G. Alloing, P. De-philip, and C. J. , Three Highly Homologous Membrane-bound Lipoproteins Participate in Oligopeptide Transport by the Ami System of the Gram-positive Streptococcus pneumoniae, Journal of Molecular Biology, vol.241, issue.1, pp.44-58, 1994.
DOI : 10.1006/jmbi.1994.1472

D. Atlan, P. Laloi, and R. Portalier, Isolation and characterization of aminopeptidase-deficient Lactobacillus bulgaricus mutants, Appl. Environ. Microbiol, vol.55, pp.1717-1723, 1989.

D. J. Banks, S. F. Porcella, K. D. Barbian, S. B. Beres, L. E. Philips et al., Metagenome: Complete Genome Sequence of a Macrolide???Resistant Serotype M6 Strain, The Journal of Infectious Diseases, vol.190, issue.4, pp.727-738, 2004.
DOI : 10.1086/422697

T. C. Barnett and S. J. , Differential Recognition of Surface Proteins in Streptococcus pyogenes by Two Sortase Gene Homologs, Journal of Bacteriology, vol.184, issue.8, pp.2181-2191, 2002.
DOI : 10.1128/JB.184.8.2181-2191.2002

R. W. Bentley, J. A. Leigh, and M. D. Collins, Intrageneric Structure of Streptococcus Based on Comparative Analysis of Small-Subunit rRNA Sequences, International Journal of Systematic Bacteriology, vol.41, issue.4, pp.487-494, 1991.
DOI : 10.1099/00207713-41-4-487

S. B. Beres, G. L. Sylva, K. D. Barbian, B. Lei, J. S. Hoff et al., Genome sequence of a serotype M3 strain of group A Streptococcus: Phage-encoded toxins, the high-virulence phenotype, and clone emergence, Proceedings of the National Academy of Sciences, vol.107, issue.4, pp.10078-10083, 2002.
DOI : 10.1172/JCI11972

H. Bierne, S. K. Mazmanian, M. Trost, M. G. Pucciarelli, G. Liu et al., Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence, Molecular Microbiology, vol.43, issue.4, pp.869-881, 2002.
DOI : 10.1074/jbc.275.13.9876

A. G. Binetti, A. Quiberoni, and J. A. Reinheimer, Phage adsorption to Streptococcus thermophilus. Influence of environmental factors and characterization of cell-receptors, Food Research International, vol.35, issue.1, pp.73-83, 2002.
DOI : 10.1016/S0963-9969(01)00121-1

A. Bolotin, B. Quinquis, P. Renault, A. Sorokin, S. D. Ehrlich et al., Complete sequence and comparative genome analysis of the dairy bacterium Streptococcus thermophilus, Nature Biotechnology, vol.16, issue.12, pp.1554-1558, 2004.
DOI : 10.1073/pnas.95.11.5849

L. Bonifait, C. Dominguez-punaro, M. Vaillancourt, K. Bart, C. Slater et al., The cell envelope subtilisin-like proteinase is a virulence determinant for Streptococcus suis, BMC Microbiology, vol.10, issue.1, p.42, 2010.
DOI : 10.1186/1471-2180-10-42

L. Bonifait, K. Vaillancourt, M. Gottschalk, M. Frenette, and D. Grenier, Purification and characterization of the subtilisin-like protease of Streptococcus suis that contributes to its virulence, Veterinary Microbiology, vol.148, issue.2-4, pp.333-373, 2011.
DOI : 10.1016/j.vetmic.2010.09.024

L. Braun, S. Dramsi, P. Dehoux, H. Bierne, G. Lindhal et al., with a novel type of surface association, Molecular Microbiology, vol.25, issue.02, pp.285-294, 1997.
DOI : 10.1046/j.1365-2958.1997.4621825.x

J. D. Bryan and S. D. , Streptococcus agalactiae CspA Is a Serine Protease That Inactivates Chemokines, Journal of Bacteriology, vol.191, issue.6, pp.1847-1854, 2009.
DOI : 10.1128/JB.01124-08

M. P. Chapot-chartier, F. Rul, M. Nardi, and G. J. , Gene Cloning and Characterization of PepC, a Cysteine Aminopeptidase from Streptococcus thermophilus, with sequence Similarity to the Eucaryotic Bleomycin Hydrolase, European Journal of Biochemistry, vol.104, issue.2, pp.497-506, 1994.
DOI : 10.1016/0378-1097(92)90685-H

P. Charbonnel, M. Lamarque, D. Aubel, J. Piard, V. Juillard et al., Qui régit la spécificité de transport des oligopeptides chez Lactococcus lactis ? Lait, pp.95-102, 2004.

F. Chavagnat, M. G. Casey, and M. J. , Purification, characterization, gene cloning, sequencing, and overexpression of aminopeptidase N from Streptococcus thermophilus A, Appl Environ Microbiol, vol.65, pp.3001-3007, 1999.

F. Chavagnat, J. Meyer, and C. M. , Purification, characterisation, cloning and sequencing of the gene encoding oligopeptidase PepO from Streptococcus thermophilus A. FEMS microbiology letters, pp.79-85, 2000.

C. C. Chen and P. P. Cleary, Complete nucleotide sequence of the streptococcal C5a peptidase gene of Streptococcus pyogenes, J. Biol. Chem, vol.263, pp.3161-3167, 1990.

J. S. Chia, Y. Y. Lee, P. T. Huang, and C. J. , Identification of Stress-Responsive Genes in Streptococcus mutans by Differential Display Reverse Transcription-PCR, Infection and Immunity, vol.69, issue.4, pp.2493-2501, 2001.
DOI : 10.1128/IAI.69.4.2493-2501.2001

J. S. Chia, L. Y. Chang, C. T. Shun, Y. Y. Chang, and J. Y. Chen, A 60-Kilodalton Immunodominant Glycoprotein Is Essential for Cell Wall Integrity and the Maintenance of Cell Shape in Streptococcus mutans, Infection and Immunity, vol.69, issue.11, pp.6987-6998, 2001.
DOI : 10.1128/IAI.69.11.6987-6998.2001

S. J. Choih, Q. T. Smith, and C. F. Schachtele, Modification of Human Parotid Saliva Proteins by Oral Streptococcus sanguis, Journal of Dental Research, vol.163, issue.1, pp.516-524, 1979.
DOI : 10.1016/0003-9969(73)90127-1

P. P. Cleary, Streptococcal C5a peptidase vaccine. US Patent 6270775, p.206, 2001.

P. P. Cleary and S. D. , Streptococcal C5a peptidase vaccine, 2002.

P. P. Cleary and S. D. , Streptococcal C5a peptidase vaccine, 2005.

P. P. Cleary and S. D. , Streptococcal C5a peptidase vaccine, 2007.

P. P. Cleary and S. D. , Streptococcal C5a peptidase vaccine, 2009.

J. N. Cole, A. Henningham, C. M. Gillen, V. Ramachandran, and W. M. , Human pathogenic streptococcal proteomics and vaccine development, PROTEOMICS ??? CLINICAL APPLICATIONS, vol.70, issue.4, pp.387-410, 2008.
DOI : 10.1093/infdis/165.2.315

URL : http://onlinelibrary.wiley.com/doi/10.1002/prca.200780048/pdf

D. Comfort and C. R. , A Comparative Genome Analysis Identifies Distinct Sorting Pathways in Gram-Positive Bacteria, Infection and Immunity, vol.72, issue.5, pp.2710-2722, 2004.
DOI : 10.1128/IAI.72.5.2710-2722.2004

T. Coolbear, R. Holland, and V. L. Crow, Parameters affecting the release of cell surface components and lysis of Lactococcus lactis subsp. cremoris, International Dairy Journal, vol.2, issue.4, pp.213-232, 1992.
DOI : 10.1016/0958-6946(92)90019-I

P. Cossart and J. R. , Sortase, a universal target for therapeutic agents against Grampositive bacteria, Proceedings of the National Academy of Sciences USA. 97, pp.5013-5015, 2000.

M. Coste, V. Rochet, J. Léonil, D. Mollé, S. Bouhallab et al., Identification of C-terminal peptides of bovine ??-casein that enhance proliferation of rat lymphocytes, Immunology Letters, vol.33, issue.1, pp.41-46, 1992.
DOI : 10.1016/0165-2478(92)90091-2

P. Courtin and F. , Interactions between microorganisms in a simple ecosystem: yogurt bacteria as a study model, Lait, vol.84, pp.25-134, 2004.
URL : https://hal.archives-ouvertes.fr/hal-00895516

M. W. Cunningham, Pathogenesis of Group A Streptococcal Infections, Clinical Microbiology Reviews, vol.13, issue.3, pp.470-511, 2000.
DOI : 10.1128/CMR.13.3.470-511.2000

J. R. Davies, G. Svensäter, and H. M. , Identification of novel LPXTG-linked surface proteins from Streptococcus gordonii, Microbiology, vol.52, issue.2, pp.1977-1988, 2009.
DOI : 10.1111/j.1348-0421.2008.00015.x

D. Mar-contreras, M. Carron, R. Montero, M. , and R. I. , Novel casein-derived peptides with antihypertensive activity, International Dairy Journal, vol.19, issue.10, pp.566-573, 2009.
DOI : 10.1016/j.idairyj.2009.05.004

C. Delorme, C. Bartholini, A. Bolotine, S. D. Ehrlich, and R. P. , Emergence of a Cell Wall Protease in the Streptococcus thermophilus Population, Applied and Environmental Microbiology, vol.76, issue.2, pp.451-60, 2010.
DOI : 10.1128/AEM.01018-09

URL : https://hal.archives-ouvertes.fr/hal-01204329

C. Delorme, Safety assessment of dairy microorganisms: Streptococcus thermophilus???, International Journal of Food Microbiology, vol.126, issue.3, 2008.
DOI : 10.1016/j.ijfoodmicro.2007.08.014

URL : https://hal.archives-ouvertes.fr/hal-01204330

S. Derzelle, A. Bolotin, M. Y. Mistou, and F. , Proteome Analysis of Streptococcus thermophilus Grown in Milk Reveals Pyruvate Formate-Lyase as the Major Upregulated Protein, Applied and Environmental Microbiology, vol.71, issue.12, pp.8597-8605, 2005.
DOI : 10.1128/AEM.71.12.8597-8605.2005

S. M. Deutsch, D. Mollé, V. Gagnaire, M. Plot, D. Atlan et al., Hydrolysis of Sequenced beta -Casein Peptides Provides New Insight into Peptidase Activity from Thermophilic Lactic Acid Bacteria and Highlights Intrinsic Resistance of Phosphopeptides, Applied and Environmental Microbiology, vol.66, issue.12, pp.5360-5367, 2000.
DOI : 10.1128/AEM.66.12.5360-5367.2000

M. K. Doeven, G. Van-den-bogaart, V. Krasnikov, and P. B. , Probing Receptor-Translocator Interactions in the Oligopeptide ABC Transporter by Fluorescence Correlation Spectroscopy, Biophysical Journal, vol.94, issue.10, pp.3956-3965, 2008.
DOI : 10.1529/biophysj.107.120964

D. Douglas, A. Frank, and M. D. , Linear ion traps in mass spectrometry, Mass Spectrometry Reviews, vol.13, issue.1, pp.1-29, 2005.
DOI : 10.1016/S0584-8547(02)00069-1

S. Dramsi, P. Trieu-cuot, and H. Bierne, Sorting sortases: a nomenclature proposal for the various sortases of Gram-positive bacteria, Research in Microbiology, vol.156, issue.3, pp.289-297, 2005.
DOI : 10.1016/j.resmic.2004.10.011

M. S. Edwards and C. J. Baker, Group B streptococcal infections in elderly adults, Clin. Infect. Dis, vol.41, pp.839-847, 2005.

S. A. Egan, D. Kurian, P. N. Ward, L. Hunt, and L. J. , Identification of sortase A (SrtA) substrates in Streptococcus uberis: evidence for an additional hexapeptide (LPXXXD) sorting motif, 2010.

M. Enright and B. Spratt, Multilocus sequence typing, Trends in Microbiology, vol.7, issue.12, pp.482-487, 1999.
DOI : 10.1016/S0966-842X(99)01609-1

M. B. Espeche-turbay, G. Savoy-de-giori, and H. E. , Release of the Cell-Envelope-Associated Proteinase of Lactobacillus delbrueckii Subspecies lactis CRL 581 Is Dependent upon pH and Temperature, Journal of Agricultural and Food Chemistry, vol.57, issue.18, pp.8607-8611, 2009.
DOI : 10.1021/jf901531q

F. A. Exterkate and A. A. , Role of calcium in activity and stability of the Lactococcus lactis cell envelope proteinase, Appl. Environ.Microbiol, vol.65, pp.1390-1396, 1999.

F. A. Exterkate, A. C. Alting, and C. J. Slangen, Specificity of two genetically related cellenvelope proteinases of Lactococcus lactis subsp.cremoris towards ? s1 -casein-(1-23)-fragment, 1991.

N. Ezzat, C. Zevaco, M. Soda, and G. G. , Partial purification and characterization of a cell wall associated proteinase from Lacoobacillus bulgaricus, Milchwissenschaft, vol.42, pp.95-97, 1987.

R. Facklam, What Happened to the Streptococci: Overview of Taxonomic and Nomenclature Changes, Clinical Microbiology Reviews, vol.15, issue.4, pp.613-630, 2002.
DOI : 10.1128/CMR.15.4.613-630.2002

J. A. Farrow and C. M. , DNA Base Composition, DNA-DNA Homology and Long-chain Fatty Acid Studies on Streptococcus thermophilus and Streptococcus salivarius, Microbiology, vol.130, issue.2, pp.357-362, 1984.
DOI : 10.1099/00221287-130-2-357

M. D. Fernandez-espla and F. , PepS from Streptococcus thermophilus . A new member of the aminopeptidase T family of thermophilic bacteria, European Journal of Biochemistry, vol.54, issue.2, pp.502-510, 1999.
DOI : 10.1111/j.1365-2621.1989.tb05960.x

M. D. Fernandez-espla, P. Garault, V. Monnet, and F. , Streptococcus thermophilus Cell Wall-Anchored Proteinase: Release, Purification, and Biochemical and Genetic Characterization, Applied and Environmental Microbiology, vol.66, issue.11, pp.4772-4778, 2000.
DOI : 10.1128/AEM.66.11.4772-4778.2000

D. Fira, M. Kojic, A. Banina, I. Spasojevic, I. Strahinic et al., Characterization of cell envelope-associated proteinases of thermophilic lactobacilli, Journal of Applied Microbiology, vol.68, issue.1, pp.123-130, 2001.
DOI : 10.1051/lait:1988425

G. Fischer, B. Decaris, and P. Leblond, Occurrence of deletions, associated with genetic instability in Streptomyces ambofaciens, 1997.

V. A. Fischetti, V. Pancholi, and S. O. , Conservation of a hexapeptide sequence in the anchor region of surface proteins from Gram-positive cocci, Molecular Microbiology, vol.4, issue.9, pp.1603-1605, 1990.
DOI : 10.1111/j.1365-2958.1990.tb02072.x

T. J. Foster and D. Mcdevitt, Their possible roles in virulence, FEMS Microbiology Letters, vol.61, issue.(Suppl 1), pp.199-205, 1994.
DOI : 10.1093/infdis/167.3.633

W. Galia, C. Perrin, M. Genay, and A. Dary, Variability and molecular typing of Streptococcus thermophilus strains displaying different proteolytic and acidifying properties, International Dairy Journal, vol.19, issue.2, pp.89-95, 2009.
DOI : 10.1016/j.idairyj.2008.08.004

C. Garandeau, H. Reglier-poupet, I. Dubail, J. L. Beretti, P. Berche et al., The Sortase SrtA of Listeria monocytogenes Is Involved in Processing of Internalin and in Virulence, Infection and Immunity, vol.70, issue.3, pp.1382-1390, 2002.
DOI : 10.1128/IAI.70.3.1382-1390.2002

P. Garault, C. Letort, V. Juillard, and V. Monnet, Branched-Chain Amino Acid Biosynthesis Is Essential for Optimal Growth of Streptococcus thermophilus in Milk, Applied and Environmental Microbiology, vol.66, issue.12, pp.5128-5133, 2000.
DOI : 10.1128/AEM.66.12.5128-5133.2000

URL : https://hal.archives-ouvertes.fr/hal-00294322

R. Gardan, C. Besset, A. Guillot, C. Gitton, and V. Monnet, The Oligopeptide Transport System Is Essential for the Development of Natural Competence in Streptococcus thermophilus Strain LMD-9, Journal of Bacteriology, vol.191, issue.14, pp.4647-4655, 2009.
DOI : 10.1128/JB.00257-09

J. E. Germond, M. Delley, C. Gilbert, and A. D. , Determination of the Domain of the Lactobacillus delbrueckii subsp. bulgaricus Cell Surface Proteinase PrtB Involved in Attachment to the Cell Wall after Heterologous Expression of the prtB Gene in Lactococcus lactis, Applied and Environmental Microbiology, vol.69, issue.6, pp.3377-3384, 2003.
DOI : 10.1128/AEM.69.6.3377-3384.2003

J. M. Ghuysen and R. Hakenbeck, Bacterial cell wall, Elsevier Science B.S, 1994.

C. Gianfaldoni, S. Maccari, L. Pancotto, G. Rossi, M. Hilleringmann et al., Sortase A Confers Protection against Streptococcus pneumoniae in Mice, Infection and Immunity, vol.77, issue.7, pp.2957-2961, 2009.
DOI : 10.1128/IAI.01516-08

C. Gilbert, D. Atlan, B. Blanc, R. Portalier, G. J. Germond et al., A new cell surface proteinase: sequencing and analysis of the prtB gene from Lactobacillus delbruekii subsp. bulgaricus., Journal of Bacteriology, vol.178, issue.11, pp.3059-3065, 1996.
DOI : 10.1128/jb.178.11.3059-3065.1996

M. Gobbetti, P. Ferranti, E. Smacchi, F. Goffredi, and F. Addeo, Production of Angiotensin-I-Converting-Enzyme-Inhibitory Peptides in Fermented Milks Started by Lactobacillus delbrueckii subsp. bulgaricus SS1 and Lactococcus lactis subsp. cremoris FT4, Applied and Environmental Microbiology, vol.66, issue.9, pp.3898-3904, 2000.
DOI : 10.1128/AEM.66.9.3898-3904.2000

M. Gobbetti, L. Stepaniak, M. De-angelis, A. Corsetti, D. Cagno et al., Latent Bioactive Peptides in Milk Proteins: Proteolytic Activation and Significance in Dairy Processing, Critical Reviews in Food Science and Nutrition, vol.42, issue.3, pp.223-239, 2002.
DOI : 10.1080/10408690290825538

J. A. Gomez-ruiz, M. Ramos, and R. I. , Identification and formation of angiotensin-converting enzyme-inhibitory peptides in Manchego cheese by high-performance liquid chromatography???tandem mass spectrometry, Journal of Chromatography A, vol.1054, issue.1-2, pp.269-277, 2004.
DOI : 10.1016/j.chroma.2004.05.022

J. A. Gomez-ruiz, G. Taborda, L. Amigo, I. Recio, and M. Ramos, Identification of ACE-inhibitory peptides in different Spanish cheeses by tandem mass spectrometry, European Food Research and Technology, vol.52, issue.196, pp.595-601, 2006.
DOI : 10.1271/bbb1961.51.2257

N. Gupta, K. K. Hixson, D. E. Culley, R. D. Smith, and P. A. Pevzner, Analyzing protease specificity and detecting in vivo proteolytic events using tandem mass spectrometry, PROTEOMICS, vol.25, issue.15, pp.2833-2844, 2010.
DOI : 10.1007/978-3-642-48380-6

B. Guss, M. Uhlen, B. Nilsson, M. Lindberg, J. Sjoquist et al., Region X, the cell-wall-attachment part of staphylococcal protein A, European Journal of Biochemistry, vol.68, issue.2, pp.413-420, 1984.
DOI : 10.1016/0076-6879(77)47010-1

D. J. Harrington and R. R. , Identification and characterisation of two extracellular proteases of Streptococcus mutans, FEMS Microbiology Letters, vol.121, issue.2, pp.237-241, 1994.
DOI : 10.1016/0378-1097(94)90132-5

T. O. Harris, D. W. Shelver, J. F. Bohnsack, and R. C. , A novel streptococcal surface protease promotes virulence, resistance to opsonophagocytosis, and cleavage of human fibrinogen, Journal of Clinical Investigation, vol.111, issue.1, 2003.
DOI : 10.1172/JCI200316270

R. Hartmann and H. , Food-derived peptides with biological activity: from research to food applications, Current Opinion in Biotechnology, vol.18, issue.2, pp.163-169, 2007.
DOI : 10.1016/j.copbio.2007.01.013

M. Hayes, C. Stanton, G. F. Fitzgerald, and R. R. , Putting microbes to work: Dairy fermentation, cell factories and bioactive peptides. Part II: Bioactive peptide functions, Biotechnology Journal, vol.51, issue.358, pp.435-449, 2007.
DOI : 10.3177/jnsv.49.451

E. M. Hebert, G. Mamone, G. Picariello, and R. R. , Characterization of the Pattern of ??s1- and ??-Casein Breakdown and Release of a Bioactive Peptide by a Cell Envelope Proteinase from Lactobacillus delbrueckii subsp. lactis CRL 581, Applied and Environmental Microbiology, vol.74, issue.12, pp.3682-3689, 2008.
DOI : 10.1128/AEM.00247-08

B. Hernandez-ledesma, L. Amigo, M. Ramos, and R. I. , Application of highperformance liquid chromatography?tandem mass spectrometry to the identification of biologically active peptides produced by milk fermentation and simulated gastrointestinal digestion, Journal of Chromatography A, pp.1049-107, 2004.

B. Hernandez-ledesma, L. Amigo, M. Ramos, and R. I. , Angiotensin Converting Enzyme Inhibitory Activity in Commercial Fermented Products. Formation of Peptides under Simulated Gastrointestinal Digestion, Journal of Agricultural and Food Chemistry, vol.52, issue.6, 2004.
DOI : 10.1021/jf034997b

B. Hernandez-ledesma, B. Miralles, L. Amigo, M. Ramos, and R. I. , Identification of antioxidant and ACE-inhibitory peptides in fermented milk, Journal of the Science of Food and Agriculture, vol.I, issue.6, 2005.
DOI : 10.1016/0165-2478(92)90091-2

R. D. Hill, E. Lahov, and D. Givol, A rennin-sensitive bond in ??s1 ??-casein, Journal of Dairy Research, vol.46, issue.01, pp.147-153, 1974.
DOI : 10.1021/bi00756a021

A. Hiron, Les transporteurs de peptides de Staphylococcus aureus, Thèse de l'Institut des Sciences et Industries du ?ivant et de l'Environnement, 2007.
URL : https://hal.archives-ouvertes.fr/pastel-00003802

A. Holck and H. Naes, Cloning, sequencing and expression of the gene encoding the cell-envelope-associated proteinase from Lactobacillus paracasei subsp. paracasei NCDO 151, Journal of General Microbiology, vol.138, issue.7, pp.1353-1364, 1992.
DOI : 10.1099/00221287-138-7-1353

M. T. Holden, H. Hauser, M. Sanders, T. H. Ngo, I. Cherevach et al., Rapid Evolution of Virulence and Drug Resistance in the Emerging Zoonotic Pathogen Streptococcus suis, PLoS ONE, vol.4, issue.7, p.6072, 2009.
DOI : 10.1371/journal.pone.0006072.s003

S. K. Hollingshead, V. A. Fischetti, and S. J. , Complete nucleotide sequence of type 6 M protein of the group A streptococcus, J. Biol. Chem, vol.261, pp.1677-1686, 1986.

P. Hols, F. Hancy, L. Fontaine, B. Grossiord, D. Prozzi et al., New insights in the molecular biology and physiology of Streptococcus thermophilus revealed by comparative genomics, FEMS Microbiol Rev, vol.29, pp.435-463, 2005.

J. Höltje and A. Tomasz, Lipoteichoic acid: a specific inhibitor of autolysin activity in Pneumococcus., Proceedings of the National Academy of Sciences, vol.72, issue.5, pp.1690-1694, 1975.
DOI : 10.1073/pnas.72.5.1690

M. J. Hughes, J. C. Moore, J. D. Lane, R. Wilson, P. K. Pribul et al., Identification of major outer surface proteins of Streptococcus agalacitae, Infect Immun, vol.10, pp.1254-1259, 2002.

L. K. Husman, D. L. Yung, S. K. Hollingshead, and S. J. , Role of putative virulence factors of Streptococcus pyogenes in mouse models of long-term throat colonization and pneumonia, Infection and Immunity, vol.65, 1997.

P. Idigoras, A. Valiente, L. Iglesias, P. Trieu-cout, and C. Poyart, Meningitis Due to Streptococcus salivarius, Journal of Clinical Microbiology, vol.39, issue.8, pp.3017-211, 2001.
DOI : 10.1128/JCM.39.8.3017.2001

T. Igarashi, E. Asaga, and N. Goto, The sortase of Streptococcus mutans mediates cell wall anchoring of a surface protein antigen, Oral Microbiology and Immunology, vol.70, issue.4, pp.266-269, 2003.
DOI : 10.1074/jbc.M109945200

U. Ilangovan, H. Ton-that, J. Iwahara, O. Schneewind, and C. R. , Structure of sortase, the transpeptidase that anchors proteins to the cell wall of Staphylococcus aureus, Proceedings of the National Academy of Sciences, vol.8, issue.4, pp.6056-6061, 2001.
DOI : 10.1007/BF00228148

Y. Ji, B. Carlson, A. Kondagunta, and P. P. Cleary, Intranasal immunization with C5a peptidase prevents nasopharyngeal colonization of mice by the group A streptococcus, Infection and Immunity, vol.65, 1997.

Y. Jinsmaa and M. Yoshikawa, Enzymatic release of neocasomorphin and ??-casomorphin from bovine ??-casein, Peptides, vol.20, issue.8, pp.957-962, 1999.
DOI : 10.1016/S0196-9781(99)00088-1

A. K. Johri, L. C. Paoletti, P. Glaser, M. Dua, P. K. Sharma et al., Group B Streptococcus: global incidence and vaccine development, Nature Reviews Microbiology, vol.60, issue.12, pp.932-942, 2006.
DOI : 10.1093/infdis/151.4.672

R. Jonquières, H. Bierne, F. Fiedler, P. Gounon, and C. P. , Interaction between the protein InlB of Listeria monocytogenes and lipoteichoic acid: a novel mechanism of protein association at the surface of Gram-positive bacteria, Molecular Microbiology, vol.176, issue.5, pp.902-914, 1999.
DOI : 10.1128/jb.176.10.2976-2985.1994

Z. E. Juarez and M. W. Stinson, An extracellular protease of Streptococcus gordonii hydrolyzes type IV collagen and collagen analogues, Infect Immun, vol.67, pp.271-278, 1999.

S. S. Kang, K. J. , L. T. , and O. K. , Flavonols Inhibit Sortases and Sortase-Mediated Staphylococcus aureus Clumping to Fibrinogen, Biological & Pharmaceutical Bulletin, vol.29, issue.8, pp.1751-1755, 2006.
DOI : 10.1248/bpb.29.1751

V. Kapur, M. W. Majesky, L. L. Li, R. A. Black, and J. M. Musser, Cleavage of interleukin 1 beta (IL-1b) precursor to produce active IL-1b by a conserved extracellular cysteine protease from Streptococcus pyogenes, Proc. Natl. Acad. Sci. USA. 90, pp.7676-7680, 1993.

Y. Kawamura, X. G. Hou, F. Sultana, H. Miura, and T. Ezaki, Determination of 16S rRNA Sequences of Streptococcus mitis and Streptococcus gordonii and Phylogenetic Relationships among Members of the Genus Streptococcus, International Journal of Systematic Bacteriology, vol.45, issue.2, pp.406-408, 1995.
DOI : 10.1099/00207713-45-2-406

A. R. Kerr, P. V. Adrian, S. Estevão, R. De-groot, G. Alloing et al., The Ami-AliA/AliB Permease of Streptococcus pneumoniae Is Involved in Nasopharyngeal Colonization but Not in Invasive Disease, Infection and Immunity, vol.72, issue.7, pp.3902-3906, 2004.
DOI : 10.1128/IAI.72.7.3902-3906.2004

N. M. Khalid and M. E. , Proteolytic Activity by Strains of Lactobacillus plantarum and Lactobacillus casei, Journal of Dairy Science, vol.73, issue.11, pp.3068-3076, 1990.
DOI : 10.3168/jds.S0022-0302(90)78994-1

A. S. Kharat and T. A. , Inactivation of the srtA Gene Affects Localization of Surface Proteins and Decreases Adhesion of Streptococcus pneumoniae to Human Pharyngeal Cells In Vitro, Infection and Immunity, vol.71, issue.5, pp.2758-2765, 2003.
DOI : 10.1128/IAI.71.5.2758-2765.2003

S. W. Kim, I. M. Chang, and O. K. , Inhibition of the Bacterial Surface Protein Anchoring Transpeptidase Sortase by Medicinal Plants, Bioscience, Biotechnology, and Biochemistry, vol.227, issue.4, pp.2751-2754, 2002.
DOI : 10.1271/bbb.65.939

C. Kocks, E. Gouin, M. Tabouret, P. Berche, H. Ohayon et al., L. monocytogenes-induced actin assembly requires the actA gene product, a surface protein, Cell, vol.68, issue.3, pp.521-531, 1992.
DOI : 10.1016/0092-8674(92)90188-I

J. Kok, K. J. Leenhouts, A. J. Haandrikman, A. M. Ledeboer, and G. Venema, Nucleotide sequence of the cell wall proteinase gene of Streptococcus cremoris Wg2, Appl Environ Microbiol, vol.54, pp.231-238, 1988.

H. J. Korhonen, Milk-derived bioactive peptides: From science to applications, Journal of Functional Foods, vol.1, issue.2, pp.177-187, 2009.
DOI : 10.1016/j.jff.2009.01.007

T. F. Kumosinski, E. M. Browna, F. Jr, and H. M. , Three-Dimensional Molecular Modeling of Bovine Caseins: ??s1-Casein, Journal of Dairy Science, vol.74, issue.9, pp.2889-2895, 1991.
DOI : 10.3168/jds.S0022-0302(91)78470-1

E. R. Kunji, I. Mierau, A. Hagting, B. Poolman, and K. W. , The proteolytic systems of lactic acid bacteria, Antonie van Leeuwenhoek, vol.70, pp.187-221, 1996.
DOI : 10.1007/978-94-009-1774-3_7

H. Laan and K. W. , Mechanism of proteinase release from Lactococcus lactis subsp. cremoris Wg2, Appl. Environ. Microbiol, vol.55, pp.3101-3106, 1989.

R. S. Labib, N. J. Calvanico, and T. T. , Studies on extracellular proteases of Streptococcus sanguis. Purification and characterization of a human IgA1 specific protease, Biochimica et Biophysica Acta (BBA) - Enzymology, vol.526, issue.2, pp.547-559, 1978.
DOI : 10.1016/0005-2744(78)90145-6

U. K. Laemmli and M. Favre, Maturation of the head of bacteriophage T4, Journal of Molecular Biology, vol.80, issue.4, pp.575-579, 1973.
DOI : 10.1016/0022-2836(73)90198-8

E. Lahov and R. W. , Antibacterial and immunostimulating casein-derived substances from milk: Casecidin, isracidin peptides, Food and Chemical Toxicology, vol.34, issue.1, pp.131-145, 1996.
DOI : 10.1016/0278-6915(95)00097-6

L. Lalioui, E. Pellegrini, S. Dramsi, M. Baptista, N. Bourgeois et al., The SrtA Sortase of Streptococcus agalactiae Is Required for Cell Wall Anchoring of Proteins Containing the LPXTG Motif, for Adhesion to Epithelial Cells, and for Colonization of the Mouse Intestine, Infection and Immunity, vol.73, issue.6, pp.3342-3350, 2005.
DOI : 10.1128/IAI.73.6.3342-3350.2005

URL : https://hal.archives-ouvertes.fr/hal-00019655

L. J. Ng, W. L. Kazmierczak, K. M. Andrzejewski, T. M. Davidsen, T. M. Wayne et al., Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6, 2007.

J. G. Lawrence and R. J. , Genomic flux: genome evolution by gene loss and acquisition. In organisation of the prokaryotic genome, pp.263-288, 1999.

S. G. Lee, V. Pancholi, and V. A. Fischetti, TG Sequence Motif of Cell Surface Proteins of Gram-positive Bacteria, Journal of Biological Chemistry, vol.179, issue.49, pp.46912-46934, 2002.
DOI : 10.1128/jb.179.21.6843-6850.1997

S. F. Lee and T. L. Boran, Roles of Sortase in Surface Expression of the Major Protein Adhesin P1, Saliva-Induced Aggregation and Adherence, and Cariogenicity of Streptococcus mutans, Infection and Immunity, vol.71, issue.2, pp.676-681, 2003.
DOI : 10.1128/IAI.71.2.676-681.2003

T. Lefébure and M. J. Stanhope, Evolution of the core and pan-genome of Streptococcus: positive selection, recombination, and genome composition, Genome Biology, vol.8, issue.5, p.71, 2007.
DOI : 10.1186/gb-2007-8-5-r71

J. A. Leigh, S. A. Egan, P. N. Ward, T. R. Field, and T. J. Coffey, Sortase anchored proteins of Streptococcus uberis play major roles in the pathogenesis of bovine mastitis in dairy cattle. Veterinary research, p.63, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00903194

A. C. Len, D. W. Harty, and J. N. , Stress-responsive proteins are upregulated in Streptococcus mutans during acid tolerance. Microbiology, pp.1339-1351, 2004.

C. Letort and J. V. , Development of a minimal chemically-defined medium for the exponential growth of Streptococcus thermophilus, Journal of Applied Microbiology, vol.29, issue.6, pp.1023-1029, 2001.
DOI : 10.1007/s002530051569

M. Liu, R. Siezen, and A. Nauta, In Silico Prediction of Horizontal Gene Transfer Events in Lactobacillus bulgaricus and Streptococcus thermophilus Reveals Protocooperation in Yogurt Manufacturing, Applied and Environmental Microbiology, vol.75, issue.12, pp.4120-4129, 2009.
DOI : 10.1128/AEM.02898-08

F. Liu, L. Du, P. Du, and G. Huo, and their interaction with the CodY homolog, FEMS Microbiology Letters, vol.297, issue.2, pp.164-72, 2009.
DOI : 10.1111/j.1574-6968.2009.01672.x

C. S. Lo and C. V. Hughes, Identification and characterization of a protease from Streptococcus oralis C104, Oral Microbiology and Immunology, vol.140, issue.3, pp.181-187, 1996.
DOI : 10.1016/0003-9969(84)90078-5

I. Lopez-exposito, A. Quiros, L. Amigo, and R. I. , Casein hydrolysates as a source of antimicrobial, antioxidant and antihypertensive peptides, Le Lait, vol.77, issue.4-5, pp.241-249, 2007.
DOI : 10.1016/S0304-4165(01)00116-7

URL : https://hal.archives-ouvertes.fr/hal-00895647

W. R. Lyon and C. M. , Trigger Factor-Mediated Prolyl Isomerization Influences Maturation of the Streptococcus pyogenes Cysteine Protease, Journal of Bacteriology, vol.185, issue.12, pp.3661-3667, 2003.
DOI : 10.1128/JB.185.12.3661-3667.2003

M. Maeno, N. Yamamoto, and T. Takano, Identification of an Antihypertensive Peptide from Casein Hydrolysate Produced by a Proteinase from Lactobacillus helveticus CP790, Journal of Dairy Science, vol.79, issue.8, pp.1316-1321, 1996.
DOI : 10.3168/jds.S0022-0302(96)76487-1

K. Makarova, A. Slesarev, Y. Wolf, A. Sorokin, B. Mirkin et al., Comparative genomics of the lactic acid bacteria, Proceedings of the National Academy of Sciences, vol.29, issue.1, 2006.
DOI : 10.1093/nar/29.1.22

F. S. Markland and S. E. , Substilisins: Primary structure, chemical and physical properties, pp.561-608, 1971.

L. A. Marraffini, A. C. Dedent, and S. O. , Sortases and the Art of Anchoring Proteins to the Envelopes of Gram-Positive Bacteria, Microbiology and Molecular Biology Reviews, vol.70, issue.1, pp.192-221, 2006.
DOI : 10.1128/MMBR.70.1.192-221.2006

P. R. Marri, W. Hao, and G. B. Golding, Gene Gain and Gene Loss in Streptococcus: Is It Driven by Habitat?, Molecular Biology and Evolution, vol.23, issue.12, pp.2379-2391, 2006.
DOI : 10.1093/molbev/msl115

C. Matar, S. S. Nadathur, A. T. Bakalinsky, and J. Goulet, Antimutagenic Effects of Milk Fermented by Lactobacillus helveticus L89 and a Protease-Deficient Derivative, Journal of Dairy Science, vol.80, issue.9, 1965.
DOI : 10.3168/jds.S0022-0302(97)76139-3

M. C. Mart?n-hernandez, A. C. Alting, and E. F. , Purification and characterization of the mature, membrane-associated cell-envelope proteinase of Lactobacillus helveticus L89, Applied Microbiology and Biotechnology, vol.40, issue.6, pp.828-834, 1994.
DOI : 10.1007/BF00173983

A. Matéos, Etude protéomique de la microhétérogénéité des caséines a et b équines : identification des variants post-transcriptionnels et de phosphorylation ; identification des sites phosphorylés de la caséine ?, 2008.

R. O. Mattos-graner, S. Jin, W. F. King, T. Chen, D. J. Smith et al., Cloning of the Streptococcus mutans Gene Encoding Glucan Binding Protein B and Analysis of Genetic Diversity and Protein Production in Clinical Isolates, Infection and Immunity, vol.69, issue.11, pp.6931-6941, 2001.
DOI : 10.1128/IAI.69.11.6931-6941.2001

F. Maruyama, M. Kobata, K. Kurokawa, K. Nishida, A. Sakurai et al., Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content, BMC Genomics, vol.10, issue.1, p.358, 2009.
DOI : 10.1186/1471-2164-10-358

S. K. Mazmanian, G. Liu, E. R. Jensen, E. Lenoy, and S. O. , Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections, Proc. Natl. Acad. Sci.USA. 97, pp.5510-5515, 2000.
DOI : 10.1056/NEJM199611073351907

S. K. Mazmanian, H. Ton-that, and O. Et-schneewind, Sortase-catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureus, Molecular Microbiology, vol.66, issue.5, pp.1049-1057, 2001.
DOI : 10.1128/jb.172.5.2462-2468.1990

M. Michaylova, K. Isawa, and L. Vlachkova, Study on yogurt bacteria isolated from plants in Bulgaria, Book of Abstracts of the 7th Symposium on Lactic Acid Bacteria, p.40, 2002.

L. Miclo, E. Roux, M. Genay, E. Brusseaux-lorson, C. Poirson et al., Article soumis 2011) Variability of hydrolysis of ?, ? s1 -and ? s2 -caseins by 10 strains of Streptococcus thermophilus and resulting bioactive peptides, J. Agric. Food Chem

M. Miguel, I. Recio, M. Ramos, M. A. Delgado, and A. M. , Antihypertensive Effect of Peptides Obtained from Enterococcus faecalis-Fermented Milk in Rats, Journal of Dairy Science, vol.89, issue.9, pp.3352-3359, 2006.
DOI : 10.3168/jds.S0022-0302(06)72372-4

P. Minkiewicz, C. J. Slangen, J. Dziuba, S. Visser, and H. Mioduszewska, Identification of peptides obtained via hydrolysis of bovine casein by chymosin using HPLC and mass spectrometry, Milchwissenschaft, vol.55, pp.14-17, 2000.

T. J. Mitchell, The pathogenesis of streptococcal infections: from Tooth decay to meningitis, Nature Reviews Microbiology, vol.183, issue.3, 2003.
DOI : 10.1128/JB.183.19.5709-5717.2001

H. Miyakawa, S. Kobayashi, S. Shimamura, and M. Tomita, Purification and Characterization of an Aminopeptidase from Lactobacillus helveticus LHE-511, Journal of Dairy Science, vol.75, issue.1, pp.27-35, 1992.
DOI : 10.3168/jds.S0022-0302(92)77734-0

V. Monnet, L. Bars, D. , and G. J. , Purification and characterization of a cell wall proteinase from Streptococcus lactis NCDO 763, Journal of Dairy Research, vol.49, issue.02, pp.247-255, 1987.
DOI : 10.1038/227680a0

V. Monnet, Streptococcus thermophilus, un streptocoque atypique et sympathique Bulletin de la Société Française de Microbiologie, pp.23-28, 2006.

D. Mora, C. Monnet, and D. D. , Balancing the loss and acquisition of pathogenic traits in food-associated bacteria, Microbiology, vol.151, issue.12, pp.3814-3816, 2005.
DOI : 10.1099/mic.0.28513-0

D. Mora, C. Monnet, C. Parini, S. Guglielmetti, A. Mariani et al., Urease biogenesis in Streptococcus thermophilus, Research in Microbiology, vol.156, issue.9, pp.897-903, 2005.
DOI : 10.1016/j.resmic.2005.04.005

M. Morice, P. Bracquart, and G. Linden, Colonial Variation and Freeze-Thaw Resistance of Streptococcus thermophilus, Journal of Dairy Science, vol.75, issue.5, pp.1197-1203, 1992.
DOI : 10.3168/jds.S0022-0302(92)77867-9

W. W. Navarre and O. Schneewind, Proteolytic cleavage and cell wall anchoring at the LPXTG motif of surface proteins in Gram-positive bacteria, Molecular Microbiology, vol.76, issue.1, pp.115-121, 1994.
DOI : 10.1146/annurev.bi.52.070183.004141

W. Navarre, S. Daefler, and O. Schneewind, Cell wall sorting of lipoproteins in Staphylococcus aureus., Journal of Bacteriology, vol.178, issue.2, pp.441-446, 1996.
DOI : 10.1128/jb.178.2.441-446.1996

W. W. Navarre and O. Schneewind, Surface proteins of Gram-positive bacteria and mechanisms of their targeting to the cell wall envelope, Microbiol, Mol. Biol. Rev, vol.63, pp.174-229, 1999.

K. F. Ng-kwai-hang and E. M. Kroeker, Rapid Separation and Quantification of Major Caseins and Whey Proteins of Bovine Milk by Polyacrylamide Gel Electrophoresis, Journal of Dairy Science, vol.67, issue.12, pp.3052-3056, 1984.
DOI : 10.3168/jds.S0022-0302(84)81671-9

J. B. Nielsen and L. J. , Glyceride-cysteine lipoproteins and secretion by Grampositive bacteria, J. Bacteriol, vol.152, pp.315-322, 1982.

A. H. Nobbs, R. M. Vajna, J. R. Johnson, Y. Zhang, S. L. Erlandsen et al., Consequences of a sortase A mutation in Streptococcus gordonii, Microbiology, vol.153, issue.12, pp.4088-4097, 2007.
DOI : 10.1099/mic.0.2007/007252-0

L. Ong, A. Henriksson, and N. P. Shah, sp., Le Lait, vol.77, issue.2, pp.149-165, 2007.
DOI : 10.1051/lait:2007004

URL : https://hal.archives-ouvertes.fr/hal-00895638

L. Ong and N. P. Shah, Release and identification of angiotensin-converting enzymeinhibitory peptides as influenced by ripening temperatures and probiotic adjuncts in Cheddar cheeses. LWT -Food Science and Technology, pp.1555-1566, 2008.

H. Ono, N. Yamamoto, M. Maeno, T. Takano, and H. Momose, Purification and characterization of a cell-wall associated proteinase of Lactobacillus helveticus CP53, pp.373-377, 1997.

M. Osaki, D. Takamatsu, Y. Shimoji, and T. Sekizaki, Characterization of Streptococcus suis Genes Encoding Proteins Homologous to Sortase of Gram-Positive Bacteria, Journal of Bacteriology, vol.184, issue.4, pp.971-982, 2002.
DOI : 10.1128/jb.184.4.971-982.2002

J. Otte, T. Lenhard, B. Flambard, and K. I. Sørensen, Influence of fermentation temperature and autolysis on ACE-inhibitory activity and peptide profiles of milk fermented by selected strains of Lactobacillus helveticus and Lactococcus lactis, International Dairy Journal, vol.21, issue.4, pp.229-238, 2011.
DOI : 10.1016/j.idairyj.2010.12.008

B. S. Park, J. G. Kim, M. R. Kim, S. F. Lee, G. R. Takeoka et al., Cell Adhesion to Fibronectin, Journal of Agricultural and Food Chemistry, vol.53, issue.23, pp.9005-9009, 2005.
DOI : 10.1021/jf051765z

I. Pastar, I. Tonic, N. Golic, M. Kojic, R. Van-kranenburg et al., Identification and Genetic Characterization of a Novel Proteinase, PrtR, from the Human Isolate Lactobacillus rhamnosus BGT10, Applied and Environmental Microbiology, vol.69, issue.10, pp.5802-5811, 2003.
DOI : 10.1128/AEM.69.10.5802-5811.2003

G. K. Paterson and M. T. , The biology of Gram-positive sortase enzymes Trends Microbiol, pp.89-95, 2004.

G. K. Paterson and T. J. Mitchell, The role of Streptococcus pneumoniae sortase A in colonisation and pathogenesis, Microbes and Infection, vol.8, issue.1, pp.145-153, 2006.
DOI : 10.1016/j.micinf.2005.06.009

S. J. Peacock, G. Lina, J. Etienne, and F. T. , Staphylococcus schleiferi subsp. schleiferi expresses a fibronectin-binding protein, Infect Immun, vol.67, pp.4272-4275, 1999.

J. A. Pederson, G. J. Mileski, B. C. Weimer, and J. L. Steele, Genetic characterization of a cell envelope-associated proteinase from Lactobacillus helveticus CNRZ32, J. Bacteriol, vol.181, pp.4592-4597, 1999.

S. B. Peng, L. Wang, J. Moomaw, R. B. Peery, P. M. Sun et al., Biochemical Characterization of Signal Peptidase I from Gram-Positive Streptococcus pneumoniae, Journal of Bacteriology, vol.183, issue.2, pp.621-627, 2001.
DOI : 10.1128/JB.183.2.621-627.2001

D. N. Perkins, D. J. Pappin, D. M. Creasy, and C. J. , Probability-based protein identification by searching sequence databases using mass spectrometry data, Electrophoresis, vol.447, issue.18, pp.3551-3567, 1999.
DOI : 10.1016/S0014-5793(99)00235-5

A. Pihlanto-leppala, T. Rokka, and H. Korhonen, Angiotensin I Converting Enzyme Inhibitory Peptides Derived from Bovine Milk Proteins, International Dairy Journal, vol.8, issue.4, pp.325-331, 1998.
DOI : 10.1016/S0958-6946(98)00048-X

A. G. Plaut, R. J. Genco, and T. T. , Isolation of an enzyme from Streptococcus sanguis which specifically cleaves IgA, J. Immunol, vol.113, pp.289-291, 1974.

C. Poyart, G. Quesne, S. Coulon, P. Berche, and P. Trieu-cuot, Identification of streptococci to species level by sequencing the gene encoding the manganese-dependent superoxide dismutase, 1998.

P. R. Race, M. L. Bentley, J. A. Melvin, A. Crow, R. K. Hughes et al., Sortase A, Journal of Biological Chemistry, vol.12, issue.11, pp.6924-6933, 2009.
DOI : 10.1107/S0907444904013253

J. L. Rasic and K. J. , Fermented fresh milk products, Manufacture and Preparations, 1978.

M. Rasmussen, H. P. Muller, and L. Bjorck, -Macroglobulin, Journal of Biological Chemistry, vol.305, issue.22, pp.15336-15344, 1999.
DOI : 10.1073/pnas.91.25.12115

A. Raz and V. A. Fischetti, Sortase A localizes to distinct foci on the Streptococcus pyogenes membrane, Proceedings of the National Academy of Sciences, vol.31, issue.47, pp.18549-18554, 2008.
DOI : 10.1016/S0580-9517(02)31007-9

A. H. Rogers, P. S. Zilm, A. L. Pfenning, and N. J. Gully, Some aspects of protease production by a strain of Streptococcus sanguis, Oral Microbiology and Immunology, vol.129, issue.2, pp.72-76, 1990.
DOI : 10.1016/0003-9969(89)90046-0

F. Rul, V. Monnet, and G. J. , Purification and Characterization of a General Aminopeptidase (St-PepN) from Streptococcus salivarius ssp. thermophilus CNRZ 302, Journal of Dairy Science, vol.77, issue.10, pp.2880-2889, 1994.
DOI : 10.3168/jds.S0022-0302(94)77228-3

F. Rul, J. C. Gripon, and V. Monnet, St-PepA, a Streptococcus thermophilus aminopeptidase with high specificity for acidic residues, Microbiology, vol.141, issue.9, pp.2281-2287, 1995.
DOI : 10.1099/13500872-141-9-2281

F. Rul and V. Monnet, Presence of additional peptidases in Streptococcus thermophilus CNRZ 302 compared to Lactococcus lactis, Journal of Applied Microbiology, vol.82, issue.6, pp.695-704, 1997.
DOI : 10.1046/j.1365-2672.1997.00185.x

E. L. Ryhänen, A. Pihlanto-leppälä, and E. Pahkala, A new type of ripened, low-fat cheese with bioactive properties, International Dairy Journal, vol.11, issue.4-7, pp.441-447, 2001.
DOI : 10.1016/S0958-6946(01)00079-6

T. Saito, T. Nakamura, H. Kitazawa, Y. Kawai, and T. Itoh, Isolation and Structural Analysis of Antihypertensive Peptides That Exist Naturally in Gouda Cheese, Journal of Dairy Science, vol.83, issue.7, 2000.
DOI : 10.3168/jds.S0022-0302(00)75013-2

J. Sambrook, E. F. Fritsch, and T. Maniatis, Molecular cloning: A laboratory manual Cold Spring Harbor, p.218, 1989.

C. Sandre, A. Gleizes, F. Forestier, R. Gorges-kergot, S. Chilmonczyk et al., A Peptide Derived from Bovine ??-Casein Modulates Functional Properties of Bone Marrow-Derived Macrophages from Germfree and Human Flora-Associated Mice, The Journal of Nutrition, vol.70, issue.592, pp.2936-2942, 2001.
DOI : 10.1007/BF00395933

D. Sanogo, D. Paquet, F. Aubert, and G. Linden, Purification of ??S1-Casein by Fast Protein Liquid Chromatography, Journal of Dairy Science, vol.72, issue.9, pp.2242-2246, 1989.
DOI : 10.3168/jds.S0022-0302(89)79354-1

D. A. Sass, S. A. Connelly, and A. J. , Streptococcus salivarius Bacteremia in a Cirrhotic Patient With Neutropenia Postesophageal Variceal Ligation, Journal of Clinical Gastroenterology, vol.40, issue.7, pp.40-654, 2006.
DOI : 10.1097/00004836-200608000-00023

K. Savijoki, H. Ingmer, and P. Varmanen, Proteolytic systems of lactic acid bacteria, Applied Microbiology and Biotechnology, vol.44, issue.12, pp.394-406, 2006.
DOI : 10.1099/00221287-146-6-1447

I. Schechter and A. Berger, On the size of the active site in proteases. I. Papain, Biochemical and Biophysical Research Communications, vol.27, issue.2, pp.157-162, 1967.
DOI : 10.1016/S0006-291X(67)80055-X

K. H. Schleifer, M. Ehrmann, U. Krusch, and H. Neve, Revival of the Species Streptococcus thermophilus (ex Orla-Jensen, 1919) nom. rev., Systematic and Applied Microbiology, vol.14, issue.4, pp.386-388, 1991.
DOI : 10.1016/S0723-2020(11)80314-0

O. Schneewind, P. Model, and V. A. Fischetti, Sorting of protein a to the staphylococcal cell wall, Cell, vol.70, issue.2, pp.267-281, 1992.
DOI : 10.1016/0092-8674(92)90101-H

G. Scolari, M. Vescovo, C. Zacconi, and F. Vescovi, Extraction and Partial Characterization of Proteolytic Activities from the Cell Surface of Lactobacillus helveticus Zuc2, Journal of Dairy Science, vol.89, issue.10, pp.3800-3809, 2006.
DOI : 10.3168/jds.S0022-0302(06)72421-3

S. Sela, A. Aviv, A. Tovi, I. Burstein, M. G. Caparon et al., Protein F: an adhesin of Streptococcus pyogenes binds fibronectin via two distinct domains, Molecular Microbiology, vol.282, issue.5, pp.1049-1055, 1993.
DOI : 10.1146/annurev.bi.52.070183.003553

S. Shahbal, D. Hemme, and M. J. Desmazeaud, strains (H-strains) correlated with a high acidification rate in milk, Le Lait, vol.71, issue.3, pp.351-357, 1991.
DOI : 10.1051/lait:1991327

URL : https://hal.archives-ouvertes.fr/hal-00929251

S. Shabhal, H. Denis, and P. R. , Characterization of a cell envelope-associated proteinase activity from Streptococcus thermophilus H-Strains, Appl Environ Microbiol, vol.59, pp.177-182, 1993.

K. M. Shammet, R. J. Brown, and D. J. Mcmahon, Proteolytic Activity of Proteinases on Macropeptide Isolated from ??-Casein, Journal of Dairy Science, vol.75, issue.6, pp.1380-1388, 1992.
DOI : 10.3168/jds.S0022-0302(92)77890-4

D. Shelver and B. J. , Expression of the Streptococcus agalactiae virulence-associated protease CspA in a soluble, active form utilizing the Gram-positive host, Lactococcus lactis, Journal of Biotechnology, vol.136, issue.3-4, 2008.
DOI : 10.1016/j.jbiotec.2008.06.002

A. Shet and P. Ferrieri, Neonatal and maternal group B streptococcal infections: a comprehensive review, Indian J. Med.Res, vol.120, pp.141-150, 2004.

A. Shihata and N. P. Shah, Proteolytic profiles of yogurt and probiotic bacteria, International Dairy Journal, vol.10, issue.5-6, pp.401-408, 2000.
DOI : 10.1016/S0958-6946(00)00072-8

M. Shimizu, S. W. Lee, S. Kaminogawa, and Y. K. , Emulsifying Properties of an N-Terminal Peptide Obtained from the Peptic Hydrolyzate of ?s1-Casein, Journal of Food Science, vol.42, issue.4, pp.1117-1120, 1984.
DOI : 10.1111/j.1365-2621.1970.tb00969.x

T. Akiyama, Complete genome sequencing and analysis of a Lancefield group G Streptococcus dysgalactiae subsp. equisimilis strain causing streptococcal toxic shock syndrome (STSS), BMC Genomics, vol.11, pp.12-17, 2011.

R. J. Siezen, Multi-domain, cell-envelope proteinases of lactic acid bacteria. Antonie Leeuwoenhoek, pp.139-155, 1999.

S. V. Silva, A. Pihlanto, and M. F. , Bioactive Peptides in Ovine and Caprine Cheeselike Systems Prepared with Proteases from Cynara cardunculus, Journal of Dairy Science, vol.89, issue.9, pp.3336-3344, 2006.
DOI : 10.3168/jds.S0022-0302(06)72370-0

D. C. Straus, S. J. Mattingly, and T. W. Milligan, Production of extracellular material by streptococci associated with subacute bacterial endocarditis, Infect. Immun, vol.17, pp.148-156, 1977.

D. C. Straus, Protease production by Streptococcus sanguis associated with subacute bacterial endocarditis, Infect. Immun, vol.38, pp.1037-1045, 1982.

Z. Sun, X. Chen, J. Wang, W. Zhao, Y. Shao et al., Complete Genome Sequence of Streptococcus thermophilus Strain ND03, Journal of Bacteriology, vol.193, issue.3, 2011.
DOI : 10.1128/JB.01374-10

A. Y. Tamime and D. H. , Yogurt: Technology and Biochemistry, Journal of Food Protection, vol.43, issue.12, pp.939-977, 1980.
DOI : 10.4315/0362-028X-43.12.939

J. Tauzin, L. Miclo, and G. J. , -casein, FEBS Letters, vol.51, issue.2, pp.369-374, 2002.
DOI : 10.1271/bbb1961.51.2557

J. Tauzin, L. Miclo, S. Roth, D. Mollé, and J. L. Gaillard, Tryptic hydrolysis of bovine ??S2-casein: identification and release kinetics of peptides, International Dairy Journal, vol.13, issue.1, pp.15-27, 2003.
DOI : 10.1016/S0958-6946(02)00127-9

B. E. Terzaghi and S. W. , Improved medium for lactic streptococci and their bacteriophages, Applied Microbiology, vol.29, pp.807-813, 1975.

H. Tettelin, K. E. Nelson, I. T. Paulsen, J. A. Eisen, T. D. Read et al., Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae, Science, vol.293, issue.5529, pp.498-506, 2001.
DOI : 10.1126/science.1061217

H. Tettelin, Streptococcal genomes provide food for thought, Nature Biotechnology, vol.45, issue.12, pp.1523-1524, 2004.
DOI : 10.1093/nar/29.1.126

H. Ton-that, A. Marraffini, and O. Schneewind, Protein sorting to the cell wall envelope of Gram-positive bacteria, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1694, issue.1-3, pp.269-278, 2004.
DOI : 10.1016/j.bbamcr.2004.04.014

G. Vanier, T. Sekizaki, M. C. Domínguez-punaro, M. Esgleas, M. Osaki et al., Disruption of srtA gene in Streptococcus suis results in decreased interactions with endothelial cells and extracellular matrix proteins, Veterinary Microbiology, vol.127, issue.3-4, pp.417-424, 2008.
DOI : 10.1016/j.vetmic.2007.08.032

S. Visser, F. A. Exterkate, C. J. Slangen, D. Veer, and G. J. , Comparative study of action of cell wall proteinases from various strains of Streptococcus cremoris on bovine ? s1, p.-casein, 1986.

P. Z. Wang and N. R. , Nucleotide sequence and expression of the beta-lactamase gene from Staphylococcus aureus plasmid pI258 in Escherichia coli, Bacillus subtilis, and Staphylococcus aureus., Journal of Bacteriology, vol.169, issue.4, pp.1763-1766, 1987.
DOI : 10.1128/jb.169.4.1763-1766.1987

C. Wang, M. Li, Y. Feng, F. Zheng, Y. Dong et al., The involvement of sortase A in high virulence of STSS-causing Streptococcus suis serotype 2, Archives of Microbiology, vol.12, issue.1, pp.23-33, 2009.
DOI : 10.3201/eid1206.051194

P. N. Ward, M. T. Holden, J. A. Leigh, N. Lennard, A. Bignell et al., Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis, BMC Genomics, vol.10, issue.1, p.54, 2009.
DOI : 10.1186/1471-2164-10-54

R. A. Welch, V. Burland, G. Plunkett, R. P. Roesch, P. Rasko et al., Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli, Proceedings of the National Academy of Sciences, vol.413, issue.6858, pp.17020-17024, 2002.
DOI : 10.1038/35101607

G. G. Whiting, J. T. Evans, S. Patel, and S. H. Gillespie, Purification of native ??-enolase from Streptococcus pneumoniae that binds plasminogen and is immunogenic, Journal of Medical Microbiology, vol.56, issue.10, pp.837-843, 2002.
DOI : 10.1086/517345

M. Yamaguchi, Y. Terao, T. Ogawa, T. Takahashi, S. Hamada et al., Role of Streptococcus sanguinis sortase A in bacterial colonization, Microbes and Infection, vol.8, issue.12-13, pp.2791-2796, 2006.
DOI : 10.1016/j.micinf.2006.08.010

N. Yamamoto, A. Akino, and T. Takano, Antihypertensive Effect of the Peptides Derived from Casein by an Extracellular Proteinase from Lactobacillus helveticus CP790, Journal of Dairy Science, vol.77, issue.4, pp.917-922, 1994.
DOI : 10.3168/jds.S0022-0302(94)77026-0

J. R. Yates, Mass Spectral Analysis in Proteomics, Annual Review of Biophysics and Biomolecular Structure, vol.33, issue.1, pp.297-316, 2004.
DOI : 10.1146/annurev.biophys.33.111502.082538

J. R. Yates, C. I. Ruse, and A. Nakorchevsky, Proteomics by Mass Spectrometry: Approaches, Advances, and Applications, Proteomics by Mass Spectrometry: Approaches, Advances, and Applications, pp.49-79, 2009.
DOI : 10.1146/annurev-bioeng-061008-124934

N. Zahraa, Le peptide ?-CN(f106-109) du lait : propriétés nutritionnelles, biologiques et techno-fonctionnelles, 2010.

4. Chez-la-souche, expliquer la libération partielle de la protéase, en effet la souche LMD-9 qui présente cette duplication possède sa protéase PRTS uniquement sous forme ancrée. La comparaison de la séquence primaire de la sortase déduite du gène srtA, chez les souches 4F44, ND03, LMD-9, PB18O, PB302 et CNRZ307, a montré que les sites catalytique (Arg, Cys, His) et actif (Gly, Lys, Ser, Ala, Thr, Ala) sont bien conservés. Six résidus d'acides aminés sont différents pour la sortase de la souche 4F44 par rapport aux autres souches. Parmi ces six résidus, le remplacement du résidu isoleucyl (I 222 ), important pour la bonne orientation du motif d'ancrage LPNTG au niveau du site actif, par le residu valyl (V 222 ) chez la souche 4F44 pourrait entraîner la libération partielle de PrtS. La séquence C-terminale de la protéase PrtS soluble de la souche 4F44 qui contient le domaine LPNTG a été caractérisée : les 2 peptides trypsiques « QVTQLPNTGENDTK » et « QVTQLPNTGENDTKYYLVPGVIIGLGTLLVSIRR » ont été identifiés en spectrométrie de masse MS/MS (ESI-FT-ICR) La présence de ces 2 peptides contenant le motif LPNTG intact indique que la liaison TG (cible de l'activité endopeptidasique de SrtA) n'est pas hydrolysée. La spécificité de coupure de PrtS de la souche 4F44 a été étudiée sur les protéines du lait : l'utilisation du surnageant de culture contenant la protéase PrtS soluble a montré que la caséine ? est préférentiellement hydrolysée par rapport aux autres protéines. Les sites de clivage sur les différentes caséines ont montrés une large spécificité de coupure vis-à-vis de résidus polaires non chargés et de résidus positivement chargés et de résidus hydrophobes encombrants, et Lys en position P1). Globalement 33 peptides à activité biologique sont obtenus avec cette enzyme ; ces peptides sont inhibiteurs de l'ECA, mitogènes, opioïdes, immunomodulants, antibactériens

. Globally, 33 bioactive peptides are obtained with this PrtS ; these peptides are antihypertensives, mitogenics, oipoide, immunomodulantors, antimicrobials