, Stroke, vol.31, issue.8, pp.1863-1870, 2000. ,
DOI : 10.1161/01.STR.31.8.1863
Plasma levels of vascular endothelial growth factor and its soluble receptor (SFlt-1) in essential hypertension, The American Journal of Cardiology, vol.87, issue.6, pp.805-807, 2001. ,
DOI : 10.1016/S0002-9149(00)01512-5
Plasma vascular endothelial growth factor level is elevated in patients with multivessel coronary artery disease, 2004. ,
Angiogenesis-dependent and independent phases of intimal hyperplasia, Circulation, vol.110, pp.2436-2443, 2004. ,
Vascular endothelial growth factor enhances cardiac allograft arteriosclerosis, Circulation, vol.105, pp.2524-2530, 2002. ,
Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis, Proc Natl Acad Sci, vol.100, pp.4736-4741, 2003. ,
VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries, Hum Gene Ther, vol.8, pp.1737-1744, 1997. ,
Gene transfers of vascular endothelial growth factor-A, vascular endothelial growth factor-B, vascular endothelial growth factor-C, and vascular endothelial growth factor-D have no effects on atherosclerosis in hypercholesterolemic low-density lipoproteinreceptor/apolipoprotein B48-deficient mice, Circulation, vol.112, pp.1347-1352, 2005. ,
Lipid parameters for measuring risk of cardiovascular disease, Nature Reviews Cardiology, vol.25, issue.4, pp.197-206, 2011. ,
DOI : 10.1016/S0828-282X(09)70715-9
Plasma vascular endothelial growth factor and its receptor Flt-1 in patients with hyperlipidemia and atherosclerosis and the effects of fluvastatin or fenofibrate, The American Journal of Cardiology, vol.87, issue.10, pp.1160-1163, 2001. ,
DOI : 10.1016/S0002-9149(01)01486-2
Successful therapy reduces levels of vascular endothelial growth factor (VEGF) in patients with hypertension and patients with hypercholesterolemia, Atherosclerosis, vol.151, issue.2, 2000. ,
DOI : 10.1016/S0021-9150(00)00477-9
Serum VEGF--as a prognostic factor of atherosclerosis, Atherosclerosis, vol.194, pp.182-188, 2007. ,
Are plasma VEGF and its soluble receptor sFlt-1 atherogenic risk factors? Cross-sectional data from the SAPHIR study, Atherosclerosis, vol.206, pp.265-269, 2009. ,
Identification of cis-and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels, Circ Res, vol.109, pp.554-563, 2011. ,
Objectives, design and recruitment of a familial and longitudinal cohort for studying gene-environment interactions in the field of cardiovascular risk: the Stanislas cohort The STANISLAS Cohort: a 10-year follow-up of supposed healthy families. Gene-environment interactions, reference values and evaluation of biomarkers in prevention of cardiovascular diseases, Clin Chem Lab Med Clin Chem Lab Med, vol.36, issue.46, pp.35-42, 1998. ,
Estimation of the concentration of low-density lipoprotein cholesterol in plasma, 1972. ,
Multiplexed discovery of sequence polymorphisms using base-specific cleavage and MALDI-TOF MS, Clin Chem Nucleic Acids Res, vol.18, issue.33, pp.499-502, 2005. ,
PLINK: a tool set for whole-genome association and population-based linkage analyses, Am J Hum Genet, vol.81, pp.559-575, 2007. ,
A navigator for human genome epidemiology, Nature Genetics, vol.38, issue.2, pp.124-125, 2008. ,
DOI : 10.1038/ng0208-124
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits, Proc Natl Acad Sci, vol.106, pp.9362-9367, 2009. ,
Genome-wide association analysis of high-density lipoprotein cholesterol in the population-based KORA study sheds new light on intergenic regions, Circ Cardiovasc Genet, vol.1, pp.10-20, 2008. ,
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans, Nat Genet, vol.40, pp.189-197, 2008. ,
Common variants at 30 loci contribute to polygenic dyslipidemia, Nat Genet, vol.41, pp.56-65, 2009. ,
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium, Diabetes, vol.60, pp.1329-1339, 2011. ,
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population, Nat Genet, vol.41, pp.35-46, 2009. ,
Genetic variants influencing circulating lipid levels and risk of coronary artery disease, Arterioscler Thromb Vasc Biol, vol.30, pp.2264-2276, 2010. ,
Newly identified loci that influence lipid concentrations and risk of coronary artery disease, Nat Genet, vol.40, pp.161-169, 2008. ,
Biological Determinants of and Reference Values for Plasma Interleukin-8, Monocyte Chemoattractant Protein-1, Epidermal Growth Factor, and Vascular Endothelial Growth Factor: Results from the STANISLAS Cohort, 43. Hunter, D. J. 2005. Gene-environment interactions in human diseases, pp.504-510, 2006. ,
DOI : 10.1373/clinchem.2005.055798
Genomewide Association Studies and Assessment of the Risk of Disease, New England Journal of Medicine, vol.363, issue.2, pp.166-176, 2010. ,
DOI : 10.1056/NEJMra0905980
Metabolic syndrome: Definition, pathophysiology, and mechanisms, American Heart Journal, vol.149, issue.1, pp.33-45, 2005. ,
DOI : 10.1016/j.ahj.2004.07.013
Diagnosis and management of the metabolic syndrome, Current Opinion in Cardiology, vol.21, issue.1, pp.2735-2752, 2005. ,
DOI : 10.1097/01.hco.0000200416.65370.a0
Metabolic syndrome-a new world-wide definition. A Consensus Statement from the International Diabetes Federation, Diabetic Medicine, vol.46, issue.5, pp.469-480, 2006. ,
DOI : 10.1001/jama.290.4.486
Appropriate definition of metabolic syndrome among Iranian adults ,
Gender differences in prevalence of the metabolic syndrome in Gulf Cooperation Council Countries: a systematic review, Diabetic Medicine, vol.13, issue.5, pp.593-597, 2010. ,
DOI : 10.1111/j.1467-789X.2009.00655.x
Metabolic syndrome-related composite factors over 5 years in the STANISLAS family study: Genetic heritability and common environ-mental influences, Clin Chim Acta, vol.3411, pp.833-839, 2010. ,
Prevalence of type 2 diabetes mellitus in Iran and its relationship with gender, urbanisation, education, marital status and occupation, Singapore Med J, vol.49, pp.571-576, 2008. ,
Metabolic syndrome: Its prevalence and relationship to socio-economic parameters in an Iranian population, Nutrition, Metabolism and Cardiovascular Diseases, vol.18, issue.3, pp.11-12, 2008. ,
DOI : 10.1016/j.numecd.2007.07.005
Prevalence of metabolic syndrome in an urban population: Tehran Lipid and Glucose Study, Diabetes Research and Clinical Practice, vol.61, issue.1, pp.29-37, 2003. ,
DOI : 10.1016/S0168-8227(03)00066-4
Predictive power of the components of metabolic syndrome in its development: a 6.5-year follow-up in the Tehran Lipid and Glucose Study (TLGS), European Journal of Clinical Nutrition, vol.77, issue.10, pp.1207-1214, 2010. ,
DOI : 10.2337/dc07-0959
Potential Link of Microalbuminuria with Metabolic Syndrome in Patients Undergoing Coronary Angiography, Archives of Medical Research, vol.40, issue.5, pp.399-405, 2009. ,
DOI : 10.1016/j.arcmed.2009.06.011
Prevalence of meta-bolic syndrome among middle aged women in Babol, Iran. Southeast Asian J Trop Med Public Health, vol.40, pp.612-628, 2009. ,
First Nationwide Study of the Prevalence of the Metabolic Syndrome and Optimal Cutoff Points of Waist Circumference in the Middle East: The National Survey of Risk Factors for Noncommunicable Diseases of Iran, Diabetes Care, vol.32, issue.6, pp.1092-1097, 2009. ,
DOI : 10.2337/dc08-1800
Metabolic Syndrome and Related Insulin Levels in Obese Children, Metabolic Syndrome and Related Disorders, vol.4, issue.3, pp.172-178, 2006. ,
DOI : 10.1089/met.2006.4.172
High Prevalence of the Metabolic Syndrome in Iranian Adolescents*, Obesity, vol.6, issue.3, pp.377-382, 2006. ,
DOI : 10.1038/oby.2006.50
[Metabolic syndrome: Epidemiology and its risks], Ann Dermatol Venereol, vol.135, pp.249-253, 2008. ,
Household Income Is Associated With the Risk of Metabolic Syndrome in a Sex-Specific Manner, Diabetes Care, vol.28, issue.2, pp.409-415, 2005. ,
DOI : 10.2337/diacare.28.2.409
Metabolic syndrome: Prevalence, risk factors and mortality in a French population of 62 000 subjects], Bull Acad Natl Med, vol.190, pp.685-697, 2006. ,
Metabolic syndrome is associated with markers of subclinical atherosclerosis in a French population-based sample, Atherosclerosis, vol.186, issue.2, pp.345-353, 2006. ,
DOI : 10.1016/j.atherosclerosis.2005.07.021
The incidence and persistence of the NCEP (National Cholesterol Education Program) metabolic syndrome. The French D.E.S.I.R. study, Diabetes & Metabolism, vol.29, issue.5, pp.526-532, 2003. ,
DOI : 10.1016/S1262-3636(07)70067-8
Epidemiology of the metabolic syndrome in 2045 French military personnel (EPIMIL study), Diabetes & Metabolism, vol.31, issue.4, pp.353-359, 2005. ,
DOI : 10.1016/S1262-3636(07)70204-5
Metabolic syn-drome and coronary heart disease risk in a population-based study of middle-aged men from France and Northern Ire-land. A nested case-control study from the PRIME cohort, Diabetes Metab, vol.32, issue.5, 2006. ,
Pr??valence des anomalies m??taboliques chez l???enfant ob??se, Archives de P??diatrie, vol.16, issue.7, pp.991-998, 2009. ,
DOI : 10.1016/j.arcped.2009.03.022
A Prospective Study on the Prevalence of Metabolic Syndrome Among Healthy French Families: Two cardiovascular risk factors (HDL cholesterol and tumor necrosis factor-??) are revealed in the offspring of parents with metabolic syndrome, Diabetes Care, vol.28, issue.3, pp.675-682, 2005. ,
DOI : 10.2337/diacare.28.3.675
Cardiovascular risk markers associated with the metabolic syndrome in a large French population: the SYMFONIE study, Diabetes & Metabolism, vol.32, issue.5, pp.467-474, 2006. ,
DOI : 10.1016/S1262-3636(07)70305-1