Silibinin protects against cisplatin-induced nephrotoxicity without compromising cisplatin or ifosfamide anti-tumour activity, British Journal of Cancer, vol.74, issue.12, pp.2036-2041, 1996. ,
DOI : 10.1038/bjc.1996.673
URL : http://www.nature.com/bjc/journal/v74/n12/pdf/bjc1996673a.pdf
Experimental design in supercritical fluid extraction of cocaine from coca leaves, Journal of Biochemical and Biophysical Methods, vol.43, issue.1-3, pp.353-366, 2000. ,
DOI : 10.1016/S0165-022X(00)00062-2
Silymarin education monograph. (1993) Herbal Res Update, pp.23-36 ,
Sources alimentaires des flavonoides. (1999) Pharmacognosie,phytochimie, plantes médicinales (3éme édition)Editions Tec and Doc Lavoisier, 1120. ,
Encyclopédie de botanique et de l'horticulture, 1997. ,
HPLC Analysis of Phenolic Acids in Melissa Officinalis, J. Liq. Chrom. & Rel Technol, issue.17, pp.24-2647, 2001. ,
The aromatic and polyphenolic composition of lemon balm (Melissa officinalis L. subsp. officinalis) tea, Pharmaceutica Acta Helvetiae, vol.72, issue.5, pp.72-301, 1998. ,
DOI : 10.1016/S0031-6865(97)00026-5
Supercritical fluid extraction from rosemary (Rosmarinus officinalis): Kinetic data, extract's global yield, composition, and antioxidant activity, J. of Supercritical Fluids, vol.35, pp.197-204, 2005. ,
Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways, Chemico-Biological Interactions, vol.156, issue.2-3, pp.141-150, 2005. ,
DOI : 10.1016/j.cbi.2005.08.005
Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes: Part I ,
Supercritical Fluid Extraction and Liquid Chromatography-Electrospray Mass Analysis of Vinblastine from Catharanthus roseus, CHEMICAL & PHARMACEUTICAL BULLETIN, vol.50, issue.9, pp.1294-1296, 2002. ,
DOI : 10.1248/cpb.50.1294
Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2, Molecular Carcinogenesis, vol.276, issue.3, pp.143-149, 2004. ,
DOI : 10.1016/0167-4838(83)90172-3
Fundamentals of Supercritical Fluids, 1989. ,
Investigation on the Effect of different Supercritical Fluid Extraction Process on the Activation of the R-134 Catalyst (2012)J. of Supercritical Fluids ,
Solvent extraction study of antioxidants from Balm ( Melissa officinalis L.) leaves, Food Chemistry, vol.80, issue.2, pp.275-282, 2003. ,
DOI : 10.1016/S0308-8146(02)00382-5
Concentration of Rosmarinic Acid with Supercritical Fluids, Kem. Ind, vol.52, issue.9, pp.427-432, 2003. ,
Supercritical fluid extraction and fractionation of different prepocessed rosemary plants, 1999. ,
Comparative studies of the rosmarinic and caffeic acid contents of Lamiaceae species, Biochemical Systematics and Ecology, vol.27, issue.7, pp.733-738, 1999. ,
DOI : 10.1016/S0305-1978(99)00007-1
Parallel determination of rosmarinic and caffeic acids by TLC-densitometry, Chromatographia, vol.59, issue.5-6, pp.322-324, 1997. ,
DOI : 10.1007/978-3-642-88488-7
Anti-Angiogenic Potential of a Cancer Chemopreventive Flavonoid Antioxidant, Silymarin: Inhibition of Key Attributes of Vascular Endothelial Cells and Angiogenic Cytokine Secretion by Cancer Epithelial Cells, Biochemical and Biophysical Research Communications, vol.276, issue.1, 2000. ,
DOI : 10.1006/bbrc.2000.3474
Food Chemistry, pp.279-285, 1988. ,
Baseflor : index botanique, écologique et chorologique de la flore de France (version 8, septembre, 1998. ,
Silymarin inhibits TNF-??-induced expression of adhesion molecules in human umbilical vein endothelial cells, FEBS Letters, vol.20, issue.1-3, pp.89-93, 2003. ,
DOI : 10.1093/carcin/20.11.2101
Cultivation of milk thistle ,
Industrial Crops and Products, pp.825-830, 2011. ,
Cisplatin Nephrotoxicity and Protection by Milk Thistle Extract in Rats, Evidence-Based Complementary and Alternative Medicine, vol.2, issue.3, pp.383-386, 2005. ,
DOI : 10.1093/ecam/neh103
Method for decaffeinating coffee with a supercritical fluid, 1988. ,
Identification of Essential oils by Gas Chromatography Quadrupole Mass Spectrometry, 2001. ,
Etude des molécules bioactives de la graine de Silybum Marianum ,
A NEW DEFICIENCY DISEASE PRODUCED BY THE RIGID EXCLUSION OF FAT FROM THE DIET, Nutrition Reviews, vol.31, issue.8, pp.345-367, 1929. ,
DOI : 10.1111/j.1753-4887.1973.tb06008.x
Calcium restriction induces cardenolide accumulation in cell suspension cultures of Digitalis thapsi L., Plant Cell Reports, vol.14, issue.12, pp.786-789, 1995. ,
DOI : 10.1007/BF00232923
Nigella sativa L.: Chemical composition and physicochemical characteristics of lipid fraction, Food Chemistry, vol.101, issue.2, pp.673-681, 2007. ,
DOI : 10.1016/j.foodchem.2006.02.022
Water soluble phenolics derivatives with dermocosmetic and therapeutic applications, 2006. ,
Colorimetric Method for Determination of Sugars and Related Substances, Analytical Chemistry, vol.28, issue.3, p.356, 1956. ,
DOI : 10.1021/ac60111a017
Detailed studies on some lipids of Silybum marianum (L.) seed oil, pp.397-402, 2003. ,
High pressure extraction of vitamin E-rich oil from Silybum marianumFood Chemistry Analytical, Nutritional and Clinical Methods Section, pp.355-364, 2001. ,
Cytoplasmic Acidification and Secondary Metabolite Production in Different Plant Cell Suspensions (A Comparative Study), Plant Physiology, vol.106, issue.2, pp.723-730, 1994. ,
DOI : 10.1104/pp.106.2.723
Silymarin Inhibits the Development of Diet-Induced Hypercholesterolemia in Rats, Planta Medica, vol.64, issue.02, pp.138-142, 1998. ,
DOI : 10.1055/s-2006-957391
Modification of platelet function and arachidonic acid metabolism by bioflavonoids, Biochemical Pharmacology, vol.33, issue.9, pp.1525-1530, 1984. ,
DOI : 10.1016/0006-2952(84)90423-4
Optimization of enzymatic pretreatment for n-hexane extraction of oil from Silybum marianum seeds using response surface methodology (2011) Food and bioproducts processing, pp.87-94 ,
), New Zealand Journal of Crop and Horticultural Science, vol.47, issue.3, pp.239-245, 2006. ,
DOI : 10.1073/pnas.96.13.7490
Posionnel analysis and determination of triacylglycerol Journal of the American oil chemist's society, pp.141-145, 1992. ,
Silybum marianum (Carduus marianus). (1995) Fitoterapia, pp.3-42 ,
Supercritical Fluids; Applications in the Pharmaceutical Industry, ChemInform, vol.13, issue.6, pp.83-91, 2003. ,
DOI : 10.1002/chin.200406268
Determination of silymarine in the extract from the dried silybum marianum fruits by high performance liquid chromatography and capillary electrophoresis, Journal of Pharmaceutical and Biomedical Analysis, vol.19, issue.3-4, pp.435-442, 1999. ,
DOI : 10.1016/S0731-7085(98)00231-3
Analysis of Fatty Acids in Silybum marianum Oil by GC-MS, pp.26-28, 1998. ,
arganier arbre du sud ouest marocain en péril à protéger Thèse pour l'obtention du diplôme d, 2003. ,
Screening of the antiradical action of vegetable oils, Journal of Food Composition and Analysis, vol.19, issue.8, pp.838-842, 2006. ,
DOI : 10.1016/j.jfca.2006.02.013
Supercritical fluid extraction and fractionation of natural matter, The Journal of Supercritical Fluids, vol.38, issue.2, pp.146-166, 2006. ,
DOI : 10.1016/j.supflu.2006.03.020
Nanodispersions of taxifolin: Impact of solid-state properties on dissolution behavior, International Journal of Pharmaceutics, vol.377, issue.1-2, pp.148-152, 2009. ,
DOI : 10.1016/j.ijpharm.2009.04.044
Colorimetry of total phenolics with phosphomolybdicphosphotungstic acid reagents, Am J Enol Vitic, vol.16, pp.144-158, 1965. ,
Anti-phalloidine and anti-??-amanitine action of silybin in comparison with compounds similar to structural parts of silybin, Experientia, vol.25, issue.8, pp.1051-1052, 1978. ,
DOI : 10.1007/978-94-011-6618-8_15
Inhibition of platelet aggregation by some flavonoids, Thrombosis Research, vol.64, issue.1, pp.91-100, 1991. ,
DOI : 10.1016/0049-3848(91)90208-E
Antioxidant Properties of the Flavonoids Silybin and (+)-Cyanidanol-3: Comparison with Butylated Hydroxyanisole and Butylated Hydroxytoluene, Planta Medica, vol.52, issue.06, pp.438-440, 1986. ,
DOI : 10.1055/s-2007-969247
), Biomedical Chromatography, vol.33, issue.6, pp.638-646, 2009. ,
DOI : 10.1007/BF03189968
HPLC-UV and LC-MS-MS Characterization of Silymarin in Milk Thistle Seeds and Corresponding Products, Journal of Nutraceuticals, Functional & Medical Foods, vol.4, issue.2, pp.37-38, 2003. ,
DOI : 10.1300/J133v04n02_05
The fatty acid compositions of Silybum marianum by, J.YanbianUniv.(Natural Science), vol.24, pp.26-28, 1998. ,
Skin Cancer Chemopreventive Effects of a Flavonoid Biophysical research communication, pp.294-301, 1998. ,
Some methodological problems in the determination of antioxidant activity using chromogen radicals: a practical case, Trends in Food Science & Technology, vol.11, issue.11, pp.419-421, 2000. ,
DOI : 10.1016/S0924-2244(01)00027-9
Detection and activity evaluation of radical scavenging compounds by using DPPH free radical and on-line HPLC-DPPH methods, European Food Research and Technology, pp.143-147, 2002. ,
DOI : 10.1007/s00217-001-0430-9
Antioxidant Determinations by the Use of a Stable Free Radical, Nature, vol.55, issue.4617, p.1200, 1958. ,
DOI : 10.1016/0006-3002(55)90038-X
Use of a free radical method to evaluate antioxidant activity. (1995) Lebensmittel-Wissenschaft und Technologie, pp.25-30 ,
URL : https://hal.archives-ouvertes.fr/hal-01197008
Kinetics and mechanisms of antioxidant activity using the DPPH free radical method, pp.609-615, 1997. ,
New Technologies for Automated Cell Counting Based on Optical Image Analysis ???The Cellscreen???, pp.1-3119, 2002. ,
DOI : 10.1007/978-94-010-0369-8_64
assay, Redox Report, vol.40, issue.2, pp.103-109, 2002. ,
DOI : 10.1016/S0021-9673(01)00548-9
URL : https://hal.archives-ouvertes.fr/hal-00740668
Synthèse et propriétés amphiphiles des carboxylates de sodium des monoesters des acides ? ? dicarboxyliques, 2004. ,
Isolation and characterization of human colonic bacteria able to hydrolyse chlorogenic acid, Journal of Applied Microbiology, vol.144, issue.6, pp.873-881, 2001. ,
DOI : 10.1099/00221287-144-8-2011
A Physical Directory: Or a Translation of the Dispensatory Made by the College of Physicians of London, 1650. ,
One-electron oxidation of quercetin and quercetin derivatives in protic and non protic media, Journal of the Chemical Society, Perkin Transactions 2, vol.2, issue.7, pp.1387-1395, 1999. ,
DOI : 10.1039/a901460h
on Antiproliferative End Points in Human Prostate Carcinoma Cells, Cancer Research, vol.65, issue.10, pp.4448-4457, 2005. ,
DOI : 10.1158/0008-5472.CAN-04-4662
Comparison of antioxidant activities of tocopherols alone and in pharmaceutical formulations, International Journal of Pharmaceutics, vol.262, issue.1-2, pp.93-99, 2003. ,
DOI : 10.1016/S0378-5173(03)00333-8
Assessment of drug???drug interaction for silymarin, Toxicology in Vitro, vol.22, issue.3, pp.610-617, 2008. ,
DOI : 10.1016/j.tiv.2007.11.020
Dermatologic therapies you've probably never heard of, Derm. Clin, vol.7, pp.19-35, 1989. ,
Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver, Journal of Hepatology, vol.9, issue.1, pp.105-113, 1989. ,
DOI : 10.1016/0168-8278(89)90083-4
Cultures human colon cell lines producting tumors in nude mice, J.Natl.Acad.Sci, vol.59, pp.221-226, 1977. ,
The problems of using one-dimensional methods to evaluate multifunctional food and biological antioxidants, Journal of the Science of Food and Agriculture, vol.299, issue.13, pp.1925-1941, 2000. ,
DOI : 10.1016/S0076-6879(99)99005-5
Mechanism-based in vitro screening of potential cancer chemopreventive agents, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.523, issue.524, pp.163-172, 2003. ,
DOI : 10.1016/S0027-5107(02)00332-9
[1] Role of free radicals and catalytic metal ions in human disease: An overview, Methods Enzymol, vol.186, pp.1-85, 1990. ,
DOI : 10.1016/0076-6879(90)86093-B
Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability, Gastroenterology, vol.96, issue.2, pp.736-749, 1989. ,
DOI : 10.1016/S0016-5085(89)80072-1
Flavonoid, Silibinin, Inhibits Proliferation and Promotes Cell-Cycle Arrest of Human Colon Cancer, Journal of Surgical Research, vol.143, issue.1, pp.58-65, 2007. ,
DOI : 10.1016/j.jss.2007.03.080
Antioxidative activities of water-soluble disaccharide chitosan derivatives, Food Research International, vol.37, issue.9, pp.883-889, 2004. ,
DOI : 10.1016/j.foodres.2004.04.007
A review of plants used in the treatment of liver disease: Part 1, Alternative Medicine Review, vol.3, pp.410-421, 1998. ,
Antioxidant activities of carotenes and xanthophylls, FEBS Letters, vol.22, issue.3, pp.240-242, 1996. ,
DOI : 10.3109/10715769509145649
Evaluation of the Total Antioxidant Activity as a Marker of the Deterioration of Apple Juice on Storage, Journal of Agricultural and Food Chemistry, vol.43, issue.7, pp.1794-1801, 1995. ,
DOI : 10.1021/jf00055a009
Primary culture of rat hepatocytes in 96-well plates: Effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screening, Toxicology in Vitro, vol.21, issue.1, pp.165-173, 2006. ,
DOI : 10.1016/j.tiv.2006.10.012
The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity, Songklanakrin. J Sci Technol, vol.26, pp.211-216, 2004. ,
Effects of Light, Oxygen, and pH on the Absorbance of 2,2-Diphenyl-1-picrylhydrazyl, Journal of Food Science, vol.70, issue.1, pp.487-490, 2003. ,
DOI : 10.1016/S0304-4165(98)00108-1
leaf, Journal of Zhejiang University SCIENCE, vol.5, issue.6, pp.676-683, 2004. ,
DOI : 10.1631/jzus.2004.0676
Multitargeted therapy of cancer by silymarin, Cancer Letters, vol.269, issue.2, pp.352-362, 2008. ,
DOI : 10.1016/j.canlet.2008.03.053
Antioxidant activity applying an improved ABTS radical cation decolorization assay, Free Radical Biology and Medicine, vol.26, issue.9-10, pp.9-101231, 1999. ,
DOI : 10.1016/S0891-5849(98)00315-3
[241 Total antioxidant status in plasma and body fluids, J. Methods Enzymol, vol.234, pp.279-293, 1994. ,
DOI : 10.1016/0076-6879(94)34095-1
Antioxidant activity of olive phenols: mechanistic investigation and characterization of oxidation products by mass spectrometry, Organic & Biomolecular Chemistry, vol.58, issue.3, pp.423-430, 2005. ,
DOI : 10.1016/S0023-6438(95)80008-5
The human colon carcinoma cell lines HT-29 and Caco-2: Two in vitro models for the study of intestinal differentiation, Biochimie, vol.68, issue.9, pp.1035-1040, 1985. ,
DOI : 10.1016/S0300-9084(86)80177-8
Investigation of Bolivian plant extracts for their radical scavenging activity and antioxidant activity, Life Sciences, vol.73, issue.13, pp.1667-168, 2003. ,
DOI : 10.1016/S0024-3205(03)00488-0
Selective Photometric Determination of Peroxycarboxylic Acids in the Presence of Hydrogen Peroxide, The Analyst, vol.122, issue.6, pp.567-571, 1997. ,
DOI : 10.1039/a700509a
Enterocyte-like differenciation and polarization of the human colon carcinoma cell lin Caco-2 in culture, Biology.Cell, vol.47, pp.323-330, 1983. ,
Standardized Methods for the Determination of Antioxidant Capacity and Phenolics in Foods and Dietary Supplements, Journal of Agricultural and Food Chemistry, vol.53, issue.10, pp.4290-4302, 2005. ,
DOI : 10.1021/jf0502698
Standardized Methods for the Determination of Antioxidant Capacity and Phenolics in Foods and Dietary Supplements, Journal of Agricultural and Food Chemistry, vol.53, issue.10, pp.4290-4302, 2005. ,
DOI : 10.1021/jf0502698
Effect of Silymarin on Chemical, Functional, and Morphological Alterations of the Liver, Scandinavian Journal of Gastroenterology, vol.23, issue.1, pp.517-538, 1982. ,
DOI : 10.1055/s-0028-1099644
Assessment of Antioxidant Activity by Using Different In Vitro Methods, Free Radical Research, vol.36, issue.2, pp.177-187, 2002. ,
DOI : 10.1080/10715760290006411
Silymarin and its components scavenge phenylglyoxylic ketyl radicals, Fitoterapia, vol.77, issue.7-8, pp.525-529, 2006. ,
DOI : 10.1016/j.fitote.2006.06.005
Silymarin: A Review of its Clinical Properties in the Management of Hepatic Disorders, BioDrugs, vol.122, issue.12, pp.465-489, 2001. ,
DOI : 10.2165/00063030-200115070-00005
HPLC Method for Evaluation of the Free Radical-scavenging Activity of Foods by Using 1,1-Diphenyl-2-picrylhydrazyl, Bioscience, Biotechnology, and Biochemistry, vol.43, issue.1, 1998. ,
DOI : 10.1016/0140-6736(92)91277-F
Scavenging Effect of Methanolic Extracts of Peanut Hulls on Free-Radical and Active-Oxygen Species, Journal of Agricultural and Food Chemistry, vol.42, issue.3, pp.629-632, 1994. ,
DOI : 10.1021/jf00039a005
Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention, Carcinogenesis, vol.20, issue.11, pp.20-2101, 1999. ,
DOI : 10.1289/ehp.97105s4971
Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclindependent kinases and associated cyclins, Clin. Cancer Res, vol.4, pp.1055-1064, 1998. ,
>0 t setting THE standard " Certificate of Analysis 'H-NMR SPECTRUM OF ,