Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC): Molecular mechanisms and novel paradigms, Pathologie Biologie, vol.58, issue.4, pp.278-287, 2010. ,
DOI : 10.1016/j.patbio.2010.05.001
Wacholder The Lancet, pp.890-907, 2007. ,
Risk of breast cancer associated with papilloma, European Journal of Surgical Oncology (EJSO), vol.34, issue.12, pp.1304-1308, 2008. ,
DOI : 10.1016/j.ejso.2008.03.013
5-Arylidene-2-imino-4-thiazolidinones: Design and synthesis of novel anti-inflammatory agents, Bioorganic & Medicinal Chemistry, vol.13, issue.13, pp.4243-4252, 2005. ,
DOI : 10.1016/j.bmc.2005.04.058
Wijers Recueil des Travaux Chimiques des Pays-Bas 1963, pp.68-74 ,
Reaction of selenium with sodium borohydride in protic solvents. A Facile Method for the introduction of selenium into organic molecules, Journal of the American Chemical Society, vol.95, issue.1, pp.197-199, 1973. ,
DOI : 10.1021/ja00782a034
One-pot synthesis of substituted 3-amino-2-nitrothiophenes and selenophenes, Tetrahedron, vol.64, issue.14, pp.3232-3235, 2008. ,
DOI : 10.1016/j.tet.2008.01.078
Ansari Acta Polonia Pharm, Drug. Res, vol.66, pp.387-392, 2009. ,
Antitumour benzothiazoles. Part 10: The synthesis and antitumour activity of benzothiazole substituted quinol derivatives, Bioorganic & Medicinal Chemistry Letters, vol.10, issue.5, pp.513-515, 2000. ,
DOI : 10.1016/S0960-894X(00)00027-5
Patellazole C: a novel cytotoxic macrolide from Lissoclinum patella, Journal of the American Chemical Society, vol.110, issue.23, pp.7919-7920, 1988. ,
DOI : 10.1021/ja00231a077
Mycothiazole, a polyketide heterocycle from a marine sponge, Journal of the American Chemical Society, vol.110, issue.13, pp.4365-4368, 1988. ,
DOI : 10.1021/ja00221a042
Thiazoles and their Benzo Derivatives, 1984. ,
DOI : 10.1016/B978-008096519-2.00087-4
One-pot synthesis of new 2,4,5-trisubstituted 1,3-thiazoles and 1,3-selenazoles, Tetrahedron, vol.65, issue.15, pp.2982-2988, 2009. ,
DOI : 10.1016/j.tet.2009.01.104
Synthesis of 3-heteroarylthioquinoline derivatives and their in??vitro antituberculosis and cytotoxicity studies, European Journal of Medicinal Chemistry, vol.46, issue.10, pp.4897-4903, 2011. ,
DOI : 10.1016/j.ejmech.2011.07.046
Synthesis and antioxidant properties of novel N-methyl-1,3,4-thiadiazol-2-amine and 4-methyl-2H-1,2,4-triazole-3(4H)-thione derivatives of benzimidazole class, Bioorganic & Medicinal Chemistry, vol.16, issue.8, pp.4294-4303, 2008. ,
DOI : 10.1016/j.bmc.2008.02.077
m, 5 H, 5 × CH), 7.66 (s, 1 H, CH, m, 2 H, 2 × CH, pp.43-50 ,
51 (m, 3 H, 3 × CH), 7.62 (s, 1 H, CH), 86 (d, 2 H, 2 × CH, J=7.5Hz), 9.70 (s, 1 H, NH), 9.92 (s, 1 H, NH), pp.3148-745 ,
71 (s, 1 H, CH), 9.76 (s, 1 H, NH), 9.92 (s, 1 H, NH), p.49 ,
(4-Méthoxyphényl)-3-thiénylamino, pp.4-217 ,
Point de fusion : 238°C RMN 1 H : (250MHz, DMSO-d 6 ) H 2.37 (s, 3 H, CH 3 ,
5-Phényl-3-thiénylamino, pp.5-9 ,
5-Phényl-3-thiénylamino, pp.5-9 ,
5-Phényl-3-thiénylamino, pp.5-9 ,
(5-Phényl-3-thiénylamino)-5, pp.5-14 ,
40-7.45 (m, 3 H, 3 × CH), 7.55 (s, 1 H, CH), pp.29-36 ,
5-Phényl-3-thiénylamino, pp.5-8 ,
43 (m, 5 H, 5 × CH), s, 1 H, CH), 7.62 (d, 2 H, 2 × CH, J=8.75Hz, pp.31-76177 ,
Preparation of thieno[2,3-b]pyrroles starting from ketene-N,S-acetals, Tetrahedron, vol.59, issue.9, pp.1557-1564, 2003. ,
DOI : 10.1016/S0040-4020(03)00054-1
Kirsch Synthesis, 1096. ,
Kirsch Phosphorus Sulfur Silicon Relat, Elem, vol.82, pp.91-97, 1993. ,
Kirsch Synthesis, p.735, 2003. ,
Kirsch Synthesis, pp.1428-1430, 2010. ,
Microwave-assisted synthesis of 2-aminothiophene-3-carboxylic acid derivatives, 3H-thieno[2,3-d]pyrimidin-4-one and 4-chlorothieno[2,3-d]pyrimidine, Tetrahedron Letters, vol.48, issue.30, pp.5261-5264, 2007. ,
DOI : 10.1016/j.tetlet.2007.05.136
Synthesis of substituted [1,3]thiazolo[4,5-b]pyridines and [1,3]thiazolo[4,5-d][1,2,3]triazines, Tetrahedron, vol.64, issue.39, pp.9309-9314, 2008. ,
DOI : 10.1016/j.tet.2008.07.017
Novel synthetic routes to thienocarbazoles via palladium or copper catalyzed amination or amidation of arylhalides and intramolecular cyclization, Tetrahedron, vol.58, issue.39, pp.7943-7949, 2002. ,
DOI : 10.1016/S0040-4020(02)00904-3
Palladium-catalyzed amination and cyclization to heteroannellated indoles and carbazoles, Tetrahedron, vol.59, issue.21, pp.3737-3743, 2003. ,
DOI : 10.1016/S0040-4020(03)00552-0
URL : http://bibliotecadigital.ipb.pt/bitstream/10198/817/1/2003T.PDF
Screening of New Antioxidant Molecules Using Flow Cytometry, Journal of Medicinal Chemistry, vol.43, issue.9, pp.1762-1769, 2000. ,
DOI : 10.1021/jm991019j
Some New Selenium Containing Analogues of Pyridocarbazoles and Indolocarbazoles, Phosphorus, Sulfur, and Silicon and the Related Elements, vol.272, issue.1, pp.353-356, 1998. ,
DOI : 10.1515/HC.1997.3.1.65
New thiophene analogues of kenpaullone: synthesis and biological evaluation in breast cancer cells, European Journal of Medicinal Chemistry, vol.40, issue.8, pp.757-763, 2005. ,
DOI : 10.1016/j.ejmech.2005.02.010
Antagonists as Novel Anticancer Agents, Journal of Medicinal Chemistry, vol.49, issue.15, pp.4526-4534, 2006. ,
DOI : 10.1021/jm051296s
Design, Synthesis, Cytoselective Toxicity, Structure???Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells, Journal of Medicinal Chemistry, vol.51, issue.5, pp.1242-1251, 2008. ,
DOI : 10.1021/jm7012024
PPAR?? as a new therapeutic target in inflammatory bowel diseases, Gut, vol.55, issue.9, pp.1341-1349, 2006. ,
DOI : 10.1136/gut.2006.093484
The Biology of Cancer, Edition Garland Science, 2007. ,
Lehembre Trends in Molecular Medicine, pp.535-542, 2007. ,
Projection de l'incidence et de la mortalité par cancer en France en 2011, 2011. ,
Bouizegarène Immuno-analyse et biologie spécialisée, pp.211-222, 2006. ,
Tabac et Cancer, 2011. ,
Regulatory Toxicology and Pharmacology, pp.268-280, 2011. ,
Pancreas cancer, tobacco smoking and consumption of alcoholic beverages: a case-control study, Cancer Letters, vol.116, issue.1, pp.27-32, 1997. ,
DOI : 10.1016/S0304-3835(97)04744-7
Ob??sit?? et cancer, La Revue de M??decine Interne, vol.30, issue.9, pp.776-782, 2009. ,
DOI : 10.1016/j.revmed.2009.04.007
Zhao Encyclopedia of Environmental Health, pp.26-38, 2011. ,
Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC): Molecular mechanisms and novel paradigms, Pathologie Biologie, vol.58, issue.4, pp.278-287, 2010. ,
DOI : 10.1016/j.patbio.2010.05.001
The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide, Journal of Hepatology, vol.45, issue.4, pp.529-538, 2006. ,
DOI : 10.1016/j.jhep.2006.05.013
Wacholder The Lancet, pp.890-907, 2007. ,
Risk of breast cancer associated with papilloma, European Journal of Surgical Oncology (EJSO), vol.34, issue.12, pp.1304-1308, 2008. ,
DOI : 10.1016/j.ejso.2008.03.013
Hunt « The Cell Cycle : An Introduction, 1993. ,
DNA Replication in Eukaryotic Cells, Annual Review of Biochemistry, vol.71, issue.1, pp.333-374, 2002. ,
DOI : 10.1146/annurev.biochem.71.110601.135425
Rosenberg Cancer: Principles and Practice of Oncology 7°ed, 2004. ,
Baron Cancer treatment reviews, pp.515-523, 2003. ,
Kamen Drug Discovery Today: Therapeutic Strategies, pp.337-343, 2005. ,
Ratain The Oncologist, pp.359-364, 1997. ,
Nouvelles approches pharmacologiques de traitement des cancers, Gastroent??rologie Clinique et Biologique, vol.28, issue.2, pp.167-180, 2004. ,
DOI : 10.1016/S0399-8320(04)94872-5
Clinical Potential of Matrix Metalloprotease Inhibitors in Cancer Therapy, Drugs, vol.41, issue.6, pp.1043-1055, 2000. ,
DOI : 10.2165/00003495-200059050-00002
Tyrosine kinase inhibitors???ZD1839 (Iressa), Current Opinion in Oncology, vol.13, issue.6, pp.491-498, 2001. ,
DOI : 10.1097/00001622-200111000-00012
Imatinib Mesylate ??? A New Oral Targeted Therapy, New England Journal of Medicine, vol.346, issue.9, pp.683-693, 2002. ,
DOI : 10.1056/NEJMra013339
Flavonoid, Silibinin, Inhibits Proliferation and Promotes Cell-Cycle Arrest of Human Colon Cancer, Journal of Surgical Research, vol.143, issue.1, pp.58-65, 2007. ,
DOI : 10.1016/j.jss.2007.03.080
Synthesis and antimicrobial activity of rhodanine derivatives, European Journal of Medicinal Chemistry, vol.32, issue.9, pp.759-762, 1997. ,
DOI : 10.1016/S0223-5234(97)88919-2
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones, European Journal of Medicinal Chemistry, vol.44, issue.5, pp.2038-2043, 2009. ,
DOI : 10.1016/j.ejmech.2008.10.006
Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents, European Journal of Medicinal Chemistry, vol.48, pp.174-178, 2012. ,
DOI : 10.1016/j.ejmech.2011.12.011
Synthesis and antimicrobial activity of some new thiazolyl thiazolidine-2,4-dione derivatives, Bioorganic & Medicinal Chemistry, vol.15, issue.18, pp.6012-6017, 2007. ,
DOI : 10.1016/j.bmc.2007.06.049
Synthesis, characterization and antimicrobial activity evaluation of new 2,4-Thiazolidinediones bearing imidazo[2,1-b][1,3,4]thiadiazole moiety, Arabian Journal of Chemistry, vol.4, issue.4, pp.465-472, 2011. ,
DOI : 10.1016/j.arabjc.2010.07.012
Synthesis and antimicrobial activity of novel 2-thiazolylimino-5-arylidene-4-thiazolidinones, Bioorganic & Medicinal Chemistry, vol.14, issue.11, pp.3859-3864, 2006. ,
DOI : 10.1016/j.bmc.2006.01.043
2-Heteroarylimino-5-benzylidene-4-thiazolidinones analogues of 2-thiazolylimino-5-benzylidene-4-thiazolidinones with antimicrobial activity: Synthesis and structure???activity relationship, Bioorganic & Medicinal Chemistry, vol.16, issue.7, pp.3714-3724, 2008. ,
DOI : 10.1016/j.bmc.2008.02.001
Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs, Bioorganic & Medicinal Chemistry, vol.18, issue.1, pp.426-432, 2010. ,
DOI : 10.1016/j.bmc.2009.10.041
[[.omega.-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents, Journal of Medicinal Chemistry, vol.37, issue.23, pp.3977-3985, 1994. ,
DOI : 10.1021/jm00049a017
Novel glitazones: Design, synthesis, glucose uptake and structure???activity relationships, Bioorganic & Medicinal Chemistry Letters, vol.20, issue.6, pp.1953-1956, 2010. ,
DOI : 10.1016/j.bmcl.2010.01.125
Synthesis, glucose uptake activity and structure???activity relationships of some novel glitazones incorporated with glycine, aromatic and alicyclic amine moieties via two carbon acyl linker, European Journal of Medicinal Chemistry, vol.46, issue.3, pp.835-844, 2011. ,
DOI : 10.1016/j.ejmech.2010.12.019
In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors, Bioorganic & Medicinal Chemistry Letters, vol.21, issue.1, pp.200-203, 2011. ,
DOI : 10.1016/j.bmcl.2010.11.041
Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications, European Journal of Medicinal Chemistry, vol.46, issue.7, pp.2797-2806, 2011. ,
DOI : 10.1016/j.ejmech.2011.03.068
Synthesis and anti-inflammatory activity of new arylidene-thiazolidine-2,4-diones as PPAR?? ligands, Bioorganic & Medicinal Chemistry, vol.18, issue.11, pp.3805-3811, 2010. ,
DOI : 10.1016/j.bmc.2010.04.045
Synthesis and Biological Evaluation of Novel 5-Benzylidenethiazolidine-2,4-dione Derivatives for the Treatment of Inflammatory Diseases, Journal of Medicinal Chemistry, vol.54, issue.7, pp.2060-2068, 2011. ,
DOI : 10.1021/jm1011534
5-Arylidene-2-imino-4-thiazolidinones: Design and synthesis of novel anti-inflammatory agents, Bioorganic & Medicinal Chemistry, vol.13, issue.13, pp.4243-4252, 2005. ,
DOI : 10.1016/j.bmc.2005.04.058
Oxindole derivatives as inhibitors of TAK1 kinase, Bioorganic & Medicinal Chemistry Letters, vol.21, issue.6, pp.1724-1727, 2011. ,
DOI : 10.1016/j.bmcl.2011.01.077
Beyond peroxisome proliferator-activated receptor ?? signaling: the multi-facets of the antitumor effect of thiazolidinediones, Endocrine Related Cancer, vol.13, issue.2, pp.401-413, 2006. ,
DOI : 10.1677/erc.1.01182
3,5-Disubstituted-thiazolidine-2,4-dione analogs as anticancer agents: Design, synthesis and biological characterization, European Journal of Medicinal Chemistry, vol.47, pp.125-137, 2012. ,
DOI : 10.1016/j.ejmech.2011.10.031
Synthesis and Anticancer Activity of Indolin-2-one Derivatives Bearing the 4-Thiazolidinone Moiety, Archiv der Pharmazie, vol.41, issue.1, pp.73-80, 2012. ,
DOI : 10.1021/jm970590k
P-Glycoprotein-Independent Apoptosis Induction by a Novel Synthetic Compound, MMPT [5-[(4-Methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone], Journal of Pharmacology and Experimental Therapeutics, vol.314, issue.1, pp.355-362, 2005. ,
DOI : 10.1124/jpet.105.085654
Antagonists as Novel Anticancer Agents, Journal of Medicinal Chemistry, vol.49, issue.15, pp.4526-4534, 2006. ,
DOI : 10.1021/jm051296s
Kirsch Synthesis, pp.2543-2546, 2010. ,
Synthesis of novel 2-aminothieno[3,2-d]thiazoles and selenolo[3,2-d]thiazoles, Tetrahedron, vol.67, issue.48, pp.9352-9357, 2011. ,
DOI : 10.1016/j.tet.2011.09.134
Heterocyclen aus CH-aciden Nitrilen, VIII. 2-Amino-thiophene aus methylenaktiven Nitrilen, Carbonylverbindungen und Schwefel, Chemische Berichte, vol.1963, issue.1, pp.94-100, 1966. ,
DOI : 10.1002/cber.19660990116
Kirsch Synthesis, pp.2935-2940, 2011. ,
Design and synthesis of some new thiophene, thienopyrimidine and thienothiadiazine derivatives of antipyrine as potential antimicrobial agents, European Journal of Medicinal Chemistry, vol.46, issue.9, pp.4566-4572, 2011. ,
DOI : 10.1016/j.ejmech.2011.07.035
Thiophene and its derivatives, p.656, 1986. ,
Substituted 3-amino-thiophenes and 3-amino-selenophenes from ?-chloro-?-cyano-cinnamonitrile, Monatshefte f???r Chemie Chemical Monthly, vol.95, issue.5, pp.455-459, 1992. ,
DOI : 10.1007/BF00817601
158. a) H. Rheinboldt Methoden der organischen chemie, schwefel-, selen-, tellurvrebindungen Selenium and Tellurium Chemistry, Ann. Chim. Thieme Verlag, p.10, 1962. ,
Chemistry of Biologically Important Synthetic Organoselenium Compounds, Chemical Reviews, vol.101, issue.7, pp.2125-2179, 2001. ,
DOI : 10.1021/cr000426w
Antioxidant-Prooxidant Properties of a New Organoselenium Compound Library, Molecules, vol.15, issue.10, pp.7292-7312, 2010. ,
DOI : 10.3390/molecules15107292
ANTIFUNGAL, ANTIBACTERIAL, ANTIVIRAL AND CYTOTOXIC ACTIVITY OF NOVEL THIO- AND SELENO-AZOLES, Pharmacological Research, vol.36, issue.3, pp.193-197, 1997. ,
DOI : 10.1006/phrs.1997.0224
Wijers Recueil des Travaux Chimiques des Pays-Bas 1963, pp.68-74 ,
Reaction of selenium with sodium borohydride in protic solvents. A Facile Method for the introduction of selenium into organic molecules, Journal of the American Chemical Society, vol.95, issue.1, pp.197-199, 1973. ,
DOI : 10.1021/ja00782a034
Kirsch Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, pp.1201-1203, 1974. ,
One-pot synthesis of substituted 3-amino-2-nitrothiophenes and selenophenes, Tetrahedron, vol.64, issue.14, pp.3232-3235, 2008. ,
DOI : 10.1016/j.tet.2008.01.078
Synthesis and antileishmanial activity of (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives, European Journal of Medicinal Chemistry, vol.39, issue.8, pp.685-690, 2004. ,
DOI : 10.1016/j.ejmech.2004.04.006
Ansari Acta Polonia Pharm, Drug. Res, vol.66, pp.387-392, 2009. ,
Antidiabetic activity of N-(6-substituted-1,3-benzothiazol-2-yl)benzenesulfonamides, Bioorganic & Medicinal Chemistry Letters, vol.18, issue.9, pp.2871-2877, 2008. ,
DOI : 10.1016/j.bmcl.2008.03.086
Antitumour benzothiazoles. Part 10: The synthesis and antitumour activity of benzothiazole substituted quinol derivatives, Bioorganic & Medicinal Chemistry Letters, vol.10, issue.5, pp.513-515, 2000. ,
DOI : 10.1016/S0960-894X(00)00027-5
Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines, Bioorganic & Medicinal Chemistry, vol.16, issue.7, p.3626, 2008. ,
DOI : 10.1016/j.bmc.2008.02.005
Ueber Bildung von Anhydroverbindungen des Orthoamidophenylmercaptans aus Thioaniliden, Berichte der deutschen chemischen Gesellschaft, vol.207, issue.1, p.1067 ,
DOI : 10.1002/cber.188601901239
Building a model of interaction at the NK-2 receptors: Polycondensed heterocycles containing the pyrimidoindole skeleton, European Journal of Medicinal Chemistry, vol.32, issue.12, p.973, 1997. ,
DOI : 10.1016/S0223-5234(97)89641-9
Patellazole C: a novel cytotoxic macrolide from Lissoclinum patella, Journal of the American Chemical Society, vol.110, issue.23, pp.7919-7920, 1988. ,
DOI : 10.1021/ja00231a077
Mycothiazole, a polyketide heterocycle from a marine sponge, Journal of the American Chemical Society, vol.110, issue.13, pp.4365-4368, 1988. ,
DOI : 10.1021/ja00221a042
Thiazoles and their Benzo Derivatives, 1984. ,
DOI : 10.1016/B978-008096519-2.00087-4
2-Alkylmercapto-4-amino-thiazole, Justus Liebigs Annalen der Chemie, vol.245, issue.1, pp.125-130, 1972. ,
DOI : 10.1002/zfch.19690090402
One-pot synthesis of new 2,4,5-trisubstituted 1,3-thiazoles and 1,3-selenazoles, Tetrahedron, vol.65, issue.15, pp.2982-2988, 2009. ,
DOI : 10.1016/j.tet.2009.01.104
Etude du m??canisme de la r??action de hantzsch des thiazoles. II. premi??re ??tape: Action des c??tones-?? halog??n??es sur les thioamides, Journal of Heterocyclic Chemistry, vol.74, issue.6, p.1205, 1976. ,
DOI : 10.1135/cccc19600108
2-(Diethylamino)thieno[1,3]oxazin-4-ones as Stable Inhibitors of Human Leukocyte Elastase, Journal of Medicinal Chemistry, vol.42, issue.26, pp.5437-5447, 1999. ,
DOI : 10.1021/jm991108w
2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers, Bioorganic & Medicinal Chemistry, vol.14, issue.7, pp.2358-2365, 2006. ,
DOI : 10.1016/j.bmc.2005.11.018
and Pd/C, The Journal of Organic Chemistry, vol.64, issue.24, pp.8962-8964, 1999. ,
DOI : 10.1021/jo991112f
A User-Friendly Entry to 2-Iodoxybenzoic Acid (IBX), The Journal of Organic Chemistry, vol.64, issue.12, pp.4537-4538, 1999. ,
DOI : 10.1021/jo9824596
Oxidation of Alcohols with o-Iodoxybenzoic Acid in DMSO: A New Insight into an Old Hypervalent Iodine Reagent, The Journal of Organic Chemistry, vol.60, issue.22, pp.7272-7276, 1995. ,
DOI : 10.1021/jo00127a036
A simple method for the oxidation of primary alcohols with o-iodoxybenzoic acid (IBX) in the presence of acetic acid, Tetrahedron, vol.66, issue.51, pp.9688-9693, 2010. ,
DOI : 10.1016/j.tet.2010.10.053
Microwave-Assisted Parallel Synthesis of Fused Heterocycles in a Novel Parallel Multimode Reactor, Journal of Combinatorial Chemistry, vol.10, issue.6, p.863, 2008. ,
DOI : 10.1021/cc800081b
Beifuss Comprehensive Organic Synthesis, pp.341-394, 1991. ,
A novel synthesis of some 2-imino-4-thiazolidinone derivatives, Journal of Heterocyclic Chemistry, vol.45, issue.1, pp.35-38, 2007. ,
DOI : 10.1271/bbb1961.46.557
Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino) phenyl-N???-phenyl-thiourea, Bioorganic & Medicinal Chemistry, vol.19, issue.18, pp.5708-5715, 2011. ,
DOI : 10.1016/j.bmc.2011.06.077
Rollas Il Farmaco, pp.577-581, 2002. ,
Synthesis and cytotoxic evaluation of thiourea and N-bis-benzothiazole derivatives: A novel class of cytotoxic agents, Bioorganic & Medicinal Chemistry Letters, vol.22, issue.1, pp.453-455, 2012. ,
DOI : 10.1016/j.bmcl.2011.10.106
Synthesis of 3-heteroarylthioquinoline derivatives and their in??vitro antituberculosis and cytotoxicity studies, European Journal of Medicinal Chemistry, vol.46, issue.10, pp.4897-4903, 2011. ,
DOI : 10.1016/j.ejmech.2011.07.046
Synthesis and antioxidant properties of novel N-methyl-1,3,4-thiadiazol-2-amine and 4-methyl-2H-1,2,4-triazole-3(4H)-thione derivatives of benzimidazole class, Bioorganic & Medicinal Chemistry, vol.16, issue.8, pp.4294-4303, 2008. ,
DOI : 10.1016/j.bmc.2008.02.077
Synthesis and antileishmanial activity of novel 5-(5-nitrofuran-2-y1)-1,3,4-thiadiazoles with piperazinyl-linked benzamidine substituents, European Journal of Medicinal Chemistry, vol.46, issue.6, pp.2602-2608, 2011. ,
DOI : 10.1016/j.ejmech.2011.03.053
Studies on fused heterocyclic 3,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazoles: synthesis and biological evaluation, Medicinal Chemistry Research, vol.100, issue.1, pp.47-54, 2011. ,
DOI : 10.3181/00379727-111-27849
1,3,4-Thiadiazole Derivatives. Synthesis, Structure Elucidation, and Structure???Antituberculosis Activity Relationship Investigation, Journal of Medicinal Chemistry, vol.47, issue.27, pp.6760-6767, 2004. ,
DOI : 10.1021/jm0495632
Synthesis, cytotoxicity and effects of some 1,2,4-triazole and 1,3,4-thiadiazole derivatives on immunocompetent cells, European Journal of Medicinal Chemistry, vol.44, issue.1, pp.63-69, 2009. ,
DOI : 10.1016/j.ejmech.2008.03.006
One-pot synthesis and anticancer studies of 2-arylamino-5-aryl-1,3,4-thiadiazoles, Bioorganic & Medicinal Chemistry Letters, vol.21, issue.8, pp.2320-2323, 2011. ,
DOI : 10.1016/j.bmcl.2011.02.083
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays, Journal of Immunological Methods, vol.65, issue.1-2, pp.55-63, 1983. ,
DOI : 10.1016/0022-1759(83)90303-4
Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of CDC25 phosphatases, Molecular Cancer Therapeutics, vol.4, issue.9, pp.1378-1387, 2005. ,
DOI : 10.1158/1535-7163.MCT-05-0168
URL : https://hal.archives-ouvertes.fr/hal-00317405
Microwave-assisted synthesis of 2-aminothiophene-3-carboxylic acid derivatives, 3H-thieno[2,3-d]pyrimidin-4-one and 4-chlorothieno[2,3-d]pyrimidine, Tetrahedron Letters, vol.48, issue.30, pp.5261-2153, 2007. ,
DOI : 10.1016/j.tetlet.2007.05.136
Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs, Bioorganic & Medicinal Chemistry, vol.18, issue.1, p.426, 2010. ,
DOI : 10.1016/j.bmc.2009.10.041
Synthesis and antimicrobial activity of novel 2-thiazolylimino-5-arylidene-4-thiazolidinones, Bioorganic & Medicinal Chemistry, vol.14, issue.11, p.3859, 2006. ,
DOI : 10.1016/j.bmc.2006.01.043
]pyrimidines, Journal of Heterocyclic Chemistry, vol.60, issue.6, p.1757, 1986. ,
DOI : 10.1002/recl.19730920614
Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs, Bioorganic & Medicinal Chemistry, vol.18, issue.1, p.426, 2010. ,
DOI : 10.1016/j.bmc.2009.10.041
Reeve's synthesis of 2-imino-4-thiazolidinone from alkyl (aryl) trichloromethylcarbinol revisited, a three-component process from aldehyde, chloroform and thiourea, Tetrahedron Letters, vol.45, issue.23, pp.4449-65, 2004. ,
DOI : 10.1016/j.tetlet.2004.04.055
Synthesis 2010, 2543 and references cited therein for the synthesis of 3-aminothiophenes ,
04 (s, 1 H, CH), 7.33 (s, 2 H ,
Yield: 76%; pale rose solid; mp 148 °C. 1 H NMR (250 MHz39 (s, 1 H, CH), CH 3 ), 4.22 (q, J = 7 Hz (m, 1 H, CH), pp.3-41 ,
45 (s, 2 H, NH 2 ) 13 C NMR (62.5 MHz, DMSO-d 6 ): d = 14, 7.35 (d, J = 7.75 Hz, 2 H, 2 CH) ,
Potent and selective thiophene urea-templated inhibitors of S6K, Bioorganic & Medicinal Chemistry Letters, vol.21, issue.2, p.849, 2011. ,
DOI : 10.1016/j.bmcl.2010.11.069
Yield: 43%; brown solid; mp 111 C. 1 H NMR (250 MHz30 (s, 1H, CH), 4.16 (q, d¼1.23 (t, J¼7.1 Hz, 3H, CH 3 ) 2H, NH 2 ), 7.20 (s, 1H, CH), pp.14-19 ,
2-selenophenecarboxylic acid (2b) Yield: 78%; pale brown solid; mp 114 C. 1 H NMR (250 MHz, DMSO-d 6 ): d¼7.26 (s, 1H, CH), J¼8.0 Hz, 2H, 2Â CH). 13 C NMR (62.5 MHz2Â CH)2Â CH), pp.98-102 ,
Yield: 95%; brown solid; mp 156 C. 1 H NMR (250 MHz, DMSO-d 6 ): d¼3.80 (s, 3H, CH 3 ), 6.96 (d, J¼8, J¼8.0 Hz, 2H, 2Â CH). 13 C NMR (62.5 MHz2Â CH)2Â CH), pp.47-55 ,
-methoxyphenyl)seleno phene (4d) Yield: 68%; brown oil. 1 H NMR (250 MHz CDCl 3 ): d¼3.78 (s, 3H, CH 3, J¼1.5 Hz, 1H, CH) J¼1.5 Hz, 1H, CH). 13 C NMR (62.5 MHz2Â CH), pp.55-59 ,
Yield: 47%; brown solid; mp 180 C. 1 H NMR (250 MHz, d¼7.30 (t, J¼7.5 Hz, 1H, CH) J¼7.5 Hz, 2H, 2Â CH), 7.62 (s, 1H, CH), 8.02 (s, 1H, CH), 9.88 (s, 1H, NH). 13 C NMR (62.5 MHz, DMSO-d 6 ): d¼122.9 (CH)2Â CH) ,
Yield: 81%; brown solid; mp 185 C. 1 H NMR (250 MHz 13 C NMR (62.5 MHz, DMSO-d 6 ): d¼55.3 (OCH 3 ) HRMS (ESI): m/z calcd for [C 12 H 12 N 2 OSSeþH] þ : 312.9908; found: 312.9823. 4.6.5. N-(5-Phenyl-3-thienyl)thiourea (5e) Yield: 86%; orange solid; mp 198 C HRMS (ESI): m/z calcd forChlorophenyl)-3-thienyl)thiourea (5f) Yield: 77%; pale brown solid, 2Â CH), 114.8 (C), 121.5 (CH), 126.7 (2Â CH), 127.7 (C), 128.1 (CH) 1H, CH), 7.38e7.44 (m, 3H, 3Â CH), 7.52 (s, 1H, CH), 7.59 (d, J¼7.25 Hz, 2H, 2Â CH), 9.89 (s, 1H, NH). 13 C NMR2Â CH) (s, 1H, CH), 7.62 (d, J¼8.5 Hz, 2H, 2Â CH), 9.88 (s, 1H, NH). 13 C NMR (62.5 MHz, DMSOd 6 ): d¼120.6 (CH)2Â CH)2Â CH)CH), pp.3-77 ,
HRMS (ESI3-thienyl)thiourea (5g) Yield: 64%; pale orange solid; mp 208 C. 1 H NMR (250 MHz, DMSO-d 6 ): d¼3.76 (s, 3H, CH 382 (s, 1H, NH) 13 C NMR (62.5 MHz, DMSO-d 6 ): d¼55.2 (OCH 3 ) HRMS (ESI): m/z calcd forthienyl)thiourea (5h) Yield: 87%; brown solid, 1H, CH), 7.41 (s, 1H, CH), 7.52 (d, J¼8.5 Hz, 2H, 2Â CH) 1250 (C]S) cm À1 . 4.6.8. N- Hz, 2H, CH 2 ), 2.88 (t, J¼8.0 Hz, 2H, CH 2 ), 7.15e7.31 (m, 4H, 4Â CH), 7.51 (s, 1H, CH), 9.30 (s, 1H, NH). 13 C NMR (62.5 MHz (C]S). HRMS (ESI): m/z calcd for, pp.3142-3163 ,
23 (s, 1H, NH), 10.48 (s, 1H, NH) 13 C NMR (62.5 MHz, DMSO-d 6 ): d¼55.2 (OCH 3 ) HRMS (ESI): m/z calcd for, J¼8.5 Hz, 2H, 2Â CH)2Â CH)2Â CH), pp.3-7797 ,
Yield: 86%; green solid; mp 149 C. 1 H NMR (250 MHz, DMSO-d 6 ): d¼7.13 (s, 2H, 2Â CH), pp.116-121 ,
HRMS (ESI): m/ z calcd for ,
HRMS (ESI): m/z calcd for, pp.310-9756 ,
Yield: 86%; green solid; mp 186 C. 1 H NMR (250 MHz, DMSO-d 6 ): d¼7.25 (s, 2H, Hz, 2H, 2Â CH). 13 C NMR (62.5 MHz, DMSO-d 6 ): d¼114.1 (CH)2Â CH)CH), p.3 ,
HRMS (ESI Yield: 91%; yellow solid; mp 233 C. 1 H NMR (250 MHz30 (s, 2H, NH 2 ) 13 C NMR (62.5 MHz, DMSO-d 6 ): d¼22 HRMS (ESI): m/z calcd forMethoxyphenyl)thieno[3,2-d][1,3]thiazol-2(1H)imine (6 0 g) Yield: 65%; orange solid; mp 259 C. 1 H NMR (250 MHz, DMSO-d 6 ): d¼3, DMSO-d 6 ): d¼2.79 (t, J¼7.0 Hz, 2H, CH 2 ), 2.91 (t, J¼7.0 Hz, 2H, CH 2 131.6 (C), 133.9 (CH) (C]N) cm À1 . References and notes 1, pp.7-10 ,
Synthesis of Pyridothienopyridines and Arylazothienopyridines, Phosphorus, Sulfur, and Silicon and the Related Elements, vol.178, issue.12, p.2639, 2003. ,
DOI : 10.1080/714040977
Synthesis of novel 2-aminothieno[3,2-d]thiazoles and selenolo[3,2-d]thiazoles, Tetrahedron, vol.67, issue.48, pp.9352-9357, 2011. ,
DOI : 10.1016/j.tet.2011.09.134