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. Hz, 04 (s, 1 H, CH), 7.33 (s, 2 H

C. Ethyl, Yield: 76%; pale rose solid; mp 148 °C. 1 H NMR (250 MHz39 (s, 1 H, CH), CH 3 ), 4.22 (q, J = 7 Hz (m, 1 H, CH), pp.3-41

. Hz, 45 (s, 2 H, NH 2 ) 13 C NMR (62.5 MHz, DMSO-d 6 ): d = 14, 7.35 (d, J = 7.75 Hz, 2 H, 2 CH)

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2. Ethyl and . Ch, Yield: 43%; brown solid; mp 111 C. 1 H NMR (250 MHz30 (s, 1H, CH), 4.16 (q, d¼1.23 (t, J¼7.1 Hz, 3H, CH 3 ) 2H, NH 2 ), 7.20 (s, 1H, CH), pp.14-19

2. and 2. Ch, 2-selenophenecarboxylic acid (2b) Yield: 78%; pale brown solid; mp 114 C. 1 H NMR (250 MHz, DMSO-d 6 ): d¼7.26 (s, 1H, CH), J¼8.0 Hz, 2H, 2Â CH). 13 C NMR (62.5 MHz2Â CH)2Â CH), pp.98-102

2. Hz, 1. Chs, and C. , Yield: 95%; brown solid; mp 156 C. 1 H NMR (250 MHz, DMSO-d 6 ): d¼3.80 (s, 3H, CH 3 ), 6.96 (d, J¼8, J¼8.0 Hz, 2H, 2Â CH). 13 C NMR (62.5 MHz2Â CH)2Â CH), pp.47-55

2. and 2. Ch, -methoxyphenyl)seleno phene (4d) Yield: 68%; brown oil. 1 H NMR (250 MHz CDCl 3 ): d¼3.78 (s, 3H, CH 3, J¼1.5 Hz, 1H, CH) J¼1.5 Hz, 1H, CH). 13 C NMR (62.5 MHz2Â CH), pp.55-59

2. and 2. Ch, Yield: 47%; brown solid; mp 180 C. 1 H NMR (250 MHz, d¼7.30 (t, J¼7.5 Hz, 1H, CH) J¼7.5 Hz, 2H, 2Â CH), 7.62 (s, 1H, CH), 8.02 (s, 1H, CH), 9.88 (s, 1H, NH). 13 C NMR (62.5 MHz, DMSO-d 6 ): d¼122.9 (CH)2Â CH)

2. , 2. Ch-1h, C. Chs, 1. , and 1. , Yield: 81%; brown solid; mp 185 C. 1 H NMR (250 MHz 13 C NMR (62.5 MHz, DMSO-d 6 ): d¼55.3 (OCH 3 ) HRMS (ESI): m/z calcd for [C 12 H 12 N 2 OSSeþH] þ : 312.9908; found: 312.9823. 4.6.5. N-(5-Phenyl-3-thienyl)thiourea (5e) Yield: 86%; orange solid; mp 198 C HRMS (ESI): m/z calcd forChlorophenyl)-3-thienyl)thiourea (5f) Yield: 77%; pale brown solid, 2Â CH), 114.8 (C), 121.5 (CH), 126.7 (2Â CH), 127.7 (C), 128.1 (CH) 1H, CH), 7.38e7.44 (m, 3H, 3Â CH), 7.52 (s, 1H, CH), 7.59 (d, J¼7.25 Hz, 2H, 2Â CH), 9.89 (s, 1H, NH). 13 C NMR2Â CH) (s, 1H, CH), 7.62 (d, J¼8.5 Hz, 2H, 2Â CH), 9.88 (s, 1H, NH). 13 C NMR (62.5 MHz, DMSOd 6 ): d¼120.6 (CH)2Â CH)2Â CH)CH), pp.3-77

2. and 2. Ch, HRMS (ESI3-thienyl)thiourea (5g) Yield: 64%; pale orange solid; mp 208 C. 1 H NMR (250 MHz, DMSO-d 6 ): d¼3.76 (s, 3H, CH 382 (s, 1H, NH) 13 C NMR (62.5 MHz, DMSO-d 6 ): d¼55.2 (OCH 3 ) HRMS (ESI): m/z calcd forthienyl)thiourea (5h) Yield: 87%; brown solid, 1H, CH), 7.41 (s, 1H, CH), 7.52 (d, J¼8.5 Hz, 2H, 2Â CH) 1250 (C]S) cm À1 . 4.6.8. N- Hz, 2H, CH 2 ), 2.88 (t, J¼8.0 Hz, 2H, CH 2 ), 7.15e7.31 (m, 4H, 4Â CH), 7.51 (s, 1H, CH), 9.30 (s, 1H, NH). 13 C NMR (62.5 MHz (C]S). HRMS (ESI): m/z calcd for, pp.3142-3163

3. Hz, 2. , 2. Ch-1h, 1. Ch-)-s, and C. , 23 (s, 1H, NH), 10.48 (s, 1H, NH) 13 C NMR (62.5 MHz, DMSO-d 6 ): d¼55.2 (OCH 3 ) HRMS (ESI): m/z calcd for, J¼8.5 Hz, 2H, 2Â CH)2Â CH)2Â CH), pp.3-7797

1. Phenylselenolo, 1. Ch-)-s, and C. , Yield: 86%; green solid; mp 149 C. 1 H NMR (250 MHz, DMSO-d 6 ): d¼7.13 (s, 2H, 2Â CH), pp.116-121

2. Ch-), HRMS (ESI): m/ z calcd for

2. Ch-), HRMS (ESI): m/z calcd for, pp.310-9756

1. Phenylthieno and C. , Yield: 86%; green solid; mp 186 C. 1 H NMR (250 MHz, DMSO-d 6 ): d¼7.25 (s, 2H, Hz, 2H, 2Â CH). 13 C NMR (62.5 MHz, DMSO-d 6 ): d¼114.1 (CH)2Â CH)CH), p.3

4. , 4. Ch-karthikeyan, M. S. Prasad, D. J. Mahalinga, and M. , HRMS (ESI Yield: 91%; yellow solid; mp 233 C. 1 H NMR (250 MHz30 (s, 2H, NH 2 ) 13 C NMR (62.5 MHz, DMSO-d 6 ): d¼22 HRMS (ESI): m/z calcd forMethoxyphenyl)thieno[3,2-d][1,3]thiazol-2(1H)imine (6 0 g) Yield: 65%; orange solid; mp 259 C. 1 H NMR (250 MHz, DMSO-d 6 ): d¼3, DMSO-d 6 ): d¼2.79 (t, J¼7.0 Hz, 2H, CH 2 ), 2.91 (t, J¼7.0 Hz, 2H, CH 2 131.6 (C), 133.9 (CH) (C]N) cm À1 . References and notes 1, pp.7-10

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