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. Spiro, body weight; SBP, systolic blood pressure; DBP, diastolic blood pressure; MBP, mean blood pressure; PP, pulse pressure; HR, heart rate; MCSA, media cross sectional area of the aorta. Dry weight and contents in proteins are expressed in mg/cm, media thickness in µm and MCSA in 10 3 µm². Values are mean ± SEM, *, p<0.05 vs. control group; ?, p<0.05 vs. Aldo-treated group. was connected to a data acquisition system (PowerLab, ADInstruments), and signals were monitored and digitally stored for analysis with the software Chart for Windows

. Mol, except for the Aldo (10 -8 mol/liter) time-response experiments (from 0 to 48 h) To investigate the intracellular pathways, the following reagents were added 30 min before Aldo (10 -8 mol/liter) addition: RNA synthesis inhibitor actinomycin D (10 -6 mol/liter; Calbiochem), two MR antagonists eplerenone (10 -6 mol/liter; Sigma) and RU28318 (10 -6 mol/liter, two Gal- 3 inhibitors MCP (10 -6 mol/liter; Econugenics) and LacNac (10 -6 mol/liter; Sigma)

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