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except for the Aldo (10 -8 mol/liter) time-response experiments (from 0 to 48 h) To investigate the intracellular pathways, the following reagents were added 30 min before Aldo (10 -8 mol/liter) addition: RNA synthesis inhibitor actinomycin D (10 -6 mol/liter; Calbiochem), two MR antagonists eplerenone (10 -6 mol/liter; Sigma) and RU28318 (10 -6 mol/liter, two Gal- 3 inhibitors MCP (10 -6 mol/liter; Econugenics) and LacNac (10 -6 mol/liter; Sigma) ,
Amersham Biosciences) and visualized using the Immun-Star western kit (Bio-rad) or ECL-Advance chemiluminescence detection system (Amersham) After densitometric analyses, optical density values were expressed as arbitrary units and ?-actin was used to normalise protein REFERENCES 1 A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone, Am J Physiol Heart Circ Physiol, vol.301, pp.2372-2382, 2011. ,
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